Gene Symbol: COX1
Description: cytochrome c oxidase subunit I
Alias: CoxI
Species: mouse
Products:     COX1

Top Publications

  1. Tominaga M, Kurihara H, Honda S, Amakawa G, Sakai T, Tomooka Y. Molecular characterization of mitocalcin, a novel mitochondrial Ca2+-binding protein with EF-hand and coiled-coil domains. J Neurochem. 2006;96:292-304 pubmed
    ..These findings suggest that mitocalcin may play roles in neuronal differentiation and function through the control of mitochondrial function. ..
  2. Bayona Bafaluy M, Acin Perez R, Mullikin J, Park J, Moreno Loshuertos R, Hu P, et al. Revisiting the mouse mitochondrial DNA sequence. Nucleic Acids Res. 2003;31:5349-55 pubmed
    ..Consequently, the mtDNA of the strain used for the mouse genome project (C57BL/6J) is proposed as the new standard for the mouse mtDNA sequence. ..
  3. Peralta S, Torraco A, Wenz T, Garcia S, Diaz F, Moraes C. Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Hum Mol Genet. 2014;23:1399-412 pubmed publisher
    ..These results showed that a partial defect in CI in neurons can lead to late-onset motor phenotypes without neuronal loss or oxidative damage. ..
  4. Kasahara A, Ishikawa K, Yamaoka M, Ito M, Watanabe N, Akimoto M, et al. Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells. Hum Mol Genet. 2006;15:871-81 pubmed
  5. Wang J, Cao Y, Chen Y, Chen Y, Gardner P, Steiner D. Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Proc Natl Acad Sci U S A. 2006;103:10636-41 pubmed
    ..Ectopic expression of HIMP1 in MIN6 beta cells protects the cells from apoptosis induced by several stimuli and prolongs their survival. These results suggest an important role for HIMP1 in stress protective programs in mitochondria. ..
  6. Carmona M, Iglesias R, Obregon M, Darlington G, Villarroya F, Giralt M. Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J Biol Chem. 2002;277:21489-98 pubmed
  7. Ju W, Kim K, Lindsey J, Angert M, Duong Polk K, Scott R, et al. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2008;49:4903-11 pubmed publisher
    ..Thus, interventions to preserve mitochondria may be useful for protecting against ON degeneration in glaucoma. ..
  8. Xu F, Ackerley C, Maj M, Addis J, Levandovskiy V, Lee J, et al. Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria. Biochem J. 2008;416:15-26 pubmed publisher
    ..This defines the site for PTCD2 action in mammalian mitochondria and suggests a possible role for dysfunction of this protein in the aetiology of heart failure...
  9. Xu L, Miyoshi H, Nishimura K, Jisaka M, Nagaya T, Yokota K. Gene expression of isoformic enzymes in arachidonate cyclooxygenase pathway and the regulation by tumor necrosis factor alpha during life cycle of adipocytes. Prostaglandins Other Lipid Mediat. 2007;83:213-8 pubmed
    ..The action of TNFalpha on preadipocytes can be modulated by the production of endogenous PGs through the induction of COX-2. ..

More Information


  1. Holvoet P, Vanhaverbeke M, Geeraert B, De Keyzer D, Hulsmans M, Janssens S. Low Cytochrome Oxidase 1 Links Mitochondrial Dysfunction to Atherosclerosis in Mice and Pigs. PLoS ONE. 2017;12:e0170307 pubmed publisher
    ..In mice and pigs, MT-COI was inversely related to insulin resistance. Low MT-COI is related to mitochondrial dysfunction, oxidative stress and atherosclerosis and plaque complexity. ..
  2. Yang H, Brosel S, Acin Perez R, Slavkovich V, Nishino I, Khan R, et al. Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. Hum Mol Genet. 2010;19:170-80 pubmed publisher
    ..These mouse models should be of use in further studies of Sco2 function, as well as in testing therapeutic approaches to treat the human disorder. ..
  3. Kolaczkowska E, Plytycz B, Arnold B, Piccard H, Opdenakker G. Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. Immunology. 2009;128:e262-74 pubmed publisher
    ..In non-transgenic mice, however, inflammatory leucocytes die apoptotically in the late stages of peritonitis as a result of COX-2-dependent PGD(2) activity. Overall, we show a dependence of COX expression on the presence of MMP-9. ..
  4. Samavati L, Lee I, Mathes I, Lottspeich F, Huttemann M. Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase. J Biol Chem. 2008;283:21134-44 pubmed publisher
    ..35 cells. We postulate that an important contributor in TNFalpha-mediated pathologies, such as sepsis, is energy paucity, which parallels the poor tissue oxygen extraction and utilization found in such patients. ..
  5. Iheagwara K, Thom S, Deutschman C, Levy R. Myocardial cytochrome oxidase activity is decreased following carbon monoxide exposure. Biochim Biophys Acta. 2007;1772:1112-6 pubmed
    ..Decreased CcOX activity following CO inhalation was likely due to decreased heme aa(3) and CcOX subunit I content. Importantly, myocardial CcOX impairment could underlie CO induced cardiac dysfunction. ..
  6. Diaz F, Thomas C, Garcia S, Hernandez D, Moraes C. Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Hum Mol Genet. 2005;14:2737-48 pubmed
    ..This COX10 KO mouse allowed us to correlate the muscle function with residual COX activity, an estimate that can help predict the progression pattern of human mitochondrial myopathies...
  7. Li X, Zhang L, Guan M. Cloning and characterization of mouse mTERF encoding a mitochondrial transcriptional termination factor. Biochem Biophys Res Commun. 2005;326:505-10 pubmed
    ..These observations suggest that the mouse mTERF is an evolutionarily conserved mitochondrial transcription termination factor, thereby promoting the termination of transcription in mitochondrial RNA. ..
  8. Gao C, Guo H, Wei J, Kuo P. Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages. Biochem Biophys Res Commun. 2003;309:120-5 pubmed
    ..CCO enzyme activity was also significantly decreased by OPN. Our results indicate that OPN inhibits CCOI expression as the result of a novel CD44-dependent transcriptional regulatory mechanism of the mitochondrial H strand. ..