Gene Symbol: Crem
Description: cAMP responsive element modulator
Alias: ICER, ICERI, cAMP-responsive element modulator, cAMP responsive element moderator, inducible cAMP early repressor
Species: mouse
Products:     Crem

Top Publications

  1. Aguado F, Díaz Ruiz C, Parlato R, MARTINEZ A, Carmona M, Bleckmann S, et al. The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity. J Neurosci. 2009;29:328-33 pubmed publisher
    ..Here, we use CREB1(Nescre)CREM(-/-) (cAMP-responsive element modulator) mutants to investigate the role of these genes in stimulus-independent ..
  2. Giachino C, De Marchis S, Giampietro C, Parlato R, Perroteau I, Schutz G, et al. cAMP response element-binding protein regulates differentiation and survival of newborn neurons in the olfactory bulb. J Neurosci. 2005;25:10105-18 pubmed
    ..Transgenic mice lacking CREB, in a null CREM genetic background, show reduced survival of newborn neurons in the OB...
  3. Martianov I, Choukrallah M, Krebs A, Ye T, Legras S, Rijkers E, et al. Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells. BMC Genomics. 2010;11:530 pubmed publisher
    CREB and CREM are closely related factors that regulate transcription in response to various stress, metabolic and developmental signals...
  4. Foulkes N, Mellstrom B, Benusiglio E, Sassone Corsi P. Developmental switch of CREM function during spermatogenesis: from antagonist to activator. Nature. 1992;355:80-4 pubmed
    ..We have previously described the CREM (cyclic AMP-responsive element modulator) gene which generates, by cell-specific splicing, alternative antagonists ..
  5. Zmrzljak U, Korencic A, Kosir R, Golicnik M, Sassone Corsi P, Rozman D. Inducible cAMP early repressor regulates the Period 1 gene of the hepatic and adrenal clocks. J Biol Chem. 2013;288:10318-27 pubmed publisher
    ..cAMP signaling through CREM (cAMP-responsive element modulator) and its variant ICER (inducible cAMP early repressor) is linked to the circadian regulation of pineal melatonin synthesis, although little is known about ..
  6. Molina C, Foulkes N, Lalli E, Sassone Corsi P. Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell. 1993;75:875-86 pubmed
    ..The induced transcript encodes a novel repressor, inducible cAMP early repressor (ICER), and is generated from an alternative intronic promoter...
  7. Nantel F, Monaco L, Foulkes N, Masquilier D, LeMeur M, Henriksen K, et al. Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature. 1996;380:159-62 pubmed
    ..Transcription activator CREM (cyclic AMP-responsive element modulator) is highly expressed in postmeiotic cells, and CREM may be responsible for ..
  8. Beissbarth T, Borisevich I, Hörlein A, Kenzelmann M, Hergenhahn M, Klewe Nebenius A, et al. Analysis of CREM-dependent gene expression during mouse spermatogenesis. Mol Cell Endocrinol. 2003;212:29-39 pubmed
    The transcription factors CREM, CREB, and ATF-1 constitute a subfamily of beta-Zip transcription factors. Several different kinase cascades regulate the activity of these proteins...
  9. Fimia G, De Cesare D, Sassone Corsi P. CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature. 1999;398:165-9 pubmed
    Transcriptional activation by CREB and CREM requires phosphorylation of a serine residue within the activation domain (Ser 133 in CREB; Ser 117 in CREM) which as a result interacts with the coactivator CBP...

More Information


  1. Bilbao A, Parkitna J, Engblom D, Perreau Lenz S, Sanchis Segura C, Schneider M, et al. Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proc Natl Acad Sci U S A. 2008;105:17549-54 pubmed publisher
    ..These findings reveal a critical role for CaMKIV in the development and persistence of cocaine-induced behaviors, through mechanisms dissociated from acute effects on gene expression and CREB-dependent transcription. ..
  2. Acimovic J, Fink M, Pompon D, Bjorkhem I, Hirayama J, Sassone Corsi P, et al. CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver. Biochem Biophys Res Commun. 2008;376:206-10 pubmed publisher
    We show for the first time that isoforms of the cAMP response element modulator Crem, regulate the circadian expression of Cyp51 and other cholesterogenic genes in the mouse liver...
