Gene Symbol: Crxos
Description: cone-rod homeobox, opposite strand
Alias: AA606869, AY590891, Crxos1, Egam1, Crx opposite strand transcript 1
Species: mouse
Products:     Crxos

Top Publications

  1. Alfano G, Vitiello C, Caccioppoli C, Caramico T, Carola A, Szego M, et al. Natural antisense transcripts associated with genes involved in eye development. Hum Mol Genet. 2005;14:913-23 pubmed
    ..In addition, we overexpressed another NAT, CrxOS, in mouse adult retina using adeno-associated viral vectors and we observed a significant decrease in the ..
  2. Saito K, Abe H, Nakazawa M, Irokawa E, Watanabe M, Hosoi Y, et al. Cloning of complementary DNAs encoding structurally related homeoproteins from preimplantation mouse embryos: their involvement in the differentiation of embryonic stem cells. Biol Reprod. 2010;82:687-97 pubmed publisher
    ..Three structurally related cDNAs (Crxos1, Crxos1 sv2, and Crxos1 tv3) that exhibited concomitant elevated expression during this critical period were ..
  3. Saito K, Ogawa A, Toyofuku K, Hosoi Y, Soma M, Iha M, et al. Relationships between homeoprotein EGAM1C and the expression of the placental prolactin gene family in mouse placentae and trophoblast stem cells. Reproduction. 2011;141:259-68 pubmed publisher
    The mouse Crxos gene encodes three structurally related homeoproteins, EGAM1, EGAM1N, and EGAM1C, as transcription and splicing variants...
  4. Soma M, Iha M, Kihara Y, Sato S, Sato Y, Sato S, et al. Preferential emergence of cell types expressing markers for primitive endoderm lineages in mouse embryonic stem cells expressing exogenous EGAM1 homeoprotein. J Biosci Bioeng. 2012;114:342-6 pubmed publisher
    ..Recently, we identified the homeoprotein EGAM1 both in preimplantation mouse embryos and mouse ES cells...
  5. Iha M, Soma M, Sato S, Mori Y, Sugawara S, Kasuga K, et al. Severe inhibition of in vitro cardiomyogenesis in mouse embryonic stem cells ectopically expressing EGAM1C homeoprotein. Biosci Biotechnol Biochem. 2012;76:1410-2 pubmed
    ..These results indicate that EGAM1C is capable of affecting terminal differentiation in mouse embryonic stem cells. ..
  6. Sato S, Morita S, Iha M, Mori Y, Sugawara S, Kasuga K, et al. Intact structure of EGAM1 homeoproteins and basic amino acid residues in the common homeodomain of EGAM1 and EGAM1C contribute to their nuclear localization in mouse embryonic stem cells. J Biosci Bioeng. 2013;116:141-6 pubmed publisher
    Recently, we identified the structurally related homeoproteins EGAM1, EGAM1N, and EGAM1C in both preimplantation mouse embryos and mouse embryonic stem (ES) cells...
  7. Sato S, Nakazawa M, Kihara Y, Kubo Y, Sato Y, Kikuchi T, et al. Partial inhibition of differentiation associated with elevated protein levels of pluripotency factors in mouse embryonic stem cells expressing exogenous EGAM1N homeoprotein. J Biosci Bioeng. 2015;120:562-9 pubmed publisher
    ..Overall, we suggest that expression of EGAM1N could inhibit differentiation, at least in part, by elevating the protein levels of pluripotency factors in MG1.19 ES cells. ..
  8. Sasaki N, Nagaoka S, Itoh M, Izawa M, Konno H, Carninci P, et al. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Genomics. 1998;49:167-79 pubmed
    ..Although the human EST project is considered to represent roughly half of all genes, our findings indicate that many early stage developmental genes remain to be identified. ..
  9. Saito R, Yamasaki T, Nagai Y, Wu J, Kajiho H, Yokoi T, et al. CrxOS maintains the self-renewal capacity of murine embryonic stem cells. Biochem Biophys Res Commun. 2009;390:1129-35 pubmed publisher
    ..Here we report the identification by in silico analysis of a homeobox-containing gene, CrxOS, that is specifically expressed in murine ES cells and is essential for their self-renewal...

More Information


  1. Iha M, Watanabe M, Kihara Y, Sugawara S, Saito K, Soma M, et al. Effect of ectopic expression of homeoprotein EGAM1C on the cell morphology, growth, and differentiation in a mouse embryonic stem cell line, MG1.19 cells. Reproduction. 2012;143:477-89 pubmed publisher
    ..19 ES cells, in addition to affecting cellular morphology and growth. ..