Gene Symbol: Csf1r
Description: colony stimulating factor 1 receptor
Alias: AI323359, CD115, CSF-1R, Csfmr, Fim-2, Fim2, Fms, M-CSF-R, M-CSFR, macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, CSF-1-R, c-fms, proto-oncogene c-Fms, proto-oncogene fms
Species: mouse
Products:     Csf1r

Top Publications

  1. Keng V, Yagi H, Ikawa M, Nagano T, Myint Z, Yamada K, et al. Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage. Biochem Biophys Res Commun. 2000;276:1155-61 pubmed
    ..These results indicate that Hex plays an essential role in progenitor cells which commit to the hepatic endoderm and in the hematopoietic differentiation of the monocyte lineage. ..
  2. Jenkins B, Grail D, Inglese M, Quilici C, Bozinovski S, Wong P, et al. Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression. Mol Cell Biol. 2004;24:1453-63 pubmed
    ..When compared to the level of expression in gp130(wt/wt) BMMs, c-fms expression was elevated in gp130(Delta STAT/Delta STAT) BMMs but reduced in gp130(Y757F/Y757F) BMMs...
  3. Palis J, Robertson S, Kennedy M, Wall C, Keller G. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development. 1999;126:5073-84 pubmed
  4. MacDonald K, Palmer J, Cronau S, Seppanen E, Olver S, Raffelt N, et al. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood. 2010;116:3955-63 pubmed publisher
    ..system requires macrophage colony-stimulating factor (CSF-1) signaling through the CSF-1 receptor (CSF1R, CD115)...
  5. Himes S, Tagoh H, Goonetilleke N, Sasmono T, Oceandy D, Clark R, et al. A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. J Leukoc Biol. 2001;70:812-20 pubmed
    The c-fms gene encodes the receptor for macrophage colony-stimulating factor-1. This gene is expressed selectively in the macrophage cell lineage...
  6. Luo J, Elwood F, Britschgi M, Villeda S, Zhang H, Ding Z, et al. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med. 2013;210:157-72 pubmed publisher
    Colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34) are functional ligands of the CSF1 receptor (CSF1R) and thus are key regulators of the monocyte/macrophage lineage...
  7. Rothwell V, Rohrschneider L. Murine c-fms cDNA: cloning, sequence analysis and retroviral expression. Oncogene Res. 1987;1:311-24 pubmed
    We have isolated and sequenced a cDNA clone coding for the murine c-fms gene. The 3677 nucleotide cDNA clone codes for a protein of 976 amino acids, which has 76% and 75% homology to the v-fms and human proteins, respectively...
  8. Dai X, Ryan G, Hapel A, Dominguez M, Russell R, Kapp S, et al. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood. 2002;99:111-20 pubmed
    ..To investigate the in vivo specificity of CSF-1 for the CSF-1R, the mouse Csf1r gene was inactivated...
  9. Dai X, Zong X, Akhter M, Stanley E. Osteoclast deficiency results in disorganized matrix, reduced mineralization, and abnormal osteoblast behavior in developing bone. J Bone Miner Res. 2004;19:1441-51 pubmed
    ..examined the micro- and ultrastructure of the developing bones of osteoclast-deficient CSF-1R-nullizygous mice (Csf1r(-/-) mice). Colony-stimulating factor-1 receptor (CSF-1R)-mediated signaling is critical for osteoclastogenesis...

More Information


  1. Nandi S, Gokhan S, Dai X, Wei S, Enikolopov G, Lin H, et al. The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation. Dev Biol. 2012;367:100-13 pubmed publisher
    ..Here we show that compared to wild type mice, CSF-1R-deficient (Csf1r-/-) mice have smaller brains of greater mass...
  2. Banaei Bouchareb L, Gouon Evans V, Samara Boustani D, Castellotti M, Czernichow P, Pollard J, et al. Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice. J Leukoc Biol. 2004;76:359-67 pubmed
    ..The demonstration of the colony-stimulating factor 1-dependent macrophage involvement in life-time pancreas development/remodeling allows us to pinpoint the tissue-modeling and remodeling functions of this leukocyte lineage. ..
