coagulation factor X


Gene Symbol: coagulation factor X
Description: coagulation factor X
Alias: Cf10, coagulation factor X, stuart factor
Species: mouse
Products:     coagulation factor X

Top Publications

  1. Johansson L, Karpf D, Hansen L, Pelzer H, Persson E. Activation peptides prolong the murine plasma half-life of human factor VII. Blood. 2011;117:3445-52 pubmed publisher
    ..Our data support that activation peptides function as plasma retention signals and constitute a new manner to extend the half-life of FVII(a). ..
  2. Dewerchin M, Liang Z, Moons L, Carmeliet P, Castellino F, Collen D, et al. Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. Thromb Haemost. 2000;83:185-90 pubmed
    Mice with a total deficiency in blood coagulation Factor X (FX) were generated by targeted replacement of an 18-kb fragment of the FX gene, comprising all exons encoding the mature FX protein, with a neo(r) cassette...
  3. Waddington S, McVey J, Bhella D, Parker A, Barker K, Atoda H, et al. Adenovirus serotype 5 hexon mediates liver gene transfer. Cell. 2008;132:397-409 pubmed publisher
    ..Liver infection by the FX-Ad5 complex is mediated through a heparin-binding exosite in the FX serine protease domain. This study reveals an unanticipated function for hexon in mediating liver gene transfer in vivo...
  4. Funnell A, Wilson M, Ballester B, Mak K, Burdach J, Magan N, et al. A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden. Am J Hum Genet. 2013;92:460-7 pubmed publisher
    ..Taken together, our findings establish ONECUT transcription factors as the missing hemophilia B Leyden regulators that operate through the -5/-6 site. ..
  5. Zaiss A, Lawrence R, Elashoff D, Esko J, Herschman H. Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate. J Biol Chem. 2011;286:24535-43 pubmed publisher
    Serum coagulation factor X (FX) is proposed to play a major role in adenovirus tropism, promoting transduction by bridging the virus to cell-surface heparan sulfate proteoglycans (HSPGs)...
  6. Malz R, Weithäuser A, Tschope C, Schultheiss H, Rauch U. Inhibition of coagulation factor Xa improves myocardial function during CVB3-induced myocarditis. Cardiovasc Ther. 2014;32:113-9 pubmed publisher
    ..In conclusion, selective inhibition of FXa improves the left ventricular function during CVB3-induced myocarditis and seems to be associated with an improved myocardial remodeling. ..
  7. Rosen E. Gene targeting in hemostasis. Factor X. Front Biosci. 2002;7:d1915-25 pubmed
    Blood coagulation Factor X (FX) is a vitamin K-dependent serine protease that plays a central role in blood clotting...
  8. Liang Z, Cooper A, Deford M, Carmeliet P, Collen D, Castellino F, et al. Cloning and characterization of a cDNA encoding murine coagulation factor X. Thromb Haemost. 1998;80:87-91 pubmed
    The cDNA encoding murine coagulation factor X (fX) was isolated and reconstructed from a lambdaZap cDNA library generated from murine liver mRNA. The cDNA contains 1486 bases starting at the 5'-translation initiation codon...
  9. Oe Y, Hayashi S, Fushima T, Sato E, Kisu K, Sato H, et al. Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy. Arterioscler Thromb Vasc Biol. 2016;36:1525-33 pubmed publisher
    ..infiltration of macrophages expressing tissue factor in diabetic kidney glomeruli; tissue factor activates coagulation factor X (FX) to FXa, which in turn stimulates protease-activated receptor 2 (PAR2) and causes inflammation...

