Genomes and Genes
Gene Symbol: Crebbp
Description: CREB binding protein
Alias: AW558298, CBP, CBP/p300, KAT3A, p300/CBP, CREB-binding protein
Publications133 found, 100 shown here
- Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylationGuang Hua Peng
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Hum Mol Genet 16:2433-52. 2007..protein-protein interaction assays, Crx was found to interact with three co-activator proteins (complexes): STAGA, Cbp and p300, all of which possess histone acetyl-transferase (HAT) activity...
- Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cellsWu Xu
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Blood 107:4407-16. 2006CREB-binding protein (CBP) and its para-log p300 are transcriptional coactivators that physically or functionally interact with over 320 mammalian and viral proteins, including 36 that are essential for B cells in mice...
- Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activationMehboob A Hussain
Metabolism Division, Department of Pediatrics and Medicine, Johns Hopkins University, 600 N Wolfe Street, CMSC 10 113, Baltimore, MD 21287, USA
Mol Cell Biol 26:7747-59. 2006..kinase A (PKA) phosphorylates CREB, resulting in recruitment of the transcriptional coactivators p300 and CREB binding protein (CBP). CBP, but not p300, is phosphorylated at serine 436 in response to insulin action...
- A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genesMarcelo A Wood
Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California at Irvine 92697, and Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Learn Mem 13:609-17. 2006..Recently, the transcriptional coactivator CREB-binding protein (CBP) was shown to be critical for hippocampus-dependent long-term memory and hippocampal synaptic plasticity...
- The transcriptional regulator CBP has defined spatial associations within interphase nucleiKirk J McManus
Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
PLoS Comput Biol 2:e139. 2006..The CREB-binding protein (CBP) is one such transcriptional regulator that, when visualised by confocal microscopy, reveals a highly punctate ..
- Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signalingMinhua Zhang
Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America
PLoS Biol 7:e1000245. 2009..Here we report that hypothalamic expression of CREB-binding protein (CBP) and CBP-binding partner Special AT-rich sequence binding protein 1 (SATB-1) is highly correlated with lifespan ..
- Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic responseSonja A Dames
Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 99:5271-6. 2002..conditions, HIF-1 activates transcription of critical adaptive genes by recruitment of the general coactivators CBP/p300 through interactions with its alpha-subunit (Hif-1 alpha)...
- Activation of cyclic-AMP response element binding protein contributes to adiponectin-stimulated interleukin-10 expression in RAW 264.7 macrophagesPil Hoon Park
Department of Pathobiology, Cleveland Clinic, OH 44195, USA
J Leukoc Biol 83:1258-66. 2008..Taken together, these data identify gAcrp-stimulated phospho-CREB as a key transcription factor responsible for gAcrp-induced IL-10 promoter activation...
- Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomainShiraz Mujtaba
Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
Mol Cell 9:575-86. 2002..is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF)...
- Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitmentCharles E Foulds
Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, UT 84112 5550, USA
Mol Cell Biol 24:10954-64. 2004..Pointed (PNT) domains, resulted in enhanced transactivation by preferential recruitment of the coactivators CREB binding protein (CBP) and p300...
- Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathwayBong Gun Ju
Howard Hughes Medical Institute, University of California, San Diego, Department and School of Medicine, La Jolla, CA 92093, USA
Cell 119:815-29. 2004..The identification of PARP-1 as a regulated promoter-specific exchange factor required for activation of specific neurogenic gene programs is likely to be prototypic of similar molecular mechanisms...
- Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcriptionPaul O Hassa
Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
J Biol Chem 280:40450-64. 2005..Thus, acetylation of PARP-1 by p300/CREB-binding protein plays an important regulatory role in NF-kappaB-dependent gene activation by enhancing its functional interaction with p300 and the Mediator complex...
- Phosphorylated CREB binds specifically to the nuclear protein CBPJ C Chrivia
Vollum Institute, Oregon Health Sciences University, Portland 97201
Nature 365:855-9. 1993..that CREB phosphorylated by protein kinase A binds specifically to a nuclear protein of M(r) 265K which we term CBP (for CREB-binding protein)...
- Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndromeY Tanaka
Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, Tsukuba, Ibaraki 305, Japan
Proc Natl Acad Sci U S A 94:10215-20. 1997b>CBP is a transcriptional coactivator required by many transcription factors for transactivation...
- Physical and functional interactions between the transcription factor PU.1 and the coactivator CBPH Yamamoto
Department of Cell Genetics, Sasaki Institute, Tokyo, Japan
Oncogene 18:1495-501. 1999..activity revealed that one of these clones was confirmed to encode a transcriptional coactivator, CREB binding protein (CBP)...
- Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding proteinY Tanaka
Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, and CREST Core Research for Evolutional Science and Technology Research Project, JST Japan Science and Technology Corporation, Tsukuba, 305 0074, Ibaraki, Japan
Mech Dev 95:133-45. 2000CREB-binding protein (CBP) is a transcriptional co-activator which is required by many transcription factors...
- Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous miceToshimasa Yamauchi
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
Nat Genet 30:221-6. 2002..9). To identify its physiological functions using a loss-of-function mutant, we analyzed CBP-deficient mice. As Crebbp null mice (Crebbp-/-) died during embryogenesis, we used Crebbp+/- mice...
- Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic miceQin Chen
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Oncogene 21:1028-37. 2002..can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the transcriptional coactivators CBP/p300...
- Essential function of p300 acetyltransferase activity in heart, lung and small intestine formationNoriko Shikama
Institute for Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
EMBO J 22:5175-85. 2003p300 and CBP are large nuclear acetyltransferases exhibiting a complex multi-domain structure...
- Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5Jeanne Françoise Roth
Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
EMBO J 22:5186-96. 2003Studies in tissue culture cells have implicated p300 and CBP acetyltransferases in myogenic regulatory factor (MRF) mediated transcription and terminal differentiation of skeletal muscle cells...
- Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatinKirk J McManus
Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2
Mol Cell Biol 23:7611-27. 2003..resolving power of laser scanning confocal microscopy with simple statistical analyses to characterize CREB binding protein (CBP)- and P300-induced changes in global histone acetylation levels at specific lysine residues...
- Solution structure of the KIX domain of CBP bound to the transactivation domain of c-MybTsaffrir Zor
Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
J Mol Biol 337:521-34. 2004..c-Myb activates transcription of target genes through direct interactions with the KIX domain of the co-activator CBP. The solution structure of the KIX domain in complex with the activation domain of c-Myb reveals a helical ..
- Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its ameliorationJuan M Alarcon
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Neuron 42:947-59. 2004..of Rubinstein-Taybi syndrome (RTS), an inheritable disorder caused by mutations in the gene encoding the CREB binding protein (CBP) and characterized by mental retardation and skeletal abnormalities...
- Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expressionLawryn H Kasper
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
EMBO J 24:3846-58. 2005..HIF-1alpha and HIF-2alpha binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription...
- Distribution of co-activators CBP and p300 during mouse oocyte and embryo developmentRoland P S Kwok
Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Reprod Dev 73:885-94. 2006cAMP response element binding protein (CREB)-binding protein (CBP) and p300 are two structurally related transcriptional co-activators that activate expression of many eukaryotic genes...
- Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtinHaibing Jiang
Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neurobiol Dis 23:543-51. 2006..Transfection of mutant huntingtin causes cell toxicity and depletion of CREB binding protein (CBP) or its recruitment into huntingtin aggregates...
- CBP and p300 are essential for renin cell identity and morphological integrity of the kidneyR Ariel Gomez
Dept of Pediatrics, Univ of Virginia School of Medicine, 409 Lane Rd, MR4 2001, Charlottesville, VA 22908, USA
Am J Physiol Heart Circ Physiol 296:H1255-62. 2009..of transcription factors to this region of the promoter is facilitated by the coactivators CREB-binding protein (CBP) and p300, which possess histone acetyltransferase activity and may be, in turn, responsible for the remodeling of ..
- Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell developmentTomofusa Fukuyama
Department of Biochemistry, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
Mol Cell Biol 29:3894-904. 2009..The transcriptional coactivators CREB binding protein (CBP) and the closely related p300, which comprise the KAT3 family of histone/protein lysine ..
- Systematic in vivo structure-function analysis of p300 in hematopoiesisErin A Kimbrel
Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital Boston and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Blood 114:4804-12. 2009Cyclic adenosine monophosphate response element binding (CREB)-binding protein (CBP) and p300 are multidomain transcriptional coactivators that help assemble large regulatory complexes at sites of active transcription...
- Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosisWilliam R Henderson
Center for Allergy and Inflammation and Department of Medicine, University of Washington, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 107:14309-14. 2010..inhibits T-cell factor/beta-catenin transcription in a cyclic AMP response-element binding protein binding protein (CBP)-dependent fashion...
- Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viabilityLuis M Valor
Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, Sant Joan d Alacant, 03550 Alicante, Spain
J Neurosci 31:1652-63. 2011..associated with mutations in the gene encoding the CREB (cAMP response element-binding protein)-binding protein (CBP) and characterized by growth impairment, learning disabilities, and distinctive facial and skeletal features...
- Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memoryRuth M Barrett
Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697 3800, USA
Neuropsychopharmacology 36:1545-56. 2011To identify the role of the histone acetyltransferase (HAT) CREB-binding protein (CBP) in neurons of the CA1 region of the hippocampus during memory formation, we examine the effects of a focal homozygous knockout of CBP on histone ..
- Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic controlDavid C Bedford
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Cell Metab 14:219-30. 2011..Mice heterozygous for the acetyltransferase CREB binding protein (CBP) are lean and insulin sensitized, but how CBP regulates energy homeostasis is unclear...
- The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cellsWai In Chan
Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom
Mol Cell Biol 31:5046-60. 2011The transcriptional coactivator Cbp plays an important role in a wide range of cellular processes, including proliferation, differentiation, and apoptosis...
- A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptorsY Kamei
Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
Cell 85:403-14. 1996..Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for limiting amounts of CBP/p300 in ..
- Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300T P Yao
Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 93:361-72. 1998The transcriptional coactivator and integrator p300 and its closely related family member CBP mediate multiple, signal-dependent transcriptional events. We have generated mice lacking a functional p300 gene...
- Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesisA Partanen
Program in Developmental Biology, The Hospital for Sick Children, and Institute of Medical Science, University of Toronto, Ontario, Canada
Int J Dev Biol 43:487-94. 1999CBP (CREBBP/CREB-binding protein) and p300 are related signal-dependent transcriptional cofactors and histone acetyltransferases...
- Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBPA L Kung
Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 14:272-7. 2000Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic malignancies...
- CREB-binding protein/p300 co-activation of crystallin gene expressionQin Chen
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 277:24081-9. 2002..In this study, we designed experiments to test whether the co-activators CREB-binding protein (CBP) and/or p300 interact with c-Maf, Prox-1, or Sox-1 to enhance transcription of crystallin genes...
- A transcription-factor-binding surface of coactivator p300 is required for haematopoiesisLawryn H Kasper
Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
Nature 419:738-43. 2002The coactivators CBP (Cre-element binding protein (CREB)-binding protein) and its paralogue p300 are thought to supply adaptor molecule and protein acetyltransferase functions to many transcription factors that regulate gene expression...
- Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewalVivienne I Rebel
Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:14789-94. 2002..We have identified a role for the transcriptional coactivators CREB-binding protein (CBP) and p300 in such HSC fate decisions. A full dose of CBP, but not p300, is crucial for HSC self-renewal...
- Inhibition of lens fiber cell morphogenesis by expression of a mutant SV40 large T antigen that binds CREB-binding protein/p300 but not pRbQin Chen
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 279:17667-73. 2004..The cells show a dramatic reduction in expression of their beta- and gamma-crystallins. Because CBP and p300 are co-activators for crystallin gene expression, we assayed for interactions between E107KDelta and CBP/..
- Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiencyNingling Kang-Decker
Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Cancer Cell 5:177-89. 2004b>CBP can function as a tumor suppressor, but the mechanisms that govern oncogenesis in its absence are unknown. Here we show that CBP inactivation in mouse thymocytes leads to lymphoma...
- Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding proteinXiao Yan Zhou
Department of Medicine and Committee on Molecular Metabolism and Nutrition, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA
Nat Med 10:633-7. 2004..of cAMP response element-binding (CREB) protein, resulting in recruitment of the coactivators CREB-binding protein (CBP) and p300 and subsequent activation of gluconeogenesis...
- Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell developmentLawryn H Kasper
Department of Biochemistry, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
Mol Cell Biol 26:789-809. 2006The global transcriptional coactivators CREB-binding protein (CBP) and the closely related p300 interact with over 312 proteins, making them among the most heavily connected hubs in the known mammalian protein-protein interactome...
- Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanismsWu Xu
Department of Biochemistry, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
EMBO J 26:2890-903. 2007..Phospho-Ser133 is required for CREB to bind the KIX domain of the coactivators CBP and p300 (CBP/p300) in vitro, although the importance of this archetype coactivator interaction for endogenous gene ..
- Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alphaHyun Seo Kang
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada
J Mol Biol 377:636-46. 2008..pulldown assays that the OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300. This provides a direct structural link between GABP and a central component of the transcriptional machinery.
- Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding proteinLing He
Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Cell 137:635-46. 2009..show that both the antidiabetic agent metformin and insulin phosphorylate the transcriptional coactivator CREB binding protein (CBP) at serine 436 via PKC iota/lambda...
- CREB binding protein is required for both short-term and long-term memory formationGuiquan Chen
Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 30:13066-77. 2010b>CREB binding protein (CBP) is a transcriptional coactivator with histone acetyltransferase activity. Our prior study suggested that CBP might be a key target of presenilins in the regulation of memory formation and neuronal survival...
- Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expressionAnne K Hennig
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS ONE 8:e69721. 2013..To further elucidate the role of these two coactivators, we conditionally knocked out Ep300 and/or CrebBP in differentiating rods or cones, using opsin-driven Cre recombinase...
- Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotencyTomoyuki Miyabayashi
Central R and D Laboratories, Asahi Kasei Corporation, Shizuoka 416 8501, Japan
Proc Natl Acad Sci U S A 104:5668-73. 2007..subunit of the serine/threonine phosphatase PP2A, prevents beta-catenin from switching coactivator usage from CBP to p300...
- Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lensYing Yang
Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA
J Mol Biol 369:917-26. 2007..Here, we identified CREB-binding protein (CBP) and p300 as major histone acetyltransferases (HATs) associated in vivo with the mouse alphaA-crystallin locus...
- Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivationsS Y Na
Department of Biology, Chonnam National University, Kwangju 500 757, Korea
J Biol Chem 273:10831-4. 1998..site was localized to a subregion of SRC-1 (amino acids 759-1141) that encompasses the previously described CBP-p300-binding domain...
- The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modulesA L Newton
Department of Biochemistry, G08, University of Sydney, Sydney, New South Wales 2006, Australia
J Biol Chem 275:15128-34. 2000cAMP-response element-binding protein-binding protein (CBP) is a transcriptional coactivator that interacts with a number of DNA-binding proteins and cofactor proteins involved in the regulation of transcription...
- Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactionsI Radhakrishnan
Department of Molecular Biology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Cell 91:741-52. 1997..activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner...
- CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuliMichel Barrot
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 99:11435-40. 2002..This control appears to be independent of the intrinsic appetitive or aversive value of the stimulus. The potential relevance of these data to addiction and mood disorders is discussed...
- Differential gene expression in the distal tip endoderm of the embryonic mouse lungYuru Liu
Department of Cell and Developmental Biology, Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
Gene Expr Patterns 2:229-33. 2002..5 lung buds, versus more proximal regions. Twenty genes were identified, assigned to different categories based on sequence analysis, and their distal expression confirmed by whole-mount in situ hybridization...
- Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-cateninCharlotte Labalette
Unité d Oncogenèse et Virologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Cell Biol 24:10689-702. 2004..It has been shown that the LIM protein FHL2 and the acetyltransferase CBP/p300 individually stimulate beta-catenin transactivating activity and that beta-catenin is acetylated by p300...
- A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndromeMasao Murakami
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, 75390 9148, USA
Proc Natl Acad Sci U S A 102:18034-9. 2005..These findings reveal key roles for TAZ and YAP in the control of TBX5-dependent transcription and suggest the involvement of these coactivators in cardiac and limb development...
- The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathwaySara Sánchez-Molina
Instituto de Biologia Molecular de Barcelona, CID, Consejo Superior de Investigaciones Cientificas, Parc Cientific de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
Biochem J 398:215-24. 2006The CBP [CREB (cAMP-response-element-binding protein)-binding protein]/p300 acetyltransferases function as transcriptional co-activators and play critical roles in cell differentiation and proliferation...
- Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locusCelina Demers
Sprott Center for Stem Cell Research, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada
Mol Cell 27:573-84. 2007....
- Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fearJin Hee Han
Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Learn Mem 15:443-53. 2008..Not only do these findings refine our knowledge of the circuitry underlying fear memory but they also provide novel insights into the neural substrates that govern the degree to which acquired fear of a tone generalizes to other tones...
- Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBPMary L Nelson
Department of Oncological Sciences, University of Utah School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA
Proc Natl Acad Sci U S A 107:10026-31. 2010..The affinity of Ets1 for the TAZ1 (or CH1) domain of the coactivator CBP was enhanced 34-fold by phosphorylation, and this binding was sensitive to ionic strength...
- Regulation of insulin gene transcription by multiple histone acetyltransferasesMegan L Sampley
Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, 741 South Limestone St, Lexington, KY 40536 0509, USA
DNA Cell Biol 31:8-14. 2012..In this report we investigated the role of the additional HAT proteins CREB binding protein (CBP), p300/CBP-associated factor (PCAF), and general control of amino-acid synthesis 5 (GCN5) in ..
- Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300Louise Wolf
Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Genetics, Albert Einstein College of Medicine, Bronx, NY10461, USA, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA, Departments of Ophthalmology and Visual Sciences, Washington University Saint Louis, Saint Louis, MO 63110, USA, Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA, Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19716, USA, Department of Surgery, Creighton University, Omaha, NE 68178, USA, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Israel 69978
Nucleic Acids Res 41:10199-214. 2013..The lysine acetyltransferases CBP and p300 function as principal enzymes that modify core histones to facilitate specific gene expression...
- CBP-Dependent memory consolidation in the prefrontal cortex supports object-location learningPhilip A Vieira
Department of Psychology and Neuroscience Program, University of California Riverside, California
Hippocampus 25:1532-40. 2015..we show that an acute hypofunction of the cyclic-AMP regulatory element binding protein (CREB) Binding Protein (CBP) histone acetyltransferase (HAT) in the medial prefrontal cortex (mPFC) results in delay-dependent disruption of ..
- Estrogen receptor beta as target for colorectal cancer preventionCecilia Williams
Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5056, USA SciLifeLab, School of Biotechnology, KTH Royal Institute of Technology, 171 21 Solna, Sweden Department of Biosciences and Nutrition, Novum, Karolinska Institutet, 141 83 Stockholm, Sweden Electronic address
Cancer Lett 372:48-56. 2016..In this review, we discuss the potential of new chemopreventive or dietary approaches based on estrogen signaling. ..
- SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activationGinam Cho
Department of Pathology, The Children s Hospital of Philadelphia, USA
J Biol Chem 284:19592-600. 2009..Taken together, our data indicate that the SIMs in Sizn1 are required for its PML-NB localization and for the full transcriptional co-activation function in BMP signaling...
- NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neuronsR Hughes
Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London, UK
Cell Death Differ 18:937-47. 2011..Furthermore, we find that the transcriptional coactivators CBP and p300 interact with NF-Y and FOXO3a and bind to this region of the bim promoter...