  3. Mantamadiotis T, Lemberger T, Bleckmann S, Kern H, Kretz O, Martin Villalba A, et al. Disruption of CREB function in brain leads to neurodegeneration. Nat Genet. 2002;31:47-54 pubmed
    ..Mice with a Crem(-/-) background and lacking Creb in the central nervous system during development show extensive apoptosis of ..
  4. Foulkes N, Borrelli E, Sassone Corsi P. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell. 1991;64:739-49 pubmed
    ..We demonstrate that while CREB is expressed uniformly in several cell types, this gene, termed CREM, shows cell-specific expression...
  5. Conti A, Kuo Y, Valentino R, Blendy J. Inducible cAMP early repressor regulates corticosterone suppression after tricyclic antidepressant treatment. J Neurosci. 2004;24:1967-75 pubmed
    ..element-modulator (CREM) gene yields activator and repressor isoforms, including the strong repressor inducible cAMP early repressor (ICER)...
  6. Chen A, Ginty D, Fan C. Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature. 2005;433:317-22 pubmed
    ..Our findings raise the possibility that PKA/CREB signalling may also contribute to other Wnt-regulated processes in embryonic patterning, stem cell renewal and cancer. ..
  7. Allagnat F, Alonso F, Martin D, Abderrahmani A, Waeber G, Haefliger J. ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells. J Biol Chem. 2008;283:5226-34 pubmed
    ..Palmitate treatment led to overexpression of the inducible cAMP early repressor (ICER-1gamma), which bound to a functional cAMP-response element located in the promoter of the CX36 ..
  8. Bleckmann S, Blendy J, Rudolph D, Monaghan A, Schmid W, Schutz G. Activating transcription factor 1 and CREB are important for cell survival during early mouse development. Mol Cell Biol. 2002;22:1919-25 pubmed
    Activating transcription factor 1 (ATF1), CREB, and the cyclic AMP (cAMP) response element modulatory protein (CREM), which constitute a subfamily of the basic leucine zipper transcription factors, activate gene expression by binding as ..
  9. Sassone Corsi P. CREM: a master-switch regulating the balance between differentiation and apoptosis in male germ cells. Mol Reprod Dev. 2000;56:228-9 pubmed
    Cyclic AMP-responsive element modulator (CREM) is a transcription factor highly expressed in the post-meiotic germ cells of the testis...
  10. Rozman D, Fink M, Fimia G, Sassone Corsi P, Waterman M. Cyclic adenosine 3',5'-monophosphate(cAMP)/cAMP-responsive element modulator (CREM)-dependent regulation of cholesterogenic lanosterol 14alpha-demethylase (CYP51) in spermatids. Mol Endocrinol. 1999;13:1951-62 pubmed
    ..b>CREM-/- mice lack the abundant germ cell-specific CYP51 mRNAs in testis while expression of somatic CYP51 transcripts is ..
  11. Nantel F, Sassone Corsi P. CREM: a transcriptional master switch during the spermatogenesis differentiation program. Front Biosci. 1996;1:d266-9 pubmed
    ..The CREM gene encodes activators and repressors of cAMP-mediated gene transcription...
  12. Blendy J, Kaestner K, Weinbauer G, Nieschlag E, Schutz G. Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature. 1996;380:162-5 pubmed
    ..We have used gene targeting to selectively eliminate the transcription factor CREM (cyclic AMP- responsive element modulator), which is thought to be important for mammalian spermatogenesis...
  13. Daniel P, Rohrbach L, Habener J. Novel cyclic adenosine 3',5'-monophosphate (cAMP) response element modulator theta isoforms expressed by two newly identified cAMP-responsive promoters active in the testis. Endocrinology. 2000;141:3923-30 pubmed
    ..CREM, whereas the cAMP-responsive P2 promoter activates the formation of messenger RNAs encoding the inducible cAMP early repressor. Here we report the identification of two additional promoters in the CREM gene, P3 and P4, that in ..
  14. Kojima N, Borlikova G, Sakamoto T, Yamada K, Ikeda T, Itohara S, et al. Inducible cAMP early repressor acts as a negative regulator for kindling epileptogenesis and long-term fear memory. J Neurosci. 2008;28:6459-72 pubmed publisher
    ..To study the physiological role of inducible cAMP early repressor (ICER), a CRE-mediated gene transcription repressor, in neuronal plasticity and LTM, we generated two ..
