Crebbp

Summary

Gene Symbol: Crebbp
Description: CREB binding protein
Alias: AW558298, CBP, CBP/p300, KAT3A, p300/CBP, CREB-binding protein
Species: mouse

Top Publications

  1. pmc Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation
    Guang Hua Peng
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 16:2433-52. 2007
  2. pmc Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells
    Wu Xu
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 107:4407-16. 2006
  3. pmc Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation
    Mehboob A Hussain
    Metabolism Division, Department of Pediatrics and Medicine, Johns Hopkins University, 600 N Wolfe Street, CMSC 10 113, Baltimore, MD 21287, USA
    Mol Cell Biol 26:7747-59. 2006
  4. pmc A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes
    Marcelo A Wood
    Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California at Irvine 92697, and Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Learn Mem 13:609-17. 2006
  5. pmc The transcriptional regulator CBP has defined spatial associations within interphase nuclei
    Kirk J McManus
    Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
    PLoS Comput Biol 2:e139. 2006
  6. pmc Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling
    Minhua Zhang
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Biol 7:e1000245. 2009
  7. pmc Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response
    Sonja A Dames
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:5271-6. 2002
  8. doi Activation of cyclic-AMP response element binding protein contributes to adiponectin-stimulated interleukin-10 expression in RAW 264.7 macrophages
    Pil Hoon Park
    Department of Pathobiology, Cleveland Clinic, OH 44195, USA
    J Leukoc Biol 83:1258-66. 2008
  9. ncbi Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
    Shiraz Mujtaba
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Mol Cell 9:575-86. 2002
  10. pmc Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
    Charles E Foulds
    Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, UT 84112 5550, USA
    Mol Cell Biol 24:10954-64. 2004

Research Grants

  1. Endocrine pancreatic cell regeneration from bone marrow
    Mehboob A Hussain; Fiscal Year: 2010
  2. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2009
  3. Insulin and Oocyte Chromatin Segregation
    Gary Smith; Fiscal Year: 2009
  4. STRUCTURAL AND FUNCTIONAL DEVELOPMENT OF THE KIDNEY
    Roberto Gomez; Fiscal Year: 2006
  5. Chemogenomics to Identify New Molecular Targets in PF
    William Henderson; Fiscal Year: 2006
  6. beta-Catenin/NF-kappaBeta and Colon Cancer
    Shahid Umar; Fiscal Year: 2004
  7. PROTEIN PHOSPHATASES AND OOCYTE MEIOSIS
    Gary Smith; Fiscal Year: 2002
  8. Web-Based System for Research Protocol Submission
    Roberto Gomez; Fiscal Year: 2003
  9. RENIN CELL FATE IN THE KIDNEY VASCULATURE
    Roberto Gomez; Fiscal Year: 2005
  10. 5-LIPOXYGENASE PRODUCTS IN ASTHMATIC IMMUNE RESPONSE
    William Henderson; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. pmc Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation
    Guang Hua Peng
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 16:2433-52. 2007
    ..protein-protein interaction assays, Crx was found to interact with three co-activator proteins (complexes): STAGA, Cbp and p300, all of which possess histone acetyl-transferase (HAT) activity...
  2. pmc Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells
    Wu Xu
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 107:4407-16. 2006
    CREB-binding protein (CBP) and its para-log p300 are transcriptional coactivators that physically or functionally interact with over 320 mammalian and viral proteins, including 36 that are essential for B cells in mice...
  3. pmc Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation
    Mehboob A Hussain
    Metabolism Division, Department of Pediatrics and Medicine, Johns Hopkins University, 600 N Wolfe Street, CMSC 10 113, Baltimore, MD 21287, USA
    Mol Cell Biol 26:7747-59. 2006
    ..kinase A (PKA) phosphorylates CREB, resulting in recruitment of the transcriptional coactivators p300 and CREB binding protein (CBP). CBP, but not p300, is phosphorylated at serine 436 in response to insulin action...
  4. pmc A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes
    Marcelo A Wood
    Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California at Irvine 92697, and Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Learn Mem 13:609-17. 2006
    ..Recently, the transcriptional coactivator CREB-binding protein (CBP) was shown to be critical for hippocampus-dependent long-term memory and hippocampal synaptic plasticity...
  5. pmc The transcriptional regulator CBP has defined spatial associations within interphase nuclei
    Kirk J McManus
    Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
    PLoS Comput Biol 2:e139. 2006
    ..The CREB-binding protein (CBP) is one such transcriptional regulator that, when visualised by confocal microscopy, reveals a highly punctate ..
