Gene Symbol: Csgalnact2
Description: chondroitin sulfate N-acetylgalactosaminyltransferase 2
Alias: 4632415D10Rik, Galnact2, chondroitin sulfate N-acetylgalactosaminyltransferase 2, beta4GalNAcT-2, chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2, chondroitin sulfate GalNAcT-2, galNAcT-2
Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K, et al
. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. J Biol Chem. 2007;282:4152-61 pubmed
..Our studies may lead to a new therapeutic intervention, ameliorating the outcome of cartilage degenerative diseases. ..
Watanabe Y, Takeuchi K, Higa Onaga S, Sato M, Tsujita M, Abe M, et al
. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J. 2010;432:47-55 pubmed publisher
..Additionally, type-II collagen fibres in developing cartilage were abnormally aggregated and disarranged in the homozygous mutant mice. These results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage. ..
Izumikawa T, Okuura Y, Koike T, Sakoda N, Kitagawa H. Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2. Biochem J. 2011;434:321-31 pubmed publisher
..Overall, these results suggest that the chain length of CS is regulated by C4ST-1 and ChGn-2 and that the enzymatic activities of these proteins play a critical role in CS elongation. ..
Sato T, Kudo T, Ikehara Y, Ogawa H, Hirano T, Kiyohara K, et al
. Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism. J Biol Chem. 2011;286:5803-12 pubmed publisher
..Our observations suggest that CSGalNAcT-1 is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan. ..
Anggraeni V, Emoto N, Yagi K, Mayasari D, Nakayama K, Izumikawa T, et al
. Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis. Biochem Biophys Res Commun. 2011;406:36-41 pubmed publisher
..Therefore, modulating their expression and activity might be a novel therapeutic strategy for atherosclerosis. ..
Izumikawa T, Sato B, Mikami T, Tamura J, Igarashi M, Kitagawa H. GlcUAÎ²1-3GalÎ²1-3GalÎ²1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1. J Biol Chem. 2015;290:5438-48 pubmed publisher
..Taken together, we conclude that the phosphorylated tetrasaccharide linkage is the preferred substrate for ChGn-1 and that ChGn-1 and XYLP cooperatively regulate the number of CS chains in growth plate cartilage. ..
Shimbo M, Suzuki R, Fuseya S, Sato T, Kiyohara K, Hagiwara K, et al
. Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2. PLoS ONE. 2017;12:e0190333 pubmed publisher
..Previous studies have suggested that two glycosyltransferases, Csgalnact1 (t1) and Csgalnact2 (t2), are critical for initiation of CS synthesis in vitro...