  15. Liu F, Lee S, Adams D, Gronowicz G, Kream B. CREM deficiency in mice alters the response of bone to intermittent parathyroid hormone treatment. Bone. 2007;40:1135-43 pubmed
    ..We previously showed that PTH induces ICER (inducible cAMP early repressor) in osteoblasts...
  16. Bird A, Flecknoe S, Tan K, Olsson P, Antony N, Mantamadiotis T, et al. cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS ONE. 2011;6:e17843 pubmed publisher
    ..5 with little or no expansion of airway luminal spaces, a phenotype also observed with the Creb1(-/-) lung on a Crem(-/-) genetic background...
  17. Harzenetter M, Novotny A, Gais P, Molina C, Altmayr F, Holzmann B. Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER. J Immunol. 2007;179:607-15 pubmed the cAMP/protein kinase A pathway leading to rapid up-regulation of the transcriptional repressor, inducible cAMP early repressor (ICER)...
  18. Mantamadiotis T, Kretz O, Ridder S, Bleckmann S, Bock D, Grone H, et al. Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice. Mol Endocrinol. 2006;20:204-11 pubmed
    ..These findings show that CREB is required for the efficient production of GHRH in hypothalamus, in addition to its previously reported role in pituitary GH production and somatotroph expansion. ..
  19. Kell C, Dehghani F, Wicht H, Molina C, Korf H, Stehle J. Distribution of transcription factor inducible cyclicAMP early repressor (ICER) in rodent brain and pituitary. J Comp Neurol. 2004;478:379-94 pubmed activator cyclicAMP responsive element binding protein (CREB) and inhibitor inducible cyclicAMP early repressor (ICER), play an important role...
  20. Barbati S, Colussi C, Bacci L, Aiello A, Re A, Stigliano E, et al. Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia. Endocrinology. 2017;158:2391-2405 pubmed publisher
    ..remodeling such as Nexilin (NEXN), versican, cyclic adenosine 5'-monophosphate-responsive element modulator (CREM), and adrenoceptor ?2A (ADRA2)...
  21. Liu Z, Zhou S, Liao L, Chen X, Meistrich M, Xu J. Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. J Biol Chem. 2010;285:2758-70 pubmed publisher
    ..the altered histone modifications in Jmjd1a-deficient germ cells caused diminished cAMP-response element modulator (Crem) recruitment to chromatin and decreased expression of the Crem coactivator Act and their target genes Tnp1 (..
  22. Nervina J, Tetradis S, Huang Y, Harrison D, Molina C, Kream B. Expression of inducible cAMP early repressor is coupled to the cAMP-protein kinase A signaling pathway in osteoblasts. Bone. 2003;32:483-90 pubmed
    We previously showed that parathyroid hormone (PTH) induces inducible cAMP early repressor (ICER) in osteoblastic cells and mouse calvariae...
  23. Gundersen B, Briand L, Onksen J, LeLay J, Kaestner K, Blendy J. Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: role of cAMP response-element modulator ?. J Neurosci. 2013;33:13673-85 pubmed publisher
    ..Upregulation of the CREB-family protein cAMP response-element modulator (CREM) was observed after CREB deletion...
  24. Kosir R, Juvan P, Perse M, Büdefeld T, Majdic G, Fink M, et al. Novel insights into the downstream pathways and targets controlled by transcription factors CREM in the testis. PLoS ONE. 2012;7:e31798 pubmed publisher
    The essential role of the Crem gene in normal sperm development is widely accepted and is confirmed by azoospermia in male mice lacking the Crem gene...
  25. Yoshida N, Comte D, Mizui M, Otomo K, Rosetti F, Mayadas T, et al. ICER is requisite for Th17 differentiation. Nat Commun. 2016;7:12993 pubmed publisher
    b>Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM)...
  26. De Cesare D, Fimia G, Brancorsini S, Parvinen M, Sassone Corsi P. Transcriptional control in male germ cells: general factor TFIIA participates in CREM-dependent gene activation. Mol Endocrinol. 2003;17:2554-65 pubmed
    ..In this physiological context, transcriptional control mediated by the activator CREM (cAMP-responsive element modulator) represents an established paradigm...
