Gene Symbol: Csf2rb2
Description: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
Alias: AIC2A, BetaIl3, Bil3, Csfgmrb, Il3r, Il3rb, Il3rb2, interleukin-3 receptor class 2 subunit beta, IL-3 receptor class 2 subunit beta, IL-3R class 2 subunit beta, colony-stimulating factor 2 receptor subunit beta-2, interleukin-3 receptor class II beta chain
Species: mouse
Products:     Csf2rb2

Top Publications

  1. Clarke M, Volpe G, Sheriff L, Walton D, Ward C, Wei W, et al. Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3. Leukemia. 2017;31:957-966 pubmed publisher
    ..MYB acts on MAPK signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2. This mechanistic insight points to pathways that might be targeted therapeutically in MPN. ..
  2. Scott C, Robb L, Papaevangeliou B, Mansfield R, Nicola N, Begley C. Reassessment of interactions between hematopoietic receptors using common beta-chain and interleukin-3-specific receptor beta-chain-null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating f. Blood. 2000;96:1588-90 pubmed
    ..GM-CSF), interleukin-3 (IL-3), and IL-5 common beta-chain (B(c)) and the gene for the IL-3 specific receptor (BIL3) were generated...
  3. Paling N, Welham M. Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling. Biochem J. 2002;368:885-94 pubmed
    ..resulting from expression of these SHP-1 variants demonstrated that the beta chain of the IL-3 receptor (Aic2A) was hypo-phosphorylated in cells expressing WT SHP-1 and hyper-phosphorylated in those expressing R459M SHP-1...
  4. Asquith K, Ramshaw H, Hansbro P, Beagley K, Lopez A, Foster P. The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation. J Immunol. 2008;180:1199-206 pubmed
  5. Norga K, Pless M, Stanulla M, TePas E, Mathey Prevot B. Multiple transcription start sites and 5' alternate splicing of murine IL-3 receptor beta-chain transcripts. Biochem Biophys Res Commun. 1994;205:886-92 pubmed
    ..These results were confirmed by RNAse-protection assay. The complex organization as evident from our data establishes an experimental framework for future experiments aimed at the study of the promoters for the murine IL-3R beta genes. ..
  6. Hara T, Miyajima A. Regulation of IL-3 receptor expression: evidence for a post-transcriptional mechanism that dominantly suppresses the expression of beta subunits. Int Immunol. 1994;6:1525-33 pubmed
    ..Two homologous beta subunits of IL-3R are present in the mouse: AIC2A is the IL-3 specific beta subunit, and AIC2B is the common beta subunit shared by IL-3, IL-5 and granulocyte ..
  7. Shalaby F, Rossant J, Yamaguchi T, Gertsenstein M, Wu X, Breitman M, et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995;376:62-6 pubmed
    ..These results indicate that Flk-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo. ..
  8. Gautier E, Chow A, Spanbroek R, Marcelin G, Greter M, Jakubzick C, et al. Systemic analysis of PPAR? in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity. J Immunol. 2012;189:2614-24 pubmed publisher
    ..In addition, this work identifies specific macrophage populations as potential targets for the anti-inflammatory actions of PPAR? agonists. ..
  9. Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer S, Belkaid Y, et al. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science. 2014;343:1249288 pubmed publisher
    ..Our findings reveal that commensal microbes promote a crosstalk between innate myeloid and lymphoid cells that leads to immune homeostasis in the intestine...

More Information


  1. Gorman D, Itoh N, Kitamura T, Schreurs J, Yonehara S, Yahara I, et al. Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family. Proc Natl Acad Sci U S A. 1990;87:5459-63 pubmed
    ..from a mouse mast cell line which is homologous to the previously characterized gene for the IL-3 receptor (AIC2A)...
  2. Schultze C, Hildebrand F, Noack S, Krettek C, Zeckey C, Neunaber C. Identification of potential biomarkers for post-traumatic complications released after trauma-hemorrhage from murine Kupffer cells and its investigation in lung and liver. Biomarkers. 2016;21:645-52 pubmed publisher
    ..Expression analysis and real-time-PCR revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5...
  3. Park L, Martin U, Sorensen R, Luhr S, Morrissey P, Cosman D, et al. Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex. Proc Natl Acad Sci U S A. 1992;89:4295-9 pubmed
    ..Coexpression of clone 71 with a cDNA corresponding to a low-affinity interleukin 3 (IL-3) receptor (AIC2A) did not alter the affinity of binding of either GM-CSF or IL-3...
  4. Carr P, Ewens C, Dai J, Ollis D, Murphy J, Jackson C, et al. Crystal structure of the mouse interleukin-3 ?-receptor: insights into interleukin-3 binding and receptor activation. Biochem J. 2014;463:393-403 pubmed publisher
    ..Molecular modelling of the IL-3-?IL-3 interface, in conjunction with previous mutational studies, suggests that divergent evolution of both ?IL-3 and IL-3 underlies their unique capacity for direct interaction and specificity. ..