- Expression patterns of histone acetyltransferases p300 and CBP during murine tooth developmentZhu Chen
State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu, 610041, China
In Vitro Cell Dev Biol Anim 48:61-8. 2012The transcription coactivators p300 and CBP were reported to have indispensable roles in various tissues during the embryonic and fetal stages...
- Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotypeEllen Steward Pentz
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 302:H2545-52. 2012..transcriptional effects are mediated by binding of cAMP responsive element binding protein with its co-activators, CBP and p300, to the cAMP response element in the renin promoter...
- Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modulesAndre J Faure
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
Genome Res 22:2163-75. 2012..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels...
- Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactionsChristopher J Romero
Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Mol Cell Biol 32:4258-69. 2012..POU1F1 to the GH promoter along with cyclic AMP (cAMP) response element binding protein (CREB) binding protein (CBP). We investigate the role of CBP as a target of IGF-1 somatotroph regulation using the MtT/S somatotroph cell line...
- Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 geneYuzhi Jia
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3008, USA
Mech Dev 129:193-207. 2012..We conclude that PIMT/NCOA6IP, which is expressed in all cells of the 3.5 day stage blastocyst, is indispensable for early embryonic development...
- Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like propertiesSarah Schwitalla
Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany
Cell 152:25-38. 2013..Thus, our data support the concept of bidirectional conversion and highlight the importance of inflammatory signaling for dedifferentiation and generation of tumor-initiating cells in vivo...
- Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironmentManickavinayaham Swarnalatha
Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
J Cell Sci 126:4636-46. 2013..to specify the proliferative and apoptotic functions of E2F1, through its dynamic interaction with the co-activator CBP or co-repressor Brg1...
- Localization of human CREBBP (CREB binding protein) to 16p13.3 by fluorescence in situ hybridizationX N Chen
Medical Genetics Birth Defects Center, Ahmanson Department of Pediatrics, Cedars Sinai Research Institute, UCLA, USA
Cytogenet Cell Genet 71:56-7. 1995..A cDNA probe for the mouse CREB binding protein was used to localize this gene (CREBBP) to human chromosome 16p13...
- Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substratesW Xu
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cell Biol 18:5659-69. 1998..Two human homologs of Gcn5p have been reported previously, hsGCN5 and hsP/CAF (p300/CREB binding protein [CBP]-associated factor)...
- Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcriptionG Pelletier
Cancer Research Centre and Department of Medical Biology Laval University Hotel Dieu de Quebec 11 cote du Palais G1R 2J6, Quebec, Canada
Mol Cell 6:1059-66. 2000..Here we show that the acetyltransferase CBP is recruited to and acetylates UBF both in vitro and in vivo...
- Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old miceQiang Li
Department of Basic Gerontology, National Institute for Longevity Sciences, Aichi, Japan
J Gerontol A Biol Sci Med Sci 57:B93-8. 2002b>CBP, a protein that binds to cyclic adenosine monophosphate-regulated enhancer-binding protein, and homologue protein, p300, have histone acetyltransferase (HAT) activity and are important in gene transcription, although their ..
- Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit CBP-NF-kappaB interaction in activated microgliaMario Delgado
Departamento Biologia Celular, Facultad de Biologia, Universidad Complutense, 28040, Madrid, Spain
Biochem Biophys Res Commun 297:1181-5. 2002..An additional regulatory element in the NF-kappaB transcriptional activity is the coactivator CBP, which links p65 with components of the basal transcriptional machinery...
- ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modulesDanette L Daniels
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Cell 10:573-84. 2002..The C-terminal armadillo repeats of beta-catenin may be an attractive target for compounds designed to disrupt aberrant beta-catenin-mediated transcription associated with various cancers...
- Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during developmentChrissa Kioussi
Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, CMM West, Room 345, 9500 Gilman Drive, La Jolla, CA 92093, USA
Cell 111:673-85. 2002....
- Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patternsJeffrey M Craig
Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
Hum Mol Genet 12:3109-21. 2003..the active centromere of a dicentric chromosome, with six of these proteins (Sin3A, PCAF, MYST, MBD2, ORC2, P300/CBP) being demonstrated at mammalian centromeres for the first time...
- Dendrite development regulated by CREST, a calcium-regulated transcriptional activatorHiroyuki Aizawa
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 303:197-202. 2004..that interacts with adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB)-binding protein (CBP) and is expressed in the developing brain...
- A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBPSachiko Matsuda
Department of Biochemistry, University of Leicester, University Road Leicester LE1 7RH, United Kingdom
J Biol Chem 279:14055-64. 2004CREB-binding protein (CBP) and p300 contain modular domains that mediate protein-protein interactions with a wide variety of nuclear factors...
- Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activationShiraz Mujtaba
Department of Physiology and Biophysics, New York University, 1425 Madison Avenue, New York, NY 10029, USA
Mol Cell 13:251-63. 2004..Here, we report that the conserved bromo-domain of the transcriptional coactivator CBP (CREB binding protein) binds specifically to p53 at the C-terminal acetylated lysine 382...
- Enhancer-mediated control of macrophage-specific arginase I expressionAnne Laure Pauleau
Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
J Immunol 172:7565-73. 2004..Identification of a powerful extrahepatic regulatory enhancer for arginase I provides potential to manipulate arginase I activity in immune cells while sparing liver urea cycle function...
- Generation of a conditional allele of the CBP gene in mouseZuwen Zhang
Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Genesis 40:82-9. 2004CREB-binding protein (CBP) is an important transcriptional cofactor for various intracellular signaling pathways, including Ca(2+)- and cAMP-mediated gene activation...
- Corepressors selectively control the transcriptional activity of PPARgamma in adipocytesHong Ping Guan
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 19:453-61. 2005..Thus, selective modulation of adipocyte PPARgamma target genes by TZDs involves the dissociation of corepressors by direct and indirect mechanisms...
- Identification of novel CBP interacting proteins in embryonic orofacial tissueXiaolong Yin
Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD Louisville, KY 40292, USA
Biochem Biophys Res Commun 329:1010-7. 2005cAMP response element-binding protein (CREB)-binding protein (CBP) plays an important role as a general co-integrator of multiple signaling pathways and interacts with a large number of transcription factors and co-factors, through its ..
- Structural basis for cooperative transcription factor binding to the CBP coactivatorRoberto N De Guzman
Department of Molecular Biology MB2, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Mol Biol 355:1005-13. 2006..of transcription requires interactions between transcriptional activators and transcriptional co-activator CREB binding protein (CBP)...
- CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatumAmir A Levine
Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, and Howard Hughes Medical Institute, 1051 Riverside Drive, New York, NY 10032, USA
Proc Natl Acad Sci U S A 102:19186-91. 2005..Here, we show that histone acetylation by the cAMP-response element binding protein (CREB)-binding protein (CBP) mediates sensitivity to cocaine by regulating expression of the fosB gene and its splice variant, DeltafosB, a ..
- A nitric oxide signaling pathway controls CREB-mediated gene expression in neuronsAntonella Riccio
Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21201, USA
Mol Cell 21:283-94. 2006..Thus, in conjunction with CREB phosphorylation, the NO pathway controls CREB-DNA binding and CRE-mediated gene expression...
- Reduced extinction of hippocampal-dependent memories in CPEB knockout miceJoanne Berger-Sweeney
Department of Biology, Wellesley College, Wellesley, Massachusetts 02481, USA
Learn Mem 13:4-7. 2006..14% of hippocampal genes have an altered expression in the CPEB knockout mouse. These data suggest that CPEB-dependent local protein synthesis may be an important cellular mechanism underlying extinction of hippocampal-dependent memories...
- Structural diversity in p160/CREB-binding protein coactivator complexesLorna Waters
Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, United Kingdom
J Biol Chem 281:14787-95. 2006..as steroid receptor coactivator 1 (SRC1), in complex with histone acetyltransferases such as CREB-binding protein (CBP) and p300...
