Cops5

Summary

Gene Symbol: Cops5
Description: COP9 signalosome subunit 5
Alias: AI303502, CSN5, Jab1, Mov34, Sgn5, COP9 signalosome complex subunit 5, COP9 (constitutive photomorphogenic) homolog, subunit 5, COP9 complex S5, Jun activation domain-binding protein 1, Jun coactivator, Kip1 C-terminus-interacting protein 2
Species: mouse
Products:     Cops5

Top Publications

  1. Tomoda K, Kubota Y, Kato J. Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. Nature. 1999;398:160-5 pubmed
    ..We have found that a mouse 38K protein (p38) encoded by the Jab1 gene interacts specifically with p27Kip1 and show here that overexpression of p38 in mammalian cells causes the ..
  2. Mori M, Yoneda Kato N, Yoshida A, Kato J. Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors. J Biol Chem. 2008;283:29011-21 pubmed publisher
    Overexpression of JAB1 is observed in a variety of human cancers, but how JAB1 is involved in tumor development remained to be investigated. Here we analyzed mice with modified Jab1 expression...
  3. Carrabino S, Carminati E, Talarico D, Pardi R, Bianchi E. Expression pattern of the JAB1/CSN5 gene during murine embryogenesis: colocalization with NEDD8. Gene Expr Patterns. 2004;4:423-31 pubmed
    ..ubiquitin-like molecule NEDD8 from the cullin component of the SCF and that requires subunit 5 of the CSN (JAB1/CSN5)...
  4. Yoshida A, Yoneda Kato N, Panattoni M, Pardi R, Kato J. CSN5/Jab1 controls multiple events in the mammalian cell cycle. FEBS Lett. 2010;584:4545-52 pubmed publisher
    ..In this study, MEFs lacking CSN5/Jab1 were generated using a CRE-flox system. MEFs ceased to proliferate upon elimination of CSN5/Jab1...
  5. Tsuge T, Matsui M, Wei N. The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. J Mol Biol. 2001;305:1-9 pubmed
    ..We conclude that the N-terminal half of CSN1 harbors the activity domain that confers most of the repression functions of CSN1 while the C-terminal half allows integration of the protein into the COP9 signalosome. ..
  6. Fukumoto A, Tomoda K, Kubota M, Kato J, Yoneda Kato N. Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation. FEBS Lett. 2005;579:1047-54 pubmed
    b>Jab1 interacts with a variety of cell cycle and signal transduction regulators to control cell proliferation, differentiation, and tumorigenesis...
  7. Fukumoto A, Tomoda K, Yoneda Kato N, Nakajima Y, Kato J. Depletion of Jab1 inhibits proliferation of pancreatic cancer cell lines. FEBS Lett. 2006;580:5836-44 pubmed
    b>Jab1 overexpression is observed in many human cancers, but its physiological significance remains to be investigated...
  8. Panattoni M, Sanvito F, Basso V, Doglioni C, Casorati G, Montini E, et al. Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development. J Exp Med. 2008;205:465-77 pubmed publisher
    ..placed at the crossroads of these programs in lower organisms, we addressed its role by conditionally deleting CSN5/JAB1, its catalytic subunit, in developing thymocytes...
  9. Tomoda K, Yoneda Kato N, Fukumoto A, Yamanaka S, Kato J. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem. 2004;279:43013-8 pubmed
    ..As the fifth component of the COP9 signalosome (CSN) complex, Jab1 (CSN5) plays a central role in the deneddylation of the cullin subunit of the Skp1-Cullin-F box protein ubiquitin ligase ..

