Gene Symbol: Crlf2
Description: cytokine receptor-like factor 2
Alias: CRLM2, Ly114, Tpte2, Tslpr, cytokine receptor-like factor 2, TSLP receptor, cytokine receptor-like molecule 2, lymphocyte antigen 114, thymic stromal lymphopoietin protein receptor, thymic stromal-derived lymphopoietin, receptor, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2, type I cytokine receptor delta 1
Species: mouse
Products:     Crlf2

Top Publications

  1. Wikman L, Boström M, Järnström A, Lundin K, Nordström T, Lindqvist C. The murine thymic stromal lymphopoietin receptor is partially expressed with an extracellular C-terminus. Mol Immunol. 2005;42:49-54 pubmed
    ..The genetically fused poly-histidine tag was also demonstrated to be functional using a Ni-NTA purification system, indicating this protein otherwise to have normal biochemical properties. ..
  2. Zhou B, Comeau M, De Smedt T, Liggitt H, Dahl M, Lewis D, et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol. 2005;6:1047-53 pubmed
    ..We show here that TSLP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor-deficient mice had considerably attenuated disease...
  3. Astrakhan A, Omori M, Nguyen T, Becker Herman S, Iseki M, Aye T, et al. Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development. Nat Immunol. 2007;8:522-31 pubmed
    ..These observations suggest that signals mediating localized TSLP expression may modulate systemic B cell development and promote humoral autoimmunity. ..
  4. Jensen C, Kharazi S, Böiers C, Cheng M, Lübking A, Sitnicka E, et al. FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis. Blood. 2008;112:2297-304 pubmed publisher
    ..Thus, the same IL-7- and FLT3 ligand-mediated signal-ing regulates alternative pathways of fetal and adult B-1 and B-2 lymphopoiesis. ..
  5. Rochman Y, Leonard W. The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis. J Immunol. 2008;181:7699-705 pubmed
    ..The receptor for TSLP contains a TSLP-specific receptor chain (TSLPR) and the IL-7R alpha-chain...
  6. Lei L, Zhang Y, Yao W, Kaplan M, Zhou B. Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol. 2011;186:2254-61 pubmed publisher
    ..These results define a novel role for TSLP in regulating the balance of airway tolerance and allergic inflammation. ..
  7. Carpino N, Thierfelder W, Chang M, Saris C, Turner S, Ziegler S, et al. Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development. Mol Cell Biol. 2004;24:2584-92 pubmed
    ..Mice deficient in Jak3 exhibit a SCID phenotype but harbor a residual B220+ splenic lymphocyte population. We demonstrate here that this residual lymphocyte population is lost in mice lacking both the gamma-like chain and Jak3. ..
  8. Al Shami A, Spolski R, Kelly J, Fry T, Schwartzberg P, Pandey A, et al. A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med. 2004;200:159-68 pubmed
    ..signals via a receptor comprising the interleukin (IL)-7 receptor alpha chain and a distinctive subunit, TSLP receptor (TSLPR), which is most related to the common cytokine receptor gamma chain, gamma(c)...
  9. Al Shami A, Spolski R, Kelly J, Keane Myers A, Leonard W. A role for TSLP in the development of inflammation in an asthma model. J Exp Med. 2005;202:829-39 pubmed
    ..Correspondingly, TSLP receptor (TSLPR) knockout (KO) mice exhibit strong Th1 responses, with high levels of interleukin (IL)-12, interferon-..

More Information


  1. Plumb A, Patton D, Seo J, Loveday E, Jean F, Ziegler S, et al. Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus. PLoS ONE. 2012;7:e50199 pubmed publisher
    ..IL-7 and TSLP share IL-7R? as part of their heterodimeric receptors with the gamma common chain (?c) and TSLPR, respectively...
  2. Zaph C, Troy A, Taylor B, Berman Booty L, Guild K, Du Y, et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007;446:552-6 pubmed
    ..These results indicate that the balance of IKK-beta-dependent gene expression in the intestinal epithelium is crucial in intestinal immune homeostasis by promoting mucosal immunity and limiting chronic inflammation. ..
  3. Park L, Martin U, Garka K, Gliniak B, Di Santo J, Muller W, et al. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med. 2000;192:659-70 pubmed
    ..cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family...
  4. Pandey A, Ozaki K, Baumann H, Levin S, Puel A, Farr A, et al. Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. Nat Immunol. 2000;1:59-64 pubmed
    ..Binding of TSLP to the thymic stromal lymphopoietin receptor (TSLPR) is increased markedly in the presence of the IL-7 receptor alpha chain (IL-7R alpha)...