  3. Lichanska A, Browne C, Henkel G, Murphy K, Ostrowski M, McKercher S, et al. Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1. Blood. 1999;94:127-38 pubmed
    ..The mouse c-fms mRNA, encoding the receptor for macrophage colony-stimulating factor (CSF-1), was expressed on phagocytic cells in ..
  4. Coniglio S, Eugenin E, Dobrenis K, Stanley E, West B, Symons M, et al. Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Mol Med. 2012;18:519-27 pubmed publisher
  5. Yue X, Favot P, Dunn T, Cassady A, Hume D. Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation. Mol Cell Biol. 1993;13:3191-201 pubmed
    The gene encoding the receptor for macrophage colony-stimulating factor 1 (CSF-1), the c-fms protooncogene, is selectively expressed in immature and mature mononuclear phagocytes and trophoblasts. Exon 1 is expressed only in trophoblasts...
  6. Tagoh H, Schebesta A, Lefevre P, Wilson N, Hume D, Busslinger M, et al. Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible. EMBO J. 2004;23:4275-85 pubmed
    The murine c-fms (Csf1r) gene encodes the macrophage colony-stimulating factor receptor, which is essential for macrophage development...
  7. Akcora D, Huynh D, Lightowler S, Germann M, Robine S, de May J, et al. The CSF-1 receptor fashions the intestinal stem cell niche. Stem Cell Res. 2013;10:203-12 pubmed publisher
    ..Nevertheless, we previously showed that germline CSF-1 receptor (Csf1r) knock out (KO) or Csf1 mutation is associated with an absence of mature PC, reduced crypt proliferation and ..
  8. Sherr C, Rettenmier C, Sacca R, Roussel M, Look A, Stanley E. The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell. 1985;41:665-76 pubmed
    The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen...
  9. Ohno H, Kubo K, Murooka H, Kobayashi Y, Nishitoba T, Shibuya M, et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006;5:2634-43 pubmed
    ..In this study, we investigated whether an inhibitor of M-CSF receptor (c-Fms) suppresses osteoclast-dependent osteolysis in bone metastatic lesions...
  10. Tagoh H, Himes R, Clarke D, Leenen P, Riggs A, Hume D, et al. Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells. Genes Dev. 2002;16:1721-37 pubmed
    Expression of the gene for the macrophage colony stimulating factor receptor (CSF-1R), c-fms, has been viewed as a hallmark of the commitment of multipotent precursor cells to macrophages...
  11. Sasmono R, Ehrnsperger A, Cronau S, Ravasi T, Kandane R, Hickey M, et al. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J Leukoc Biol. 2007;82:111-23 pubmed
    ..is controlled by macrophage colony-stimulating factor (CSF-1), which binds to a receptor (CSF-1R) encoded by the c-fms proto-oncogene...
  12. Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, et al. Origin of the lamina propria dendritic cell network. Immunity. 2009;31:513-25 pubmed publisher
    ..lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands...
  13. Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai X, et al. Langerhans cells arise from monocytes in vivo. Nat Immunol. 2006;7:265-73 pubmed
    ..These results identify Gr-1(hi) monocytes as the direct precursors for LCs in vivo and establish the importance of the CSF-1 receptor in this process. ..
  14. He Y, Rhodes S, Chen S, Wu X, Yuan J, Yang X, et al. c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions. PLoS ONE. 2012;7:e46900 pubmed publisher
    ..Here, we show that M-CSF binding to its receptor, c-Fms, results in increased c-Fms activation in Nf1(+/) (-) osteoclast progenitors, mediating multiple gain-in-functions ..
  15. Erblich B, Zhu L, Etgen A, Dobrenis K, Pollard J. Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. PLoS ONE. 2011;6:e26317 pubmed publisher
    ..b>Csf1r nulls rarely survive to adulthood and therefore to study the role of CSF-1R in olfaction we used the viable null ..
  16. Li J, Chen K, Zhu L, Pollard J. Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis. 2006;44:328-35 pubmed
    ..To distinguish cell type specific phenotypes, we have created a conditional allele of the Csf1r by placing LoxP sites around Exon 5 of the Csf1r gene in mice...
