Gene Symbol: Crhr1
Description: corticotropin releasing hormone receptor 1
Alias: CRF1R, CRFR1, Crhr, corticotropin-releasing factor receptor 1, CRF 1 receptor, CRF-R-1, CRF-R1, CRF-R1alpha, CRFR-1, CRH receptor subtype-1 isoform-3, CRH-R-1, CRH-R1
Species: mouse
Products:     Crhr1

Top Publications

  1. Andrew S, Xu X, Baross Francis A, Narayanan L, Milhausen K, Liskay R, et al. Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis. 2000;21:1291-5 pubmed
    ..These variances in mutation accumulation may also play a role, in part, in the differences seen in prevalence of MSH2 and PMS2 germline mutations in hereditary non-polyposis colorectal cancer patients. ..
  2. Garlow S, Boone E, Li W, Owens M, Nemeroff C. Genetic analysis of the hypothalamic corticotropin-releasing factor system. Endocrinology. 2005;146:2362-8 pubmed
    ..There are QTL for all four targets on chromosome 12. There are a number of neurodevelopmental genes in very close proximity to the transcript abundance QTL that are potential candidate genes. ..
  3. Sandi C, Cordero M, Ugolini A, Varea E, Caberlotto L, Large C. Chronic stress-induced alterations in amygdala responsiveness and behavior--modulation by trait anxiety and corticotropin-releasing factor systems. Eur J Neurosci. 2008;28:1836-48 pubmed publisher
    ..Here we examined the impact of chronic unpredictable stress (CUS) on this effect of CRF and whether blockade of CRFR1 could prevent stress-induced changes in the electrophysiological response, the animal's behavior and in cell ..
  4. King J, Bishop G. Localization of the type 1 corticotropin releasing factor receptor (CRF-R1) in the embryonic mouse cerebellum. J Neurocytol. 2003;32:305-16 pubmed
  5. Sztainberg Y, Kuperman Y, Tsoory M, Lebow M, Chen A. The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1. Mol Psychiatry. 2010;15:905-17 pubmed publisher
    ..the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor receptor type 1 (CRFR1) expression levels in the limbic system...
  6. Contarino A, Papaleo F. The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal. Proc Natl Acad Sci U S A. 2005;102:18649-54 pubmed
    ..This study reveals a cardinal role for CRF/CRF1 receptor pathways in the negative affective states of opiate withdrawal and suggests therapeutic strategies for the treatment of opiate addiction. ..
  7. Gammie S, Stevenson S. Intermale aggression in corticotropin-releasing factor receptor 1 deficient mice. Behav Brain Res. 2006;171:63-9 pubmed
    ..CRF receptor 1 (CRFR1) is the primary receptor for CRF and in this study, we examined in detail isolation-induced intermale aggression ..
  8. Heinrich N, Meyer M, Furkert J, Sasse A, Beyermann M, Bönigk W, et al. Corticotropin-releasing factor (CRF) agonists stimulate testosterone production in mouse leydig cells through CRF receptor-1. Endocrinology. 1998;139:651-8 pubmed
  9. Smith G, Aubry J, Dellu F, Contarino A, Bilezikjian L, Gold L, et al. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. 1998;20:1093-102 pubmed
    ..Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and CRFR2) have been described...

More Information


  1. Coste S, Murray S, Stenzel Poore M. Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress. Peptides. 2001;22:733-41 pubmed
    ..Together these models provide new insights into the role of CRH pathways in promoting stability through adaptive changes, a process known as allostasis. ..
  2. Timpl P, Spanagel R, Sillaber I, Kresse A, Reul J, Stalla G, et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet. 1998;19:162-6 pubmed
    ..Two CRH receptors, Crhr1 and Crhr2, have been identified in the mouse...
  3. Bale T, Vale W. Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses. J Neurosci. 2003;23:5295-301 pubmed
    ..As mediators of the stress response, corticotropin-releasing factor (CRF) and its receptors (CRFR1 and CRFR2) have been implicated in the propensity for developing stress-related mood disorders...
