Commd1

Summary

Gene Symbol: Commd1
Description: COMM domain containing 1
Alias: AI256843, Murr1, U2/Mu, COMM domain-containing protein 1, U2af1-rs1 region 1, copper metabolism domain containing 1, protein Murr1
Species: mouse
Products:     Commd1

Top Publications

  1. van De Sluis B, Rothuizen J, Pearson P, van Oost B, Wijmenga C. Identification of a new copper metabolism gene by positional cloning in a purebred dog population. Hum Mol Genet. 2002;11:165-73 pubmed
    ..While screening genes and expressed sequence tags in this region for mutations we found that exon 2 of the MURR1 gene is deleted in both alleles of all affected Bedlington terriers and in single alleles in obligate carriers...
  2. Nabetani A, Hatada I, Morisaki H, Oshimura M, Mukai T. Mouse U2af1-rs1 is a neomorphic imprinted gene. Mol Cell Biol. 1997;17:789-98 pubmed
    ..An analysis of genome structure of this gene revealed that the whole gene is located in an intron of the Murr1 gene...
  3. Miyayama T, Hiraoka D, Kawaji F, Nakamura E, Suzuki N, Ogra Y. Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line. Biochem J. 2010;429:53-61 pubmed publisher
    A novel function of COMMD1 {COMM [copper metabolism MURR1 (mouse U2af1-rs1 region 1)]-domain-containing 1}, a protein relevant to canine copper toxicosis, was examined in the mouse hepatoma cell line Hepa 1-6 with multi-disciplinary ..
  4. van De Sluis B, Muller P, Duran K, Chen A, Groot A, Klomp L, et al. Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice. Mol Cell Biol. 2007;27:4142-56 pubmed
    b>COMMD1 (previously known as MURR1) belongs to a novel family of proteins termed the copper metabolism gene MURR1 domain (COMMD) family...
  5. Vonk W, Wijmenga C, Berger R, van De Sluis B, Klomp L. Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1. J Biol Chem. 2010;285:28991-9000 pubmed publisher
    ..is a regulated final step in SOD1 maturation and implicate the recently characterized copper homeostasis protein COMMD1 in this process...
  6. Murata K, Fang C, Terao C, Giannopoulou E, Lee Y, Lee M, et al. Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis. Immunity. 2017;47:66-79.e5 pubmed publisher
    Hypoxia augments inflammatory responses and osteoclastogenesis by incompletely understood mechanisms. We identified COMMD1 as a cell-intrinsic negative regulator of osteoclastogenesis that is suppressed by hypoxia...
  7. Vonk W, Bartuzi P, de Bie P, Kloosterhuis N, Wichers C, Berger R, et al. Liver-specific Commd1 knockout mice are susceptible to hepatic copper accumulation. PLoS ONE. 2011;6:e29183 pubmed publisher
    ..We have identified COMMD1 as the gene underlying copper toxicosis in Bedlington terriers...
  8. Geng H, Wittwer T, Dittrich Breiholz O, Kracht M, Schmitz M. Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination. EMBO Rep. 2009;10:381-6 pubmed publisher
    ..Tumour necrosis factor-induced phosphorylation of p65 at Ser468 allows binding of COMMD1 and cullin 2, components of a multimeric ubiquitin ligase complex mediating p65 ubiquitination...
  9. Gregory R, O Neill L, Randall T, Fournier C, Khosla S, Turner B, et al. Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. J Biol Chem. 2002;277:11728-34 pubmed
    ..Furthermore, it seems that the allelic U2af1-rs1 acetylation determines DNase I sensitivity/chromatin conformation. ..