  27. Hedrich C, Crispin J, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, et al. cAMP responsive element modulator (CREM) ? mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells. J Biol Chem. 2014;289:2361-70 pubmed publisher
    ..We recently linked the transcription factor cAMP responsive element modulator (CREM) ?, which is expressed at increased levels in T cells from SLE patients and lupus prone MRL/..
  28. Parlato R, Otto C, Begus Y, Stotz S, Schutz G. Specific ablation of the transcription factor CREB in sympathetic neurons surprisingly protects against developmentally regulated apoptosis. Development. 2007;134:1663-70 pubmed
    ..Thus, our analysis indicates that the activity of cell-autonomous pro-survival signalling is operative in developing sympathetic neurons in the absence of CREB. ..
  29. Bodor J, Fehervari Z, Diamond B, Sakaguchi S. ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells. Eur J Immunol. 2007;37:884-95 pubmed
    Here, we report that inducible cAMP early repressor/cAMP response element modulator (ICER/CREM) is induced early in CD25(+)CD4(+) regulatory T cell (T(R)) assays mainly in activated Foxp3(-) effector T cells and this induction correlates ..
  30. Vourekas A, Zheng K, Fu Q, Maragkakis M, Alexiou P, Ma J, et al. The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015;29:617-29 pubmed publisher
    ..Our results support a model in which MOV10L1 RNA helicase activity promotes unwinding and funneling of the single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing. ..
  31. Wu R, Zeng Y, Pan I, Wu M. Androgen Receptor Coactivator ARID4B Is Required for the Function of Sertoli Cells in Spermatogenesis. Mol Endocrinol. 2015;29:1334-46 pubmed publisher
    ..Together, our study identified ARID4B to be a key regulator of Sertoli cell function important for male germ cell development. ..
  32. Antony N, Weir J, McDougall A, Mantamadiotis T, Meikle P, Cole T, et al. cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS ONE. 2013;8:e59763 pubmed publisher
    ..Taken together these results demonstrate that Creb1 is essential for the induction and maintenance of Scd1 in developing fetal mouse lung epithelial cells. ..
  33. Urano A, Endoh M, Wada T, Morikawa Y, Itoh M, Kataoka Y, et al. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol Cell Biol. 2005;25:6834-45 pubmed
    ..These results may have clinical implications in the understanding of human male infertility. ..
  34. Brindle P, Linke S, Montminy M. Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors. Nature. 1993;364:821-4 pubmed
    ..CREB that contains Ser133 and is termed the kinase-inducible domain (KID)2, which also occurs in the CREB-related CREM-alpha and -beta proteins, although these are transcriptional repressors...
  35. Masquilier D, Foulkes N, Mattei M, Sassone Corsi P. Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. Cell Growth Differ. 1993;4:931-7 pubmed
    The CREM (cyclic AMP-responsive element modulator) gene encodes multiple regulators of the cyclic AMP transcriptional response. CREM expression has been linked with several key physiological aspects of neuroendocrine pathways...
  36. Liu F, Huang Y, Kream B. Identification of novel cAMP responsive element modulator (CREM) isoforms expressed by osteoblasts. Calcif Tissue Int. 2005;77:91-5 pubmed
    ..We showed previously that parathyroid hormone induces the CREM P2 promoter products known as ICER (inducible cAMP early repressor) in osteoblasts...
  37. Jin S, Blendy J, Thomas S. Cyclic AMP response element-binding protein is required for normal maternal nurturing behavior. Neuroscience. 2005;133:647-55 pubmed
    ..maternal behavior phenotype was present in mice with a null mutation of the cyclic AMP response element modulator (Crem) gene...
  38. Muniz L, Molina C. The transcriptional repressor ICER binds to multiple loci throughout the genome. Biochem Biophys Res Commun. 2016;478:1462-5 pubmed publisher
    ..One of these factors, Inducible cAMP Early Repressor (ICER) has been implicated in the transcriptional regulation of cAMP inducible genes during ..