  6. pmc Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling
    Minhua Zhang
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Biol 7:e1000245. 2009
    ..Here we report that hypothalamic expression of CREB-binding protein (CBP) and CBP-binding partner Special AT-rich sequence binding protein 1 (SATB-1) is highly correlated with lifespan ..
  7. pmc Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response
    Sonja A Dames
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:5271-6. 2002
    ..conditions, HIF-1 activates transcription of critical adaptive genes by recruitment of the general coactivators CBP/p300 through interactions with its alpha-subunit (Hif-1 alpha)...
  8. doi Activation of cyclic-AMP response element binding protein contributes to adiponectin-stimulated interleukin-10 expression in RAW 264.7 macrophages
    Pil Hoon Park
    Department of Pathobiology, Cleveland Clinic, OH 44195, USA
    J Leukoc Biol 83:1258-66. 2008
    ..Taken together, these data identify gAcrp-stimulated phospho-CREB as a key transcription factor responsible for gAcrp-induced IL-10 promoter activation...
  9. ncbi Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
    Shiraz Mujtaba
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Mol Cell 9:575-86. 2002
    ..is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF)...
  10. pmc Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
    Charles E Foulds
    Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, UT 84112 5550, USA
    Mol Cell Biol 24:10954-64. 2004
    ..Pointed (PNT) domains, resulted in enhanced transactivation by preferential recruitment of the coactivators CREB binding protein (CBP) and p300...
  11. ncbi Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway
    Bong Gun Ju
    Howard Hughes Medical Institute, University of California, San Diego, Department and School of Medicine, La Jolla, CA 92093, USA
    Cell 119:815-29. 2004
    ..The identification of PARP-1 as a regulated promoter-specific exchange factor required for activation of specific neurogenic gene programs is likely to be prototypic of similar molecular mechanisms...
  12. ncbi Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 280:40450-64. 2005
    ..Thus, acetylation of PARP-1 by p300/CREB-binding protein plays an important regulatory role in NF-kappaB-dependent gene activation by enhancing its functional interaction with p300 and the Mediator complex...
  13. ncbi Phosphorylated CREB binds specifically to the nuclear protein CBP
    J C Chrivia
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 365:855-9. 1993
    ..that CREB phosphorylated by protein kinase A binds specifically to a nuclear protein of M(r) 265K which we term CBP (for CREB-binding protein)...
  14. pmc Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome
    Y Tanaka
    Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, Tsukuba, Ibaraki 305, Japan
    Proc Natl Acad Sci U S A 94:10215-20. 1997
    b>CBP is a transcriptional coactivator required by many transcription factors for transactivation...
  15. ncbi Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP
    H Yamamoto
    Department of Cell Genetics, Sasaki Institute, Tokyo, Japan
    Oncogene 18:1495-501. 1999
    ..activity revealed that one of these clones was confirmed to encode a transcriptional coactivator, CREB binding protein (CBP)...
  16. ncbi Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein
    Y Tanaka
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, and CREST Core Research for Evolutional Science and Technology Research Project, JST Japan Science and Technology Corporation, Tsukuba, 305 0074, Ibaraki, Japan
    Mech Dev 95:133-45. 2000
    CREB-binding protein (CBP) is a transcriptional co-activator which is required by many transcription factors...
  17. ncbi Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
    Toshimasa Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Nat Genet 30:221-6. 2002
    ..9). To identify its physiological functions using a loss-of-function mutant, we analyzed CBP-deficient mice. As Crebbp null mice (Crebbp-/-) died during embryogenesis, we used Crebbp+/- mice...
  18. ncbi Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice
    Qin Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Oncogene 21:1028-37. 2002
    ..can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the transcriptional coactivators CBP/p300...
  19. pmc Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation
    Noriko Shikama
    Institute for Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
    EMBO J 22:5175-85. 2003
    p300 and CBP are large nuclear acetyltransferases exhibiting a complex multi-domain structure...
  20. pmc Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5
    Jeanne Françoise Roth
    Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    EMBO J 22:5186-96. 2003
    Studies in tissue culture cells have implicated p300 and CBP acetyltransferases in myogenic regulatory factor (MRF) mediated transcription and terminal differentiation of skeletal muscle cells...
  21. pmc Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin
    Kirk J McManus
    Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2
    Mol Cell Biol 23:7611-27. 2003
    ..resolving power of laser scanning confocal microscopy with simple statistical analyses to characterize CREB binding protein (CBP)- and P300-induced changes in global histone acetylation levels at specific lysine residues...
