Genomes and Genes
Gene Symbol: Cryga
Description: crystallin, gamma A
Alias: Cryg-4, DGcry-4, gamma-crystallin A, gamma-A-crystallin, gamma-crystallin 4
- Wigle J, Chowdhury K, Gruss P, Oliver G. Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999;21:318-22 pubmed..Our data provide evidence that the progression of terminal fibre differentiation and elongation is dependent on Prox1 activity during lens development. ..
- Masaki S, Watanabe T. Linkage analysis of the mutation locus in the eye lens obsolescence (Elo) mouse. Genomics. 1989;5:259-63 pubmed..Among 223 mice analyzed, recombination between Elo and Idh-1 loci was observed in three offsprings; and that between Cryg-1 or Cryg-4 and Idh-1 loci, in one offspring. No recombination occurred between Cryg-1 and Cryg-4 alleles. ..
- Goring D, Breitman M, Tsui L. Temporal regulation of six crystallin transcripts during mouse lens development. Exp Eye Res. 1992;54:785-95 pubmed..The utility of the PCR technique in studying the relative abundance of steady-state gamma-crystallin mRNAs was also investigated. ..
- Zneimer S, Womack J. Regional localization of the fibronectin and gamma crystallin genes to mouse chromosome 1 by in situ hybridization. Cytogenet Cell Genet. 1988;48:238-41 pubmed..Genes in this conserved region of mouse chromosome 1 are also involved in resistance to intracellular pathogens, and the chromosomal localization of this region may facilitate the identification of homologous genes in other species. ..
- Medina Martinez O, Shah R, Jamrich M. Pitx3 controls multiple aspects of lens development. Dev Dyn. 2009;238:2193-201 pubmed publisher..In general, our study shows that the abnormal phenotype of the ak lenses is not due to just one molecular pathway, rather in the absence of Pitx3 expression multiple aspects of lens development are disrupted. ..
- Liu Y, Zacksenhaus E. E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses. Oncogene. 2000;19:6065-73 pubmed..Thus, inactivation of E2F1 reduces ectopic cell proliferation and stage-specific p53-dependent apoptosis but does not rescue the differentiation defects associated with loss of Rb during lens development. ..
- Graw J, Jung M, Loster J, Klopp N, Soewarto D, Fella C, et al. Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse. Genomics. 1999;62:67-73 pubmed..The mutation will be referred to as Cryba1(po1). This particular mouse mutation provides an excellent animal model for a human congenital zonular cataract with suture opacities, which is caused by a mutation in the homologous gene. ..
- Favor J. A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983;110:367-82 pubmed
- Ehling U, Favor J, Kratochvilova J, Neuhauser Klaus A. Dominant cataract mutations and specific-locus mutations in mice induced by radiation or ethylnitrosourea. Mutat Res. 1982;92:181-92 pubmed
- Hu X, Nie Q, Yi M, Li T, Wang Z, Huang Z, et al. The tumor suppressor, p53 regulates the ?A-crystallin gene during mouse lens development. Curr Mol Med. 2014;14:1197-204 pubmed..Together, our results reveal that p53 regulates ?A-crystallin gene expression during mouse lens development. Thus, p53 directly regulates all 3 types of crystallin genes to control lens differentiation. ..
- Tasheva E, Ke A, Deng Y, Jun C, Takemoto L, Koester A, et al. Differentially expressed genes in the lens of mimecan-null mice. Mol Vis. 2004;10:403-16 pubmed..Our results provide insight into the function of mimecan in the lens and enable further characterization of molecular mechanisms by which this protein exerts its biological roles. ..
- Gonzalez M, Ruggiero F, Chang Q, Shi Y, Rich M, Kraner S, et al. Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions. Neuron. 1999;24:567-83 pubmed..These results demonstrate a novel role for neurotrophin signaling through TrkB receptors on muscle fibers in the ongoing maintenance of postsynaptic AChR regions. ..
- Nishiguchi S, Wood H, Kondoh H, Lovell Badge R, Episkopou V. Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 1998;12:776-81 pubmed..It appears that the direct interaction of the SOX1 protein with a promoter element conserved in all gamma-crystallin genes is responsible for their expression. ..
- Skow L, Donner M, Huang S, Gardner J, Taylor B, Beamer W, et al. Mapping of mouse gamma crystallin genes on chromosome 1. Biochem Genet. 1988;26:557-70 pubmed..This study found no evidence of recombination hot spots within the gamma crystallin gene cluster. ..
- Brakenhoff R, Henskens H, van Rossum M, Lubsen N, Schoenmakers J. Activation of the gamma E-crystallin pseudogene in the human hereditary Coppock-like cataract. Hum Mol Genet. 1994;3:279-83 pubmed..Reactivation of the psi gamma E gene and concomitant overexpression of the gamma-crystallin fragment could be the cause of the Coppock-like cataract. ..
- Shinohara T, Robinson E, Appella E, Piatigorsky J. Multiple gamma-crystallins of the mouse lens: fractionation of mRNAs by cDNA cloning. Proc Natl Acad Sci U S A. 1982;79:2783-7 pubmed..These data indicate that there are at least four similar gamma-crystallin mRNAs and suggest (but do not establish) the existence of a closely related family of gamma-crystallin genes. ..
- Favor J. Characterization of dominant cataract mutations in mice: penetrance, fertility and homozygous viability of mutations recovered after 250 mg/kg ethylnitrosourea paternal treatment. Genet Res. 1984;44:183-97 pubmed
- Klopp N, Favor J, Loster J, Lutz R, Neuhauser Klaus A, Prescott A, et al. Three murine cataract mutants (Cat2) are defective in different gamma-crystallin genes. Genomics. 1998;52:152-8 pubmed..candidate gene approach to analyze the entire Cryg cluster, an A-->G transition was found in exon 2 of Cryga for the ENU-436 mutation and is designated Cryga1Neu...
