Crebbp

Summary

Gene Symbol: Crebbp
Description: CREB binding protein
Alias: AW558298, CBP, CBP/p300, KAT3A, p300/CBP, CREB-binding protein
Species: mouse
Products:     Crebbp

Top Publications

  1. Peng G, Chen S. Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. Hum Mol Genet. 2007;16:2433-52 pubmed
    ..protein-protein interaction assays, Crx was found to interact with three co-activator proteins (complexes): STAGA, Cbp and p300, all of which possess histone acetyl-transferase (HAT) activity...
  2. Hartman H, Yu J, Alenghat T, Ishizuka T, Lazar M. The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. EMBO Rep. 2005;6:445-51 pubmed
    ..The match between the specificity of acetyl-histone deacetylation by HDAC3 and the histone-binding preference of N-CoR/SMRT allows the co-repressor complex to stabilize and propagate repression of nuclear hormone receptor gene targets. ..
  3. Yin X, Warner D, Roberts E, Pisano M, Greene R. Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53. Int J Mol Med. 2005;16:251-6 pubmed
    cAMP response element-binding protein (CREB)-binding protein (CBP) is a multifunctional transcriptional co-activator that plays important roles in cell proliferation and differentiation...
  4. Xu W, Fukuyama T, Ney P, Wang D, Rehg J, Boyd K, et al. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood. 2006;107:4407-16 pubmed
    CREB-binding protein (CBP) and its para-log p300 are transcriptional coactivators that physically or functionally interact with over 320 mammalian and viral proteins, including 36 that are essential for B cells in mice...
  5. Hussain M, Porras D, Rowe M, West J, Song W, Schreiber W, et al. Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation. Mol Cell Biol. 2006;26:7747-59 pubmed
    ..kinase A (PKA) phosphorylates CREB, resulting in recruitment of the transcriptional coactivators p300 and CREB binding protein (CBP). CBP, but not p300, is phosphorylated at serine 436 in response to insulin action...
  6. Kasper L, Fukuyama T, Biesen M, Boussouar F, Tong C, de Pauw A, et al. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol. 2006;26:789-809 pubmed
    The global transcriptional coactivators CREB-binding protein (CBP) and the closely related p300 interact with over 312 proteins, making them among the most heavily connected hubs in the known mammalian protein-protein interactome...
  7. Kang Decker N, Tong C, Boussouar F, Baker D, Xu W, Leontovich A, et al. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell. 2004;5:177-89 pubmed
    b>CBP can function as a tumor suppressor, but the mechanisms that govern oncogenesis in its absence are unknown. Here we show that CBP inactivation in mouse thymocytes leads to lymphoma...
  8. Yang Y, Wolf L, Cvekl A. Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens. J Mol Biol. 2007;369:917-26 pubmed
    ..Here, we identified CREB-binding protein (CBP) and p300 as major histone acetyltransferases (HATs) associated in vivo with the mouse alphaA-crystallin locus...
  9. Tang Y, Zhao W, Chen Y, Zhao Y, Gu W. Acetylation is indispensable for p53 activation. Cell. 2008;133:612-26 pubmed publisher
    ..Our study identifies p53 acetylation as an indispensable event that destabilizes the p53-Mdm2 interaction and enables the p53-mediated stress response. ..
  10. Lee C, Arai M, Martinez Yamout M, Dyson H, Wright P. Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. Biochemistry. 2009;48:2115-24 pubmed publisher
    Molecular interactions between the tumor suppressor p53 and the transcriptional coactivators CBP/p300 are critical for the regulation of p53 transactivation and stability...

Detail Information

Publications70

  1. Peng G, Chen S. Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. Hum Mol Genet. 2007;16:2433-52 pubmed
    ..protein-protein interaction assays, Crx was found to interact with three co-activator proteins (complexes): STAGA, Cbp and p300, all of which possess histone acetyl-transferase (HAT) activity...
  2. Hartman H, Yu J, Alenghat T, Ishizuka T, Lazar M. The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. EMBO Rep. 2005;6:445-51 pubmed
    ..The match between the specificity of acetyl-histone deacetylation by HDAC3 and the histone-binding preference of N-CoR/SMRT allows the co-repressor complex to stabilize and propagate repression of nuclear hormone receptor gene targets. ..
