Gene Symbol: Cryba2
Description: crystallin, beta A2
Alias: E130107M19Rik, beta-crystallin A2, beta-A2 crystallin, betaA2-crystallin, lens structural protein
Species: mouse
Products:     Cryba2

Top Publications

  1. Hulsebos T, Jenkins N, Gilbert D, Copeland N. The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5. Genomics. 1995;25:574-6 pubmed
    ..e., Crybb2, Crybb3, and Cryba4) to the central region of mouse chromosome 5. The homologue of human CRYBB2P1 is absent in mouse. These assignments define a new region of homology in human and mouse. ..
  2. Dimanlig P, Faber S, Auerbach W, Makarenkova H, Lang R. The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Development. 2001;128:4415-24 pubmed
    ..This pathway forms a basis for future analysis of lens induction mechanism. ..
  3. Petri A, Ahnfelt Rønne J, Frederiksen K, Edwards D, Madsen D, Serup P, et al. The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol. 2006;37:301-16 pubmed
    ..These data suggest that Irx1 and Irx2 serve an evolutionary conserved role in the regulation of alpha-cell-specific gene expression. ..
  4. Xie Q, Cvekl A. The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops. J Biol Chem. 2011;286:43259-71 pubmed publisher
  5. Jin C, Chen J, Meng Q, Carreira V, Tam N, Geh E, et al. Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol. 2013;374:96-107 pubmed publisher
    ..Using LCM and expression array, our studies have uncovered novel molecular signatures of MAP3K1 in embryonic eyelid closure. ..
  6. Hulsebos T, Cerosaletti K, Fournier R, Sinke R, Rocchi M, Marzella R, et al. Identification of the human beta A2 crystallin gene (CRYBA2): localization of the gene on human chromosome 2 and of the homologous gene on mouse chromosome 1. Genomics. 1995;28:543-8 pubmed
    By using primers synthesized on the basis of the bovine beta A2 crystallin gene sequence, we amplified exons 5 and 6 of the human gene (CRYBA2)...
  7. Hulsebos T, Gilbert D, Delattre O, Smink L, Dunham I, Westerveld A, et al. Assignment of the beta B1 crystallin gene (CRYBB1) to human chromosome 22 and mouse chromosome 5. Genomics. 1995;29:712-8 pubmed
    ..These assignments complete the mapping and identification of the human and mouse homologues of the major beta crystallins genes that are expressed in the bovine lens. ..
  8. Lovicu F, Overbeek P. Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice. Development. 1998;125:3365-77 pubmed
  9. Gonzalez M, Ruggiero F, Chang Q, Shi Y, Rich M, Kraner S, et al. Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions. Neuron. 1999;24:567-83 pubmed
    ..These results demonstrate a novel role for neurotrophin signaling through TrkB receptors on muscle fibers in the ongoing maintenance of postsynaptic AChR regions. ..

More Information


  1. Ring B, Cordes S, Overbeek P, Barsh G. Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development. 2000;127:307-17 pubmed
    ..Our results indicate that Maf directly activates many if not all of the (beta)-crystallin genes, and suggest a model for coordinating cell cycle withdrawal with terminal differentiation. ..
  2. Sergeev Y, Hejtmancik J, Wingfield P. Energetics of domain-domain interactions and entropy driven association of beta-crystallins. Biochemistry. 2004;43:415-24 pubmed
  3. Yoshimoto A, Saigou Y, Higashi Y, Kondoh H. Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development. 2005;132:4437-48 pubmed
    ..26 kb promoter, and are separate from lens-specific regulation. This is the first demonstration of the significance of Smad interaction in modulating Sip1 activity. ..
  4. Puk O, Ahmad N, Wagner S, Hrabe de Angelis M, Graw J. First mutation in the ?A2-crystallin encoding gene is associated with small lenses and age-related cataracts. Invest Ophthalmol Vis Sci. 2011;52:2571-6 pubmed publisher
    ..Using a positional candidate approach, the ?A2-crystallin encoding gene Cryba2 was sequenced; a T?C exchange at cDNA position 139 led to a p.S47P amino-acid alteration...
  5. Min J, Zhang Y, Moskophidis D, Mivechi N. Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004;40:205-17 pubmed
    ..Mutations in genes controlling eye development and in lens structural protein genes are associated with multiple ocular developmental disorders, including cataracts and other ..