  17. Huynh D, Akcora D, Malaterre J, Chan C, Dai X, Bertoncello I, et al. CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response. PLoS ONE. 2013;8:e56951 pubmed publisher
    ..Colons from Csf1r null and Csf1(op/op) mice were isolated and sectioned for IHC identification of enterocytes, enteroendocrine cells,..
  18. Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330:841-5 pubmed publisher
    ..These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders...
  19. Chihara T, Suzu S, Hassan R, Chutiwitoonchai N, Hiyoshi M, Motoyoshi K, et al. IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation. Cell Death Differ. 2010;17:1917-27 pubmed publisher
    Macrophage colony-stimulating factor (M-CSF) regulates the production, survival and function of macrophages through Fms, the receptor tyrosine kinase...
  20. Liu H, Leo C, Chen X, Wong B, Williams L, Lin H, et al. The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1. Biochim Biophys Acta. 2012;1824:938-45 pubmed publisher
    ..negative cooperativity of CSF-1 at the receptor-recognition sites, in combination with the difference in hydrophobicity which dictates a more stable IL-34:CSF-1R complex compared to the CSF-1:CSF-1R complex. ..
  21. Chang Y, Albright S, Lee F. Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development. J Neuroimmunol. 1994;52:9-17 pubmed
    ..Transcripts encoding the M-CSF receptor (c-fms) were also detected at all of these time points...
  22. Ide H, Seligson D, Memarzadeh S, Xin L, Horvath S, Dubey P, et al. Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proc Natl Acad Sci U S A. 2002;99:14404-9 pubmed
    ..These observations correlate CSF-1R expression with changes in the growth and development of the normal and neoplastic prostate. ..
  23. Jose M, Le Meur Y, Atkins R, Chadban S. Blockade of macrophage colony-stimulating factor reduces macrophage proliferation and accumulation in renal allograft rejection. Am J Transplant. 2003;3:294-300 pubmed
    ..importance of M-CSF in driving macrophage proliferation during acute rejection, we blocked the M-CSF receptor, c-fms, in a mouse model of acute renal allograft rejection...
  24. Murase S, Hayashi Y. Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells. J Neurosci. 1998;18:10481-92 pubmed
    To investigate whether the c-fms proto-oncogene plays a role in the CNS, we examined its expression in mouse brain...
  25. Felix R, Hofstetter W, Wetterwald A, Cecchini M, Fleisch H. Role of colony-stimulating factor-1 in bone metabolism. J Cell Biochem. 1994;55:340-9 pubmed
    ..The expression of CSF-1 receptors, encoded by the proto-oncogene c-fms, by osteoclast precursors and osteoclasts, suggested an effect of this cytokine not only during osteoclast ..
  26. Ginhoux F, Liu K, Helft J, Bogunovic M, Greter M, Hashimoto D, et al. The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med. 2009;206:3115-30 pubmed publisher
    ..DCs are related to lymphoid organ CD8(+) DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8)...
  27. Sapi E, Kacinski B. The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 1999;220:1-8 pubmed
    Colony stimulating factor (CSF-1) and its receptor (CSF-1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation...
  28. Irvine K, Burns C, Wilks A, Su S, Hume D, Sweet M. A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. FASEB J. 2006;20:1921-3 pubmed
    ..CSF-1R inhibitors such as CYC10268 provide a powerful tool to dissect the role of the CSF-1/CSF-1R signaling system in a range of biological systems and have potential for a number of therapeutic applications. ..
  29. Stanley E, Berg K, Einstein D, Lee P, Pixley F, Wang Y, et al. Biology and action of colony--stimulating factor-1. Mol Reprod Dev. 1997;46:4-10 pubmed
    ..The CSF-1R is a tyrosine kinase encoded by the c-fms proto-oncogene product...
  30. Wei S, Nandi S, Chitu V, Yeung Y, Yu W, Huang M, et al. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol. 2010;88:495-505 pubmed publisher
    ..Thus, the different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues. ..