  39. Kuttkat N, Mohs A, Ohl K, Hooiveld G, Longerich T, Tenbrock K, et al. Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic liver disease. Gut. 2017;66:908-919 pubmed publisher
    ..The cyclic AMP-responsive element modulator-α (CREMα) is a central mediator of T-cell pathogenesis, which contributes to increased IL-17 expression in patients with ..
  40. Han W, Takamatsu Y, Yamamoto H, Kasai S, Endo S, Shirao T, et al. Inhibitory role of inducible cAMP early repressor (ICER) in methamphetamine-induced locomotor sensitization. PLoS ONE. 2011;6:e21637 pubmed publisher
    The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is highly expressed in the central nervous system and functions as a repressor of cAMP response element-binding protein (CREB) transcription...
  41. Kuramochi Miyagawa S, Kimura T, Ijiri T, Isobe T, Asada N, Fujita Y, et al. Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development. 2004;131:839-49 pubmed
    ..These data indicate that MILI is essential for the differentiation of spermatocytes. ..
  42. Ciccone N, Xu S, Lacza C, Carroll R, Kaiser U. Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factors. Mol Cell Biol. 2010;30:1028-40 pubmed publisher
    ..a transcriptional repressor(s) to attenuate the action of CRE binding protein (CREB) and show that inducible cAMP early repressor (ICER) fulfills such a role...
  43. Grootegoed J, Baarends W, Roest H, Hoeijmakers J. Knockout mouse model and gametogenic failure. Mol Cell Endocrinol. 1998;145:161-6 pubmed
    ..The focus will be on the mHR6B gene knockout mouse, which shows male infertility. The mHR6B gene encodes an ubiquitin-conjugating enzyme, and the data point to an important role of the ubiquitin pathway in gametogenesis. ..
  44. Blendy J, Kaestner K, Schmid W, Gass P, Schutz G. Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. EMBO J. 1996;15:1098-106 pubmed
    ..Together with the up-regulation of the cAMP response element modulator protein (CREM) mRNA and protein levels demonstrated previously in CREB mutant mice, we suggest that the up-regulation of CREB ..
  45. Hammerich L, Warzecha K, Stefkova M, Bartneck M, Ohl K, Gassler N, et al. Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice. Hepatology. 2015;61:990-1002 pubmed publisher
    ..The transcription factor, cyclic adenosine monophosphate-responsive element modulator alpha (CREMα) can endorse differentiation of T lymphocytes toward T-helper (Th)17 cells, thereby promoting autoimmunity in ..
  46. Seidl M, Steingräber A, Wolf C, Sur T, Hildebrandt I, Witten A, et al. Transcription factor cAMP response element modulator (Crem) restrains Pdgf-dependent proliferation of vascular smooth muscle cells in mice. Pflugers Arch. 2015;467:2165-77 pubmed publisher
    Transcription factors of the cAMP response element-binding protein (Creb)/cAMP response element modulator (Crem) family were linked to the switch from a contractile to a proliferating phenotype in vascular smooth muscle cells (VSMCs)...
  47. Maldonado R, Smadja C, Mazzucchelli C, Sassone Corsi P, Mazucchelli C. Altered emotional and locomotor responses in mice deficient in the transcription factor CREM. Proc Natl Acad Sci U S A. 1999;96:14094-9 pubmed
    ..These are the products of three genes in the mouse, CREB, CRE modulator (CREM), and ATF-1...
  48. Modarressi M, Behnam B, Cheng M, Taylor K, Wolfe J, van der Hoorn F. Tsga10 encodes a 65-kilodalton protein that is processed to the 27-kilodalton fibrous sheath protein. Biol Reprod. 2004;70:608-15 pubmed
    ..Our results suggest the possibility that Tsga10 plays a role in the sperm tail fibrous sheath. ..
  49. Wistuba J, Schlatt S, Cantauw C, von Schönfeldt V, Nieschlag E, Behr R. Transplantation of wild-type spermatogonia leads to complete spermatogenesis in testes of cyclic 3',5'-adenosine monophosphate response element modulator-deficient mice. Biol Reprod. 2002;67:1052-7 pubmed
    The cAMP response element modulator (CREM) gene encodes transcription factors that are highly expressed in spermatids. A deficiency of the CREM gene leads to male infertility in mice due to round spermatid maturation arrest...
