Genomes and Genes
Gene Symbol: Cldn1
Description: claudin 1
Alias: AI596271, claudin-1
- Fujibe M, Chiba H, Kojima T, Soma T, Wada T, Yamashita T, et al. Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions. Exp Cell Res. 2004;295:36-47 pubmed..These findings indicate that Thr203 of claudin-1 is required to enhance the barrier function of claudin-1-based tight junctions, probably via its phosphorylation and subsequent integration into tight junctions. ..
- Lopardo T, Lo Iacono N, Marinari B, Giustizieri M, Cyr D, Merlo G, et al. Claudin-1 is a p63 target gene with a crucial role in epithelial development. PLoS ONE. 2008;3:e2715 pubmed publisher..These findings reinforce the hypothesis that these two genes might be linked in a common regulatory pathway and that Claudin-1 may is an important p63 target gene involved in the pathogenesis of ectodermal dysplasias. ..
- Kirschner N, Rosenthal R, Furuse M, Moll I, Fromm M, Brandner J. Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes. J Invest Dermatol. 2013;133:1161-9 pubmed publisher..The absence of the TJ protein claudin-1 (Cldn1) in mice results in a skin-barrier defect characterized by lethal water loss...
- Turksen K, Troy T. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development. 2002;129:1775-84 pubmed..In addition, the epidermal phenotype of these transgenic mice, which is very reminiscent of that in pre-term infant skin, suggest that they will be an important and novel model for studies on human premature EPB-related morbidity. ..
- Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, et al. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol. 2002;156:1099-111 pubmed..These findings provide the first evidence that continuous claudin-based TJs occur in the epidermis and that these TJs are crucial for the barrier function of the mammalian skin. ..
- Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol. 1999;147:891-903 pubmed..We concluded that distinct species of claudins can interact within and between TJ strands, except in some combinations. This mode of assembly of claudins could increase the diversity of the structure and functions of TJ strands. ..
- Zimmerli S, Hauser C. Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1. J Invest Dermatol. 2007;127:2381-90 pubmed..Claudin-1 may thus have an important function in adhesion and/or migration of LC. ..
- Sasaki H, Matsui C, Furuse K, Mimori Kiyosue Y, Furuse M, Tsukita S. Dynamic behavior of paired claudin strands within apposing plasma membranes. Proc Natl Acad Sci U S A. 2003;100:3971-6 pubmed
- Morita K, Furuse M, Fujimoto K, Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A. 1999;96:511-6 pubmed..These findings indicated that multiple claudin family members are involved in the formation of TJ strands in various tissues. ..
- Troy T, Arabzadeh A, Yerlikaya S, Turksen K. Claudin immunolocalization in neonatal mouse epithelial tissues. Cell Tissue Res. 2007;330:381-8 pubmed..g., Cldn1, Cldn6, Cldn11, and Cldn18, and the presence of Cldn3 and Cldn5 in various neonatal mouse epithelia including the ..
- Van den Bossche J, Laoui D, Morias Y, Movahedi K, Raes G, De Baetselier P, et al. Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumour-elicited macrophages in vivo. Scand J Immunol. 2012;75:588-98 pubmed publisher..We observed an induction of claudin-1 (Cldn1), Cldn2 and Cldn11 genes by IL-4 in different mouse macrophage populations...
- Ohazama A, Sharpe P. Expression of claudins in murine tooth development. Dev Dyn. 2007;236:290-4 pubmed
- Hasegawa K, Wakino S, Simic P, Sakamaki Y, Minakuchi H, Fujimura K, et al. Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med. 2013;19:1496-504 pubmed publisher..These results suggest that Sirt1 in PTs protects against albuminuria in diabetes by maintaining NMN concentrations around glomeruli, thus influencing podocyte function. ..
- Sun X, Park C, Deng W, Potter S, Dey S. Uterine inactivation of muscle segment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation. FASEB J. 2016;30:1425-35 pubmed publisher..Sun, X., Park, C. B., Deng, W., Potter, S. S., Dey, S. K. Uterine inactivation of muscle segment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation. ..
- Indra A, Dupé V, Bornert J, Messaddeq N, Yaniv M, Mark M, et al. Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation. Development. 2005;132:4533-44 pubmed..Finally, we demonstrate that cell-specific targeted somatic mutations can be created at various times during the development of mouse embryos cell-specifically expressing the tamoxifen-activatable Cre-ER(T2) recombinase. ..
