Cpt2

Summary

Gene Symbol: Cpt2
Description: carnitine palmitoyltransferase 2
Alias: AI323697, CPTII, carnitine O-palmitoyltransferase 2, mitochondrial, CPT II, carnitine palmitoyltransferase II
Species: mouse
Products:     Cpt2

Top Publications

  1. Gelb B. Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993;18:651-5 pubmed
    The mouse carnitine palmitoyltransferase II gene has been isolated and its genomic structure determined. The gene contained five exons, including an unusually long 1305-nt exon 4...
  2. Uenaka R, Kuwajima M, Ono A, Matsuzawa Y, Hayakawa J, Inohara N, et al. Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice. J Biochem. 1996;119:533-40 pubmed
    ..When the JVS mice were treated with carnitine, CPT I gene expression was repressed to the level of normal mice. Therefore, the increased expression of the CPT I gene was associated with carnitine deficiency. ..
  3. Morillas M, Clotet J, Rubi B, Serra D, Arino J, Hegardt F, et al. Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues. Biochem J. 2000;351 Pt 2:495-502 pubmed
    ..Our data demonstrate that both etomoxir and malonyl-CoA inhibit COT by interacting with the same sites. ..
  4. Nomura M, Liu J, Rovira I, Gonzalez Hurtado E, Lee J, Wolfgang M, et al. Fatty acid oxidation in macrophage polarization. Nat Immunol. 2016;17:216-7 pubmed publisher
  5. Gonzalez Hurtado E, Lee J, Choi J, Selen Alpergin E, Collins S, Horton M, et al. Loss of macrophage fatty acid oxidation does not potentiate systemic metabolic dysfunction. Am J Physiol Endocrinol Metab. 2017;312:E381-E393 pubmed publisher
    ..dysfunction in high-fat diet-induced obesity, we generated mice with a myeloid-specific knockout of carnitine palmitoyltransferase II (CPT2 MÏ•-KO), an obligate step in mitochondrial long-chain fatty acid oxidation...
  6. Pereyra A, Hasek L, Harris K, Berman A, Damen F, Goergen C, et al. Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy. J Biol Chem. 2017;292:18443-18456 pubmed publisher
    ..the loss of an obligate enzyme in mitochondrial long-chain fatty acid oxidation, carnitine palmitoyltransferase 2 (CPT2), on muscle and heart structure, function, and molecular signatures in a muscle- and heart-specific CPT2-deficient ..
  7. Hotta K, Kuwajima M, Ono A, Uenaka R, Nakajima H, Miyagawa J, et al. Altered expression of carnitine palmitoyltransferase II in liver, muscle, and heart of mouse strain with juvenile visceral steatosis. Biochim Biophys Acta. 1996;1289:131-5 pubmed
    We conducted a quantitative study of the effect of carnitine deficiency on the mRNA level of carnitine palmitoyltransferase II in the liver, muscle and heart of mice with juvenile visceral steatosis, a strain that is systematically ..
  8. Gentile L, Monti M, Sebastiano V, Merico V, Nicolai R, Calvani M, et al. Single-cell quantitative RT-PCR analysis of Cpt1b and Cpt2 gene expression in mouse antral oocytes and in preimplantation embryos. Cytogenet Genome Res. 2004;105:215-21 pubmed
    ..We have carried out a study to determine the relative number of transcripts of Cpt1b and Cpt2 genes encoding for m-CPT-I and CPT-II enzymes, during mouse preimplantation development...
  9. Lai L, Leone T, Zechner C, Schaeffer P, Kelly S, Flanagan D, et al. Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev. 2008;22:1948-61 pubmed publisher
    ..We conclude that PGC-1alpha and PGC-1beta share roles that collectively are necessary for the postnatal metabolic and functional maturation of heart and BAT. ..

More Information

Publications13

  1. Lee J, Ellis J, Wolfgang M. Adipose fatty acid oxidation is required for thermogenesis and potentiates oxidative stress-induced inflammation. Cell Rep. 2015;10:266-79 pubmed publisher
    ..to whole-body metabolism, we generated mice with an adipose-specific knockout of carnitine palmitoyltransferase 2 (CPT2(A-/-)), an obligate step in mitochondrial long-chain fatty acid oxidation...
  2. Tzeng J, Byun J, Park J, Yamamoto T, Schesing K, Tian B, et al. An Ideal PPAR Response Element Bound to and Activated by PPARα. PLoS ONE. 2015;10:e0134996 pubmed publisher
    ..Taken altogether, the provided PPRE sequence definition contributes to the understanding of PPARα signaling by identifying PPARα direct target genes with functional PPARα response elements. ..
  3. Lee J, Choi J, Aja S, Scafidi S, Wolfgang M. Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality. Cell Rep. 2016;14:1308-1316 pubmed publisher
    ..Here, mice with an adipose-specific defect in fatty acid oxidation (Cpt2(A-/-)) were subjected to varying temperatures to determine the role of adipose bioenergetics in environmental ..
  4. Lee J, Choi J, Scafidi S, Wolfgang M. Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation. Cell Rep. 2016;16:201-212 pubmed publisher
    ..oxidation on this process, we generated mice with a liver-specific knockout of carnitine palmitoyltransferase 2 (Cpt2(L-/-)), an obligate step in mitochondrial long-chain fatty acid ?-oxidation...