  50. Müller F, Lewin G, Matus M, Neumann J, Riemann B, Wistuba J, et al. Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM gene. FASEB J. 2003;17:103-5 pubmed
    ..Here, we address the specific role of transcription factor CREM for cardiac function in CREM mutant mice with complete inactivation of the CREM gene...
  51. Ahlmann M, Varga G, Sturm K, Lippe R, Benedyk K, Viemann D, et al. The cyclic AMP response element modulator {alpha} suppresses CD86 expression and APC function. J Immunol. 2009;182:4167-74 pubmed publisher
    The cAMP response element modulator (CREM)alpha is a widely expressed transcriptional repressor that is important for the termination of the T cell immune response and contributes to the abnormal T cell function in patients with systemic ..
  52. Lonze B, Riccio A, Cohen S, Ginty D. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron. 2002;34:371-85 pubmed
    ..Thus, during their period of neurotrophin dependency, peripheral neurons require CREB-mediated gene expression for both survival and growth in vivo. ..
  53. Thompson I, Ciccone N, Zhou Q, Xu S, Khogeer A, Carroll R, et al. GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER. Mol Endocrinol. 2016;30:348-60 pubmed publisher
    ..Two transcription factors, cAMP-response element-binding protein (CREB) and inducible cAMP early repressor (ICER), have been implicated in the regulation of rat Fshb gene expression...
  54. Shawlot W, Vazquez Chantada M, Wallingford J, Finnell R. Rfx2 is required for spermatogenesis in the mouse. Genesis. 2015;53:604-611 pubmed publisher
    ..Our results indicate that Rfx2 is not essential for embryonic development in the mouse but is required for spermatogenesis. genesis 53:604-611, 2015. © 2015 Wiley Periodicals, Inc. ..
  55. Pennington D, Silva Santos B, Shires J, Theodoridis E, Pollitt C, Wise E, et al. The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol. 2003;4:991-8 pubmed
    ..Thus, normal gammadelta cell development is dependent on the development of conventional alphabeta T cells. ..
  56. Parlato R, Rieker C, Turiault M, Tronche F, Schutz G. Survival of DA neurons is independent of CREM upregulation in absence of CREB. Genesis. 2006;44:454-64 pubmed
    cAMP response element binding protein (CREB) and the related factors CREM (cAMP response element modulator) and ATF1 (activation transcription factor 1) are bZIP-domain-containing transcription factors activated through cAMP and other ..
  57. Sawka Verhelle D, Escoubet Lozach L, Fong A, Hester K, Herzig S, Lebrun P, et al. PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation. J Biol Chem. 2004;279:17772-84 pubmed dramatically up-regulated during macrophage differentiation and phosphorylation of CREB-1 and the related factor CREM-1 are stimulated by M-CSF in a SAPK2/p38-dependent manner...
  58. Chennathukuzhi V, Morales C, El Alfy M, Hecht N. The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells. Proc Natl Acad Sci U S A. 2003;100:15566-71 pubmed
    ..coimmunoprecipitates with TB-RBP in a RNA-protein complex containing specific cAMP-responsive element modulator (CREM)-regulated mRNAs...
  59. Tenbrock K, Kyttaris V, Ahlmann M, Ehrchen J, Tolnay M, Melkonyan H, et al. The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain. J Immunol. 2005;175:5975-80 pubmed
    ..We have identified a new cis-binding site for the cAMP response element (CRE) modulator (CREM) on the TCR zeta promoter, centered on the -390 nucleotide...
  60. Vazquez Chona F, Khan A, Chan C, Moore A, Dash P, Hernandez M, et al. Genetic networks controlling retinal injury. Mol Vis. 2005;11:958-70 pubmed
    ..Using genetic linkage analysis of natural transcript variation, we identified regulatory loci and candidate regulators that control transcript levels of acute phase genes. ..
  61. Nagamori I, Yomogida K, Adams P, Sassone Corsi P, Nojima H. Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation. J Biol Chem. 2006;281:15073-81 pubmed
    ..Our analysis here of the expression of these genes in the testis of the cAMP-responsive element modulator (CREM)-null mouse revealed that 54 TISP genes are under the transcriptional regulation of CREM...