  22. ncbi Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb
    Tsaffrir Zor
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 337:521-34. 2004
    ..c-Myb activates transcription of target genes through direct interactions with the KIX domain of the co-activator CBP. The solution structure of the KIX domain in complex with the activation domain of c-Myb reveals a helical ..
  23. ncbi Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration
    Juan M Alarcon
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 42:947-59. 2004
    ..of Rubinstein-Taybi syndrome (RTS), an inheritable disorder caused by mutations in the gene encoding the CREB binding protein (CBP) and characterized by mental retardation and skeletal abnormalities...
  24. pmc Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression
    Lawryn H Kasper
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 24:3846-58. 2005
    ..HIF-1alpha and HIF-2alpha binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription...
  25. ncbi Distribution of co-activators CBP and p300 during mouse oocyte and embryo development
    Roland P S Kwok
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Reprod Dev 73:885-94. 2006
    cAMP response element binding protein (CREB)-binding protein (CBP) and p300 are two structurally related transcriptional co-activators that activate expression of many eukaryotic genes...
  26. ncbi Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin
    Haibing Jiang
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurobiol Dis 23:543-51. 2006
    ..Transfection of mutant huntingtin causes cell toxicity and depletion of CREB binding protein (CBP) or its recruitment into huntingtin aggregates...
  27. pmc CBP and p300 are essential for renin cell identity and morphological integrity of the kidney
    R Ariel Gomez
    Dept of Pediatrics, Univ of Virginia School of Medicine, 409 Lane Rd, MR4 2001, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 296:H1255-62. 2009
    ..of transcription factors to this region of the promoter is facilitated by the coactivators CREB-binding protein (CBP) and p300, which possess histone acetyltransferase activity and may be, in turn, responsible for the remodeling of ..
  28. pmc Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development
    Tomofusa Fukuyama
    Department of Biochemistry, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Mol Cell Biol 29:3894-904. 2009
    ..The transcriptional coactivators CREB binding protein (CBP) and the closely related p300, which comprise the KAT3 family of histone/protein lysine ..
  29. doi Systematic in vivo structure-function analysis of p300 in hematopoiesis
    Erin A Kimbrel
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital Boston and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Blood 114:4804-12. 2009
    Cyclic adenosine monophosphate response element binding (CREB)-binding protein (CBP) and p300 are multidomain transcriptional coactivators that help assemble large regulatory complexes at sites of active transcription...
  30. pmc Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
    William R Henderson
    Center for Allergy and Inflammation and Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 107:14309-14. 2010
    ..inhibits T-cell factor/beta-catenin transcription in a cyclic AMP response-element binding protein binding protein (CBP)-dependent fashion...
  31. doi Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability
    Luis M Valor
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, Sant Joan d Alacant, 03550 Alicante, Spain
    J Neurosci 31:1652-63. 2011
    ..associated with mutations in the gene encoding the CREB (cAMP response element-binding protein)-binding protein (CBP) and characterized by growth impairment, learning disabilities, and distinctive facial and skeletal features...
  32. pmc Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory
    Ruth M Barrett
    Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697 3800, USA
    Neuropsychopharmacology 36:1545-56. 2011
    To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in neurons of the CA1 region of the hippocampus during memory formation, we examine the effects of a focal homozygous knockout of CBP on histone ..
  33. pmc Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control
    David C Bedford
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Metab 14:219-30. 2011
    ..Mice heterozygous for the acetyltransferase CREB binding protein (CBP) are lean and insulin sensitized, but how CBP regulates energy homeostasis is unclear...
  34. pmc The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells
    Wai In Chan
    Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom
    Mol Cell Biol 31:5046-60. 2011
    The transcriptional coactivator Cbp plays an important role in a wide range of cellular processes, including proliferation, differentiation, and apoptosis...
  35. ncbi A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
    Y Kamei
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Cell 85:403-14. 1996
    ..Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for limiting amounts of CBP/p300 in ..
  36. ncbi Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
    T P Yao
    Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 93:361-72. 1998
    The transcriptional coactivator and integrator p300 and its closely related family member CBP mediate multiple, signal-dependent transcriptional events. We have generated mice lacking a functional p300 gene...