  4. Muller M, Zimmermann S, Sillaber I, Hagemeyer T, Deussing J, Timpl P, et al. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci. 2003;6:1100-7 pubmed
    ..To differentiate the CNS pathways involving CRH and CRH receptor 1 (Crhr1) that modulate behavior from those that regulate neuroendocrine function, we generated a conditional knockout ..
  5. Goldberg L, Aujla P, Raetzman L. Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis. Dev Biol. 2011;358:23-32 pubmed publisher
    ..Taken together, these findings show that Notch signaling is sufficient to prevent corticotrope and melanotrope differentiation, resulting in dysregulation of the HPA axis. ..
  6. Salomons A, Arndt S, Lavrijsen M, Kirchhoff S, Ohl F. Expression of CRFR1 and Glu5R mRNA in different brain areas following repeated testing in mice that differ in habituation behaviour. Behav Brain Res. 2013;246:1-9 pubmed publisher
    ..Further, we investigated mRNA expression of CRFR1 and mGlu5R in the prelimbic cortex and amygdala, since these transmitter systems are not only involved in the ..
  7. Liu R, Yang X, Liao X, Xie X, Su Y, Li J, et al. Early postnatal stress suppresses the developmental trajectory of hippocampal pyramidal neurons: the role of CRHR1. Brain Struct Funct. 2016;221:4525-4536 pubmed
    ..In this study, we stressed male mice from postnatal day 2 (P2) to P9, and examined the potential role of CRHR1 in postnatal stress-induced structural remodeling of hippocampal CA3 pyramidal neurons directly after stress (P9), ..
  8. Treweek J, Jaferi A, Colago E, Zhou P, Pickel V. Electron microscopic localization of corticotropin-releasing factor (CRF) and CRF receptor in rat and mouse central nucleus of the amygdala. J Comp Neurol. 2009;512:323-35 pubmed publisher
    ..The findings have important implications for understanding CRF mediation of rapid responses to stress. ..
  9. Kash T, Nobis W, Matthews R, Winder D. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. J Neurosci. 2008;28:13856-65 pubmed publisher
  10. Hermann H, Lutz B. Coexpression of the cannabinoid receptor type 1 with the corticotropin-releasing hormone receptor type 1 in distinct regions of the adult mouse forebrain. Neurosci Lett. 2005;375:13-8 pubmed
    ..In trying to detail functional interactions between CB1 and the CRH receptor type 1 (CRHR1), we performed double-label-in situ hybridisation on mouse forebrain sections to localise the transcripts encoding ..
  11. Juriloff D, Harris M, Dewell S. A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci. Birth Defects Res A Clin Mol Teratol. 2004;70:509-18 pubmed
    ..The clf1 region contains 10 known genes (Arf2, Cdc27, Crhr1, Gosr2, Itgb3, Mapt, Myl4, Nsf, Wnt3, and Wnt9b). The clf2 region contains 17 known genes with human orthologs...
  12. Campbell S, Zhang C, Monte L, Roe A, Rice K, TACHE Y, et al. Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. J Alzheimers Dis. 2015;43:967-76 pubmed publisher
    ..has shown that stress-induced tau-P requires activation of the type-1 corticotropin-releasing factor receptor (CRFR1)...
  13. Sparta D, Ferraro F, Fee J, Knapp D, Breese G, Thiele T. The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling. Alcohol Clin Exp Res. 2009;33:31-42 pubmed publisher
    ..p. injections. The ADE in C57BL/6J mice can be modeled using the operant self-administration paradigm and increased ethanol self-administration associated with the ADE is modulated by CRF-1 receptor signaling. ..
  14. Rissman R, Staup M, Lee A, Justice N, Rice K, Vale W, et al. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proc Natl Acad Sci U S A. 2012;109:6277-82 pubmed publisher
    ..In contrast, CRFR1 and CRFR double-KO mice did not exhibit repeated stress-induced alterations in tau-P or solubility...