  31. Yoder M, Hiatt K, Dutt P, Mukherjee P, Bodine D, Orlic D. Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity. 1997;7:335-44 pubmed
    ..Surprisingly, 37-fold more CD34+c-Kit+ cells reside in the day 9 yolk sac than in the P-Sp. In sum, definitive HSC are coexistent, but not equal in number, in the murine yolk sac and P-Sp prior to fetal liver colonization. ..
  32. de Parseval N, Bordereaux D, Varlet P, Gisselbrecht S, Sola B. Isolation of new oncogenic forms of the murine c-fms gene. J Virol. 1995;69:3597-604 pubmed
    The c-fms gene encodes the receptor for the macrophage colony-stimulating factor, which plays a key role in the proliferation and differentiation of cells of the myelomonocytic lineage...
  33. Kaupmann K, Becker Follmann J, Scherer G, Jockusch H, Starzinski Powitz A. The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. Genomics. 1992;14:488-90 pubmed
    ..The gene order cen-Junb-Um-Tat-(Cdh3/Aprt) was determined. The human homologue CDH3 was mapped to chromosome 16q24.1-qter by analyzing human/mouse somatic cell hybrids. ..
  34. DeFalco T, Bhattacharya I, Williams A, Sams D, Capel B. Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A. 2014;111:E2384-93 pubmed publisher
    ..These findings reveal a previously unappreciated role for macrophages in testis morphogenesis and suggest that macrophages are an intermediary between neovascularization and organ architecture during fetal organogenesis. ..
  35. Melcher M, Unger B, Schmidt U, Rajantie I, Alitalo K, Ellmeier W. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. J Immunol. 2008;180:8048-56 pubmed
    ..Taken together, our study shows that Tec and Btk regulate M-CSFR signaling-induced macrophage survival and provides a novel link between Tec family kinases and the regulation of caspase-11 and GM-CSFRalpha expression. ..
  36. Dowdy C, Xie R, Frederick D, Hussain S, Zaidi S, Vradii D, et al. Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation. Hum Mol Genet. 2010;19:1048-57 pubmed publisher
    ..We propose that compromising the C-terminal functions of Runx1 is a common mechanism for the pathological consequences of a variety of somatic mutations and Runx1-related leukemic fusion proteins observed in human patients. ..
  37. Krysinska H, Hoogenkamp M, Ingram R, Wilson N, Tagoh H, Laslo P, et al. A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene. Mol Cell Biol. 2007;27:878-87 pubmed
    ..low-level transcription and partial chromatin reorganization of myeloid cell-specific genes including the c-fms (csf1R) locus. Expression of the c-fms gene is dependent on the Ets family transcription factor PU...
  38. Sauter K, Bouhlel M, O Neal J, Sester D, Tagoh H, Ingram R, et al. The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus. PLoS ONE. 2013;8:e54935 pubmed publisher
    ..However, the molecular details of how FIRE activity is regulated and how it impacts the Csf1r promoter have not been characterised...
  39. Ishida Kitagawa N, Tanaka K, Bao X, Kimura T, Miura T, Kitaoka Y, et al. Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J Biol Chem. 2012;287:17493-502 pubmed publisher
    ..Together, these results suggested that the Siglec-15-DAP12-Syk-signaling cascade plays a critical role in functional osteoclast formation...
  40. Kawakami T, Lichtnekert J, Thompson L, Karna P, Bouabe H, Hohl T, et al. Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. J Immunol. 2013;191:3358-72 pubmed publisher
    ..In summary, resident kidney MPCs comprise discrete subpopulations, which cannot be simply classified into the conventional entities, and they produce anti-inflammatory and tissue-homeostatic factors to differing degrees. ..
  41. Reedijk M, Liu X, van der Geer P, Letwin K, Waterfield M, Hunter T, et al. Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions. EMBO J. 1992;11:1365-72 pubmed
    ..Complex formation between the CSF-1R and PI 3'-kinase can therefore be reconstructed in vitro in a specific interaction involving the phosphorylated receptor KI and the SH2 domains of p85 alpha. ..
