Genomes and Genes
Gene Symbol: Cox10
Description: cytochrome c oxidase assembly protein 10
Alias: 2410004F01Rik, AU042636, protoheme IX farnesyltransferase, mitochondrial, COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase, heme O synthase
- Diaz F, Thomas C, Garcia S, Hernandez D, Moraes C. Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Hum Mol Genet. 2005;14:2737-48 pubmedWe have created a mouse model with an isolated cytochrome c oxidase (COX) deficiency by disrupting the COX10 gene in skeletal muscle. Missense mutations in COX10 have been previously associated with mitochondrial disorders...
- Pinto M, Nissanka N, Peralta S, Brambilla R, Diaz F, Moraes C. Pioglitazone ameliorates the phenotype of a novel Parkinson's disease mouse model by reducing neuroinflammation. Mol Neurodegener. 2016;11:25 pubmed publisher..In order to analyze the role of Complex IV in PD, we knocked out Cox10 (essential for the maturation of COXI, a catalytic subunit of Complex IV) in dopaminergic neurons...
- Tan H, Yang K, Li Y, Shaw T, Wang Y, Blanco D, et al. Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation. Immunity. 2017;46:488-503 pubmed publisher..Genetic perturbation revealed physiological roles for mitochondrial enzyme COX10-mediated oxidative phosphorylation in TÂ cell quiescence exit...
- Supplie L, Düking T, Campbell G, Diaz F, Moraes C, Gotz M, et al. Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo. J Neurosci. 2017;37:4231-4242 pubmed publisher..respiration in vitro and in vivo A novel mouse mutant (GLASTCreERT2::Cox10flox/flox) was generated, in which the administration of tamoxifen causes mutant astrocytes to fail ..