  15. Yamagata S, Kageyama K, Akimoto K, Watanuki Y, Suda T, Daimon M. Regulation of corticotropin-releasing factor and urocortin 2/3 mRNA by leptin in hypothalamic N39 cells. Peptides. 2013;50:1-7 pubmed publisher
    ..Leptin may contribute to a stress response or anorectic effect via the regulation of CRF and Ucn2/3 in the hypothalamus. ..
  16. Kadmiel M, Matson B, Espenschied S, Lenhart P, Caron K. Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation. PLoS ONE. 2017;12:e0181597 pubmed publisher
  17. Makino S, Tanaka Y, Nazarloo H, Noguchi T, Nishimura K, Hashimoto K. Expression of type 1 corticotropin-releasing hormone (CRH) receptor mRNA in the hypothalamic paraventricular nucleus following restraint stress in CRH-deficient mice. Brain Res. 2005;1048:131-7 pubmed
  18. von Wolff G, Avrabos C, Stepan J, Wurst W, Deussing J, Holsboer F, et al. Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation. J Psychiatr Res. 2011;45:256-61 pubmed publisher
    ..of neuronal excitation on its passage through the HF and absent in mice lacking the CRH receptor type 1 (CRHR1)...
  19. Bale T, Picetti R, Contarino A, Koob G, Vale W, Lee K. Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. J Neurosci. 2002;22:193-9 pubmed
    ..are critical coordinators of homeostasis whose actions are mediated through their receptors, CRF receptor 1 (CRFR1) and CRFR2, found throughout the CNS and periphery...
  20. Morisot N, Contarino A. The CRF1 and the CRF2 receptor mediate recognition memory deficits and vulnerability induced by opiate withdrawal. Neuropharmacology. 2016;105:500-507 pubmed publisher
    ..These findings bring initial evidence of a complex physiopathological role for the CRF system in cognitive deficits and the long-lasting vulnerability induced by opiate drugs. ..
  21. Deussing J, Kühne C, Pütz B, Panhuysen M, Breu J, Stenzel Poore M, et al. Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity. J Cereb Blood Flow Metab. 2007;27:1476-95 pubmed
    ..A direct role of the CRH/CRH-R1 system was supported by demonstrating Crhr1 expression in the adult murine cerebral vasculature...
  22. Justice N, Huang L, Tian J, Cole A, Pruski M, Hunt A, et al. Posttraumatic stress disorder-like induction elevates β-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses. J Neurosci. 2015;35:2612-23 pubmed publisher
    ..Together, these data demonstrate that exposure to PTSD-like trauma can drive AD pathogenesis, which directly perturbs CRF signaling, thereby enhancing chronic PTSD symptoms while increasing risk for AD-related dementia. ..
  23. Im E, Rhee S, Park Y, Fiocchi C, TACHE Y, Pothoulakis C. Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis. Gastroenterology. 2010;138:2457-67, 2467.e1-5 pubmed publisher
    ..We investigated the functions of CRHR1 and CRHR2 signaling during intestinal inflammation and angiogenesis...
  24. Giardino W, Ryabinin A. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. Alcohol Clin Exp Res. 2013;37:1161-70 pubmed publisher
  25. Verleye M, Andre N, Gillardin J. Lack of interaction between etifoxine and CRF1 and CRF2 receptors in rodents. Neurosci Res. 2006;56:53-60 pubmed
    ..The selective anxiolytic properties of etifoxine appear unrelated to an antagonist activity at the CRF1 and CRF2 receptors. The decrease in CRF activity produced by etifoxine may be related to its GABAergic properties. ..
  26. Weiss D, Butler S, Fesi J, Long C, Valentino R, Canning D, et al. Putting the past behind us: Social stress-induced urinary retention can be overcome. J Pediatr Urol. 2015;11:188-94 pubmed publisher
    ..We suspect that additional CsA responsive neural changes play a pivotal role in the abnormal voiding phenotype following social stress. ..