- Quinlan P, Oda S, Breitman M, Tsui L. The mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes. Genes Dev. 1987;1:637-44 pubmed..4 +/- 0.9 cM, whereas that between gamma 6 and the distantly linked gamma 2 gene is 2.7 +/- 1.3 cM. Our data also suggest the possibility of recombination hot spots with the gamma-crystallin gene cluster. ..
- Graw J, Neuhäuser Klaus A, Klopp N, Selby P, Löster J, Favor J. Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse. Invest Ophthalmol Vis Sci. 2004;45:1202-13 pubmed..Crygc(MNU8), Cryge(Z2), Crygd(ENU4011), and Cryge(ADD15306)), to dense nuclear opacity and ruptured lenses (Cryga(ENU469))...
- Everett C, Glenister P, Taylor D, Lyon M, Kratochvilova Loester J, Favor J. Mapping of six dominant cataract genes in the mouse. Genomics. 1994;20:429-34 pubmed..A third mutant, provisionally designated Npp, mapped to Chromosome 5, 1.3 +/- 0.9 cM from the locus of W, and thus probably has a homologue on human Chromosome 4. ..
- Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, et al. HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004;23:4297-306 pubmed
- Yamada R, Mizutani Koseki Y, Koseki H, Takahashi N. Requirement for Mab21l2 during development of murine retina and ventral body wall. Dev Biol. 2004;274:295-307 pubmed..Our results reveal that Mab21l2 plays crucial roles in retina and in ventral body wall formation. ..
- Min J, Zhang Y, Moskophidis D, Mivechi N. Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004;40:205-17 pubmed..Thus, HSF4 fulfills a central role in controlling spatial and temporal expression of genes critical for correct development and function of the lens. ..
- Sandilands A, Hutcheson A, Long H, Prescott A, Vrensen G, Löster J, et al. Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J. 2002;21:6005-14 pubmed..The mutant gamma-crystallins initially disrupt nuclear function, but then this progresses to a full cataract phenotype. ..
- Lok S, Tsui L, Shinohara T, Piatigorsky J, Gold R, Breitman M. Analysis of the mouse gamma-crystallin gene family: assignment of multiple cDNAs to discrete genomic sequences and characterization of a representative gene. Nucleic Acids Res. 1984;12:4517-29 pubmed..Moreover, a highly conserved region, 50 nucleotides in length, immediately precedes the TATA box of both the mouse and rat genes, suggesting that this sequence may be important in gene regulation. ..
- Yoshimoto A, Saigou Y, Higashi Y, Kondoh H. Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development. 2005;132:4437-48 pubmed..26 kb promoter, and are separate from lens-specific regulation. This is the first demonstration of the significance of Smad interaction in modulating Sip1 activity. ..
- Ho H, Chang K, Nichols J, Li M. Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells. Mech Dev. 2009;126:18-29 pubmed publisher..Thus, Pitx3 is essential to maintain lens epithelial phenotype and prevent inappropriate fibre cell differentiation during lens development. ..
- Yamada R, Mizutani Koseki Y, Hasegawa T, Osumi N, Koseki H, Takahashi N. Cell-autonomous involvement of Mab21l1 is essential for lens placode development. Development. 2003;130:1759-70 pubmed..We conclude that Mab21l1 expression dependent on PAX6 is essential for lens placode growth and for formation of the lens vesicle; lack of Mab21l1 expression causes reduced expression of Foxe3 in a cell-autonomous manner. ..
- Murer Orlando M, Paterson R, Lok S, Tsui L, Breitman M. Differential regulation of gamma-crystallin genes during mouse lens development. Dev Biol. 1987;119:260-7 pubmed..This complex pattern of gene regulation presumably accounts for one of the mechanisms determining the spatial distribution of different gamma-crystallins within the lens. ..
- Breitman M, Lok S, Wistow G, Piatigorsky J, Treton J, Gold R, et al. Gamma-crystallin family of the mouse lens: structural and evolutionary relationships. Proc Natl Acad Sci U S A. 1984;81:7762-6 pubmed..The significance of these differences in terms of the structure and function of the gamma-crystallins in the mouse lens is discussed. ..
- Kawauchi S, Takahashi S, Nakajima O, Ogino H, Morita M, Nishizawa M, et al. Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem. 1999;274:19254-60 pubmed..The expression of crystallin genes was severely impaired in the c-maf-null mutant mouse lens. These results demonstrate that c-Maf is an indispensable regulator of lens differentiation during murine development. ..
- Santhiya S, Abd alla S, Loster J, Graw J. Reduced levels of gamma-crystallin transcripts during embryonic development of murine Cat2nop mutant lenses. Graefes Arch Clin Exp Ophthalmol. 1995;233:795-800 pubmed..This result represents an additional line of argument that the gamma-crystallin genes may be the target of the mutation in the Cat2 mice. ..
- Kim S, Cheong C, Sohn Y, Goo Y, Oh W, Park J, et al. Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002;22:8409-14 pubmed..Our results provide a novel insight into the molecular and histopathological mechanism of posterior lenticonus with cataract and attest to the importance of ASC-2 as a pivotal transcriptional coactivator of nuclear receptors in vivo...
- Jones S, Jomary C, Grist J, Makwana J, Neal M. Retinal expression of gamma-crystallins in the mouse. Invest Ophthalmol Vis Sci. 1999;40:3017-20 pubmed
- Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, et al. Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009;238:2280-91 pubmed publisher..Thus, these observations suggest that GATA-3 is essential for lens cells differentiation and proper cell cycle control. ..