  3. Yin X, Warner D, Roberts E, Pisano M, Greene R. Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53. Int J Mol Med. 2005;16:251-6 pubmed
    cAMP response element-binding protein (CREB)-binding protein (CBP) is a multifunctional transcriptional co-activator that plays important roles in cell proliferation and differentiation...
  4. Xu W, Fukuyama T, Ney P, Wang D, Rehg J, Boyd K, et al. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood. 2006;107:4407-16 pubmed
    CREB-binding protein (CBP) and its para-log p300 are transcriptional coactivators that physically or functionally interact with over 320 mammalian and viral proteins, including 36 that are essential for B cells in mice...
  5. Hussain M, Porras D, Rowe M, West J, Song W, Schreiber W, et al. Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation. Mol Cell Biol. 2006;26:7747-59 pubmed
    ..kinase A (PKA) phosphorylates CREB, resulting in recruitment of the transcriptional coactivators p300 and CREB binding protein (CBP). CBP, but not p300, is phosphorylated at serine 436 in response to insulin action...
  6. Kasper L, Fukuyama T, Biesen M, Boussouar F, Tong C, de Pauw A, et al. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol. 2006;26:789-809 pubmed
    The global transcriptional coactivators CREB-binding protein (CBP) and the closely related p300 interact with over 312 proteins, making them among the most heavily connected hubs in the known mammalian protein-protein interactome...
  7. Kang Decker N, Tong C, Boussouar F, Baker D, Xu W, Leontovich A, et al. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell. 2004;5:177-89 pubmed
    b>CBP can function as a tumor suppressor, but the mechanisms that govern oncogenesis in its absence are unknown. Here we show that CBP inactivation in mouse thymocytes leads to lymphoma...
  8. Yang Y, Wolf L, Cvekl A. Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens. J Mol Biol. 2007;369:917-26 pubmed
    ..Here, we identified CREB-binding protein (CBP) and p300 as major histone acetyltransferases (HATs) associated in vivo with the mouse alphaA-crystallin locus...
  9. Tang Y, Zhao W, Chen Y, Zhao Y, Gu W. Acetylation is indispensable for p53 activation. Cell. 2008;133:612-26 pubmed publisher
    ..Our study identifies p53 acetylation as an indispensable event that destabilizes the p53-Mdm2 interaction and enables the p53-mediated stress response. ..
  10. Lee C, Arai M, Martinez Yamout M, Dyson H, Wright P. Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP. Biochemistry. 2009;48:2115-24 pubmed publisher
    Molecular interactions between the tumor suppressor p53 and the transcriptional coactivators CBP/p300 are critical for the regulation of p53 transactivation and stability...
  11. Hennig A, Peng G, Chen S. Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression. PLoS ONE. 2013;8:e69721 pubmed publisher
    ..To further elucidate the role of these two coactivators, we conditionally knocked out Ep300 and/or CrebBP in differentiating rods or cones, using opsin-driven Cre recombinase...
  12. Kang H, Nelson M, Mackereth C, Schärpf M, Graves B, McIntosh L. Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha. J Mol Biol. 2008;377:636-46 pubmed publisher
    ..pulldown assays that the OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300. This provides a direct structural link between GABP and a central component of the transcriptional machinery.
  13. Gomez R, Pentz E, Jin X, Cordaillat M, Sequeira Lopez M. CBP and p300 are essential for renin cell identity and morphological integrity of the kidney. Am J Physiol Heart Circ Physiol. 2009;296:H1255-62 pubmed publisher
    ..of transcription factors to this region of the promoter is facilitated by the coactivators CREB-binding protein (CBP) and p300, which possess histone acetyltransferase activity and may be, in turn, responsible for the remodeling of ..
  14. Ferreon J, Lee C, Arai M, Martinez Yamout M, Dyson H, Wright P. Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc Natl Acad Sci U S A. 2009;106:6591-6 pubmed publisher
    ..of p53 is regulated by interactions with the ubiquitin ligase HDM2 and the general transcriptional coactivators CBP and p300...