  27. Stevens S, Shaw T, Dykhuizen E, Lessov N, Hill J, Wurst W, et al. Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: a potential link to microglia and atrocytes that express CRH-R1. J Cereb Blood Flow Metab. 2003;23:1151-9 pubmed
    ..The authors suggest that astrocytes and microglia are cellular targets of CRH, which could serve as a link between CRH and inflammatory responses in ischemic injury via CRH-R1. ..
  28. Dunn H, Walther C, Godin C, Hall R, Ferguson S. Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling. J Biol Chem. 2013;288:15023-34 pubmed publisher
    The corticotropin-releasing factor (CRF) receptor 1 (CRFR1) is a target for the treatment of psychiatric diseases such as depression, schizophrenia, anxiety disorder, and bipolar disorder...
  29. Schmidt M, Schmidt M, Oitzl M, Müller M, Ohl F, Wurst W, et al. Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice. Neuroscience. 2003;119:589-95 pubmed
    ..It has been hypothesized that the CRH receptor 1 (CRHr1) may play an important regulatory role during development by mediating the effects of maternal deprivation...
  30. Schierloh A, Deussing J, Wurst W, Zieglgänsberger W, Rammes G. Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. Neurosci Lett. 2007;416:82-6 pubmed
    ..Using hippocampal slices, we investigated the neuronal excitability in mice lacking CRHR1 (Crhr1(-/-))...
  31. Huising M, van der Meulen T, Vaughan J, Matsumoto M, Donaldson C, Park H, et al. CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. Proc Natl Acad Sci U S A. 2010;107:912-7 pubmed publisher
    ..We demonstrate the presence of CRF receptor type 1 (CRFR1) on primary beta cells and show that activation of pancreatic CRFR1 promotes insulin secretion, thus contributing ..
  32. Xiong Y, Xie L, Abou Samra A. Signaling properties of mouse and human corticotropin-releasing factor (CRF) receptors: decreased coupling efficiency of human type II CRF receptor. Endocrinology. 1995;136:1828-34 pubmed
    ..Concentrations of 10 (or less) nM r/hCRF had no effect on IP generation. hCRF-RII did not mediate stimulation of IP even at 1000 nM r/hCRF.(ABSTRACT TRUNCATED AT 400 WORDS) ..
  33. Cipriano A, Gomes K, Nunes de Souza R. CRF receptor type 1 (but not type 2) located within the amygdala plays a role in the modulation of anxiety in mice exposed to the elevated plus maze. Horm Behav. 2016;81:59-67 pubmed publisher
    ..Neither spatiotemporal nor complementary measures were changed by intra-Amy ASV-30. These results suggest that CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the EPM. ..
  34. Tan L, Vaughan J, Perrin M, Rivier J, Sawchenko P. Distribution of corticotropin-releasing factor (CRF) receptor binding in the mouse brain using a new, high-affinity radioligand, [125 I]-PD-Sauvagine. J Comp Neurol. 2017;525:3840-3864 pubmed publisher
    ..Though lacking in ideal resolution, in vitro binding of the PD-sauvagine radioligand currently provides the most sensitive and accurate available tool for localizing CRF receptors in rodent brain. ..
  35. Nie Z, Zorrilla E, Madamba S, Rice K, Roberto M, Siggins G. Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala. ScientificWorldJournal. 2009;9:68-85 pubmed publisher
  36. Sotnikov S, Markt P, Malik V, Chekmareva N, Naik R, Sah A, et al. Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala. Transl Psychiatry. 2014;4:e359 pubmed publisher
    ..bidirectionally be rescued by appropriate environmental stimuli, (ii) corticotropin-releasing hormone receptor 1 (Crhr1), critically involved in trait anxiety, shows bidirectional alterations in its expression in the basolateral ..
