Gene Symbol: Colec11
Description: collectin sub-family member 11
Alias: CL-K1, collectin-11, collectin kidney protein 1
Rooryck C, Diaz Font A, Osborn D, Chabchoub E, Hernandez Hernandez V, Shamseldin H, et al
. Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nat Genet. 2011;43:197-203 pubmed publisher
..Here we studied 11 families with 3MC syndrome and identified two mutated genes, COLEC11 and MASP1, both of which encode proteins in the lectin complement pathway (collectin kidney 1 (CL-K1) and MASP-1 ..
Troegeler A, Lugo Villarino G, Hansen S, Rasolofo V, Henriksen M, Mori K, et al
. Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis. PLoS ONE. 2015;10:e0132692 pubmed publisher
..These findings indicate that CL-LK might be of interest for future diagnostic and treatment monitoring purposes. ..
Hwang I, Mori K, Ohtani K, Matsuda Y, Roy N, Kim Y, et al
. Collectin Kidney 1 Plays an Important Role in Innate Immunity against Streptococcus pneumoniae Infection. J Innate Immun. 2017;9:217-228 pubmed publisher
..pneumoniae infection might cause higher CL-K1-/- mice lethality. Our results suggest that CL-K1 might play an important role in host protection against S. pneumoniae infection through the activation of the lectin complement pathway. ..
Motomura W, Yoshizaki T, Ohtani K, Okumura T, Fukuda M, Fukuzawa J, et al
. Immunolocalization of a novel collectin CL-K1 in murine tissues. J Histochem Cytochem. 2008;56:243-52 pubmed
..It is of interest that this profile of CL-K1 expression is unique among the collectins. Together these histological findings may be useful for understanding the biological function of this novel collectin. ..
Farrar C, Tran D, Li K, Wu W, Peng Q, Schwaeble W, et al
. Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury. J Clin Invest. 2016;126:1911-25 pubmed publisher
..have described how the recently discovered C-type lectin collectin-11 (CL-11, also known as CL-K1 and encoded by COLEC11) recognizes an abnormal pattern of L-fucose on postischemic renal tubule cells and activates a destructive ..