  15. Fukuyama T, Kasper L, Boussouar F, Jeevan T, van Deursen J, Brindle P. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol. 2009;29:3894-904 pubmed publisher
    ..The transcriptional coactivators CREB binding protein (CBP) and the closely related p300, which comprise the KAT3 family of histone/protein lysine ..
  16. He L, SABET A, Djedjos S, Miller R, Sun X, Hussain M, et al. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell. 2009;137:635-46 pubmed publisher
    ..show that both the antidiabetic agent metformin and insulin phosphorylate the transcriptional coactivator CREB binding protein (CBP) at serine 436 via PKC iota/lambda...
  17. Dames S, Martinez Yamout M, De Guzman R, Dyson H, Wright P. Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc Natl Acad Sci U S A. 2002;99:5271-6 pubmed
    ..conditions, HIF-1 activates transcription of critical adaptive genes by recruitment of the general coactivators CBP/p300 through interactions with its alpha-subunit (Hif-1 alpha)...
  18. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996;85:403-14 pubmed
    ..Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for limiting amounts of CBP/p300 in ..
  19. Henderson W, Chi E, Ye X, Nguyen C, Tien Y, Zhou B, et al. Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010;107:14309-14 pubmed publisher
    ..inhibits T-cell factor/beta-catenin transcription in a cyclic AMP response-element binding protein binding protein (CBP)-dependent fashion...
  20. Kung A, Rebel V, Bronson R, Ch Ng L, Sieff C, Livingston D, et al. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 2000;14:272-7 pubmed
    Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic malignancies...
  21. Partanen A, Motoyama J, Hui C. Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis. Int J Dev Biol. 1999;43:487-94 pubmed
    CBP (CREBBP/CREB-binding protein) and p300 are related signal-dependent transcriptional cofactors and histone acetyltransferases...
  22. Yao T, Oh S, Fuchs M, Zhou N, Ch Ng L, Newsome D, et al. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell. 1998;93:361-72 pubmed
    The transcriptional coactivator and integrator p300 and its closely related family member CBP mediate multiple, signal-dependent transcriptional events. We have generated mice lacking a functional p300 gene...
  23. Kimbrel E, Lemieux M, Xia X, Davis T, Rebel V, Kung A. Systematic in vivo structure-function analysis of p300 in hematopoiesis. Blood. 2009;114:4804-12 pubmed publisher
    Cyclic adenosine monophosphate response element binding (CREB)-binding protein (CBP) and p300 are multidomain transcriptional coactivators that help assemble large regulatory complexes at sites of active transcription...
  24. Kwok R, Liu X, Smith G. Distribution of co-activators CBP and p300 during mouse oocyte and embryo development. Mol Reprod Dev. 2006;73:885-94 pubmed
    cAMP response element binding protein (CREB)-binding protein (CBP) and p300 are two structurally related transcriptional co-activators that activate expression of many eukaryotic genes...
  25. Kasper L, Boussouar F, Boyd K, Xu W, Biesen M, Rehg J, et al. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J. 2005;24:3846-58 pubmed
    ..HIF-1alpha and HIF-2alpha binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription...
  26. Jiang H, Poirier M, Liang Y, Pei Z, Weiskittel C, Smith W, et al. Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin. Neurobiol Dis. 2006;23:543-51 pubmed
    ..Transfection of mutant huntingtin causes cell toxicity and depletion of CREB binding protein (CBP) or its recruitment into huntingtin aggregates...
  27. De Guzman R, Wojciak J, Martinez Yamout M, Dyson H, Wright P. CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding. Biochemistry. 2005;44:490-7 pubmed
    The transcriptional coactivator protein CBP and its paralog p300 each contain two homologous zinc-containing TAZ domains, which constitute the interaction sites for a number of transcription factors...
  28. Zor T, De Guzman R, Dyson H, Wright P. Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb. J Mol Biol. 2004;337:521-34 pubmed
    ..c-Myb activates transcription of target genes through direct interactions with the KIX domain of the co-activator CBP. The solution structure of the KIX domain in complex with the activation domain of c-Myb reveals a helical ..