  5. Headley M, Zhou B, Shih W, Aye T, Comeau M, Ziegler S. TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses. J Immunol. 2009;182:1641-7 pubmed
    ..This study provides new insight into the unique features of the asthma pathology contributed by the innate and adaptive immune responses in response to TSLP stimulation. ..
  6. He R, Oyoshi M, Garibyan L, Kumar L, Ziegler S, Geha R. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A. 2008;105:11875-80 pubmed publisher
    ..immunization of mice with ovalbumin (OVA), a potential model of atopic dermatitis, was severely impaired in TSLPR(-/-) mice, as evidenced by decreased infiltration of eosinophils and decreased local expression of T helper 2 (Th2)..
  7. Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, et al. Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat Struct Mol Biol. 2014;21:375-82 pubmed publisher
    ..mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR) and the shared interleukin 7 receptor ?-chain (IL-7R?) to evoke membrane-proximal receptor-receptor contacts ..
  8. Vonarbourg C, Mortha A, Bui V, Hernandez P, Kiss E, Hoyler T, et al. Regulated expression of nuclear receptor ROR?t confers distinct functional fates to NK cell receptor-expressing ROR?t(+) innate lymphocytes. Immunity. 2010;33:736-51 pubmed publisher
    ..Our data also define a previously unappreciated role of ROR?t? NKR-LTi cells for the onset or maintenance of inflammatory bowel diseases...
  9. Shi L, Leu S, Xu F, Zhou X, Yin H, Cai L, et al. Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells. Clin Immunol. 2008;129:202-10 pubmed publisher
    ..However, the role of TSLP receptor (TSLPR) in allergen-induced Th2 priming, and the effects of TSLP signaling blocking on the development of ..
  10. Gompers A, Su Feher L, Ellegood J, Copping N, Riyadh M, Stradleigh T, et al. Germline Chd8 haploinsufficiency alters brain development in mouse. Nat Neurosci. 2017;20:1062-1073 pubmed publisher
    ..This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development. ..
  11. Blagoev B, Nielsen M, Angrist M, Chakravarti A, Pandey A. Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. Gene. 2002;284:161-8 pubmed
    ..We have cloned the TSLP receptor from rat and find that the WSXWX motif commonly found in extracellular domains of cytokine receptors is ..
  12. Yamaguchi E, Chiba S, Kumano K, Kunisato A, Takahashi T, Takahashi T, et al. Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice. Immunol Lett. 2002;81:59-64 pubmed
    ..These findings may represent that expression of various Notch ligands in APCs has a physiological relevance in each organ. ..
  13. Kim B, Siracusa M, Saenz S, Noti M, Monticelli L, Sonnenberg G, et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci Transl Med. 2013;5:170ra16 pubmed publisher
    ..Collectively, these results demonstrate an essential role for IL-33- and IL-25-independent group 2 ILCs in promoting skin inflammation. ..
  14. Wu C, He S, Peng Y, Kushwaha K, Lin J, Dong J, et al. TSLPR deficiency attenuates atherosclerotic lesion development associated with the inhibition of TH17 cells and the promotion of regulator T cells in ApoE-deficient mice. J Mol Cell Cardiol. 2014;76:33-45 pubmed publisher
    We generated thymic stromal lymphopoietin R-chain deficient apolipoprotein E-double knockout (ApoE-TSLPR DKO) mice to directly explore the role of thymic stromal lymphopoietin (TSLP) in atherogenesis...
  15. Iijima K, Kobayashi T, Hara K, Kephart G, Ziegler S, McKenzie A, et al. IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure. J Immunol. 2014;193:1549-59 pubmed publisher
    ..Mice deficient in IL-33R (Il1rl1(-/-)) and thymic stromal lymphopoietin receptor (Tslpr(-/-)) showed significant reduction in airway inflammation, IgE Ab levels, and airway hyperresponsiveness...
  16. Noti M, Wojno E, Kim B, Siracusa M, Giacomin P, Nair M, et al. Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med. 2013;19:1005-13 pubmed publisher
    ..Together, these data suggest that the TSLP-basophil axis contributes to the pathogenesis of EoE and could be therapeutically targeted to treat this disease. ..