  37. ncbi Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis
    A Partanen
    Program in Developmental Biology, The Hospital for Sick Children, and Institute of Medical Science, University of Toronto, Ontario, Canada
    Int J Dev Biol 43:487-94. 1999
    CBP (CREBBP/CREB-binding protein) and p300 are related signal-dependent transcriptional cofactors and histone acetyltransferases...
  38. pmc Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
    A L Kung
    Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 14:272-7. 2000
    Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic malignancies...
  39. ncbi CREB-binding protein/p300 co-activation of crystallin gene expression
    Qin Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:24081-9. 2002
    ..In this study, we designed experiments to test whether the co-activators CREB-binding protein (CBP) and/or p300 interact with c-Maf, Prox-1, or Sox-1 to enhance transcription of crystallin genes...
  40. ncbi A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
    Lawryn H Kasper
    Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
    Nature 419:738-43. 2002
    The coactivators CBP (Cre-element binding protein (CREB)-binding protein) and its paralogue p300 are thought to supply adaptor molecule and protein acetyltransferase functions to many transcription factors that regulate gene expression...
  41. pmc Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
    Vivienne I Rebel
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:14789-94. 2002
    ..We have identified a role for the transcriptional coactivators CREB-binding protein (CBP) and p300 in such HSC fate decisions. A full dose of CBP, but not p300, is crucial for HSC self-renewal...
  42. ncbi Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb
    Qin Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:17667-73. 2004
    ..The cells show a dramatic reduction in expression of their beta- and gamma-crystallins. Because CBP and p300 are co-activators for crystallin gene expression, we assayed for interactions between E107KDelta and CBP/..
  43. ncbi Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency
    Ningling Kang-Decker
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Cell 5:177-89. 2004
    b>CBP can function as a tumor suppressor, but the mechanisms that govern oncogenesis in its absence are unknown. Here we show that CBP inactivation in mouse thymocytes leads to lymphoma...
  44. ncbi Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein
    Xiao Yan Zhou
    Department of Medicine and Committee on Molecular Metabolism and Nutrition, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA
    Nat Med 10:633-7. 2004
    ..of cAMP response element-binding (CREB) protein, resulting in recruitment of the coactivators CREB-binding protein (CBP) and p300 and subsequent activation of gluconeogenesis...
  45. pmc Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development
    Lawryn H Kasper
    Department of Biochemistry, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Mol Cell Biol 26:789-809. 2006
    The global transcriptional coactivators CREB-binding protein (CBP) and the closely related p300 interact with over 312 proteins, making them among the most heavily connected hubs in the known mammalian protein-protein interactome...
  46. pmc Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms
    Wu Xu
    Department of Biochemistry, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    EMBO J 26:2890-903. 2007
    ..Phospho-Ser133 is required for CREB to bind the KIX domain of the coactivators CBP and p300 (CBP/p300) in vitro, although the importance of this archetype coactivator interaction for endogenous gene ..
  47. pmc Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha
    Hyun Seo Kang
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada
    J Mol Biol 377:636-46. 2008
    ..pulldown assays that the OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300. This provides a direct structural link between GABP and a central component of the transcriptional machinery.
  48. pmc Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
    Ling He
    Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell 137:635-46. 2009
    ..show that both the antidiabetic agent metformin and insulin phosphorylate the transcriptional coactivator CREB binding protein (CBP) at serine 436 via PKC iota/lambda...
  49. pmc CREB binding protein is required for both short-term and long-term memory formation
    Guiquan Chen
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:13066-77. 2010
    b>CREB binding protein (CBP) is a transcriptional coactivator with histone acetyltransferase activity. Our prior study suggested that CBP might be a key target of presenilins in the regulation of memory formation and neuronal survival...
  50. pmc Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression
    Anne K Hennig
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 8:e69721. 2013
    ..To further elucidate the role of these two coactivators, we conditionally knocked out Ep300 and/or CrebBP in differentiating rods or cones, using opsin-driven Cre recombinase...
  51. pmc Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
    Tomoyuki Miyabayashi
    Central R and D Laboratories, Asahi Kasei Corporation, Shizuoka 416 8501, Japan
    Proc Natl Acad Sci U S A 104:5668-73. 2007
    ..subunit of the serine/threonine phosphatase PP2A, prevents beta-catenin from switching coactivator usage from CBP to p300...
  52. pmc Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens
    Ying Yang
    Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA
    J Mol Biol 369:917-26. 2007
    ..Here, we identified CREB-binding protein (CBP) and p300 as major histone acetyltransferases (HATs) associated in vivo with the mouse alphaA-crystallin locus...