  29. Lill N, Grossman S, Ginsberg D, DeCaprio J, Livingston D. Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997;387:823-7 pubmed
    The adenovirus E1A and SV40 large-T-antigen oncoproteins bind to members of the p300/CBP transcriptional coactivator family. Binding of p300/CBP is implicated in the transforming mechanisms of E1A and T-antigen oncoproteins...
  30. Chen Q, Liang D, Fromm L, Overbeek P. Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRb. J Biol Chem. 2004;279:17667-73 pubmed
    ..The cells show a dramatic reduction in expression of their beta- and gamma-crystallins. Because CBP and p300 are co-activators for crystallin gene expression, we assayed for interactions between E107KDelta and CBP/..
  31. McManus K, Hendzel M. Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin. Mol Cell Biol. 2003;23:7611-27 pubmed
    ..resolving power of laser scanning confocal microscopy with simple statistical analyses to characterize CREB binding protein (CBP)- and P300-induced changes in global histone acetylation levels at specific lysine residues...
  32. Tanaka Y, Naruse I, Maekawa T, Masuya H, Shiroishi T, Ishii S. Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc Natl Acad Sci U S A. 1997;94:10215-20 pubmed
    b>CBP is a transcriptional coactivator required by many transcription factors for transactivation...
  33. Chen Q, Dowhan D, Liang D, Moore D, Overbeek P. CREB-binding protein/p300 co-activation of crystallin gene expression. J Biol Chem. 2002;277:24081-9 pubmed
    ..In this study, we designed experiments to test whether the co-activators CREB-binding protein (CBP) and/or p300 interact with c-Maf, Prox-1, or Sox-1 to enhance transcription of crystallin genes...
  34. Chen Q, Ash J, Branton P, Fromm L, Overbeek P. Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice. Oncogene. 2002;21:1028-37 pubmed
    ..can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the transcriptional coactivators CBP/p300...
  35. Miyabayashi T, Teo J, Yamamoto M, McMillan M, Nguyen C, Kahn M. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A. 2007;104:5668-73 pubmed
    ..subunit of the serine/threonine phosphatase PP2A, prevents beta-catenin from switching coactivator usage from CBP to p300...
  36. McManus K, Stephens D, Adams N, Islam S, Freemont P, Hendzel M. The transcriptional regulator CBP has defined spatial associations within interphase nuclei. PLoS Comput Biol. 2006;2:e139 pubmed
    ..The CREB-binding protein (CBP) is one such transcriptional regulator that, when visualised by confocal microscopy, reveals a highly punctate ..
  37. Wood M, Attner M, Oliveira A, Brindle P, Abel T. A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learn Mem. 2006;13:609-17 pubmed
    ..Recently, the transcriptional coactivator CREB-binding protein (CBP) was shown to be critical for hippocampus-dependent long-term memory and hippocampal synaptic plasticity...
  38. Chan W, Hannah R, Dawson M, Pridans C, Foster D, Joshi A, et al. The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells. Mol Cell Biol. 2011;31:5046-60 pubmed publisher
    The transcriptional coactivator Cbp plays an important role in a wide range of cellular processes, including proliferation, differentiation, and apoptosis...
  39. Bedford D, Kasper L, Wang R, Chang Y, Green D, Brindle P. Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metab. 2011;14:219-30 pubmed publisher
    ..Mice heterozygous for the acetyltransferase CREB binding protein (CBP) are lean and insulin sensitized, but how CBP regulates energy homeostasis is unclear...
  40. Barrett R, Malvaez M, Kramár E, Matheos D, Arrizon A, Cabrera S, et al. Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology. 2011;36:1545-56 pubmed publisher
    To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in neurons of the CA1 region of the hippocampus during memory formation, we examine the effects of a focal homozygous knockout of CBP on histone ..
  41. Chen G, Zou X, Watanabe H, van Deursen J, Shen J. CREB binding protein is required for both short-term and long-term memory formation. J Neurosci. 2010;30:13066-77 pubmed publisher
    b>CREB binding protein (CBP) is a transcriptional coactivator with histone acetyltransferase activity. Our prior study suggested that CBP might be a key target of presenilins in the regulation of memory formation and neuronal survival...
