Gene Symbol: Cs
Description: citrate synthase
Alias: 2610511A05Rik, 9030605P22Rik, Ahl4, BB234005, Cis, citrate synthase, mitochondrial, citrate (Si)-synthase
Chow K, Ma Z, Cai J, Pierce W, Hersh L. Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Biochim Biophys Acta. 2005;1723:292-301 pubmed
..Using an immobilized nardilysin column, mitochondrial malate dehydrogenase (mMDH) and citrate synthase (CS) were isolated from a fractionated rat brain extract...
Zheng Q, Ding D, Yu H, Salvi R, Johnson K. A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice. Neurobiol Aging. 2009;30:1693-705 pubmed publisher
..chromosome substitution strains, and a linkage backcross to map a locus on distal Chromosome 10, designated ahl4, that contributes to the early-onset hearing loss of A/J mice...
Xu F, Ackerley C, Maj M, Addis J, Levandovskiy V, Lee J, et al
. Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria. Biochem J. 2008;416:15-26 pubmed publisher
..This defines the site for PTCD2 action in mammalian mitochondria and suggests a possible role for dysfunction of this protein in the aetiology of heart failure...
Chess D, Khairallah R, O Shea K, Xu W, Stanley W. A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload. Am J Physiol Heart Circ Physiol. 2009;297:H1585-93 pubmed publisher
..Furthermore, a high-fat diet preserved MCAD and citrate synthase activities during pressure overload, suggesting that it may help maintain mitochondrial oxidative capacity in failing myocardium. ..
Ratkevicius A, Carroll A, Kilikevicius A, Venckunas T, McDermott K, Gray S, et al
. H55N polymorphism as a likely cause of variation in citrate synthase activity of mouse skeletal muscle. Physiol Genomics. 2010;42A:96-102 pubmed publisher
Citrate synthase (CS) is an enzyme of the Krebs cycle that plays a key role in mitochondrial metabolism...
Johnson K, Gagnon L, Longo Guess C, Kane K. Association of a citrate synthase missense mutation with age-related hearing loss in A/J mice. Neurobiol Aging. 2012;33:1720-9 pubmed publisher
We previously mapped a locus (ahl4) on distal Chromosome 10 that contributes to the age-related hearing loss of A/J strain mice...
Zhang L, Mori J, Wagg C, Lopaschuk G. Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding. FEBS Lett. 2012;586:996-1003 pubmed publisher
..Hence, HFD may initiate early cardiac metabolic alterations through the eIF4E/cyclin D1/E2F1/PDK4 axis. ..
de Castro BrÃ¡s L, Cates C, DeLeon Pennell K, Ma Y, Iyer R, Halade G, et al
. Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle. Antioxid Redox Signal. 2014;21:1974-85 pubmed publisher
To evaluate the role of matrix metalloproteinase (MMP)-9 deletion on citrate synthase (CS) activity postmyocardial infarction (MI). We fractionated left ventricle (LV) samples using a differential solubility-based approach...
Szczesny B, Brunyánszki A, Olah G, Mitra S, Szabo C. Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Nucleic Acids Res. 2014;42:13161-73 pubmed publisher
..In summary, we conclude that mitochondrial PARP1, in opposite to nuclear PARP1, exerts a negative effect on several mitochondrial-specific transactions including the repair of the mitochondrial DNA. ..