  37. Inda C, Dos Santos Claro P, Bonfiglio J, Senin S, Maccarrone G, Turck C, et al. Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol. 2016;214:181-95 pubmed publisher
    Corticotropin-releasing hormone receptor 1 (CRHR1) activates G protein-dependent and internalization-dependent signaling mechanisms...
  38. Pisarchik A, Slominski A. Corticotropin releasing factor receptor type 1: molecular cloning and investigation of alternative splicing in the hamster skin. J Invest Dermatol. 2002;118:1065-72 pubmed
  39. van Kempen T, Dodos M, Woods C, Marques Lopes J, Justice N, Iadecola C, et al. Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing factor type 1 receptor following slow-pressor angiotensin II hypertension. Neuroscience. 2015;307:83-97 pubmed publisher
    ..Moreover, these results suggest that sexual dimorphism in AngII-induced hypertension is reflected by NMDA receptor trafficking in presumptive sympathoexcitatory neurons in the RVLM. ..
  40. Salim S, Hite B, Eikenburg D. Activation of the CRF(1) receptor causes ERK1/2 mediated increase in GRK3 expression in CATH.a cells. FEBS Lett. 2007;581:3204-10 pubmed
    ..This observation has important implications for the regulation of stress signaling in the brain. ..
  41. Gonzales X, Deshmukh A, Pulse M, Johnson K, Jones H. Stress-induced differences in primary and secondary resistance against bacterial sepsis corresponds with diverse corticotropin releasing hormone receptor expression by pulmonary CD11c+ MHC II+ and CD11c- MHC II+ APCs. Brain Behav Immun. 2008;22:552-64 pubmed publisher
  42. Buckinx R, Bagyánszki M, Avula L, Adriaensen D, Van Nassauw L, Timmermans J. Expression of corticotropin-releasing factor and urocortins in the normal and Schistosoma mansoni-infected mouse ileum. Cell Tissue Res. 2015;359:453-463 pubmed publisher
    ..mansoni-induced intestinal inflammation, which warrants further functional investigation with specific focus on CRF2, given the exclusive binding of UCN2 and UCN3 to this receptor. ..
  43. Martínez Laorden E, Garcia Carmona J, Baroja Mazo A, Romecín P, Atucha N, Milanés M, et al. Corticotropin-releasing factor (CRF) receptor-1 is involved in cardiac noradrenergic activity observed during naloxone-precipitated morphine withdrawal. Br J Pharmacol. 2014;171:688-700 pubmed publisher
  44. Juriloff D, Harris M, Dewell S, Brown C, Mager D, Gagnier L, et al. Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice. Birth Defects Res A Clin Mol Teratol. 2005;73:103-13 pubmed
    ..Gosr2, Wnt9b, Wnt3, Nsf, Arf2, Crhr1, Mapt, Cdc27, Myl4, Itgb3, chr11_20.152, chr11_20.154, chr11_20.155, and chr11_20...
  45. Chen Y, Bender R, Brunson K, Pomper J, Grigoriadis D, Wurst W, et al. Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus. Proc Natl Acad Sci U S A. 2004;101:15782-7 pubmed
    ..Taken together, these findings suggest that endogenous CRF, if released excessively by previous early postnatal stress, might influence neuronal connectivity and thus function of the immature hippocampus. ..
  46. Pisarchik A, Slominski A. Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. FASEB J. 2001;15:2754-6 pubmed
    ..We suggest that a polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, and external stress (UV), and that cAMP-dependent pathways and TPA may regulate CRH-R1. ..
  47. Contarino A, Dellu F, Koob G, Smith G, Lee K, Vale W, et al. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Brain Res. 1999;835:1-9 pubmed
    ..Two distinct CRF receptor subtypes, CRFR1 and CRFR2, are thought to mediate CRF actions in the CNS...
