Genomes and Genes
Gene Symbol: Crlf1
Description: cytokine receptor-like factor 1
Alias: CLF-1, CRLM-3, CRLM3, NR6, NR6.1, cytokine receptor-like factor 1, cytokine receptor-like molecule 3, cytokine-like factor 1, novel cytokine receptor 6
- KASS D, Yu G, Loh K, Savir A, Borczuk A, Kahloon R, et al. Cytokine-like factor 1 gene expression is enriched in idiopathic pulmonary fibrosis and drives the accumulation of CD4+ T cells in murine lungs: evidence for an antifibrotic role in bleomycin injury. Am J Pathol. 2012;180:1963-78 pubmed publisher..Cytokine receptor-like factor 1 (CRLF1) was among the most highly up-regulated genes in IPF lungs, compared with normal controls...
- Kann M, Bae E, Lenz M, Li L, Trannguyen B, Schumacher V, et al. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015;142:1254-66 pubmed publisher..5. Lastly, we show that Gas1 is selectively required for FGF-stimulated AKT signaling in vitro. In summary, our data suggest a model in which WT1 modulates receptor tyrosine kinase signaling in NPCs by directing the expression of Gas1. ..
- Phelep A, Laouari D, Bharti K, Burtin M, Tammaccaro S, Garbay S, et al. MITF - A controls branching morphogenesis and nephron endowment. PLoS Genet. 2017;13:e1007093 pubmed publisher..Collectively, these results uncover a novel transcriptional network that controls branching morphogenesis during kidney development and identifies one of the first modifier genes of nephron endowment. ..
- Caruana G, Cullen McEwen L, Nelson A, Kostoulias X, Woods K, Gardiner B, et al. Spatial gene expression in the T-stage mouse metanephros. Gene Expr Patterns. 2006;6:807-25 pubmed..This study has identified genes spatially expressed in regions of the developing kidney involved in branching morphogenesis, nephrogenesis and the development of the collecting duct system, calyces, renal pelvis and ureter. ..