  53. ncbi Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations
    S Y Na
    Department of Biology, Chonnam National University, Kwangju 500 757, Korea
    J Biol Chem 273:10831-4. 1998
    ..site was localized to a subregion of SRC-1 (amino acids 759-1141) that encompasses the previously described CBP-p300-binding domain...
  54. ncbi The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules
    A L Newton
    Department of Biochemistry, G08, University of Sydney, Sydney, New South Wales 2006, Australia
    J Biol Chem 275:15128-34. 2000
    cAMP-response element-binding protein-binding protein (CBP) is a transcriptional coactivator that interacts with a number of DNA-binding proteins and cofactor proteins involved in the regulation of transcription...
  55. ncbi Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions
    I Radhakrishnan
    Department of Molecular Biology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 91:741-52. 1997
    ..activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner...
  56. pmc CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
    Michel Barrot
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 99:11435-40. 2002
    ..This control appears to be independent of the intrinsic appetitive or aversive value of the stimulus. The potential relevance of these data to addiction and mood disorders is discussed...
  57. ncbi Differential gene expression in the distal tip endoderm of the embryonic mouse lung
    Yuru Liu
    Department of Cell and Developmental Biology, Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Gene Expr Patterns 2:229-33. 2002
    ..5 lung buds, versus more proximal regions. Twenty genes were identified, assigned to different categories based on sequence analysis, and their distal expression confirmed by whole-mount in situ hybridization...
  58. pmc Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin
    Charlotte Labalette
    Unité d Oncogenèse et Virologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Cell Biol 24:10689-702. 2004
    ..It has been shown that the LIM protein FHL2 and the acetyltransferase CBP/p300 individually stimulate beta-catenin transactivating activity and that beta-catenin is acetylated by p300...
  59. pmc A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
    Masao Murakami
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, 75390 9148, USA
    Proc Natl Acad Sci U S A 102:18034-9. 2005
    ..These findings reveal key roles for TAZ and YAP in the control of TBX5-dependent transcription and suggest the involvement of these coactivators in cardiac and limb development...
  60. pmc The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway
    Sara Sánchez-Molina
    Instituto de Biologia Molecular de Barcelona, CID, Consejo Superior de Investigaciones Cientificas, Parc Cientific de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Biochem J 398:215-24. 2006
    The CBP [CREB (cAMP-response-element-binding protein)-binding protein]/p300 acetyltransferases function as transcriptional co-activators and play critical roles in cell differentiation and proliferation...
  61. pmc Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus
    Celina Demers
    Sprott Center for Stem Cell Research, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
    Mol Cell 27:573-84. 2007
    ....
  62. pmc Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear
    Jin Hee Han
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Learn Mem 15:443-53. 2008
    ..Not only do these findings refine our knowledge of the circuitry underlying fear memory but they also provide novel insights into the neural substrates that govern the degree to which acquired fear of a tone generalizes to other tones...
  63. pmc Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP
    Mary L Nelson
    Department of Oncological Sciences, University of Utah School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA
    Proc Natl Acad Sci U S A 107:10026-31. 2010
    ..The affinity of Ets1 for the TAZ1 (or CH1) domain of the coactivator CBP was enhanced 34-fold by phosphorylation, and this binding was sensitive to ionic strength...
  64. pmc Regulation of insulin gene transcription by multiple histone acetyltransferases
    Megan L Sampley
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, 741 South Limestone St, Lexington, KY 40536 0509, USA
    DNA Cell Biol 31:8-14. 2012
    ..In this report we investigated the role of the additional HAT proteins CREB binding protein (CBP), p300/CBP-associated factor (PCAF), and general control of amino-acid synthesis 5 (GCN5) in ..
  65. pmc Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300
    Louise Wolf
    Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, Department of Surgery, Creighton University, Omaha, NE 68178, USA, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978
    Nucleic Acids Res 41:10199-214. 2013
    ..The lysine acetyltransferases CBP and p300 function as principal enzymes that modify core histones to facilitate specific gene expression...
  66. pmc CBP-Dependent memory consolidation in the prefrontal cortex supports object-location learning
    Philip A Vieira
    Department of Psychology and Neuroscience Program, University of California Riverside, California
    Hippocampus 25:1532-40. 2015
    ..we show that an acute hypofunction of the cyclic-AMP regulatory element binding protein (CREB) Binding Protein (CBP) histone acetyltransferase (HAT) in the medial prefrontal cortex (mPFC) results in delay-dependent disruption of ..