  48. Sanford C, Soden M, Baird M, Miller S, Schulkin J, Palmiter R, et al. A Central Amygdala CRF Circuit Facilitates Learning about Weak Threats. Neuron. 2017;93:164-178 pubmed publisher
    ..We further show that excitability of genetically isolated CRF-receptive (CRFR1) neurons in the CeA is potently enhanced by CRF and that CRFR1 signaling in the CeA is critical for discriminative ..
  49. Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl A, et al. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science. 2011;333:1903-7 pubmed publisher
    The corticotropin-releasing hormone receptor 1 (CRHR1) critically controls behavioral adaptation to stress and is causally linked to emotional disorders...
  50. Schmidt M, Deussing J, Oitzl M, Ohl F, Levine S, Wurst W, et al. Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. Eur J Neurosci. 2006;24:2291-8 pubmed
    ..the current study we investigated the function of specific brain corticotropin-releasing hormone receptor type 1 (CRHR1) subpopulations in the control of the HPA axis during postnatal development under basal conditions as well as ..
  51. Chotiwat C, Kelso E, Harris R. The effects of repeated restraint stress on energy balance and behavior of mice with selective deletion of CRF receptors. Stress. 2010;13:203-13 pubmed publisher
    ..We tested the effect of RRS in mice deficient in corticotropin releasing factor receptor one (CRFR1-KO) or two (CRFR2-KO). Wild type (WT) and CRFR2-KO, but not CRFR1-KO, mice lost weight during RRS...
  52. Sillaber I, Rammes G, Zimmermann S, Mahal B, Zieglgänsberger W, Wurst W, et al. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science. 2002;296:931-3 pubmed
    ..Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism. ..
  53. Pastor R, McKinnon C, Scibelli A, Burkhart Kasch S, Reed C, Ryabinin A, et al. Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism. Proc Natl Acad Sci U S A. 2008;105:9070-5 pubmed publisher
    ..A CRF/CRF1-mediated mechanism involving the HPA axis is proposed for acquisition, whereas an extrahypothalamic CRF/CRF1 participation is suggested for expression of sensitization to EtOH. ..
  54. Graf C, Kuehne C, Panhuysen M, Puetz B, Weber P, Holsboer F, et al. Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells. Mol Cell Endocrinol. 2012;362:29-38 pubmed publisher
    ..Its cognate receptor CRH receptor type 1 (CRHR1) is a potential novel target for the therapeutic intervention in major depressive disorder...
  55. Kamprath K, Plendl W, Marsicano G, Deussing J, Wurst W, Lutz B, et al. Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling. Genes Brain Behav. 2009;8:203-11 pubmed publisher
    ..Pharmacological blockade of CB(1) receptors by rimonabant in mice deficient for the CRH receptor type 1 (CRHR1(-/-)) or type 2 (CRHR2(-/-)), and in respective wild-type littermates, resulted in a sustained fear response in ..
  56. Briquet Laugier V, Xia Y, Rooke K, Mehrabian M, Lusis A, Doolittle M. Mapping of three members of the mouse protein disulfide isomerase family. Mamm Genome. 1998;9:176-7 pubmed
  57. Magalhaes A, Holmes K, Dale L, Comps Agrar L, Lee D, Yadav P, et al. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci. 2010;13:622-9 pubmed publisher
    ..are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R)...
  58. Assil Kishawi I, Abou Samra A. Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptor. J Biol Chem. 2002;277:32558-61 pubmed
    Contact sites between the corticotropin-releasing factor receptor type 1 (CRFR1), the sauvagine (SVG) radioligands [Tyr(0),Gln(1)]SVG ((125)I-YQS) and [Tyr(0),Gln(1), Leu(17)]SVG ((125)I-YQLS) were examined...
  59. Chen A, Blount A, Vaughan J, Brar B, Vale W. Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids. Endocrinology. 2004;145:2445-57 pubmed
    ..We found a significant increase in Ucn II mRNA levels in the skin, but not in skeletal muscle, of both CRFR1- and CRFR2-null mice compared with their wild-type littermates...
