Gene Symbol: Crocc
Description: ciliary rootlet coiled-coil, rootletin
Alias: rootletin, ciliary rootlet coiled-coil protein, crocc
Gilliam J, Chang J, Sandoval I, Zhang Y, Li T, Pittler S, et al
. Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell. 2012;151:1029-41 pubmed publisher
..The structures of the outer segment membranes support a model for disk morphogenesis in which basal disks are enveloped by the plasma membrane. ..
Segade F, Broekelmann T, Pierce R, Mecham R. Revised genomic structure of the human MAGP1 gene and identification of alternate transcripts in human and mouse tissues. Matrix Biol. 2000;19:671-82 pubmed
..The alternatively spliced forms show restricted patterns of expression relative to the canonical isoform. ..
Yadav S, Sharma N, Liu C, Dong L, Li T, Swaroop A. Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis. Development. 2016;143:1491-501 pubmed publisher
..We suggest that CP110 has unique context-dependent functions, acting as both a suppressor and a promoter of ciliogenesis. ..
Yang J, Gao J, Adamian M, Wen X, Pawlyk B, Zhang L, et al
. The ciliary rootlet maintains long-term stability of sensory cilia. Mol Cell Biol. 2005;25:4129-37 pubmed
..In this study, we carried out targeted disruption in mice of the gene for rootletin, a component of the rootlet. In the mutant, ciliated cells are devoid of rootlets...
Zou J, Luo L, Shen Z, Chiodo V, Ambati B, Hauswirth W, et al
. Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors. Invest Ophthalmol Vis Sci. 2011;52:2343-51 pubmed publisher
..The combined hRK and AAV gene delivery system could be an effective gene therapy approach to treat retinal degeneration in USH2D patients. ..
Grossman G, Ebke L, Beight C, Jang G, Crabb J, Hagstrom S. Protein partners of dynamin-1 in the retina. Vis Neurosci. 2013;30:129-39 pubmed publisher
..This finding is confirmed by western blot analysis. Results further implicate dynamin-1 in vesicular protein transport processes relevant to synaptic and post-Golgi pathways and indicate a possible role in photoreceptor stability. ..
Sugiyama Y, Shelley E, Yoder B, Kozmik Z, May Simera H, Beales P, et al
. Non-essential role for cilia in coordinating precise alignment of lens fibres. Mech Dev. 2016;139:10-7 pubmed publisher
..Taken together, these results indicate that primary cilia do not play an essential role in the precise cellular alignment/orientation of fibre cells. Thus, it appears that in the lens cilia are not required to establish PCP. ..
Yang J, Li T. The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp Cell Res. 2005;309:379-89 pubmed
..role in intracellular transport, we investigated the interaction between kinesin light chains (KLCs) and rootletin, the structural component of ciliary rootlets...
Yang J, Adamian M, Li T. Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells. Mol Biol Cell. 2006;17:1033-40 pubmed
b>Rootletin, a major structural component of the ciliary rootlet, is located at the basal bodies and centrosomes in ciliated and nonciliated cells, respectively...