More Information


  1. Tai S, Herzog R, Margaritis P, Arruda V, Chu K, Golden J, et al. A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X. J Thromb Haemost. 2008;6:339-45 pubmed
    ..This viable low-FX mouse model will facilitate the development of FX-directed therapies as well as investigation of the FX role in embryonic development. ..
  2. Borensztajn K, Aberson H, Peppelenbosch M, Spek C. FXa-induced intracellular signaling links coagulation to neoangiogenesis: potential implications for fibrosis. Biochim Biophys Acta. 2009;1793:798-805 pubmed publisher
    ..Overall, our results establish a link between the coagulation cascade and angiogenesis during fibrosis. ..
  3. Sumi A, Yamanaka Hanada N, Bai F, Makino T, Mizukami H, Ono T. Roles of coagulation pathway and factor Xa in the progression of diabetic nephropathy in db/db mice. Biol Pharm Bull. 2011;34:824-30 pubmed
    The active type of coagulation factor X (factor Xa) activates various cell-types through protease-activated receptor 2 (PAR2). We previously reported that a factor Xa inhibitor could suppress Thy-1 nephritis...
  4. Gleeson E, O Donnell J, Hams E, Ni Ainle F, Kenny B, Fallon P, et al. Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells. Haematologica. 2014;99:185-93 pubmed publisher
  5. Shimosawa M, Sakamoto K, Tomari Y, Kamikado K, Otsuka H, Liu N, et al. Lipopolysaccharide-triggered acute aggravation of mesangioproliferative glomerulonephritis through activation of coagulation in a high IgA strain of ddY mice. Nephron Exp Nephrol. 2009;112:e81-91 pubmed publisher
    ..The present data suggest that tissue factor and factor V induction by LPS may in part accelerate mesangioproliferative glomerulonephritis through activation of factor X and downstream proinflammatory and procoagulant mechanisms. ..
  6. Heidtmann H, Kontermann R. Cloning and recombinant expression of mouse coagulation factor X. Thromb Res. 1998;92:33-41 pubmed
    Engineering of recombinant coagulation factor X variants, which can be activated by tumor-associated proteinases may lead to the development of new therapeutic molecules...
  7. Liang Z, Cooper A, Rosen E, Castellino F. Chromosomal arrangement of the murine coagulation factor VII and factor X genes. Thromb Haemost. 1998;80:524-5 pubmed
  8. Sen P, Nayak R, Clark C, Gopalakrishnan R, Esmon C, Pendurthi U, et al. Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C. Blood. 2011;118:2635-6 pubmed publisher
  9. Lee W, Ku S, Bae J. Factor Xa inhibits HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice. Thromb Haemost. 2014;112:757-69 pubmed publisher
    ..Collectively, these results suggest that FXa may be regarded as a candidate therapeutic agent for treating vascular inflammatory diseases by inhibiting the HMGB1 signalling pathway. ..
  10. Muczynski V, Aymé G, Regnault V, Vasse M, Borgel D, Legendre P, et al. Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions. Blood. 2017;129:2443-2454 pubmed publisher
    Recently, we have identified scavenger receptor class A member I (SR-AI) as a receptor for coagulation factor X (FX), mediating the formation of an FX reservoir at the macrophage surface...
  11. Schuliga M, Jaffar J, Berhan A, Langenbach S, Harris T, Waters D, et al. Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity. Am J Physiol Lung Cell Mol Physiol. 2017;312:L772-L782 pubmed publisher
    ..Our data suggest that annexin A2 contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa. Extracellular annexin A2 is a potential target for the treatment of IPF. ..
  12. Kurdi M, Cherel G, Lenting P, Denis C, Christophe O. Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance. PLoS ONE. 2012;7:e45111 pubmed publisher
    ..Altogether our data lead to the conclusion that FX interaction with macrophages through its N-glycans protects it from a rapid clearance explaining its relatively long circulatory half-life. ..
  13. Scotton C, Krupiczojc M, Konigshoff M, Mercer P, Lee Y, Kaminski N, et al. Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest. 2009;119:2550-63 pubmed publisher
    ..Here we report that expression of coagulation factor X (FX) is locally increased in human and murine fibrotic lung tissue, with marked immunostaining associated ..
  14. Aasrum M, Prydz H. Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development. Biochemistry (Mosc). 2002;67:25-32 pubmed
    ..Both TF/FVIIa and FXa can trigger intracellular signaling events in certain cell types. Signaling by coagulation proteases and protease-activated receptors (PARs) may have important roles in embryonic development. ..
  15. Cooper A, Liang Z, Castellino F, Rosen E. Cloning and characterization of the murine coagulation factor X gene. Thromb Haemost. 2000;83:732-5 pubmed
    The gene encoding murine coagulation factor X (fX) was isolated and characterized from a lamdaFIX II library generated from murine genomic DNA...
  16. Shinagawa K, Martin J, Ploplis V, Castellino F. Coagulation factor Xa modulates airway remodeling in a murine model of asthma. Am J Respir Crit Care Med. 2007;175:136-43 pubmed
  17. Muczynski V, Bazaa A, Loubière C, Harel A, Cherel G, Denis C, et al. Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X. Blood. 2016;127:778-86 pubmed publisher
    Beside its classical role in the coagulation cascade, coagulation factor X (FX) is involved in several major biological processes including inflammation and enhancement of virus-induced immune responses...
  18. Koizumi T, Hendel E, Lalley P, Tchetgen M, Nadeau J. Homologs of genes and anonymous loci on human chromosome 13 map to mouse chromosomes 8 and 14. Mamm Genome. 1995;6:263-8 pubmed
    ..To genetically map these mouse homologs (Cf10, Col4a1, Col4a2, D14H13S26, D8H13S35, and Pcca-rs), we used interspecific and intersubspecific mapping panels...