Gene Symbol: Creb3l2
Description: cAMP responsive element binding protein 3-like 2
Alias: BBF2H7, C530025K05Rik, SCIRR69, cyclic AMP-responsive element-binding protein 3-like protein 2, cAMP-responsive element-binding protein 3-like protein 2
Kondo S, Hino S, Saito A, Kanemoto S, Kawasaki N, Asada R, et al
. Activation of OASIS family, ER stress transducers, is dependent on its stabilization. Cell Death Differ. 2012;19:1939-49 pubmed publisher
..BBF2 human homolog on chromosome 7 (BBF2H7) and old astrocyte specifically induced substance (OASIS), ER-resident transmembrane proteins, have recently been ..
Kondo S, Saito A, Hino S, Murakami T, Ogata M, Kanemoto S, et al
. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. Mol Cell Biol. 2007;27:1716-29 pubmed
..We report here that BBF2H7 (BBF2 human homolog on chromosome 7), an ER-resident transmembrane protein with the bZIP domain in the cytoplasmic ..
Saito A, Hino S, Murakami T, Kanemoto S, Kondo S, Saitoh M, et al
. Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis. Nat Cell Biol. 2009;11:1197-204 pubmed publisher
..b>BBF2H7 (BBF2 human homologue on chromosome 7), an ER-resident basic leucine zipper transcription factor, is activated in ..
Saito A, Kanemoto S, Zhang Y, Asada R, Hino K, Imaizumi K. Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2. Mol Cell. 2014;53:127-39 pubmed publisher
The endoplasmic reticulum (ER) stress transducer BBF2H7/CREB3L2 is an ER-resident transmembrane transcription factor...
Sheng Z, Li L, Zhu L, Smith T, Demers A, Ross A, et al
. A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nat Med. 2010;16:671-7 pubmed publisher
..signaling cascade leads to induction of the transcription factor cAMP response element-binding protein-3-like-2 (CREB3L2), which directly activates ATF5 expression...
Liu Y, Que H, Ma Z, Yang S, Ni Y, Luo Z, et al
. Transcription factor SCIRR69 involved in the activation of brain-derived neurotrophic factor gene promoter II in mechanically injured neurons. Neuromolecular Med. 2013;15:605-22 pubmed publisher
The spinal cord injury and regeneration-related gene #69 (SCIRR69), which was identified in our screen for genes upregulated after spinal cord injury, encode a protein belonging to the cAMP response element-binding protein (CREB)/ATF ..
Hino K, Saito A, Kido M, Kanemoto S, Asada R, Takai T, et al
. Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes. J Biol Chem. 2014;289:13810-20 pubmed publisher
The endoplasmic reticulum (ER) stress transducer, box B-binding factor 2 human homolog on chromosome 7 (BBF2H7), is a basic leucine zipper (bZIP) transmembrane transcription factor...
Darnay B, Reddy S, Aggarwal B. Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells. J Biol Chem. 1994;269:19687-90 pubmed
..This p80 TNF receptor-associated protein and the associated kinase described here are referred to as p80-TRAP and p80-TRAK, respectively. ..
Izumi S, Saito A, Kanemoto S, Kawasaki N, Asada R, Iwamoto H, et al
. The endoplasmic reticulum stress transducer BBF2H7 suppresses apoptosis by activating the ATF5-MCL1 pathway in growth plate cartilage. J Biol Chem. 2012;287:36190-200 pubmed publisher
b>BBF2H7 (box B-binding factor 2 human homolog on chromosome 7) is a basic leucine zipper transmembrane transcription factor that belongs to the cyclic AMP-responsive element-binding protein (CREB)/activating transcription factor (ATF) ..