Genomes and Genes
Gene Symbol: Crybb3
Description: crystallin, beta B3
Alias: AI852419, beta-crystallin B3, beta-B3 crystallin
- Hulsebos T, Gilbert D, Delattre O, Smink L, Dunham I, Westerveld A, et al. Assignment of the beta B1 crystallin gene (CRYBB1) to human chromosome 22 and mouse chromosome 5. Genomics. 1995;29:712-8 pubmed..These assignments complete the mapping and identification of the human and mouse homologues of the major beta crystallins genes that are expressed in the bovine lens. ..
- Lovicu F, Overbeek P. Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice. Development. 1998;125:3365-77 pubmed
- Min J, Zhang Y, Moskophidis D, Mivechi N. Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004;40:205-17 pubmed..Thus, HSF4 fulfills a central role in controlling spatial and temporal expression of genes critical for correct development and function of the lens. ..
- Logan C, Rajakaruna S, Bowen C, Radice G, Robinson M, Menko A. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017;428:118-134 pubmed publisher..The dependence of migration of the fiber cell apical domains along the EFI for lens morphogenesis on N-cadherin provides new insight into the process of tissue development. ..
- Hulsebos T, Jenkins N, Gilbert D, Copeland N. The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5. Genomics. 1995;25:574-6 pubmedThe human beta crystallin genes CRYBB2, CRYBB2P1, CRYBB3, and CRYBA4 are located in 22q11.2. Using interspecific backcross analysis, we mapped the mouse homologues of CRYBB2, CRYBB3, and CRYBA4 (i.e...
- Reneker L, Overbeek P. Lens-specific expression of PDGF-A alters lens growth and development. Dev Biol. 1996;180:554-65 pubmed..Elevated levels of PDGF-A enhance proliferation, but also appear to induce some aspects of the fiber cell differentiation pathway. ..
- Gonzalez M, Ruggiero F, Chang Q, Shi Y, Rich M, Kraner S, et al. Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions. Neuron. 1999;24:567-83 pubmed..These results demonstrate a novel role for neurotrophin signaling through TrkB receptors on muscle fibers in the ongoing maintenance of postsynaptic AChR regions. ..
- Ring B, Cordes S, Overbeek P, Barsh G. Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development. 2000;127:307-17 pubmed..Our results indicate that Maf directly activates many if not all of the (beta)-crystallin genes, and suggest a model for coordinating cell cycle withdrawal with terminal differentiation. ..
- Maeda Y, Funata N, Takahama S, Sugata Y, Yonekawa H. Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm Genome. 2001;12:278-83 pubmed..The rct locus essential for the onset of the cataract was tightly linked to D4Mit278 on Chromosome (Chr) 4 with no recombination. The mrct locus was closely linked to D5Mit239 (chi2 = 66.3, P < 0.00001) on Chr 5. ..
- Graw J, Loster J, Soewarto D, Fuchs H, Reis A, Wolf E, et al. Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse. Invest Ophthalmol Vis Sci. 2001;42:1574-80 pubmed..Because an increasing number of beta- and gamma-crystallin mutations have been reported, a detailed phenotype-genotype correlation will allow a clearer functional understanding of beta- and gamma-crystallins. ..
- Dimanlig P, Faber S, Auerbach W, Makarenkova H, Lang R. The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Development. 2001;128:4415-24 pubmed..This pathway forms a basis for future analysis of lens induction mechanism. ..
- Lachke S, Alkuraya F, Kneeland S, Ohn T, Aboukhalil A, Howell G, et al. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011;331:1571-6 pubmed publisher..These findings demonstrate a role for RGs in vertebrate organogenesis...