  60. Molander A, Vengeliene V, Heilig M, Wurst W, Deussing J, Spanagel R. Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. Neuropsychopharmacology. 2012;37:1047-56 pubmed publisher
    Corticotropin-releasing hormone (CRH) and its receptor, CRH receptor-1 (CRHR1), have a key role in alcoholism...
  61. Klingenspor M, Bodnar J, Xia Y, Welch C, Lusis A, Reue K. Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively. Mamm Genome. 1997;8:539-40 pubmed
  62. Miguel T, Nunes de Souza R. Anxiogenic and antinociceptive effects induced by corticotropin-releasing factor (CRF) injections into the periaqueductal gray are modulated by CRF1 receptor in mice. Horm Behav. 2011;60:292-300 pubmed publisher
    ..2?l), a CRF2 receptor antagonist, did not alter the CRF effects. Present results are suggestive that CRF1 (but not CRF2) receptors play a crucial role in the anxiogenic and antinociceptive effects induced by CRF in the dPAG in mice. ..
  63. Romero A, Garcia Carmona J, Laorden M, Puig M. Role of CRF1 receptor in post-incisional plasma extravasation and nociceptive responses in mice. Toxicol Appl Pharmacol. 2017;332:121-128 pubmed publisher
    ..Our results show that CRF/CRF1 receptors seem to be a protective role in latent pain sensitization induced by surgery and in the local inflammatory response to injury. ..
  64. Ramot A, Jiang Z, Tian J, Nahum T, Kuperman Y, Justice N, et al. Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. Nat Neurosci. 2017;20:385-388 pubmed publisher
  65. Osada T, Sakaki Y, Takeuchi T. Puromycin-sensitive aminopeptidase gene (Psa) maps to mouse chromosome 11. Genomics. 1999;56:361-2 pubmed
  66. Paneda C, Huitron Resendiz S, Frago L, Chowen J, Picetti R, de Lecea L, et al. Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. J Neurosci. 2009;29:4155-61 pubmed publisher
    ..Our results suggest that NPS receptors may be an important target for drug abuse research and treatment and that CRF(1) mediates the cocaine-seeking and locomotor stimulant effects of NPS, but not its effects on anxiety-like behavior...
  67. Chen Y, Dubé C, Rice C, Baram T. Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci. 2008;28:2903-11 pubmed publisher
    ..In addition, mice lacking the CRFR(1) receptor had augmented spine density. These findings support a mechanistic role for CRH-CRFR(1) signaling in stress-evoked spine loss and dendritic remodeling. ..
  68. Kuperman Y, Weiss M, Dine J, Staikin K, Golani O, Ramot A, et al. CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting. Cell Metab. 2016;23:1185-1199 pubmed publisher
    Signaling by the corticotropin-releasing factor receptor type 1 (CRFR1) plays an important role in mediating the autonomic response to stressful challenges. Multiple hypothalamic nuclei regulate sympathetic outflow...
  69. Vergetaki A, Jeschke U, Vrekoussis T, Taliouri E, Sabatini L, Papakonstanti E, et al. Galectin-1 overexpression in endometriosis and its regulation by neuropeptides (CRH, UCN) indicating its important role in reproduction and inflammation. PLoS ONE. 2014;9:e114229 pubmed publisher
    ..of CRH and UCN in galectin-1 expression in Ishikawa cell line and macrophages and investigated the implication of CRHR1 in these responses. Eutopic and ectopic endometrium specimens, Ishikawa cell line and mice macrophages were used...
  70. Nguyen N, Keck M, Hetzenauer A, Thoeringer C, Wurst W, Deussing J, et al. Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge. Psychopharmacology (Berl). 2006;188:374-85 pubmed
  71. Million M, Wang L, Stenzel Poore M, Coste S, Yuan P, Lamy C, et al. Enhanced pelvic responses to stressors in female CRF-overexpressing mice. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1429-38 pubmed
  72. Gammie S, Bethea E, Stevenson S. Altered maternal profiles in corticotropin-releasing factor receptor 1 deficient mice. BMC Neurosci. 2007;8:17 pubmed
    ..In this study, we examined the maternal profile of mice missing the CRF receptor 1 (CRFR1)...