  17. Han H, Headley M, Xu W, Comeau M, Zhou B, Ziegler S. Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages. J Immunol. 2013;190:904-12 pubmed publisher
    ..This population of macrophages is associated with allergic inflammation. We therefore reasoned that TSLP/TSLPR signaling may be involved in the differentiation and activation of aaMs during allergic airway inflammation...
  18. Guimond M, Leonard W, Spolski R, Rossi S, Veenstra R, Hollander G, et al. Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor. Blood. 2008;111:969-70 pubmed publisher
  19. Schaeffer M, Han S, Chtanova T, van Dooren G, Herzmark P, Chen Y, et al. Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol. 2009;182:6379-93 pubmed publisher
    ..Our data represent the first direct observation of the dynamics of T cell-parasite interactions within living tissue and provide a new perspective for understanding immune responses to persistent pathogens in the brain. ..
  20. Rochman Y, Dienger Stambaugh K, Richgels P, Lewkowich I, Kartashov A, Barski A, et al. TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state. Sci Signal. 2018;11: pubmed publisher
    ..pathogenic TH2 cell responses upon exposure to house dust mites compared to mice that received TSLP receptor-deficient CD4+ T cells...
  21. Mao Y, Peng Y, Zeng Q, Cheng L, Wang B, Mao X, et al. A Potential Mechanism of High-Dose Ticagrelor in Modulating Platelet Activity and Atherosclerosis Mediated by Thymic Stromal Lymphopoietin Receptor. PLoS ONE. 2015;10:e0141464 pubmed publisher
    Abnormal expression of thymic stromal lymphopoietin (TSLP) and its receptor (TSLPR) was found in patients with acute coronary syndrome. Ticagrelor, an oral platelet ADP P2Y12 receptor antagonist, is widely used in these patients...
  22. Yu K, Dong Q, Mao X, Meng K, Zhao X, Ji Q, et al. Disruption of the TSLP-TSLPR-LAP signaling between epithelial and dendritic cells through hyperlipidemia contributes to regulatory T-Cell defects in atherosclerotic mice. Atherosclerosis. 2015;238:278-88 pubmed publisher
    ..Moreover, thymic stromal lymphopoietin (TSLP)/thymic stromal lymphopoietin receptor (TSLPR) signaling in myeloid dendritic cells (DCs) promote Treg differentiation...
  23. Lay M, Céspedes P, Palavecino C, León M, Díaz R, Salazar F, et al. Human metapneumovirus infection activates the TSLP pathway that drives excessive pulmonary inflammation and viral replication in mice. Eur J Immunol. 2015;45:1680-95 pubmed publisher
    ..hMPV infection induced lung infiltration of OX40L(+) CD11b(+) DCs. Mice lacking the TSLP receptor deficient mice (tslpr(-/-) ) showed reduced lung inflammation and hMPV replication...
  24. Hillen M, Hartgring S, Willis C, Radstake T, Hack C, Lafeber F, et al. The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade. PLoS ONE. 2015;10:e0130830 pubmed publisher
    ..Arthritis was induced with proteoglycan in wildtype mice (WT) and in mice deficient for the TSLP receptor subunit (TSLPR-/-). Both mice genotypes were treated with anti-IL-7R or phosphate buffered saline...
  25. Mohapatra A, Van Dyken S, Schneider C, Nussbaum J, Liang H, Locksley R. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol. 2016;9:275-86 pubmed publisher
    ..Thus, ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organizational hierarchies in other organs. ..
  26. Francis O, Milford T, Martinez S, Baez I, Coats J, Mayagoitia K, et al. A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis. Haematologica. 2016;101:417-26 pubmed publisher
    ..Genetic alterations that cause overexpression of its receptor component, cytokine receptor-like factor 2 (CRLF2), lead to high-risk B-cell acute lymphoblastic leukemia implicating this signaling pathway in leukemogenesis...
  27. Patton D, Plumb A, Redpath S, Osborne L, Perona Wright G, Abraham N. The development and survival but not function of follicular B cells is dependent on IL-7R? Tyr449 signaling. PLoS ONE. 2014;9:e88771 pubmed publisher
    ..Marginal zone B cells were unaffected by the IL-7R?(449F/449F) mutation. Any role for TSLP was ruled out, as TSLPR(-/-) mice had an identical B cell phenotype to wild-type mice...
  28. Hams E, Armstrong M, Barlow J, Saunders S, Schwartz C, Cooke G, et al. IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. Proc Natl Acad Sci U S A. 2014;111:367-72 pubmed publisher
    ..These results suggest the potential of therapeutically targeting IL-25 and ILC2 for the treatment of human fibrotic diseases. ..