  42. Auffray C, Fogg D, Narni Mancinelli E, Senechal B, Trouillet C, Saederup N, et al. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med. 2009;206:595-606 pubmed publisher
    ..CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs. ..
  43. Endele M, Loeffler D, Kokkaliaris K, Hilsenbeck O, Skylaki S, Hoppe P, et al. CSF-1-induced Src signaling can instruct monocytic lineage choice. Blood. 2017;129:1691-1701 pubmed publisher
    ..Moreover, c-Src activity is sufficient to drive M fate, even in nonmyeloid cells. ..
  44. Wilhelmsen K, Copp J, Glenn G, Hoffman R, Tucker P, van der Geer P. Purification and identification of protein-tyrosine kinase-binding proteins using synthetic phosphopeptides as affinity reagents. Mol Cell Proteomics. 2004;3:887-95 pubmed
    ..Novel protein-protein interactions may provide useful targets for the development of drugs that interfere with the activation of signaling cascades used by protein-tyrosine kinases to turn on cell division. ..
  45. Stoecker K, Weigelt K, Ebert S, Karlstetter M, Walczak Y, Langmann T. Induction of STAP-1 promotes neurotoxic activation of microglia. Biochem Biophys Res Commun. 2009;379:121-6 pubmed publisher
    ..STAP-1 overexpression also leads to an interaction with the M-CSF receptor/c-Fms diminishing its ligand-dependent phosphorylation...
  46. Clarke M, Volpe G, Sheriff L, Walton D, Ward C, Wei W, et al. Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3. Leukemia. 2017;31:957-966 pubmed publisher
    ..MYB acts on MAPK signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2. This mechanistic insight points to pathways that might be targeted therapeutically in MPN. ..
  47. Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, et al. PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Nat Med. 2010;16:580-5, 1p following 585 pubmed publisher
    ..1 to stimulate the expression of macrophage colony-stimulating factor receptor (CSF1R, also known as M-CSFR, c-FMS or CD115). Studies using PU.1-deficient mice showed that PU...
  48. Hoggan M, Halden N, Buckler C, Kozak C. Genetic mapping of the mouse c-fms proto-oncogene to chromosome 18. J Virol. 1988;62:1055-6 pubmed
    ..X mouse somatic cell hybrids were analyzed by Southern blot hybridization with a probe specific for the cellular c-fms proto-oncogene...
  49. Ikeda O, Sekine Y, Kakisaka M, Tsuji S, Muromoto R, Ohbayashi N, et al. STAP-2 regulates c-Fms/M-CSF receptor signaling in murine macrophage Raw 264.7 cells. Biochem Biophys Res Commun. 2007;358:931-7 pubmed
    Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages...
  50. Osborne J, den Elzen N, Lichanska A, Costelloe E, Yamada T, Cassady A, et al. Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS. J Leukoc Biol. 1998;64:692-701 pubmed
    ..Attempts to express mDEP-1 constitutively in the macrophage cell line RAW264 were unsuccessful, with results suggesting that the gene product inhibits cell proliferation. ..
  51. Passey R, Williams E, Lichanska A, Wells C, Hu S, Geczy C, et al. A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. J Immunol. 1999;163:2209-16 pubmed
    ..The S100A8 null provides a new model for studying fetal-maternal interactions during implantation. ..
  52. Sakai Y, Miyawaki S, Shimizu A, Ohno K, Watanabe T. A molecular genetic linkage map of mouse chromosome 18, including spm, Grl-1, Fim-2/c-fms, and Mbp. Biochem Genet. 1991;29:103-13 pubmed
    ..m. molossinus, Chinese mice of wild origin, and M. m. yamashinai) carry the Grl-1b, Fim-2b, and Mbpb alleles. Only castaneus strains carry the intermediate combination of the Grl-1b, Fim-2a, and Mbpb alleles. ..
  53. Elmore M, Najafi A, Koike M, Dagher N, Spangenberg E, Rice R, et al. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron. 2014;82:380-97 pubmed publisher
    The colony-stimulating factor 1 receptor (CSF1R) is a key regulator of myeloid lineage cells...