More Information

Publications41

  1. Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, et al. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J Biol Chem. 2002;277:2302-10 pubmed
    The fifth component of the COP9 signalosome complex, Jab1/CSN5, directly binds to and induces specific down-regulation of the cyclin-dependent kinase inhibitor p27 (p27(Kip1))...
  2. Bashur L, Chen D, Chen Z, Liang B, Pardi R, Murakami S, et al. Loss of jab1 in osteochondral progenitor cells severely impairs embryonic limb development in mice. J Cell Physiol. 2014;229:1607-17 pubmed publisher
    The transcriptional cofactor Jab1 controls cell proliferation, apoptosis, and differentiation in diverse developmental processes by regulating the activity of various transcription factors...
  3. Pick E, Golan A, Zimbler J, Guo L, Sharaby Y, Tsuge T, et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS ONE. 2012;7:e43980 pubmed publisher
    ..The CSN possesses a highly conserved deneddylase activity that centers at the JAMM motif of the Csn5 subunit but requires other subunits in a complex assembly...
  4. Chopra S, Fernandez De Mattos S, Lam E, Mann D. Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1. J Biol Chem. 2002;277:32413-6 pubmed
    ..Previous studies have implicated the c-Jun co-activator protein Jab1 as a regulator of intracellular p27(Kip1) levels...
  5. Teng E, Todd L, Ribar T, Lento W, DiMascio L, Means A, et al. Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells. Mol Biol Cell. 2011;22:1312-20 pubmed publisher
    ..binding of p27(kip1) to its inhibitor, the COP9 signalosome subunit jun activation-domain binding protein 1 (Jab1), leading to its down-regulation...
  6. Berndt K, Kim M, Meinhardt A, Klug J. Macrophage migration inhibitory factor does not modulate co-activation of androgen receptor by Jab1/CSN5. Mol Cell Biochem. 2008;307:265-71 pubmed
    ..Endocytosed or endogenous MIF interacts with Jun activation domain-binding protein 1 (Jab1), originally described as transcriptional co-activator for the transcription factor AP-1, that is also known as ..
  7. Berse M, Bounpheng M, Huang X, Christy B, Pollmann C, Dubiel W. Ubiquitin-dependent degradation of Id1 and Id3 is mediated by the COP9 signalosome. J Mol Biol. 2004;343:361-70 pubmed
    ..regulators and substrates of the ubiquitin system Id1 and Id3, but not Id2 and Id4, bind to the CSN subunit CSN5. Pull-down experiments revealed that Id3 physically interacts with the CSN complex...
  8. Cayli S, Klug J, Chapiro J, Fröhlich S, Krasteva G, Orel L, et al. COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP. J Biol Chem. 2009;284:34944-53 pubmed publisher
    ..Here, we show that p97/VCP colocalizes and directly interacts with subunit 5 of the CSN (CSN5) in vivo and is associated with the entire CSN complex in an ATP-dependent manner...
  9. Yoshida A, Yoneda Kato N, Kato J. CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner. Sci Rep. 2013;3:1054 pubmed publisher
    The fifth component (CSN5) of the mammalian COP9 signalosome complex plays an essential role in cell proliferation and senescence, but its molecular mediator remains to be determined...
  10. Asano K, Vornlocher H, Richter Cook N, Merrick W, Hinnebusch A, Hershey J. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. J Biol Chem. 1997;272:27042-52 pubmed
    ..The subunit composition of eIF3 appears to be highly conserved in Drosophila melanogaster, C. elegans, and Arabidopsis thaliana, whereas only 5 homologs of the 10 subunits of mammalian eIF3 are encoded in S. cerevisiae. ..
  11. Wang H, Dey D, Carrera I, Minond D, Bianchi E, Xu S, et al. COPS5 (Jab1) protein increases ? site processing of amyloid precursor protein and amyloid ? peptide generation by stabilizing RanBP9 protein levels. J Biol Chem. 2013;288:26668-77 pubmed publisher
    ..RanBP9 and regulate A? levels, we used a two-hybrid analysis against a human brain cDNA library and identified COPS5 as a novel RanBP9-interacting protein...
  12. Huang Y, Iwamoto K, Kurosaki T, Nasu M, Ueda S. The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved in the onset of neurodegenerative diseases. Neurosci Lett. 2005;382:175-8 pubmed
    ..We obtained Jun-activation-domain-binding protein 1 (Jab1) as a new Brn-2 binding protein...
  13. Deng X, Dubiel W, Wei N, Hofmann K, Mundt K, Colicelli J, et al. Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. Trends Genet. 2000;16:202-3 pubmed
  14. Oh W, Lee E, Sung Y, Yang M, Ghim J, Lee H, et al. Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2. J Biol Chem. 2006;281:17457-65 pubmed
    ..Here, we showed that Jab1 facilitates p53 nuclear exclusion and its subsequent degradation in coordination with Hdm2...
  15. He F, Lu D, Jiang B, Wang Y, Liu Q, Liu Q, et al. X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling. Biochim Biophys Acta. 2013;1832:595-605 pubmed publisher
    ..The current study identified Jun activation domain-binding protein (Jab1/CSN5) in the COP9 signalosome (CSN) complex as a novel proteolytic target for the CUL4B ubiquitin ligase complex...
  16. Rockel B, Schmaler T, Huang X, Dubiel W. Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes. Biochem Biophys Res Commun. 2014;450:991-7 pubmed publisher
    ..This structure, called the horseshoe, is formed by the PCI domain subunits. CSN5 and CSN6 point away from the horseshoe...
  17. Gu Y, Chen Q, Gu Z, Shi Y, Yao Y, Wang J, et al. Ubiquitin carboxyl-terminal hydrolase L1 contributes to the oocyte selective elimination in prepubertal mouse ovaries. Sheng Li Xue Bao. 2009;61:175-84 pubmed