- Kramer F, White K, Kubbies M, Swisshelm K, Weber B. Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. Hum Genet. 2000;107:249-56 pubmed..Recently, a claudin-1 (CLDN1) cDNA has been isolated from human mammary epithelial cells (HMECs)...
- Liu B, Liu Y, Du Y, Mardaryev A, Yang W, Chen H, et al. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013;140:780-8 pubmed publisher..Together, these data establish Cbx4 as a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development...
- Kuramitsu K, Ikeda W, Inoue N, Tamaru Y, Takai Y. Novel role of nectin: implication in the co-localization of JAM-A and claudin-1 at the same cell-cell adhesion membrane domain. Genes Cells. 2008;13:797-805 pubmed publisher..Nectin-3 required afadin, a nectin- and F-actin-binding protein, for this ability. In conclusion, nectin plays a novel role in the co-localization of JAM and claudin at the same CAMD. ..
- Nico B, Frigeri A, Nicchia G, Corsi P, Ribatti D, Quondamatteo F, et al. Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Glia. 2003;42:235-51 pubmed..The BBB alterations suggest that changes in vascular permeability are involved in the pathogenesis of the neurological dysfunction associated with DMD. ..
- Kostka G, Giltay R, Bloch W, Addicks K, Timpl R, Fassler R, et al. Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice. Mol Cell Biol. 2001;21:7025-34 pubmed..The data indicate a strong but restricted abnormality in some endothelial compartments which, together with some kidney and lung defects, may be responsible for early death. ..
- Citi S, Cordenonsi M. Tight junction proteins. Biochim Biophys Acta. 1998;1448:1-11 pubmed
- Timmons B, Mitchell S, Gilpin C, Mahendroo M. Dynamic changes in the cervical epithelial tight junction complex and differentiation occur during cervical ripening and parturition. Endocrinology. 2007;148:1278-87 pubmed..b>Claudin 1 mRNA expression is increased, whereas claudin 2 expression declines...
- Bondow B, Faber M, Wojta K, Walker E, Battle M. E-cadherin is required for intestinal morphogenesis in the mouse. Dev Biol. 2012;371:1-12 pubmed publisher..In summary, our data demonstrate that E-cadherin is essential for intestinal epithelial morphogenesis and homeostasis during embryonic development. ..
- Sumigray K, Zhou K, Lechler T. Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. PLoS ONE. 2014;9:e101824 pubmed publisher..These data demonstrate that desmosome disruption results in extensive transcriptional and posttranslational changes that alter the activity of other cell adhesion structures...
- Niimi T, Nagashima K, Ward J, Minoo P, Zimonjic D, Popescu N, et al. claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Mol Cell Biol. 2001;21:7380-90 pubmed..These unique features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in lung and stomach. ..
- Patel R, Myers L, Kurundkar A, Maheshwari A, Nusrat A, Lin P. Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Am J Pathol. 2012;180:626-35 pubmed publisher..Probiotics may prevent intestinal inflammatory diseases by regulating intestinal tight junction protein expression and barrier function. The use of heat-killed probiotics may provide therapeutic benefit while minimizing adverse effects. ..
- Szabo R, Peters D, Kosa P, Camerer E, Bugge T. Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet. 2014;10:e1004470 pubmed publisher..Our results reveal unexpected complementary roles of matriptase-prostasin- and PAR-2-dependent proteolytic signaling in the establishment of placental epithelial barrier function and overall embryonic survival. ..
- Zhou Q, Costinean S, Croce C, Brasier A, Merwat S, Larson S, et al. MicroRNA 29 targets nuclear factor-ÎºB-repressing factor and Claudin 1 to increase intestinal permeability. Gastroenterology. 2015;148:158-169.e8 pubmed publisher..but not IBS with constipation or controls) had increased levels of MIR29A and B, but reduced levels of Claudin-1 (CLDN1) and nuclear factor-ÎºB-repressing factor (NKRF)...
- Wardill H, Bowen J, Van Sebille Y, Secombe K, Coller J, Ball I, et al. TLR4-Dependent Claudin-1 Internalization and Secretagogue-Mediated Chloride Secretion Regulate Irinotecan-Induced Diarrhea. Mol Cancer Ther. 2016;15:2767-2779 pubmed..72 Â± 18.80 Î¼A/cm2; P = 0.023). Results suggest that TLR4-dependent claudin-1 internalization and secondary anion secretion contribute to irinotecan-induced diarrhea. Mol Cancer Ther; 15(11); 2767-79. Â©2016 AACR. ..
