Gene Symbol: Crlf1
Description: cytokine receptor-like factor 1
Alias: CLF-1, CRLM-3, CRLM3, NR6, NR6.1, cytokine receptor-like factor 1, cytokine receptor-like molecule 3, cytokine-like factor 1, novel cytokine receptor 6
Species: mouse
Products:     Crlf1

Top Publications

  1. Uemura A, Takizawa T, Ochiai W, Yanagisawa M, Nakashima K, Taga T. Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3. Cytokine. 2002;18:1-7 pubmed
    ..These results suggest that CLC plays a role in astrocyte differentiation via STAT3 activation within the developing brain. ..
  2. Elson G, Graber P, Losberger C, Herren S, Gretener D, Menoud L, et al. Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J Immunol. 1998;161:1371-9 pubmed
    ..These results suggest that CLF-1 is a novel soluble cytokine receptor subunit or part of a novel cytokine complex, possibly playing a regulatory role in the immune system and during fetal development. ..
  3. Alexander W, Rakar S, Robb L, Farley A, Willson T, Zhang J, et al. Suckling defect in mice lacking the soluble haemopoietin receptor NR6. Curr Biol. 1999;9:605-8 pubmed
    ..We report here the isolation of NR6, a haemopoietin receptor that, like the p40 subunit of interleukin-12 (IL-12) [3] and the EBI3 gene induced by ..
  4. Forger N, Prevette D, Delapeyrière O, de Bovis B, Wang S, Bartlett P, et al. Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. J Neurosci. 2003;23:8854-8 pubmed
    ..The in vivo actions of CLC and CLF can account for many of the effects of CNTFRalpha on developing motoneurons. ..
  5. Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfò M, et al. Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol. 2011;359:163-75 pubmed publisher
    ..As an initial step in this direction we describe a regulatory pathway involving the anti-apoptotic gene Bcl2 that controls cell survival in early thyroid development. ..
  6. Jin W, Dai J, Zhou H, Xia Q, Zou H, Zeng R. Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry. Rapid Commun Mass Spectrom. 2004;18:2169-76 pubmed
    ..The use of the linear ion trap considerably enabled exploitation of nanoflow-HPLC/MS/MS, and in addition MS/MS/MS has great potential in phosphoproteome research of relatively complex samples. ..
  7. de Bovis B, Derouet D, Gauchat J, Elson G, Gascan H, Delapeyrière O. clc is co-expressed with clf or cntfr in developing mouse muscles. Cell Commun Signal. 2005;3:1 pubmed
    ..CONCLUSION: This expression pattern is in favor of CLC, associated either with CLF or sCNTFR, being an important player in the signal triggered by the CNTF receptor being required for motoneuron development. ..
  8. Crabé S, Guay Giroux A, Tormo A, Duluc D, Lissilaa R, Guilhot F, et al. The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling. J Immunol. 2009;183:7692-702 pubmed publisher
    ..The identification of a new IL-6R ligand is therefore important for a complete understanding of the mechanism of action of this emerging class of immunosuppressors. ..
  9. Perälä N, Jakobson M, Ola R, Fazzari P, Penachioni J, Nymark M, et al. Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney. Differentiation. 2011;81:81-91 pubmed publisher

More Information


  1. KASS D, Yu G, Loh K, Savir A, Borczuk A, Kahloon R, et al. Cytokine-like factor 1 gene expression is enriched in idiopathic pulmonary fibrosis and drives the accumulation of CD4+ T cells in murine lungs: evidence for an antifibrotic role in bleomycin injury. Am J Pathol. 2012;180:1963-78 pubmed publisher
    ..Cytokine receptor-like factor 1 (CRLF1) was among the most highly up-regulated genes in IPF lungs, compared with normal controls...
  2. Kann M, Bae E, Lenz M, Li L, Trannguyen B, Schumacher V, et al. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015;142:1254-66 pubmed publisher
    ..5. Lastly, we show that Gas1 is selectively required for FGF-stimulated AKT signaling in vitro. In summary, our data suggest a model in which WT1 modulates receptor tyrosine kinase signaling in NPCs by directing the expression of Gas1. ..
  3. Phelep A, Laouari D, Bharti K, Burtin M, Tammaccaro S, Garbay S, et al. MITF - A controls branching morphogenesis and nephron endowment. PLoS Genet. 2017;13:e1007093 pubmed publisher
    ..Collectively, these results uncover a novel transcriptional network that controls branching morphogenesis during kidney development and identifies one of the first modifier genes of nephron endowment. ..
  4. Caruana G, Cullen McEwen L, Nelson A, Kostoulias X, Woods K, Gardiner B, et al. Spatial gene expression in the T-stage mouse metanephros. Gene Expr Patterns. 2006;6:807-25 pubmed
    ..This study has identified genes spatially expressed in regions of the developing kidney involved in branching morphogenesis, nephrogenesis and the development of the collecting duct system, calyces, renal pelvis and ureter. ..