  29. Iseki M, Omori Miyake M, Xu W, Sun X, Takaki S, Rawlings D, et al. Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4. Int Immunol. 2012;24:183-95 pubmed publisher
  30. Zhang Y, Zhou X, Zhou B. DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation. Eur J Immunol. 2012;42:1735-43 pubmed publisher
  31. Fujio K, Nosaka T, Kojima T, Kawashima T, Yahata T, Copeland N, et al. Molecular cloning of a novel type 1 cytokine receptor similar to the common gamma chain. Blood. 2000;95:2204-10 pubmed
    ..These results suggest that delta1 is a subunit of cytokine receptor that may be involved in multiple receptor systems and play a regulatory role in the immune system and hematopoiesis. ..
  32. Vogt T, Link A, Perrin J, Finke D, Luther S. Novel function for interleukin-7 in dendritic cell development. Blood. 2009;113:3961-8 pubmed publisher
  33. Nishiura H, Kido M, Aoki N, Iwamoto S, Maruoka R, Ikeda A, et al. Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice. J Immunol. 2012;188:190-7 pubmed publisher
    ..was expressed in the inflamed stomach and that the serum anti-parietal cell Ab levels in neonatal thymectomized TSLPR-deficient mice (NTx-TSLPR(-/-) mice) were significantly elevated over those in NTx-TSLPR(+/+) mice...
  34. Ochiai S, Jagot F, Kyle R, Hyde E, White R, Prout M, et al. Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells. Proc Natl Acad Sci U S A. 2018;115:1033-1038 pubmed publisher
  35. Magalhaes J, Rubino S, Travassos L, Le Bourhis L, Duan W, Sellge G, et al. Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci U S A. 2011;108:14896-901 pubmed publisher
    ..Such understanding will influence the rational design of therapeutics that could reprogram the immune system during an active Th1-mediated disease, such as Crohn's disease. ..
  36. Iliev I, Mileti E, Matteoli G, Chieppa M, Rescigno M. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol. 2009;2:340-50 pubmed publisher
    ..Thus, we have uncovered an essential mechanism in which EC control of DC function is required for tolerance induction. ..
  37. Van Dyken S, Mohapatra A, Nussbaum J, Molofsky A, Thornton E, Ziegler S, et al. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?? T cells. Immunity. 2014;40:414-24 pubmed publisher
  38. Shane H, Klonowski K. A direct and nonredundant role for thymic stromal lymphopoietin on antiviral CD8 T cell responses in the respiratory mucosa. J Immunol. 2014;192:2261-70 pubmed publisher
    ..Activated CD8 T cells express the TSLP receptor (TSLPR), yet a direct role for TSLP in CD8 T cell immunity in the mucosa has not been described...
  39. Massacand J, Stettler R, Meier R, Humphreys N, Grencis R, Marsland B, et al. Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function. Proc Natl Acad Sci U S A. 2009;106:13968-73 pubmed publisher
    ..However, we now report that the interaction of TSLP with its receptor (TSLPR) has no functional impact on the development of protective Th2 immune responses after infection with 2 helminth ..
  40. Jia L, Zhang W, Zhang H, Li T, Wang Y, Qin Y, et al. Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection. J Pathol. 2015;236:373-83 pubmed publisher
    ..Taken together, our results demonstrated that mechanical stress-induced ER stress promotes SMCs apoptosis, inflammation and degeneration, providing insight into TAAD formation and progression. ..
  41. Zhong J, Liu X, Pandey A. Effects of transmembrane and juxtamembrane domains on proliferative ability of TSLP receptor. Mol Immunol. 2010;47:1207-15 pubmed publisher
    ..that requires a heterodimeric receptor complex composed of the interleukin-7 receptor alpha chain and the TSLP receptor, which is related to the common gamma chain...
  42. Hoyler T, Klose C, Souabni A, Turqueti Neves A, Pfeifer D, Rawlins E, et al. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity. 2012;37:634-48 pubmed publisher
    ..Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates. ..
  43. Mazzucchelli R, Hixon J, Spolski R, Chen X, Li W, Hall V, et al. Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. Blood. 2008;112:3283-92 pubmed publisher
    ..Surprisingly, mice deficient in IL-7 or the other chain of the TSLP receptor (TSLPR) developed relatively normal numbers of Treg cells...