  54. Arnò B, Grassivaro F, Rossi C, Bergamaschi A, Castiglioni V, Furlan R, et al. Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex. Nat Commun. 2014;5:5611 pubmed publisher
    ..Finally, we show that the depletion of microglia in mice lacking receptor for colony-stimulating factor-1 (Csf-1R) reduces BPs into the cerebral cortex. ..
  55. Aikawa Y, Yamagata K, Katsumoto T, Shima Y, Shino M, Stanley E, et al. Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells. Cancer Sci. 2015;106:227-36 pubmed publisher
    ..1 or ablation of cells expressing CSF-1R. Kinase inhibitors specific for CSF-1R prolong survival time. These findings indicate that PU.1-mediated upregulation of CSF-1R is a critical effector of MLL leukemogenesis. ..
  56. Kitamura T, Qian B, Soong D, Cassetta L, Noy R, Sugano G, et al. CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. J Exp Med. 2015;212:1043-59 pubmed publisher
    ..These data suggest that inhibition of CCR1, the distal part of this signaling relay, may have a therapeutic impact in metastatic disease with lower toxicity than blocking upstream targets. ..
  57. Simpson E, McLaren A, Chandler P, Tomonari K. Expression of H-Y antigen by female mice carrying Sxr. Transplantation. 1984;37:17-21 pubmed
    ..They also show that the presence of H-Y in adult females does not impair reproduction. ..
  58. Myles G, Brandt C, Carlberg K, Rohrschneider L. Tyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalization. Mol Cell Biol. 1994;14:4843-54 pubmed
    The receptor (Fms) for macrophage colony-stimulating factor (M-CSF) is a member of the tyrosine kinase class of growth factor receptors...
  59. Moriyama H, Yamamoto T, Takatsuka H, Umezu H, Tokunaga K, Nagano T, et al. Expression of macrophage colony-stimulating factor and its receptor in hepatic granulomas of Kupffer-cell-depleted mice. Am J Pathol. 1997;150:2047-60 pubmed
    ..In situ hybridization demonstrated the expression of M-CSF mRNA and c-fms mRNA in Kupffer cells and monocyte-derived macrophages in the sinusoid and granulomas...
  60. Buchberg A, Brownell E, Nagata S, Jenkins N, Copeland N. A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics. 1989;122:153-61 pubmed
    ..the known linkage homologies that exist between murine chromosome 11 and human chromosomes (Mpo, Ngfr, Pdgfr and Fms). Two of the latter genes, Mpo and Ngfr, mapped to mouse chromosome 11...
  61. Bohlen C, Bennett F, Tucker A, Collins H, Mulinyawe S, Barres B. Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures. Neuron. 2017;94:759-773.e8 pubmed publisher
    ..These data indicate that the specialized gene expression profile of mature microglia requires continuous instructive signaling from the intact CNS. ..
  62. Rohde C, Schrum J, Lee A. A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation. J Biol Chem. 2004;279:43448-61 pubmed
    ..These findings may have implications for the oncogenic conversion of c-Kit and Flt3 with JMD mutations. ..
  63. Digiacomo G, Ziche M, Dello Sbarba P, Donnini S, Rovida E. Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2. FASEB J. 2015;29:2545-54 pubmed publisher
    ..7 ng/ml; ECâ‚…â‚€ PGE2, 16.7 nM). These results indicated that PGE2 transactivates CSF-1R and synergizes with its signaling at ERK1/2 level in promoting macrophage migration. ..
  64. Lenzo J, Turner A, Cook A, Vlahos R, Anderson G, Reynolds E, et al. Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation. Immunol Cell Biol. 2012;90:429-40 pubmed publisher
    ..A correlation has been observed between macrophage numbers and the severity of certain inflammatory conditions, and it could be that CSF-1 and GM-CSF contribute to the control of these numbers in the ways proposed. ..
  65. Sauter K, Pridans C, Sehgal A, Tsai Y, Bradford B, Raza S, et al. Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. J Leukoc Biol. 2014;96:265-74 pubmed publisher
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