Gene Symbol: Col8a1
Description: collagen, type VIII, alpha 1
Alias: Col8a-1, collagen alpha-1(VIII) chain, procollagen type VIII alpha 1
Species: mouse
Products:     Col8a1

Top Publications

  1. Muragaki Y, Shiota C, Inoue M, Ooshima A, Olsen B, Ninomiya Y. alpha 1(VIII)-collagen gene transcripts encode a short-chain collagen polypeptide and are expressed by various epithelial, endothelial and mesenchymal cells in newborn mouse tissues. Eur J Biochem. 1992;207:895-902 pubmed
  2. Hirano S, Yonezawa T, Hasegawa H, Hattori S, Greenhill N, Davis P, et al. Astrocytes express type VIII collagen during the repair process of brain cold injury. Biochem Biophys Res Commun. 2004;317:437-43 pubmed
    ..These data indicate that type VIII collagen plays an important role in glial scar formation during the repair process by astrocytes. ..
  3. Hopfer U, Fukai N, Hopfer H, Wolf G, Joyce N, Li E, et al. Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye. FASEB J. 2005;19:1232-44 pubmed
    ..the function of collagen VIII in mice by targeted inactivation of the genes encoding the two polypeptide subunits, Col8a1 and Col8a2...
  4. Adiguzel E, Hou G, Mulholland D, Hopfer U, Fukai N, Olsen B, et al. Migration and growth are attenuated in vascular smooth muscle cells with type VIII collagen-null alleles. Arterioscler Thromb Vasc Biol. 2006;26:56-61 pubmed
    ..This study suggests that SMCs can modify the matrix microenvironment by producing type VIII collagen, using it to overlay type I collagen, and generating a substrate favorable for migration. ..
  5. Skrbic B, Engebretsen K, Strand M, Lunde I, Herum K, Marstein H, et al. Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice. Cardiovasc Res. 2015;106:32-42 pubmed publisher
    ..Lack of colVIII reduces myofibroblast differentiation and fibrosis and promotes early mortality and LV dilatation in response to pressure overload in mice. ..
  6. Walker D, Vacha S, Kirby M, Lo C. Connexin43 deficiency causes dysregulation of coronary vasculogenesis. Dev Biol. 2005;284:479-98 pubmed
  7. Iruela Arispe M, Sage E. Expression of type VIII collagen during morphogenesis of the chicken and mouse heart. Dev Biol. 1991;144:107-18 pubmed
    ..The contribution of this collagen to cardiac morphogenesis might reside, in part, in its ability to influence the differentiation of the myocardium and formation of the cardiac valves. ..
  8. Adiguzel E, Hou G, Sabatini P, Bendeck M. Type VIII collagen signals via ?1 integrin and RhoA to regulate MMP-2 expression and smooth muscle cell migration. Matrix Biol. 2013;32:332-41 pubmed publisher
    ..In conclusion, we have shown that type VIII collagen signals through beta-1 integrin receptors to suppress RhoA, allowing optimal configuration of the cytoskeleton, and the stimulation of MMP-2-dependent cell migration. ..
  9. Loeffler I, Liebisch M, Wolf G. Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy. Am J Physiol Renal Physiol. 2012;303:F733-45 pubmed publisher

More Information


  1. Cherepanova O, Pidkovka N, Sarmento O, Yoshida T, Gan Q, Adiguzel E, et al. Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration. Circ Res. 2009;104:609-18 pubmed publisher
    ..POVPC increased expression of type VIII collagen alpha1 chain (Col8a1) mRNA in cultured VSMCs and in vivo in rat carotid arteries by 9-fold and 4-fold, respectively...
  2. Zhao Y, Jia L, Mao X, Xu H, Wang B, Liu Y. siRNA-targeted COL8A1 inhibits proliferation, reduces invasion and enhances sensitivity to D-limonence treatment in hepatocarcinoma cells. IUBMB Life. 2009;61:74-9 pubmed publisher
    The COL8A1 (collagen type VIII, alpha-1) gene, which encodes the alpha 1 chain of collagen, type VIII, may modulate migration, proliferation and adherence of various cells...
  3. Hopfer U, Hopfer H, Meyer Schwesinger C, Loeffler I, Fukai N, Olsen B, et al. Lack of type VIII collagen in mice ameliorates diabetic nephropathy. Diabetes. 2009;58:1672-81 pubmed publisher
    ..Finally, Col8a1 was stably overexpressed in mesangial cells...
  4. Loeffler I, Hopfer U, Koczan D, Wolf G. Type VIII collagen modulates TGF-?1-induced proliferation of mesangial cells. J Am Soc Nephrol. 2011;22:649-63 pubmed publisher
    ..VIII collagen, a nonfibrillar protein that exists as a heterodimer composed of ?1(VIII) and ?2(VIII), encoded by Col8a1 and Col8a2, respectively...
  5. Schwab K, Patterson L, Hartman H, Song N, Lang R, Lin X, et al. Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol. 2007;5:15 pubmed
    ..In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity. ..
  6. Kvansakul M, Bogin O, Hohenester E, Yayon A. Crystal structure of the collagen alpha1(VIII) NC1 trimer. Matrix Biol. 2003;22:145-52 pubmed
  7. Lopes J, Adiguzel E, Gu S, Liu S, Hou G, Heximer S, et al. Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis. Am J Pathol. 2013;182:2241-53 pubmed publisher
    ..We discovered that apolipoprotein E (ApoE) is an endogenous repressor of the Col8a1 chain, and, therefore, in ApoE knockout mice, type VIII collagen was up-regulated...
  8. Muragaki Y, Jacenko O, Apte S, Mattei M, Ninomiya Y, Olsen B. The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1. J Biol Chem. 1991;266:7721-7 pubmed
    ..By in situ hybridization we demonstrate that the alpha 2(VIII) gene is located in the p32.3-p34.3 region of the short arm of chromosome 1. ..