  44. Hiroyama T, Iwama A, Morita Y, Nakamura Y, Shibuya A, Nakauchi H. Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells. Biochem Biophys Res Commun. 2000;272:224-9 pubmed
    ..These data strongly suggest that CRLM-2 is a novel cytokine receptor involved in the regulation of hematopoietic system. ..
  45. Ramalingam T, Pesce J, Mentink Kane M, Madala S, Cheever A, Comeau M, et al. Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin. J Immunol. 2009;182:6452-9 pubmed publisher
    ..Here, using TSLPR(-/-) mice, we show that while TSLPR signaling participates in the development of Schistosoma mansoni egg-induced ..
  46. Larson R, Zimmerli S, Comeau M, Itano A, Omori M, Iseki M, et al. Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses. J Immunol. 2010;184:2974-84 pubmed publisher
    ..b>TSLPR-deficient mice exhibited a dramatically reduced response, including markedly reduced local infiltration by ..
  47. Tsai M, Chen C, Mukai K, Song C, Thompson L, Ziegler S, et al. Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice. Am J Pathol. 2010;177:2411-20 pubmed publisher
    ..Rabgef1-/-TSLPR-/- mice, which lack TSLP/TSLP receptor (TSLPR) signaling, had levels of blood neutrophils, spleen myeloid cells, and serum IL-4, IgG1, and IgE levels ..
  48. Rochman Y, Kashyap M, Robinson G, Sakamoto K, Gomez Rodriguez J, Wagner K, et al. Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A. 2010;107:19455-60 pubmed publisher
    ..TSLP signals via IL-7R? and a specific TSLPR subunit that is highly related to the common cytokine receptor ? chain, ?(c)...
  49. Erdmann R, Gartner J, Leonard W, Ellison C. Lack of functional TSLP receptors mitigates Th2 polarization and the establishment and growth of 4T1 primary breast tumours but has different effects on tumour quantities in the lung and brain. Scand J Immunol. 2013;78:408-18 pubmed publisher
    ..We found that, in Tslpr(-/-) mice, the mean tumour diameters were smaller from days 27 to 40, and relatively fewer tumour cells were ..
  50. Larson R, Comeau M, Ziegler S. Cutting edge: allergen-specific CD4 T cells respond indirectly to thymic stromal lymphopoietin to promote allergic responses in the skin. J Immunol. 2013;190:4474-7 pubmed publisher
    ..This indirect effect of TSLP on CD4 T cells is due in part to the presence of TSLP exclusively in the allergen-sensitized and -challenged skin, rather than the draining lymph nodes. ..
  51. Siracusa M, Saenz S, Wojno E, Kim B, Osborne L, Ziegler C, et al. Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity. 2013;39:1158-70 pubmed publisher
    ..These data identify that TSLP-induced EMH contributes to the development of allergic inflammation and indicate that EMH is a conserved mechanism of innate immunity. ..
  52. Willart M, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht B, et al. Interleukin-1? controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med. 2012;209:1505-17 pubmed publisher
    ..These findings put IL-1? upstream in the cytokine cascade leading to epithelial and DC activation in response to inhaled HDM allergen...
  53. Asada Y, Nakae S, Ishida W, Hori K, Sugita J, Sudo K, et al. Roles of Epithelial Cell-Derived Type 2-Initiating Cytokines in Experimental Allergic Conjunctivitis. Invest Ophthalmol Vis Sci. 2015;56:5194-202 pubmed publisher
    ..RW)-induced experimental allergic conjunctivitis (EAC) models by using IL-25 knockout (KO), IL-33 KO, and TSLP receptor (TSLPR) KO mice...
  54. Taylor B, Zaph C, Troy A, Du Y, Guild K, Comeau M, et al. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J Exp Med. 2009;206:655-67 pubmed publisher
    ..epithelial cells (IECs) produce thymic stromal lymphopoietin (TSLP); however, the in vivo influence of TSLP-TSLP receptor (TSLPR) interactions on immunity and inflammation in the intestine remains unclear...
  55. Yao W, Zhang Y, Jabeen R, Nguyen E, Wilkes D, Tepper R, et al. Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. Immunity. 2013;38:360-72 pubmed publisher
    ..Together, our results demonstrate that TSLP promotes Th9 cell differentiation and function and define a requirement for IL-9 in TSLP-induced allergic inflammation. ..