  62. Koga T, Hedrich C, Mizui M, Yoshida N, Otomo K, Lieberman L, et al. CaMK4-dependent activation of AKT/mTOR and CREM-? underlies autoimmunity-associated Th17 imbalance. J Clin Invest. 2014;124:2234-45 pubmed publisher
    ..of CaMK4 reduced Il17 transcription through decreased activation of the cAMP response element modulator ? (CREM-?) and reduced activation of the AKT/mTOR pathway, which is known to enhance Th17 differentiation...
  63. Bodor J, Fehervari Z, Diamond B, Sakaguchi S. Regulatory T cell-mediated suppression: potential role of ICER. J Leukoc Biol. 2007;81:161-7 pubmed
    ..suppression of IL-2 production in responder CD25- T lymphocytes and the potential involvement of inducible cAMP early repressor (ICER) in this suppression...
  64. Tenbrock K, Juang Y, Leukert N, Roth J, Tsokos G. The transcriptional repressor cAMP response element modulator alpha interacts with histone deacetylase 1 to repress promoter activity. J Immunol. 2006;177:6159-64 pubmed
    Transcriptional repression is a fundamental mechanism of gene regulation. cAMP response element (CRE) modulator (CREM)alpha is an ubiquitously expressed transcription factor and a counterpart of the activator CREB...
  65. Xiao P, Hu L, Li J, Lin W, Chen X, Xu P. NSSR1 is regulated in testes development and cryptorchidism and promotes the exon 5-included splicing of CREB transcripts. Mol Reprod Dev. 2007;74:1363-72 pubmed
    ..RT-PCR analysis demonstrated that the alternative splicing of CREB and CREM genes was altered in the cryptorchid testes...
  66. Stock A, Booth S, Cerundolo V. Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans. J Exp Med. 2011;208:761-73 pubmed publisher
    ..Given the role of PGE2 in regulating the development of RA-producing DCs, modulating this pathway may prove a novel means to control the development of gut-tropic immune responses. ..
  67. Wu H, Chen Y, Miao S, Zhang C, Zong S, Koide S, et al. Sperm associated antigen 8 (SPAG8), a novel regulator of activator of CREM in testis during spermatogenesis. FEBS Lett. 2010;584:2807-15 pubmed publisher
    cAMP response element modulator (CREM)-mediated gene expression is an essential regulatory mechanism for germ cell differentiation...
  68. Chandhoke T, Huang Y, Liu F, Gronowicz G, Adams D, Harrison J, et al. Osteopenia in transgenic mice with osteoblast-targeted expression of the inducible cAMP early repressor. Bone. 2008;43:101-109 pubmed publisher
    b>ICER is a member of the CREM family of basic leucine zipper transcription factors that acts as a dominant negative regulator of gene transcription...
  69. Deng W, Lin H. miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev Cell. 2002;2:819-30 pubmed
    ..mice display spermatogenic arrest at the beginning of the round spermatid stage, resembling the phenotype of CREM, a master regulator of spermiogenesis...
  70. Vang A, Ben Sasson S, Dong H, KREAM B, Deninno M, Claffey M, et al. PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS ONE. 2010;5:e12011 pubmed publisher
    ..that DP suppresses proliferation and cytokine expression of Teff cells from Crem-/- mice lacking the inducible cAMP early repressor (ICER). Importantly, endothelial cells also express PDE8...
  71. Grady G, Mason S, Stephen J, Zuniga Pflucker J, Michie A. Cyclic adenosine 5'-monophosphate response element binding protein plays a central role in mediating proliferation and differentiation downstream of the pre-TCR complex in developing thymocytes. J Immunol. 2004;173:1802-10 pubmed
    ..We addressed the importance of this activation by expressing a naturally occurring inhibitor of CREB, inducible cAMP early repressor in wild-type fetal liver-derived lymphoid progenitor cells, and assessed their developmental potential...
  72. Lewin G, Matus M, Basu A, Frebel K, Rohsbach S, Safronenko A, et al. Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction. Circulation. 2009;119:79-88 pubmed publisher transcription factors cAMP response element-binding protein (CREB) and cyclic AMP response element modulator (CREM) represents a fundamental mechanism of cyclic AMP-dependent gene control possibly implicated in beta(1)AR-mediated ..