  42. Chrivia J, Kwok R, Lamb N, Hagiwara M, Montminy M, Goodman R. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993;365:855-9 pubmed
    ..that CREB phosphorylated by protein kinase A binds specifically to a nuclear protein of M(r) 265K which we term CBP (for CREB-binding protein)...
  43. Tanaka Y, Naruse I, Hongo T, Xu M, Nakahata T, Maekawa T, et al. Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein. Mech Dev. 2000;95:133-45 pubmed
    CREB-binding protein (CBP) is a transcriptional co-activator which is required by many transcription factors...
  44. Zhou X, Shibusawa N, Naik K, Porras D, Temple K, Ou H, et al. Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med. 2004;10:633-7 pubmed
    ..of cAMP response element-binding (CREB) protein, resulting in recruitment of the coactivators CREB-binding protein (CBP) and p300 and subsequent activation of gluconeogenesis...
  45. De Guzman R, Martinez Yamout M, Dyson H, Wright P. Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J Biol Chem. 2004;279:3042-9 pubmed
    The TAZ1 domain of the homologous transcriptional coactivators CREB-binding protein (CBP) and p300 forms a complex with CITED2 (CBP/p300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible ..
  46. Roth J, Shikama N, Henzen C, Desbaillets I, Lutz W, Marino S, et al. Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J. 2003;22:5186-96 pubmed
    Studies in tissue culture cells have implicated p300 and CBP acetyltransferases in myogenic regulatory factor (MRF) mediated transcription and terminal differentiation of skeletal muscle cells...
  47. Oike Y, Takakura N, Hata A, Kaname T, Akizuki M, Yamaguchi Y, et al. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis. Blood. 1999;93:2771-9 pubmed
    CREB-binding protein (CBP) and the closely related adenovirus E1A-associated 300-kD protein (p300) function as coactivators of transcription factors such as CREB, c-Fos, c-Jun, c-Myb, and several nuclear receptors...
  48. Kasper L, Boussouar F, Ney P, Jackson C, Rehg J, van Deursen J, et al. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature. 2002;419:738-43 pubmed
    The coactivators CBP (Cre-element binding protein (CREB)-binding protein) and its paralogue p300 are thought to supply adaptor molecule and protein acetyltransferase functions to many transcription factors that regulate gene expression...
  49. Kwok R, Lundblad J, Chrivia J, Richards J, Bachinger H, Brennan R, et al. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature. 1994;370:223-6 pubmed
    ..We have previously identified a nuclear protein of M(r)265K, CBP, that binds specifically to the PKA-phosphorylated form of CREB...
  50. Yamamoto H, Kihara Negishi F, Yamada T, Hashimoto Y, Oikawa T. Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP. Oncogene. 1999;18:1495-501 pubmed
    ..activity revealed that one of these clones was confirmed to encode a transcriptional coactivator, CREB binding protein (CBP)...
  51. Valor L, Pulopulos M, Jimenez Minchan M, Olivares R, Lutz B, Barco A. Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability. J Neurosci. 2011;31:1652-63 pubmed publisher
    ..associated with mutations in the gene encoding the CREB (cAMP response element-binding protein)-binding protein (CBP) and characterized by growth impairment, learning disabilities, and distinctive facial and skeletal features...
  52. Yamauchi T, Oike Y, Kamon J, Waki H, Komeda K, Tsuchida A, et al. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat Genet. 2002;30:221-6 pubmed
    ..9). To identify its physiological functions using a loss-of-function mutant, we analyzed CBP-deficient mice. As Crebbp null mice (Crebbp-/-) died during embryogenesis, we used Crebbp+/- mice...
  53. Ferreon J, Martinez Yamout M, Dyson H, Wright P. Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc Natl Acad Sci U S A. 2009;106:13260-5 pubmed publisher
    ..by recruitment of cellular proteins that include cyclic-AMP response element binding (CREB) binding protein (CBP)/p300 and the retinoblastoma protein (pRb)...
  54. Rebel V, Kung A, Tanner E, Yang H, Bronson R, Livingston D. Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal. Proc Natl Acad Sci U S A. 2002;99:14789-94 pubmed
    ..We have identified a role for the transcriptional coactivators CREB-binding protein (CBP) and p300 in such HSC fate decisions. A full dose of CBP, but not p300, is crucial for HSC self-renewal...
