Csgalnact1

Summary

Gene Symbol: Csgalnact1
Description: chondroitin sulfate N-acetylgalactosaminyltransferase 1
Alias: 4732435N03Rik, CSGalNAcT-1, chondroitin sulfate N-acetylgalactosaminyltransferase 1, beta1,4 N-acetylgalactosaminyltransferase, beta4GalNAcT-1, chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1
Species: mouse
Products:     Csgalnact1

Top Publications

  1. Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K, et al. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. J Biol Chem. 2007;282:4152-61 pubmed
    ..Our studies may lead to a new therapeutic intervention, ameliorating the outcome of cartilage degenerative diseases. ..
  2. Watanabe Y, Takeuchi K, Higa Onaga S, Sato M, Tsujita M, Abe M, et al. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J. 2010;432:47-55 pubmed publisher
    ..To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)-null mice...
  3. Wilson D, Phamluong K, Lin W, Barck K, Carano R, Diehl L, et al. Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning. Dev Biol. 2012;363:413-25 pubmed publisher
    ..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1. ..
  4. Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, et al. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Blood. 2012;120:914-23 pubmed publisher
    ..Thus, the genes identified in our survey show high expression in ECs; further analysis of these genes should facilitate our understanding of the molecular mechanisms of vascular development in the mouse. ..
  5. Shimbo M, Suzuki R, Fuseya S, Sato T, Kiyohara K, Hagiwara K, et al. Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2. PLoS ONE. 2017;12:e0190333 pubmed publisher
    ..Previous studies have suggested that two glycosyltransferases, Csgalnact1 (t1) and Csgalnact2 (t2), are critical for initiation of CS synthesis in vitro...
  6. Sato T, Kudo T, Ikehara Y, Ogawa H, Hirano T, Kiyohara K, et al. Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism. J Biol Chem. 2011;286:5803-12 pubmed publisher
    ..b>Csgalnact1(-/-) mice were viable and fertile but exhibited slight dwarfism...
  7. Izumikawa T, Sato B, Mikami T, Tamura J, Igarashi M, Kitagawa H. GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1. J Biol Chem. 2015;290:5438-48 pubmed publisher
    ..Taken together, we conclude that the phosphorylated tetrasaccharide linkage is the preferred substrate for ChGn-1 and that ChGn-1 and XYLP cooperatively regulate the number of CS chains in growth plate cartilage. ..