Gene Symbol: Cpt2
Description: carnitine palmitoyltransferase 2
Alias: AI323697, CPTII, carnitine O-palmitoyltransferase 2, mitochondrial, CPT II, carnitine palmitoyltransferase II
Gelb B. Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993;18:651-5 pubmed
The mouse carnitine palmitoyltransferase II gene has been isolated and its genomic structure determined. The gene contained five exons, including an unusually long 1305-nt exon 4...
Uenaka R, Kuwajima M, Ono A, Matsuzawa Y, Hayakawa J, Inohara N, et al
. Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice. J Biochem. 1996;119:533-40 pubmed
..When the JVS mice were treated with carnitine, CPT I gene expression was repressed to the level of normal mice. Therefore, the increased expression of the CPT I gene was associated with carnitine deficiency. ..
Morillas M, Clotet J, Rubi B, Serra D, Arino J, Hegardt F, et al
. Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues. Biochem J. 2000;351 Pt 2:495-502 pubmed
..Our data demonstrate that both etomoxir and malonyl-CoA inhibit COT by interacting with the same sites. ..
Nomura M, Liu J, Rovira I, Gonzalez Hurtado E, Lee J, Wolfgang M, et al
. Fatty acid oxidation in macrophage polarization. Nat Immunol. 2016;17:216-7 pubmed publisher
Gonzalez Hurtado E, Lee J, Choi J, Selen Alpergin E, Collins S, Horton M, et al
. Loss of macrophage fatty acid oxidation does not potentiate systemic metabolic dysfunction. Am J Physiol Endocrinol Metab. 2017;312:E381-E393 pubmed publisher
..dysfunction in high-fat diet-induced obesity, we generated mice with a myeloid-specific knockout of carnitine palmitoyltransferase II (CPT2 MÏ•-KO), an obligate step in mitochondrial long-chain fatty acid oxidation...
Pereyra A, Hasek L, Harris K, Berman A, Damen F, Goergen C, et al
. Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy. J Biol Chem. 2017;292:18443-18456 pubmed publisher
..the loss of an obligate enzyme in mitochondrial long-chain fatty acid oxidation, carnitine palmitoyltransferase 2 (CPT2), on muscle and heart structure, function, and molecular signatures in a muscle- and heart-specific CPT2-deficient ..
Hotta K, Kuwajima M, Ono A, Uenaka R, Nakajima H, Miyagawa J, et al
. Altered expression of carnitine palmitoyltransferase II in liver, muscle, and heart of mouse strain with juvenile visceral steatosis. Biochim Biophys Acta. 1996;1289:131-5 pubmed
We conducted a quantitative study of the effect of carnitine deficiency on the mRNA level of carnitine palmitoyltransferase II in the liver, muscle and heart of mice with juvenile visceral steatosis, a strain that is systematically ..
Gentile L, Monti M, Sebastiano V, Merico V, Nicolai R, Calvani M, et al
. Single-cell quantitative RT-PCR analysis of Cpt1b and Cpt2 gene expression in mouse antral oocytes and in preimplantation embryos. Cytogenet Genome Res. 2004;105:215-21 pubmed
..We have carried out a study to determine the relative number of transcripts of Cpt1b and Cpt2 genes encoding for m-CPT-I and CPT-II enzymes, during mouse preimplantation development...
Lai L, Leone T, Zechner C, Schaeffer P, Kelly S, Flanagan D, et al
. Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev. 2008;22:1948-61 pubmed publisher
..We conclude that PGC-1alpha and PGC-1beta share roles that collectively are necessary for the postnatal metabolic and functional maturation of heart and BAT. ..