Col12a1

Summary

Gene Symbol: Col12a1
Description: collagen, type XII, alpha 1
Alias: AW743884, collagen alpha-1(XII) chain, procollagen, type XII, alpha 1
Species: mouse

Top Publications

  1. ncbi Collagen XII mutation disrupts matrix structure of periodontal ligament and skin
    E Reichenberger
    Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    J Dent Res 79:1962-8. 2000
  2. ncbi The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6
    S P Oh
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    Genomics 14:225-31. 1992
  3. ncbi Primary structure of the long and short splice variants of mouse collagen XII and their tissue-specific expression during embryonic development
    K Böhme
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Dyn 204:432-45. 1995
  4. ncbi Mechanical strain increases expression of type XII collagen in murine osteoblastic MC3T3-E1 cells
    Katsuhiko Arai
    Department of Tissue Physiology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Cell Struct Funct 33:203-10. 2008
  5. ncbi Recruitment and maintenance of tendon progenitors by TGFbeta signaling are essential for tendon formation
    Brian A Pryce
    Shriners Hospital for Children, Research Division, Portland, OR 97239, USA
    Development 136:1351-61. 2009
  6. ncbi Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance
    Jacqueline D Peacock
    Department of Molecular and Cellular Pharmacology, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Dev Dyn 237:3051-8. 2008
  7. ncbi The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature
    Il Man Kim
    Department of Medicine and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 280:22278-86. 2005
  8. ncbi Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development
    Ava E Brent
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 132:515-28. 2005
  9. ncbi New semidominant mutations that affect mouse development
    Debora Bogani
    Laboratory of Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX111 0RD, UK
    Genesis 40:109-117. 2004
  10. ncbi Structural variation of type XII collagen at its carboxyl-terminal NC1 domain generated by tissue-specific alternative splicing
    A M Kania
    Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts, 02115, USA
    J Biol Chem 274:22053-9. 1999

Scientific Experts

  • Katsuhiko Arai
  • D R Gerecke
  • Yayoi Izu
  • Manuel Koch
  • Brian A Pryce
  • Jacqueline D Peacock
  • Il Man Kim
  • Ava E Brent
  • B R Olsen
  • E Reichenberger
  • Debora Bogani
  • Daniela Zwolanek
  • Karl J Jepsen
  • Byeong Cha
  • David E Birk
  • Valerie Williams
  • Mei Sun
  • Guido Veit
  • Spencer S Watson
  • Julia A Staverosky
  • N Y Karimbux
  • Nicholas D Murchison
  • I Nishimura
  • Nicole Dünker
  • Ronen Schweitzer
  • Joy Lincoln
  • Karl E Kadler
  • A M Kania
  • Yinhui Lu
  • R L MacNeil
  • Sneha Ramakrishna
  • Clifford J Tabin
  • Helena M Yoder
  • Robert H Costa
  • Il-Man Kim
  • Vladimir V Kalinichenko
  • Thomas Braun
  • Galina A Gusarova
  • Ruth Arkell
  • Zuzanna Tymowska-Lalanne
  • Jennifer Davies
  • Paul Elms
  • Jonathan Flint
  • Pat Nolan
  • David A Keays
  • Michelle Goldsworthy
  • Roger D Cox
  • Valerie Wilson
  • Nick Warr
  • G Rao
  • R W Taylor
  • S Baur
  • K Böhme
  • C Sukotjo
  • S P Oh
  • S T Baur
  • Y Shigeyama
  • M J Somerman
  • J E Berry
  • C L Strayhorn
  • M F Seldin
  • J M Rochelle
  • R A DePinho
  • K Chen
  • P Guida
  • N Schreiber-Agus
  • L Alland
  • L Chin
  • A I Skoultchi
  • P S Oh
  • Y Li
  • E D Hay
  • C M Griffith