  73. Chu K, Koob G, Cole M, Zorrilla E, Roberts A. Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. Pharmacol Biochem Behav. 2007;86:813-21 pubmed
    ..In addition, a model is presented that may be useful for studies examining underlying mechanisms of the ethanol addiction process as well as for testing potential therapeutics. ..
  74. Sakamoto R, Matsubara E, Nomura M, Wang L, Kawahara Y, Yanase T, et al. Roles for corticotropin-releasing factor receptor type 1 in energy homeostasis in mice. Metabolism. 2013;62:1739-48 pubmed publisher
    Expression of corticotropin-releasing factor type 1 receptor (CRFR1) has been shown on pancreatic ? cells, and its activation potentiates glucose-stimulated insulin secretion (GSIS)...
  75. Wang X, Su Y, Wagner K, Avrabos C, Scharf S, Hartmann J, et al. Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nat Neurosci. 2013;16:706-13 pubmed publisher
    Stress impairs cognition via corticotropin-releasing hormone receptor 1 (CRHR1), but the molecular link between abnormal CRHR1 signaling and stress-induced cognitive impairments remains unclear...
  76. Simard M, Cote M, Provost P, Tremblay Y. Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation. Reprod Biol Endocrinol. 2010;8:134 pubmed publisher
    ..b>Crhr1 mRNA co-localized with Pomc mRNA in cells surrounding the proximal epithelium on GD 15.5 and 16.5...
  77. Huang C, Shih M, Hsu N, Chien Y, Chung B. Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression. Endocrinology. 2012;153:4749-56 pubmed
    ..Thus, the corticosterone synthesized in situ by the fetus is required for negative feedback suppression of the hypothalamus-pituitary-adrenal axis and for catecholamine synthesis in adrenal medulla. ..
  78. Hwa L, Holly E, DeBold J, Miczek K. Social stress-escalated intermittent alcohol drinking: modulation by CRF-R1 in the ventral tegmental area and accumbal dopamine in mice. Psychopharmacology (Berl). 2016;233:681-90 pubmed publisher
    ..CRF-R1 may be a mechanism for balancing the dysregulation of stress and reward in alcohol use disorders. ..
  79. Darlington T, McCarthy R, Cox R, Miyamoto Ditmon J, Gallego X, Ehringer M. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Genes Brain Behav. 2016;15:474-90 pubmed publisher
    ..between ethanol consumption and wheel running include multiple potassium channel genes, Oprm1, Prkcg, Stxbp1, Crhr1, Gabra3, Slc6a13, Stx1b, Pomc, Rassf5 and Camta2...
  80. Sherrin T, Todorovic C, Zeyda T, Tan C, Wong P, Hon P, et al. Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system. Mol Psychiatry. 2009;14:291-307 pubmed publisher
    ..In sum, our results provide a novel model for the interaction of the CRF and CCK systems contributing to the development of hypersensitive emotional circuitry. ..
  81. Narla C, Scidmore T, Jeong J, Everest M, Chidiac P, Poulter M. A switch in G protein coupling for type 1 corticotropin-releasing factor receptors promotes excitability in epileptic brains. Sci Signal. 2016;9:ra60 pubmed publisher
    ..These observations indicate that seizures produce changes in neuronal signaling that can increase seizure occurrence by converting a beneficial stress response into an epileptic trigger. ..
  82. Roe A, Staup M, Serrats J, Sawchenko P, Rissman R. Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors. Eur J Neurosci. 2011;34:448-56 pubmed publisher
    ..and double CRFR knockouts with only subtle variation, which included a reliable exaggeration of tau-P responses in CRFR1-deficient mice...