More Information

Publications22

  1. Joh K, Yatsuki H, Higashimoto K, Mukai T, Soejima H. Antisense transcription occurs at the promoter of a mouse imprinted gene, commd1, on the repressed paternal allele. J Biochem. 2009;146:771-4 pubmed publisher
    The Commd1 gene is imprinted in the adult mouse brain and is predominantly expressed from the maternal allele. A paternally expressing imprinted gene, U2af1-rs1, resides in the first intron of Commd1 in an antisense orientation...
  2. Wang Y, Joh K, Masuko S, Yatsuki H, Soejima H, Nabetani A, et al. The mouse Murr1 gene is imprinted in the adult brain, presumably due to transcriptional interference by the antisense-oriented U2af1-rs1 gene. Mol Cell Biol. 2004;24:270-9 pubmed
    The mouse Murr1 gene contains an imprinted gene, U2af1-rs1, in its first intron. U2af1-rs1 shows paternal allele-specific expression and is transcribed in the direction opposite to that of the Murr1 gene...
  3. Wang Y, Joh K, Mukai T. Identification of a novel isoform of Murr1 transcript, U2mu, which is transcribed from the portions of two closely located but oppositely oriented genes. Genes Genet Syst. 2002;77:377-81 pubmed
    ..a novel transcript in mouse that is transcribed from the portions of two independent genes, U2af1-rs1 and Murr1, and we designated it U2mu...
  4. Fuchs S, Resch K, Thiel C, Ulbrich M, Platzer M, Jockusch H, et al. Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genet. 2002;3:14 pubmed
    ..The possibility arises that there might be hitherto unknown effects of mutations, in addition to structural changes of the mRNA or regulatory abnormalities. ..
  5. de Bie P, van De Sluis B, Burstein E, Duran K, Berger R, Duckett C, et al. Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochem J. 2006;398:63-71 pubmed
    ..The small ubiquitously expressed COMMD6 consists primarily of the COMM domain. Therefore COMMD1 and COMMD6 were analysed further as prototype members of the COMMD protein family...
  6. van De Sluis B, Groot A, Wijmenga C, Vooijs M, Klomp L. COMMD1: a novel protein involved in the proteolysis of proteins. Cell Cycle. 2007;6:2091-8 pubmed
    b>COMMD1 is a protein which is associated with multiple cellular pathways, including NFkappaB signaling, copper homeostasis and sodium transport. Recently we found that COMMD1 is also essential for normal mouse embryogenesis...
  7. Zhang Z, Joh K, Yatsuki H, Wang Y, Arai Y, Soejima H, et al. Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice. Gene. 2006;366:77-86 pubmed
    Human MURR1 is an orthologue of mouse Murr1 gene, which was previously reported to be imprinted only in adult brain with a maternal allele-predominant expression and to contain another imprinted gene, U2af1-rs1, in the first intron...
  8. Baecker T, Mangus K, Pfaender S, Chhabra R, Boeckers T, Grabrucker A. Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses. Biometals. 2014;27:715-30 pubmed publisher
    ..Some factors, such as prenatal zinc deficiency, dysfunction of metallothioneins as well as deletion of COMMD1, all affect brain metal-ion homeostasis and have been associated with ASD...
  9. Bartuzi P, Wijshake T, Dekker D, Fedoseienko A, Kloosterhuis N, Youssef S, et al. A cell-type-specific role for murine Commd1 in liver inflammation. Biochim Biophys Acta. 2014;1842:2257-65 pubmed publisher
    ..Copper Metabolism MURR1 Domain-containing 1 (COMMD1), a protein with functions in multiple pathways, has been shown to suppress NF-?B activity...
  10. Roberts E, Lau C, da Silveira T, Yang S. Developmental expression of Commd1 in the liver of the Jackson toxic milk mouse. Biochem Biophys Res Commun. 2007;363:921-5 pubmed
    ..Other copper-binding proteins include COMMD1, which is inactive in the Bedlington terrier hereditary copper toxicosis, and XIAP, which regulates apoptosis...
  11. Materia S, Cater M, Klomp L, Mercer J, La Fontaine S. Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. J Biol Chem. 2012;287:2485-99 pubmed publisher
    ..Clusterin and COMMD1 were previously identified as interacting partners of these Cu-ATPases...
  12. Li H, Chan L, Bartuzi P, Melton S, Weber A, Ben Shlomo S, et al. Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer. Gastroenterology. 2014;147:184-195.e3 pubmed publisher
    ..Copper metabolism MURR1 domain containing 1 (COMMD1), a regulator of various transport pathways, has been shown to limit NF-?B activation...
  13. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
    ..patients with X-linked intellectual disability caused by mutations in CCDC22 are hypercholesterolaemic, and that COMMD1-deficient dogs and liver-specific Commd1 knockout mice have elevated plasma LDL cholesterol levels...