  55. Shikama N, Lutz W, Kretzschmar R, Sauter N, Roth J, Marino S, et al. Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J. 2003;22:5175-85 pubmed
    p300 and CBP are large nuclear acetyltransferases exhibiting a complex multi-domain structure...
  56. Xu W, Kasper L, Lerach S, Jeevan T, Brindle P. Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms. EMBO J. 2007;26:2890-903 pubmed
    ..Phospho-Ser133 is required for CREB to bind the KIX domain of the coactivators CBP and p300 (CBP/p300) in vitro, although the importance of this archetype coactivator interaction for endogenous gene ..
  57. Alarcon J, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel E, et al. Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron. 2004;42:947-59 pubmed
    ..of Rubinstein-Taybi syndrome (RTS), an inheritable disorder caused by mutations in the gene encoding the CREB binding protein (CBP) and characterized by mental retardation and skeletal abnormalities...
  58. Ghoshal S, Pasham S, Odom D, Furr H, McGrane M. Vitamin A depletion is associated with low phosphoenolpyruvate carboxykinase mRNA levels during late fetal development and at birth in mice. J Nutr. 2003;133:2131-6 pubmed
    ..development on d 11, whereas retinoid X receptor alpha (RXRalpha) and nuclear coactivator CREB-binding protein (CBP) were expressed from d 16 onward...
  59. Stefanko D, Barrett R, Ly A, Reolon G, Wood M. Modulation of long-term memory for object recognition via HDAC inhibition. Proc Natl Acad Sci U S A. 2009;106:9447-52 pubmed publisher
    ..research has demonstrated a pivotal role for cyclicAMP response element binding protein (CREB)-binding protein (CBP), a histone acetyltransferase, in long-term memory for novel object recognition (NOR)...
  60. Tini M, Benecke A, Um S, Torchia J, Evans R, Chambon P. Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell. 2002;9:265-77 pubmed
    ..We report that TDG associates with transcriptional coactivators CBP and p300 and that the resulting complexes are competent for both the excision step of repair and histone ..
  61. Seo T, Lee D, Lee B, Chung J, Choe J. Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) binds to, and inhibits transactivation of, CREB-binding protein. Biochem Biophys Res Commun. 2000;270:23-7 pubmed
    ..biochemical analysis, we demonstrate that KSHV vIRF1 binds to a transcriptional coactivator CREB-binding protein (CBP) in vivo and in vitro. KSHV vIRF1 binds to the KIX domain and CH/3 region of CBP...
  62. Haettig J, Stefanko D, Multani M, Figueroa D, McQuown S, Wood M. HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner. Learn Mem. 2011;18:71-9 pubmed publisher
    ..enzymes, such as the histone acetyltransferase (HAT) CREB (cyclic-AMP response element binding) binding protein (CBP), are pivotal for the transcriptional regulation required for long-term memory...
  63. Barrot M, Olivier J, Perrotti L, DiLeone R, Berton O, Eisch A, et al. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci U S A. 2002;99:11435-40 pubmed
    ..This control appears to be independent of the intrinsic appetitive or aversive value of the stimulus. The potential relevance of these data to addiction and mood disorders is discussed. ..
  64. Zhang M, Fu Z, Tian D, Liu E, Dai J, Wang L. Investigation of the interaction between CREB-binding protein and STAT4/STAT6. Mol Biol Rep. 2011;38:4805-11 pubmed publisher
    Coactivator CBP (CREB-binding protein) has been implicated in the regulation of transcription for all signal transducer and activator of transcription factors (STATs); however, the mechanism remains unclear...
  65. Pentz E, Cordaillat M, Carretero O, Tucker A, Sequeira Lopez M, Gomez R. Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype. Am J Physiol Heart Circ Physiol. 2012;302:H2545-52 pubmed publisher
    ..transcriptional effects are mediated by binding of cAMP responsive element binding protein with its co-activators, CBP and p300, to the cAMP response element in the renin promoter...
  66. Song H, Moon M, Choe H, Han D, Jang C, Kim A, et al. Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer's disease. Mol Neurodegener. 2015;10:13 pubmed publisher
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