  56. Ashbaugh J, Brambilla R, Karmally S, Cabello C, Malek T, Bethea J. IL7R? contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages. J Immunol. 2013;190:4525-34 pubmed publisher
    ..Taken together, these data indicate that multiple cell types use IL7R? signaling in the development of EAE, and inhibition of this pathway should be considered as a new therapeutic avenue for MS. ..
  57. Ando T, Matsumoto K, Namiranian S, Yamashita H, Glatthorn H, Kimura M, et al. Mast cells are required for full expression of allergen/SEB-induced skin inflammation. J Invest Dermatol. 2013;133:2695-2705 pubmed publisher
    ..Therefore, this clinically relevant model provides mechanistic insights into the pathogenic mechanism of human AD. ..
  58. Hara K, Iijima K, Elias M, Seno S, Tojima I, Kobayashi T, et al. Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa. J Immunol. 2014;192:4032-42 pubmed publisher
    ..These findings provide mechanistic insights into the development of type 2 immunity to airborne allergens and recognize airway UA as a key player that regulates the process in respiratory mucosa. ..
  59. Akasaki S, Matsushita K, Kato Y, Fukuoka A, Iwasaki N, Nakahira M, et al. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. Int Immunol. 2016;28:65-76 pubmed publisher
    ..Chronic AR mice were nasally administrated ragweed pollen on consecutive days for 3 weeks. In both models, TSLP receptor (TSLPR)-deficient mice showed defective sneezing responses and reduced serum ragweed-specific IgE levels ..
  60. Olkhanud P, Rochman Y, Bodogai M, Malchinkhuu E, Wejksza K, Xu M, et al. Thymic stromal lymphopoietin is a key mediator of breast cancer progression. J Immunol. 2011;186:5656-62 pubmed publisher
    ..The cancer-promoting activity of TSLP primarily required signaling through the TSLP receptor on CD4(+) T cells, promoting Th2-skewed immune responses and production of immunosuppressive factors such as ..
  61. Connor L, Tang S, Cognard E, Ochiai S, Hilligan K, Old S, et al. Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles. J Exp Med. 2017;214:125-142 pubmed publisher
    ..Thus, the priming of Th2 responses is associated with distinct transcriptional signatures in DCs in vivo, reflecting the diverse environments in which Th2 immune responses are initiated. ..
  62. Joo S, Fukuyama Y, Park E, Yuki Y, Kurashima Y, Ouchida R, et al. Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response. Mucosal Immunol. 2017;10:901-911 pubmed publisher
    ..Here, we found that the levels of TSLP and TSLPR were upregulated in the mucosal DCs of mice nasally immunized with pneumococcal surface protein A (PspA) plus ..
  63. Stier M, Zhang J, Goleniewska K, Cephus J, Rusznak M, Wu L, et al. IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow. J Exp Med. 2018;215:263-281 pubmed publisher
    ..Collectively, these data demonstrate that IL-33 plays a critical role in promoting ILC2 egress from the bone marrow. ..
  64. Reardon C, Lechmann M, Brüstle A, Gareau M, Shuman N, Philpott D, et al. Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity. 2011;35:223-35 pubmed publisher
    ..Signaling through TSLPR on nonhematopoietic cells was sufficient for recovery from DSS-induced colitis...
  65. Han H, Thelen T, Comeau M, Ziegler S. Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis. J Clin Invest. 2014;124:5442-52 pubmed publisher
    ..These results demonstrate a role for TSLP and IL-25 in the atopic march from skin sensitization to food allergic responses and provide a model system for the generation of potential therapeutic interventions. ..
  66. Di Piazza M, Nowell C, Koch U, Durham A, Radtke F. Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting. Cancer Cell. 2012;22:479-93 pubmed publisher
    ..Genetic ablation of TSLP receptor (TSLPR) perturbs T-cell-mediated protection and results in the accumulation of CD11b(+)Gr1(+) myeloid cells...
  67. Jensen C, Böiers C, Kharazi S, Lübking A, Ryden T, Sigvardsson M, et al. Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development. Blood. 2008;111:2083-90 pubmed
    ..These findings implicate a permissive role of cytokine receptors of the hematopoietin and tyrosine kinase families in early T lymphopoiesis. ..
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    ..These data indicate that the CD45R(lo-neg)CD19(+) population includes B-1 B cell-specified progenitors and support models proposing distinct developmental pathways for B-1 B cells. ..
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    ..UNK cells expressed TSLPR, and study of gd10...
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    ..We also prepared mice deficient in TSLP receptors in LCs by using TSLP receptor-deficient mice with bone marrow chimeric technique...