- Traweger A, Fang D, Liu Y, Stelzhammer W, Krizbai I, Fresser F, et al. The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch. J Biol Chem. 2002;277:10201-8 pubmed..In addition, we provide evidence that Itch is specifically involved in the ubiquitination of occludin in vivo, and that the degradation of occludin is sensitive to proteasome inhibition. ..
- Takahashi S, Iwamoto N, Sasaki H, Ohashi M, Oda Y, Tsukita S, et al. The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells. J Cell Sci. 2009;122:985-94 pubmed publisher..These findings suggest that LNX1p80 is involved in the ubiquitylation, endocytosis and lysosomal degradation of claudins, and that the turnover of TJs is regulated by ubiquitylation. ..
- Qin W, Ren Q, Liu T, Huang Y, Wang J. MicroRNA-155 is a novel suppressor of ovarian cancer-initiating cells that targets CLDN1. FEBS Lett. 2013;587:1434-9 pubmed publisherPrevious cDNA microarrays indicated that CLDN1 (claudin-1) is an important gene for ovarian cancer-initiating cell (OCIC) invasion and adhesion...
- Dalessandri T, Crawford G, Hayes M, Castro Seoane R, Strid J. IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin. Nat Commun. 2016;7:12080 pubmed publisher..These findings show that IL-13 acts as a molecular bridge between IELs and ECs, and reveal a critical host-defensive role for type-2 immunity in regulating EC tissue homeostasis and carcinogenesis. ..
- Westmoreland J, Drosos Y, Kelly J, Ye J, Means A, Washington M, et al. Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012;241:583-94 pubmed publisher..Our results underscored a distinctive, dynamic distribution of certain claudins in both the developing pancreas and the pancreatic epithelium undergoing neoplastic transformation. ..
- Pfeiffer F, Schäfer J, Lyck R, Makrides V, Brunner S, Schaeren Wiemers N, et al. Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol. 2011;122:601-14 pubmed publisher..Our observations suggest that stabilizing BBB barrier function by therapeutic targeting of TJs may be beneficial in treating MS, especially when anti-inflammatory treatments have failed...
- Sugawara T, Iwamoto N, Akashi M, Kojima T, Hisatsune J, Sugai M, et al. Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice. J Dermatol Sci. 2013;70:12-8 pubmed publisher..Claudin-1-deficient (Cldn1(-/-)) mice die within one day of birth accompanied by excessive transepidermal water loss, indicating a critical ..
- Itoh M, Sasaki H, Furuse M, Ozaki H, Kita T, Tsukita S. Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol. 2001;154:491-7 pubmed..We also discuss the importance of this model from the perspective of the general molecular mechanisms behind the recruitment of PAR proteins to plasma membranes. ..
- Aravindakshan J, Chen X, Sairam M. Differential expression of claudin family proteins in mouse ovarian serous papillary epithelial adenoma in aging FSH receptor-deficient mutants. Neoplasia. 2006;8:984-94 pubmed..More importantly, this study identifies claudin-11 overexpression in mouse ovarian serous cystadenoma. ..
- Dravis C, Henkemeyer M. Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues. Dev Biol. 2011;355:138-51 pubmed publisher..Finally, the developmental phenotypes described here mirror common human midline birth defects found with the VACTERL association, suggesting a molecular link to bidirectional signaling through B-subclass Ephs and ephrins. ..
- Parkinson S, Le Good J, Whelan R, Whitehead P, Parker P. Identification of PKCzetaII: an endogenous inhibitor of cell polarity. EMBO J. 2004;23:77-88 pubmed..The data demonstrate a regulatory role for PKCzetaII in the maintenance of cell transformation and the development of cell polarity. ..
- Chang T, Ito K, Ko T, Liu Q, Salto Tellez M, Yeoh K, et al. Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells. Gastroenterology. 2010;138:255-65.e1-3 pubmed publisher..Claudin-1 is down-regulated during the epithelial-mesenchymal transition; RUNX3 might therefore act as a tumor suppressor to antagonize the epithelial-mesenchymal transition. ..