Detail Information

Publications15

  1. ncbi Collagen XII mutation disrupts matrix structure of periodontal ligament and skin
    E Reichenberger
    Department of Cell Biology, Harvard Medical School, Boston, MA, USA
    J Dent Res 79:1962-8. 2000
    ..The skin of transgenic mice revealed the lack of matrix fiber structure in the papillary dermis. These results indicated that the dominant interference mutation of collagen XII disorganized the ECM architecture of PDL and skin...
  2. ncbi The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6
    S P Oh
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    Genomics 14:225-31. 1992
    ..In the mouse, Col12a1 is located on chromosome 9, as determined by linkage analysis using DNA from interspecific backcrosses with Mus ..
  3. ncbi Primary structure of the long and short splice variants of mouse collagen XII and their tissue-specific expression during embryonic development
    K Böhme
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Dyn 204:432-45. 1995
    ..An exception is dermis, which is positive for the long form up to embryonic day 15, but negative at day 18, when only the short form RNA can be detected...
  4. ncbi Mechanical strain increases expression of type XII collagen in murine osteoblastic MC3T3-E1 cells
    Katsuhiko Arai
    Department of Tissue Physiology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Cell Struct Funct 33:203-10. 2008
    ..These data will provide new information on the mechanical strain-mediated transcriptional control of alpha 1(XII)-mediated fibrillogenesis in the bone...
  5. ncbi Recruitment and maintenance of tendon progenitors by TGFbeta signaling are essential for tendon formation
    Brian A Pryce
    Shriners Hospital for Children, Research Division, Portland, OR 97239, USA
    Development 136:1351-61. 2009
    ....
  6. ncbi Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance
    Jacqueline D Peacock
    Department of Molecular and Cellular Pharmacology, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Dev Dyn 237:3051-8. 2008
    ..Expression of col1a1, col1a2, col2a1, and col3a1 remain high, along with col12a1 in remodeling valves...
  7. ncbi The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature
    Il Man Kim
    Department of Medicine and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 280:22278-86. 2005
    ..In summary, development of mouse lungs depends on the Foxm1 transcription factor, which regulates expression of genes essential for mesenchyme proliferation, extracellular matrix remodeling, and vasculogenesis...
  8. ncbi Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development
    Ava E Brent
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 132:515-28. 2005
    ....
  9. ncbi New semidominant mutations that affect mouse development
    Debora Bogani
    Laboratory of Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX111 0RD, UK
    Genesis 40:109-117. 2004
    ..In one coat spotting mutant the homozygous condition is lethal before neural crest cell production commences. The mutated genes often function in processes additional to those alluded to by the heterozygous phenotype...
  10. ncbi Structural variation of type XII collagen at its carboxyl-terminal NC1 domain generated by tissue-specific alternative splicing
    A M Kania
    Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts, 02115, USA
    J Biol Chem 274:22053-9. 1999
    ..4) followed by a terminal basic region (pI = 13.8). Because the short NC1 domain lacks these features, structural variations in the type XII collagen NC1 domain suggests different functional roles in a tissue-specific fashion...
  11. ncbi Expression of type I and XII collagen during development of the periodontal ligament in the mouse
    R L MacNeil
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    Arch Oral Biol 43:779-87. 1998
    ..These findings suggest that type XII expression is timed with the alignment and organization of PDL fibres and is limited in tooth development to cells within the periodontal ligament...
  12. ncbi Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13
    D R Gerecke
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown 02129 2017, USA
    Genomics 41:236-42. 1997
    ..An isolated genomic clone was used to map the locus of the COL12A1 gene to chromosome 6q12-q13, very close to the locus of the FACIT collagen genes COL9A1 and COL19A1...
  13. ncbi Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1
    G Rao
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Oncogene 12:1165-72. 1996
    ....
  14. ncbi Tissue-specific expression of type XII collagen during mouse embryonic development
    S P Oh
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    Dev Dyn 196:37-46. 1993
    ....
  15. ncbi Type XII collagen regulates osteoblast polarity and communication during bone formation
    Yayoi Izu
    Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Cell Biol 193:1115-30. 2011
    ..The data demonstrate important regulatory roles for type XII collagen in osteoblast differentiation and bone matrix formation...