- CREB-binding proteins (CBP) as a transcriptional coactivator of GATA-2HuiJie Jiang
College of Life Sciences, Ludong University, Yantai, 264025, China
Sci China C Life Sci 51:191-8. 2008..CREB-binding proteins (CBP) are essential transcriptional coactivators for a large number of regulated DNA-binding transcription factors, ..
- Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylationJunghee Lee
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA
Hum Mol Genet 17:1774-82. 2008..We found that the monoallelic deletion of CREB binding protein (CBP) results in the induction of ERG-associated protein with SET domain (ESET) and increases ..
- Exendin-4 stimulation of cyclin A2 in beta-cell proliferationWoo Jin Song
Metabolism Division, Departments of Pediatrics and Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Diabetes 57:2371-81. 2008..We have examined effects, in particular those mediated through intracellular cAMP signaling, of the incretin hormone analog exendin-4 on cell cycle regulation in beta-cells...
- Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosisNilkantha Sen
Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Nat Cell Biol 10:866-73. 2008..Here we show that nuclear GAPDH is acetylated at Lys 160 by the acetyltransferase p300/CREB binding protein (CBP) through direct protein interaction, which in turn stimulates the acetylation and catalytic activity ..
- Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBPSeunghee Lee
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 62:641-54. 2009..RA then facilitates the recruitment of a histone acetyltransferase CBP to the Ngn2/RAR-complex, markedly inducing histone H3/H4-acetylation...
- Endocrine pancreatic cell regeneration from bone marrowMehboob A Hussain; Fiscal Year: 2010..4) To identify the cell type within BM that contributes to the pancreatic endocrine cell population. The long-term goal of these studies is to evaluate transplantation of BM derived cells as a potential treatment for diabetes mellitus. ..
- Redox Signaling in Osteoblast DifferentiationNandini Ghosh Choudhury; Fiscal Year: 2009..Understanding the signal transduction pathways of osteoblast differentiation may result in the development of therapeutic modalities for the human diseases where lack of bone formation is the pathology. ..
- Insulin and Oocyte Chromatin SegregationGary Smith; Fiscal Year: 2009..abstract_text> ..
- STRUCTURAL AND FUNCTIONAL DEVELOPMENT OF THE KIDNEYRoberto Gomez; Fiscal Year: 2006..It is anticipated that the Center of Excellence will build on the achievements of the past five years and will lead to improved management of infants and children with renal and urological diseases...
- Chemogenomics to Identify New Molecular Targets in PFWilliam Henderson; Fiscal Year: 2006..These studies represent a focused effort using chemogenomics to identify, develop, and validate small molecule inhibitors of AP-1/TGFBeta-driven profibrotic gene expression as novel therapies in PF patients. ..
- beta-Catenin/NF-kappaBeta and Colon CancerShahid Umar; Fiscal Year: 2004..By studying a mechanistic basis of NF-kappaB and beta-catenin mediated increases in cell census, in the absence and presence of chronic inflammation, we may identify new treatment strategies for reducing cancer risk. ..
- PROTEIN PHOSPHATASES AND OOCYTE MEIOSISGary Smith; Fiscal Year: 2002..These studies will provide novel information concerning control of oocyte maturation and spindle formation that may subsequently influence the developmental competency of resulting embryos. ..
- Web-Based System for Research Protocol SubmissionRoberto Gomez; Fiscal Year: 2003..We will try to reach small institutions by annoucements and demonstrations at local, regional and national meetings of the Society for Research Administration, International. ..
- RENIN CELL FATE IN THE KIDNEY VASCULATURERoberto Gomez; Fiscal Year: 2005..The studies should generate fundamental new knowledge on JG cell differentiation and function and open new avenues for the understanding, prevention and treatment of hypertension and kidney diseases. ..
- 5-LIPOXYGENASE PRODUCTS IN ASTHMATIC IMMUNE RESPONSEWilliam Henderson; Fiscal Year: 2008..abstract_text> ..