  5. Mirza S, Chen J, Wen B, Ewens C, Dai J, Murphy J, et al. Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3. J Biol Chem. 2010;285:22370-81 pubmed publisher
  6. Chen J, Gao X, Yang L, Fu W, Liang L, Li J, et al. Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation. Sci Rep. 2016;6:26003 pubmed publisher
    ..The β chain cytokine receptor Csf2rb2 was identified as a downstream molecule of Notch signaling in hematopoietic cells...
  7. Tao W, Lin H, Sun T, Samanta A, Arlinghaus R. BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor. Oncogene. 2008;27:3194-200 pubmed
    ..All of these findings indicate that Bcr-Abl oncoprotein requires the IL-3 receptor/Jak2/Stat5 pathways for oncogenic transformation of NIH 3T3 fibroblasts. ..
  8. Huang H, Lin Y, Chen C, Chang T. Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells. J Cell Biochem. 2005;96:361-75 pubmed
  9. Liboi E, Jubinsky P, Andrews N, Nathan D, Mathey Prevot B. Enhanced expression of interleukin-3 and granulocyte-macrophage colony-stimulating factor receptor subunits in murine hematopoietic cells stimulated with hematopoietic growth factors. Blood. 1992;80:1183-9 pubmed
    b>AIC2A and AIC2B are closely related genes encoding components of the receptors for murine interleukin-3 (IL-3) (AIC2A) and granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5 (AIC2B)...
  10. Bone H, Welham M. Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2 following IL-3 stimulation. Contribution of Shc PTB and SH2 domains. Cell Signal. 2000;12:183-94 pubmed
    ..signalling pathways and demonstrate that Shc associates with the beta subunits of the human (betac) and murine (Aic2A) IL-3 receptors, SHIP and Gab2 following IL-3 stimulation...
  11. Hara T, Miyajima A. Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3). EMBO J. 1992;11:1875-84 pubmed
    ..In contrast to the human, the mouse has two distinct but related genes, AIC2A and AIC2B, both of which are homologous to the human beta c gene...
  12. Wang H, Ogorochi T, Arai K, Miyajima A. Structure of mouse interleukin 3 (IL-3) binding protein (AIC2A). Amino acid residues critical for IL-3 binding. J Biol Chem. 1992;267:979-83 pubmed
    Despite the high degree of sequence homology between two mouse proteins AIC2A and AIC2B (91% at the amino acid level), only the AIC2A protein binds interleukin 3 (IL-3)...
  13. Nishinakamura R, Nakayama N, Hirabayashi Y, Inoue T, Aud D, McNeil T, et al. Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal. Immunity. 1995;2:211-22 pubmed
    ..These data define the role of beta c in vivo, and show a phenotype that is likely to be the cumulative effect of loss of GM-CSF and IL-5 stimulation. ..
  14. Lesokhin A, Hohl T, Kitano S, Cortez C, Hirschhorn Cymerman D, Avogadri F, et al. Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment. Cancer Res. 2012;72:876-86 pubmed publisher
    ..Our results argue that therapeutic targeting of monocytic MDSCs would enhance outcomes in immunotherapy. ..
  15. Kenkel J, Tseng W, Davidson M, Tolentino L, Choi O, Bhattacharya N, et al. An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer. Cancer Res. 2017;77:4158-4170 pubmed publisher
    ..Therapeutic strategies to block the accumulation and immunosuppressive activity of such cells may help prevent PDAC progression and metastatic relapse after surgical resection. Cancer Res; 77(15); 4158-70. ©2017 AACR. ..
  16. Kreslavsky T, Vilagos B, Tagoh H, Poliakova D, Schwickert T, Wöhner M, et al. Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol. 2017;18:442-455 pubmed publisher
    ..Bhlhe41 directly repressed the expression of cell-cycle regulators and inhibitors of BCR signaling while enabling pro-survival cytokine signaling. Thus, Bhlhe41 controls the development, BCR repertoire and self-renewal of B-1a cells. ..
  17. Gorman D, Itoh N, Jenkins N, Gilbert D, Copeland N, Miyajima A. Chromosomal localization and organization of the murine genes encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3, granulocyte/macrophage colony-stimulating factor, and interleukin 5 receptors. J Biol Chem. 1992;267:15842-8 pubmed
    Chromosomal genes for two mouse homologous beta subunits (AIC2A and AIC2B) of the interleukin-3, granulocyte/macrophage colony-stimulating factor, and interleukin-5 receptors were characterized...
  18. Giacomin P, Siracusa M, Walsh K, Grencis R, Kubo M, Comeau M, et al. Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. J Immunol. 2012;189:4371-8 pubmed publisher
    ..Collectively, these data suggest that the TSLP-basophil pathway may represent a new target in the design of therapeutic intervention strategies to promote or limit Th2 cytokine-dependent immunity and inflammation. ..