    ..protein expression was increased, to some degree in association with Jun activation domain-binding protein 1 (Jab1) and cyclin-dependent kinase inhibitor p27(Kipl)...
  18. Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, et al. The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc Natl Acad Sci U S A. 2011;108:E577-85 pubmed publisher
    ..These data indicate that D-DT is a MIF-like cytokine with an overlapping spectrum of activities that are important for our understanding of MIF-dependent physiology and pathology. ..
  19. Bae M, Ahn M, Jeong J, Bae M, Lee Y, Bae S, et al. Jab1 interacts directly with HIF-1alpha and regulates its stability. J Biol Chem. 2002;277:9-12 pubmed
    ..Here, using the yeast two-hybrid screening system, we found that HIF-1alpha interacts with Jab1 (Jun activation domain-binding protein-1), which is a coactivator of AP-1 transcription factor and fifth subunit of ..
  20. Wang R, Wang H, Carrera I, Xu S, Lakshmana M. COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brain. J Biol Chem. 2015;290:9299-309 pubmed publisher
    ..We demonstrated previously that COPS5 regulates Aβ generation in neuronal cell lines in a RanBP9-dependent manner...
  21. Bounpheng M, Melnikova I, Dodds S, Chen H, Copeland N, Gilbert D, et al. Characterization of the mouse JAB1 cDNA and protein. Gene. 2000;242:41-50 pubmed
    b>JAB1 was originally described as a transcriptional coactivator of c-Jun and Jun D. Recent data suggests that JAB1 is a component of a large protein complex, the JAB1 signalosome in mammals and the COP9 complex in plants...
  22. Porrello E, Rivellini C, Dina G, Triolo D, Del Carro U, Ungaro D, et al. Jab1 regulates Schwann cell proliferation and axonal sorting through p27. J Exp Med. 2014;211:29-43 pubmed publisher
    ..We now report that the nuclear Jun activation domain-binding protein 1 (Jab1) may transduce laminin211 signals to regulate Schwann cell number and differentiation during axonal sorting...
  23. Panattoni M, Maiorino L, Lukács A, Zentilin L, Mazza D, Sanvito F, et al. The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver. Hepatology. 2014;59:2331-43 pubmed publisher
    ..Herein we ablated COPS5, the CSNs catalytic subunit, in the liver, to investigate its role in cell cycle reentry by differentiated ..
  24. Chen D, Bashur L, Liang B, Panattoni M, Tamai K, Pardi R, et al. The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo. J Cell Sci. 2013;126:234-43 pubmed publisher
    The evolutionarily conserved transcriptional cofactor Jab1 plays critical roles in cell differentiation, proliferation, and apoptosis by modulating the activity of diverse factors and regulating the output of various signaling pathways...
  25. Kim E, Yoon S, Kim E, Kim Y, Lee H, Kim K, et al. Function of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradation. PLoS ONE. 2011;6:e25870 pubmed publisher
    ..we found the expression of the COP9 constitutive photomorphogenic homolog subunit 3 (CSN3) and subunit 5 (CSN5) changes as oocytes mature for the first time, and there is no report regarding roles of COP9 in the mammalian ..
  26. Sitte S, Gläsner J, Jellusova J, Weisel F, Panattoni M, Pardi R, et al. JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression. J Immunol. 2012;188:2677-86 pubmed publisher
    Jun activation domain-binding protein 1 (JAB1) regulates ubiquitin-dependent protein degradation by deneddylation of cullin-based ubiquitin ligases and, therefore, plays a central role in regulating proliferation and apoptosis...
  27. Tsujimoto I, Yoshida A, Yoneda Kato N, Kato J. Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells. FEBS Lett. 2012;586:4326-31 pubmed publisher
    ..Here we show that disruption of the fifth component (CSN5) prevented the formation of tumors by p53-null cells transformed with an active form of Ras in subcutaneously ..
  28. Deng Z, Pardi R, Cheadle W, Xiang X, Zhang S, Shah S, et al. Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages. Blood. 2011;117:4796-804 pubmed publisher
    ..Here, we show that the COP9 signalosome subunit 5 (CSN5) is required for activation of proinflammatory kinases p38 and Erk and for down-regulation of the expression of ..
  29. Bemis L, Chan D, Finkielstein C, Qi L, Sutphin P, Chen X, et al. Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev. 2004;18:739-44 pubmed
    Mammalian oxygen homeostasis is dependent on the HIF family of transcription factors. The CSN subunit, CSN5, binds both the CODD of HIF-1 alpha and the pVHL tumor suppressor...
  30. Tian L, Peng G, Parant J, Leventaki V, Drakos E, Zhang Q, et al. Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene. 2010;29:6125-37 pubmed publisher
    Jun activation domain-binding protein 1 (JAB1) is a multifunctional protein that participates in the control of cell proliferation and the stability of multiple proteins...
  31. Omede A, Zi M, Prehar S, Maqsood A, Stafford N, Mamas M, et al. The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochem Biophys Res Commun. 2016;479:708-714 pubmed publisher
    ..First, we found that OXGR1 forms a molecular complex with the COP9 signalosome complex subunit 5 (CSN5)...
  32. Asare Y, Ommer M, Azombo F, Alampour Rajabi S, Sternkopf M, Sanati M, et al. Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A. 2017;114:E2766-E2775 pubmed publisher
    Constitutive photomorphogenesis 9 (COP9) signalosome 5 (CSN5), an isopeptidase that removes neural precursor cell-expressed, developmentally down-regulated 8 (NEDD8) moieties from cullins (thus termed "deNEDDylase") and a subunit of the ..