  67. pmc Estrogen receptor beta as target for colorectal cancer prevention
    Cecilia Williams
    Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5056, USA SciLifeLab, School of Biotechnology, KTH Royal Institute of Technology, 171 21 Solna, Sweden Department of Biosciences and Nutrition, Novum, Karolinska Institutet, 141 83 Stockholm, Sweden Electronic address
    Cancer Lett 372:48-56. 2016
    ..In this review, we discuss the potential of new chemopreventive or dietary approaches based on estrogen signaling. ..
  68. pmc SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation
    Ginam Cho
    Department of Pathology, The Children s Hospital of Philadelphia, USA
    J Biol Chem 284:19592-600. 2009
    ..Taken together, our data indicate that the SIMs in Sizn1 are required for its PML-NB localization and for the full transcriptional co-activation function in BMP signaling...
  69. pmc NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons
    R Hughes
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London, UK
    Cell Death Differ 18:937-47. 2011
    ..Furthermore, we find that the transcriptional coactivators CBP and p300 interact with NF-Y and FOXO3a and bind to this region of the bim promoter...
  70. doi Expression patterns of histone acetyltransferases p300 and CBP during murine tooth development
    Zhu Chen
    State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu, 610041, China
    In Vitro Cell Dev Biol Anim 48:61-8. 2012
    The transcription coactivators p300 and CBP were reported to have indispensable roles in various tissues during the embryonic and fetal stages...
  71. pmc Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype
    Ellen Steward Pentz
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 302:H2545-52. 2012
    ..transcriptional effects are mediated by binding of cAMP responsive element binding protein with its co-activators, CBP and p300, to the cAMP response element in the renin promoter...
  72. pmc Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    Andre J Faure
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2163-75. 2012
    ..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels...
  73. pmc Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions
    Christopher J Romero
    Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mol Cell Biol 32:4258-69. 2012
    ..POU1F1 to the GH promoter along with cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP). We investigate the role of CBP as a target of IGF-1 somatotroph regulation using the MtT/S somatotroph cell line...
  74. pmc Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene
    Yuzhi Jia
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3008, USA
    Mech Dev 129:193-207. 2012
    ..We conclude that PIMT/NCOA6IP, which is expressed in all cells of the 3.5 day stage blastocyst, is indispensable for early embryonic development...
  75. doi Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
    Sarah Schwitalla
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
    Cell 152:25-38. 2013
    ..Thus, our data support the concept of bidirectional conversion and highlight the importance of inflammatory signaling for dedifferentiation and generation of tumor-initiating cells in vivo...
  76. doi Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment
    Manickavinayaham Swarnalatha
    Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    J Cell Sci 126:4636-46. 2013
    ..to specify the proliferative and apoptotic functions of E2F1, through its dynamic interaction with the co-activator CBP or co-repressor Brg1...
  77. ncbi Localization of human CREBBP (CREB binding protein) to 16p13.3 by fluorescence in situ hybridization
    X N Chen
    Medical Genetics Birth Defects Center, Ahmanson Department of Pediatrics, Cedars Sinai Research Institute, UCLA, USA
    Cytogenet Cell Genet 71:56-7. 1995
    ..A cDNA probe for the mouse CREB binding protein was used to localize this gene (CREBBP) to human chromosome 16p13...
  78. pmc Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates
    W Xu
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 18:5659-69. 1998
    ..Two human homologs of Gcn5p have been reported previously, hsGCN5 and hsP/CAF (p300/CREB binding protein [CBP]-associated factor)...
  79. ncbi Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription
    G Pelletier
    Cancer Research Centre and Department of Medical Biology Laval University Hotel Dieu de Quebec 11 cote du Palais G1R 2J6, Quebec, Canada
    Mol Cell 6:1059-66. 2000
    ..Here we show that the acetyltransferase CBP is recruited to and acetylates UBF both in vitro and in vivo...
  80. ncbi Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice
    Qiang Li
    Department of Basic Gerontology, National Institute for Longevity Sciences, Aichi, Japan
    J Gerontol A Biol Sci Med Sci 57:B93-8. 2002
    b>CBP, a protein that binds to cyclic adenosine monophosphate-regulated enhancer-binding protein, and homologue protein, p300, have histone acetyltransferase (HAT) activity and are important in gene transcription, although their ..