  19. Itoh N, Yonehara S, Schreurs J, Gorman D, Maruyama K, Ishii A, et al. Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science. 1990;247:324-7 pubmed
    ..A sequence comparison of the IL-3 receptor with other cytokine receptors (erythropoietin, IL-4, IL-6, and the beta chain IL-2 receptor) revealed a common motif of a distinct receptor gene family. ..
  20. Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo Cantero J, et al. GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity. 2012;36:1031-46 pubmed publisher
    ..Thus, Csf-2 is important in vaccine-induced CD8(+) T cell immunity through the regulation of nonlymphoid tissue DC homeostasis rather than control of inflammatory DCs in vivo. ..
  21. Herbarth B, Pingault V, Bondurand N, Kuhlbrodt K, Hermans Borgmeyer I, Puliti A, et al. Mutation of the Sry-related Sox10 gene in Dominant megacolon, a mouse model for human Hirschsprung disease. Proc Natl Acad Sci U S A. 1998;95:5161-5 pubmed
  22. Siracusa M, Saenz S, Hill D, Kim B, Headley M, Doering T, et al. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature. 2011;477:229-33 pubmed publisher
  23. McClanahan T, Dalrymple S, Barkett M, Lee F. Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hematopoietic cells. Blood. 1993;81:2903-15 pubmed
    ..The defined temporal order for the expression of these genes suggests that they may be useful as markers for multiple stages in the development of different hematopoietic cell lineages during embryogenesis. ..
  24. Nicola N, Robb L, Metcalf D, Cary D, Drinkwater C, Begley C. Functional inactivation in mice of the gene for the interleukin-3 (IL-3)-specific receptor beta-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells. Blood. 1996;87:2665-74 pubmed
  25. Chin H, Nakamura N, Kamiyama R, Miyasaka N, Ihle J, Miura O. Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. Blood. 1996;88:4415-25 pubmed
    ..induces binding of Stat5 to the tyrosine-phosphorylated Epo receptor (EpoR) or IL-3 receptor beta subunit (betaIL3), respectively, in IL-3-dependent 32D cells expressing the EpoR...
  26. Pingault V, Puliti A, Prehu M, Samadi A, Bondurand N, Goossens M. Human homology and candidate genes for the Dominant megacolon locus, a mouse model of Hirschsprung disease. Genomics. 1997;39:86-9 pubmed
    ..Three genes (Smstr3, Lgals1, and Pdgfb) are possible Dom candidates, as they do not recombine with the Dom mutation in a 252 Dom/+ animal backcross. ..
  27. Mirza S, Chen J, Murphy J, Young I. The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors. J Biol Chem. 2010;285:24759-68 pubmed publisher
    ..Our data are most consistent with a role for the domain 1 D-E loop disulfide of hbetac and beta(IL-3) in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling. ..
  28. Kim S, Prout M, Ramshaw H, Lopez A, LeGros G, Min B. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J Immunol. 2010;184:1143-7 pubmed publisher
    ..Our results reveal a previously unknown role of IL-3 in recruiting basophils to the LN and demonstrate that basophils are not necessarily associated with the development of Th2 immunity during parasite infection...
  29. Sköld M, Behar S. Tuberculosis triggers a tissue-dependent program of differentiation and acquisition of effector functions by circulating monocytes. J Immunol. 2008;181:6349-60 pubmed
    ..This report provides the first direct evidence for monocyte differentiation into both the macrophage and DC lineages in vivo following infection with a live human pathogen. ..
  30. Schreurs J, Hung P, May W, Arai K, Miyajima A. AIC2A is a component of the purified high affinity mouse IL-3 receptor: temperature-dependent modulation of AIC2A structure. Int Immunol. 1991;3:1231-42 pubmed
    ..The gene for a 115 kDa, low affinity IL-3 binding protein (AIC2A) was recently cloned...
  31. Fung M, Mak N, Leung K, Hapel A. Distinguishing between mouse IL-3 and IL-3 receptor-like (IL-5/GM-CSF receptor converter) mRNAs using the polymerase chain reaction method. J Immunol Methods. 1992;149:97-103 pubmed
    ..In contrast, neither species of mRNA was detected in the T lymphoma cell line (EL-4). The ratio of IL-3 receptor-like mRNA to IL-3 receptor mRNA was usually greater than 1, except in 32D cl-23 cells where it was 0.66. ..
  32. Jubinsky P, Krijanovski O, Nathan D, Tavernier J, Sieff C. The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood. 1997;90:1867-73 pubmed
    ..This suggests that these cytokine receptors exist as a large supercomplex and offers the first molecular explanation for the synergistic effects of IL-3 and GM-CSF with Epo during erythropoiesis. ..