Gene Symbol: Crtap
Description: cartilage associated protein
Alias: 5730529N23Rik, CASP, Leprel3, P3h5, cartilage-associated protein
Species: mouse
Products:     Crtap

Top Publications

  1. Morello R, Tonachini L, Monticone M, Viggiano L, Rocchi M, Cancedda R, et al. cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse cartilage associated protein. Matrix Biol. 1999;18:319-24 pubmed
    ..isolated and characterized a cDNA coding for a novel developmentally regulated chick embryo protein, cartilage associated protein (CASP). Here we describe the isolation and characterization of the cDNAs coding for the mouse CASP...
  2. Morello R, Bertin T, Chen Y, Hicks J, Tonachini L, Monticone M, et al. CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta. Cell. 2006;127:291-304 pubmed
    ..b>CRTAP shares homology with a family of putative prolyl 3-hydroxylases (P3Hs), but it does not contain their common ..
  3. Baldridge D, Lennington J, Weis M, Homan E, Jiang M, Munivez E, et al. Generalized connective tissue disease in Crtap-/- mouse. PLoS ONE. 2010;5:e10560 pubmed publisher
    Mutations in CRTAP (coding for cartilage-associated protein), LEPRE1 (coding for prolyl 3-hydroxylase 1 [P3H1]) or PPIB (coding for Cyclophilin B [CYPB]) cause recessive forms of osteogenesis imperfecta and loss or decrease of type I ..
  4. Homan E, Lietman C, Grafe I, Lennington J, Morello R, Napierala D, et al. Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues. PLoS Genet. 2014;10:e1004121 pubmed publisher
    Mutations in the genes encoding cartilage associated protein (CRTAP) and prolyl 3-hydroxylase 1 (P3H1 encoded by LEPRE1) were the first identified causes of recessive Osteogenesis Imperfecta (OI)...
  5. Pang A, Taylor H, Johnson W, Alexander S, Chen Y, Su Y, et al. Identification of differentially expressed genes in mouse spermatogenesis. J Androl. 2003;24:899-911 pubmed
    ..Many of the genes identified were not previously characterized. This study highlights new targets for manipulation to unravel the molecular mechanism of spermatogenesis. ..
  6. Massaad C, Amin S, Hu L, Mei Y, Klann E, Pautler R. Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease. PLoS ONE. 2010;5:e10561 pubmed publisher
    ..These findings directly link free radicals of specific mitochondrial origin to AD-associated vascular and neuronal pathology. ..
  7. Ishikawa Y, Bachinger H. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1·cartilage-associated protein·cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. J Biol Chem. 2013;288:31437-46 pubmed publisher
    ..We have tested the enzyme activities on model substrates in vitro using a GCRALCG peptide and the P3H1 complex. Our results suggest that this complex could function as a disulfide isomerase in the rough endoplasmic reticulum. ..
  8. Tonachini L, Morello R, Monticone M, Skaug J, Scherer S, Cancedda R, et al. cDNA cloning, characterization and chromosome mapping of the gene encoding human cartilage associated protein (CRTAP). Cytogenet Cell Genet. 1999;87:191-4 pubmed
    ..cDNA clones coding for a novel developmentally regulated avian and mouse embryo protein, CASP for Cartilage Associated Protein. Here we describe the isolation and characterization of the gene coding for the human CASP...
  9. Fratzl Zelman N, Morello R, Lee B, Rauch F, Glorieux F, Misof B, et al. CRTAP deficiency leads to abnormally high bone matrix mineralization in a murine model and in children with osteogenesis imperfecta type VII. Bone. 2010;46:820-6 pubmed publisher
    Cartilage-associated protein (CRTAP) is an essential cofactor for the proper post-translational chain modification and collagen folding...

More Information


  1. Grafe I, Yang T, Alexander S, Homan E, Lietman C, Jiang M, et al. Excessive transforming growth factor-? signaling is a common mechanism in osteogenesis imperfecta. Nat Med. 2014;20:670-5 pubmed publisher
    ..we show that excessive transforming growth factor-? (TGF-?) signaling is a mechanism of OI in both recessive (Crtap(-/-)) and dominant (Col1a2(tm1.1Mcbr)) OI mouse models...