  81. ncbi Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit CBP-NF-kappaB interaction in activated microglia
    Mario Delgado
    Departamento Biologia Celular, Facultad de Biologia, Universidad Complutense, 28040, Madrid, Spain
    Biochem Biophys Res Commun 297:1181-5. 2002
    ..An additional regulatory element in the NF-kappaB transcriptional activity is the coactivator CBP, which links p65 with components of the basal transcriptional machinery...
  82. ncbi ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules
    Danette L Daniels
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 10:573-84. 2002
    ..The C-terminal armadillo repeats of beta-catenin may be an attractive target for compounds designed to disrupt aberrant beta-catenin-mediated transcription associated with various cancers...
  83. ncbi Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development
    Chrissa Kioussi
    Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 111:673-85. 2002
    ....
  84. ncbi Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns
    Jeffrey M Craig
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Hum Mol Genet 12:3109-21. 2003
    ..the active centromere of a dicentric chromosome, with six of these proteins (Sin3A, PCAF, MYST, MBD2, ORC2, P300/CBP) being demonstrated at mammalian centromeres for the first time...
  85. ncbi Dendrite development regulated by CREST, a calcium-regulated transcriptional activator
    Hiroyuki Aizawa
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 303:197-202. 2004
    ..that interacts with adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB)-binding protein (CBP) and is expressed in the developing brain...
  86. ncbi A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP
    Sachiko Matsuda
    Department of Biochemistry, University of Leicester, University Road Leicester LE1 7RH, United Kingdom
    J Biol Chem 279:14055-64. 2004
    CREB-binding protein (CBP) and p300 contain modular domains that mediate protein-protein interactions with a wide variety of nuclear factors...
  87. ncbi Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation
    Shiraz Mujtaba
    Department of Physiology and Biophysics, New York University, 1425 Madison Avenue, New York, NY 10029, USA
    Mol Cell 13:251-63. 2004
    ..Here, we report that the conserved bromo-domain of the transcriptional coactivator CBP (CREB binding protein) binds specifically to p53 at the C-terminal acetylated lysine 382...
  88. ncbi Enhancer-mediated control of macrophage-specific arginase I expression
    Anne Laure Pauleau
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    J Immunol 172:7565-73. 2004
    ..Identification of a powerful extrahepatic regulatory enhancer for arginase I provides potential to manipulate arginase I activity in immune cells while sparing liver urea cycle function...
  89. ncbi Generation of a conditional allele of the CBP gene in mouse
    Zuwen Zhang
    Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Genesis 40:82-9. 2004
    CREB-binding protein (CBP) is an important transcriptional cofactor for various intracellular signaling pathways, including Ca(2+)- and cAMP-mediated gene activation...
  90. pmc Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes
    Hong Ping Guan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 19:453-61. 2005
    ..Thus, selective modulation of adipocyte PPARgamma target genes by TZDs involves the dissociation of corepressors by direct and indirect mechanisms...
  91. ncbi Identification of novel CBP interacting proteins in embryonic orofacial tissue
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD Louisville, KY 40292, USA
    Biochem Biophys Res Commun 329:1010-7. 2005
    cAMP response element-binding protein (CREB)-binding protein (CBP) plays an important role as a general co-integrator of multiple signaling pathways and interacts with a large number of transcription factors and co-factors, through its ..
  92. ncbi Structural basis for cooperative transcription factor binding to the CBP coactivator
    Roberto N De Guzman
    Department of Molecular Biology MB2, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 355:1005-13. 2006
    ..of transcription requires interactions between transcriptional activators and transcriptional co-activator CREB binding protein (CBP)...
  93. pmc CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum
    Amir A Levine
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, and Howard Hughes Medical Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:19186-91. 2005
    ..Here, we show that histone acetylation by the cAMP-response element binding protein (CREB)-binding protein (CBP) mediates sensitivity to cocaine by regulating expression of the fosB gene and its splice variant, DeltafosB, a ..
  94. ncbi A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons
    Antonella Riccio
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21201, USA
    Mol Cell 21:283-94. 2006
    ..Thus, in conjunction with CREB phosphorylation, the NO pathway controls CREB-DNA binding and CRE-mediated gene expression...
  95. ncbi Reduced extinction of hippocampal-dependent memories in CPEB knockout mice
    Joanne Berger-Sweeney
    Department of Biology, Wellesley College, Wellesley, Massachusetts 02481, USA
    Learn Mem 13:4-7. 2006
    ..14% of hippocampal genes have an altered expression in the CPEB knockout mouse. These data suggest that CPEB-dependent local protein synthesis may be an important cellular mechanism underlying extinction of hippocampal-dependent memories...
