Gene Symbol: Clstn1
Description: calsyntenin 1
Alias: 1810034E21Rik, Cst-1, Cstn1, calsyntenin-1, alc-alpha, alcadein alpha
Species: mouse
Products:     Clstn1

Top Publications

  1. Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, et al. Calsyntenin-1 docks vesicular cargo to kinesin-1. Mol Biol Cell. 2006;17:3651-63 pubmed
    ..In summary, our results indicate that calsyntenin-1 links a certain type of vesicular and tubulovesicular organelles to the Kinesin-1 motor. ..
  2. Vogt L, Schrimpf S, Meskenaite V, Frischknecht R, Kinter J, Leone D, et al. Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Mol Cell Neurosci. 2001;17:151-66 pubmed
    ..Thus, calsyntenin-1 may link extracellular proteolysis in the synaptic cleft and postsynaptic Ca2+ signaling. ..
  3. Araki Y, Kawano T, Taru H, Saito Y, Wada S, Miyamoto K, et al. The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J. 2007;26:1475-86 pubmed
    ..Inappropriate interactions of Alc- and APP-containing vesicles with kinesin-1 may promote aberrant APP metabolism in Alzheimer's disease. ..
  4. Hintsch G, Zurlinden A, Meskenaite V, Steuble M, Fink Widmer K, Kinter J, et al. The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns. Mol Cell Neurosci. 2002;21:393-409 pubmed
    ..Based on their distinct expression patterns and the differences in their cytoplasmic segments, we suggest a cell-type-specific functional role for the three calsyntenins in excitatory synaptic transmission. ..
  5. Khan Q, Press C, Sehic A, Landin M, Risnes S, Osmundsen H. Expression of prion gene and presence of prion protein during development of mouse molar tooth germ. Eur J Oral Sci. 2010;118:559-65 pubmed publisher
    ..g. enamel matrix proteins (Amelx, Ambn, Enam), Aplp1, Clstn1, and Clu]...
  6. Ster J, Steuble M, Orlando C, Diep T, Akhmedov A, Raineteau O, et al. Calsyntenin-1 regulates targeting of dendritic NMDA receptors and dendritic spine maturation in CA1 hippocampal pyramidal cells during postnatal development. J Neurosci. 2014;34:8716-27 pubmed publisher
    ..Thus, these results highlight a key role for calsyntenin-1 in the transport of NMDA receptors to synaptic targets, which is necessary for the maturation of neuronal circuits during early development...
  7. Steuble M, Gerrits B, Ludwig A, Mateos J, Diep T, Tagaya M, et al. Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles. Proteomics. 2010;10:3775-88 pubmed publisher
  8. Vagnoni A, Rodriguez L, Manser C, De Vos K, Miller C. Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1. J Cell Sci. 2011;124:1032-42 pubmed publisher
    ..Thus, phosphorylation of KLC1ser460 represents a mechanism for selectively regulating the binding and trafficking of calsyntenin-1. ..
  9. Maruta C, Saito Y, Hata S, Gotoh N, Suzuki T, Yamamoto T. Constitutive cleavage of the single-pass transmembrane protein alcadein? prevents aberrant peripheral retention of Kinesin-1. PLoS ONE. 2012;7:e43058 pubmed publisher
    ..This role might exemplify the functional relevance of the constitutive cleavage of single-pass transmembrane proteins. ..

More Information


  1. Takei N, Sobu Y, Kimura A, Urano S, Piao Y, Araki Y, et al. Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage. J Biol Chem. 2015;290:987-95 pubmed publisher
    ..These results indicate that regulated intramembrane proteolysis of Alcα by γ-secretase regulates APP trafficking and the production of Aβ in vivo. ..