  96. ncbi Structural diversity in p160/CREB-binding protein coactivator complexes
    Lorna Waters
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, United Kingdom
    J Biol Chem 281:14787-95. 2006
    ..as steroid receptor coactivator 1 (SRC1), in complex with histone acetyltransferases such as CREB-binding protein (CBP) and p300...
  97. doi CREB-binding proteins (CBP) as a transcriptional coactivator of GATA-2
    HuiJie Jiang
    College of Life Sciences, Ludong University, Yantai, 264025, China
    Sci China C Life Sci 51:191-8. 2008
    ..CREB-binding proteins (CBP) are essential transcriptional coactivators for a large number of regulated DNA-binding transcription factors, ..
  98. pmc Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation
    Junghee Lee
    Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
    Hum Mol Genet 17:1774-82. 2008
    ..We found that the monoallelic deletion of CREB binding protein (CBP) results in the induction of ERG-associated protein with SET domain (ESET) and increases ..
  99. pmc Exendin-4 stimulation of cyclin A2 in beta-cell proliferation
    Woo Jin Song
    Metabolism Division, Departments of Pediatrics and Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Diabetes 57:2371-81. 2008
    ..We have examined effects, in particular those mediated through intracellular cAMP signaling, of the incretin hormone analog exendin-4 on cell cycle regulation in beta-cells...
  100. pmc Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis
    Nilkantha Sen
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nat Cell Biol 10:866-73. 2008
    ..Here we show that nuclear GAPDH is acetylated at Lys 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, which in turn stimulates the acetylation and catalytic activity ..
  101. pmc Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP
    Seunghee Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 62:641-54. 2009
    ..RA then facilitates the recruitment of a histone acetyltransferase CBP to the Ngn2/RAR-complex, markedly inducing histone H3/H4-acetylation...

Research Grants10

  1. Endocrine pancreatic cell regeneration from bone marrow
    Mehboob A Hussain; Fiscal Year: 2010
    ..4) To identify the cell type within BM that contributes to the pancreatic endocrine cell population. The long-term goal of these studies is to evaluate transplantation of BM derived cells as a potential treatment for diabetes mellitus. ..
  2. Redox Signaling in Osteoblast Differentiation
    Nandini Ghosh Choudhury; Fiscal Year: 2009
    ..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..
  3. Insulin and Oocyte Chromatin Segregation
    Gary Smith; Fiscal Year: 2009
    ..abstract_text> ..
  4. STRUCTURAL AND FUNCTIONAL DEVELOPMENT OF THE KIDNEY
    Roberto Gomez; Fiscal Year: 2006
    ..It is anticipated that the Center of Excellence will build on the achievements of the past five years and will lead to improved management of infants and children with renal and urological diseases...
  5. Chemogenomics to Identify New Molecular Targets in PF
    William Henderson; Fiscal Year: 2006
    ..These studies represent a focused effort using chemogenomics to identify, develop, and validate small molecule inhibitors of AP-1/TGFBeta-driven profibrotic gene expression as novel therapies in PF patients. ..
  6. beta-Catenin/NF-kappaBeta and Colon Cancer
    Shahid Umar; Fiscal Year: 2004
    ..By studying a mechanistic basis of NF-kappaB and beta-catenin mediated increases in cell census, in the absence and presence of chronic inflammation, we may identify new treatment strategies for reducing cancer risk. ..
  7. PROTEIN PHOSPHATASES AND OOCYTE MEIOSIS
    Gary Smith; Fiscal Year: 2002
    ..These studies will provide novel information concerning control of oocyte maturation and spindle formation that may subsequently influence the developmental competency of resulting embryos. ..
  8. Web-Based System for Research Protocol Submission
    Roberto Gomez; Fiscal Year: 2003
    ..We will try to reach small institutions by annoucements and demonstrations at local, regional and national meetings of the Society for Research Administration, International. ..
  9. RENIN CELL FATE IN THE KIDNEY VASCULATURE
    Roberto Gomez; Fiscal Year: 2005
    ..The studies should generate fundamental new knowledge on JG cell differentiation and function and open new avenues for the understanding, prevention and treatment of hypertension and kidney diseases. ..
  10. 5-LIPOXYGENASE PRODUCTS IN ASTHMATIC IMMUNE RESPONSE
    William Henderson; Fiscal Year: 2008
    ..abstract_text> ..