- Kitajiri S, Furuse M, Morita K, Saishin Kiuchi Y, Kido H, Ito J, et al. Expression patterns of claudins, tight junction adhesion molecules, in the inner ear. Hear Res. 2004;187:25-34 pubmed..These findings, i.e., very complex expression patterns of claudin species in the inner ear, would reflect the importance and the complexity of the barrier function of TJs in the inner ear. ..
- LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein J, Olson E, et al. Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell. 2010;19:807-18 pubmed publisher..Our data identify critical requirements for HDAC1/2 in epidermal development and indicate that HDAC1/2 directly mediate repressive functions of p63 and suppress p53 activity. ..
- Roh M, Liu C, Laurinec S, Margolis B. The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. J Biol Chem. 2002;277:27501-9 pubmed..that the 6th and 8th PDZ domains of PATJ can interact with the carboxyl termini of zona occludens-3 (ZO-3) and claudin 1, respectively. PATJ missing the 6th PDZ domain was found to mislocalize away from cell contacts...
- Kyoko O, Kono H, Ishimaru K, Miyake K, Kubota T, Ogawa H, et al. Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis. PLoS ONE. 2014;9:e98016 pubmed publisher..Occludin and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis. ..
- DiTommaso T, Cottle D, Pearson H, SchlÃ¼ter H, Kaur P, Humbert P, et al. Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet. 2014;10:e1004706 pubmed publisher..with functionally defective tight junctions that are characterised by mislocalization of the integral protein CLDN1. We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to ..
- Ihrie R, Marques M, Nguyen B, Horner J, Papazoglu C, Bronson R, et al. Perp is a p63-regulated gene essential for epithelial integrity. Cell. 2005;120:843-56 pubmed..These findings demonstrate that Perp is a key effector in the p63 developmental program, playing an essential role in an adhesion subprogram central to epithelial integrity and homeostasis. ..
- Kim Y, Cho N, Cheon S, Kim K. Bortezomib, a proteasome inhibitor, alleviates atopic dermatitis by increasing claudin 1 protein expression. Biochem Biophys Res Commun. 2017;493:744-750 pubmed publisher..One of the causes of AD is dysfunction of tight junctions through reduction of claudin 1 expression in the epidermal barrier of the skin...
- Haid S, Windisch M, Bartenschlager R, Pietschmann T. Mouse-specific residues of claudin-1 limit hepatitis C virus genotype 2a infection in a human hepatocyte cell line. J Virol. 2010;84:964-75 pubmed publisherRecently, claudin-1 (CLDN1) was identified as a host protein essential for hepatitis C virus (HCV) infection...
- Van Itallie C, Mitic L, Anderson J. Claudin-2 forms homodimers and is a component of a high molecular weight protein complex. J Biol Chem. 2011;286:3442-50 pubmed publisher..Our results suggest that BN-PAGE may be a useful tool in understanding tight junction structure. ..
- Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, et al. Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015;5:12982 pubmed publisher..These results collectively suggest that Shp2 is a critical signaling protein that is required to maintain Sertoli cell function and could serve as a novel target for male infertility therapies. ..
- Hellstrom M, Gerhardt H, Kalén M, Li X, Eriksson U, Wolburg H, et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001;153:543-53 pubmed
- Guillemot L, Schneider Y, Brun P, Castagliuolo I, Pizzuti D, Martines D, et al. Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. J Cell Sci. 2012;125:5005-14 pubmed publisher
- Yu Z, Lin K, Bhandari A, Spencer J, Xu X, Wang N, et al. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol. 2006;299:122-36 pubmed..These findings indicate that the Get-1 and LMO4 genes interact functionally to regulate epidermal terminal differentiation. ..
- Inai T, Sengoku A, Hirose E, Iida H, Shibata Y. Freeze-fracture electron microscopic study of tight junction strands in HEK293 cells and MDCK II cells expressing claudin-1 mutants in the second extracellular loop. Histochem Cell Biol. 2009;131:681-90 pubmed publisher..These results suggest that changes in the TJ morphology due to the expression of either 1CLDeltaFYmyc or 1CLDeltaPLmyc may be caused by some factors specific to epithelial MDCK II cells including endogenous claudins. ..
- Ohta H, Adachi H, Inaba M. Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J Vet Med Sci. 2006;68:149-55 pubmed
- Gruber R, BÃ¶rnchen C, Rose K, Daubmann A, Volksdorf T, Wladykowski E, et al. Diverse regulation of claudin-1 and claudin-4 in atopic dermatitis. Am J Pathol. 2015;185:2777-89 pubmed publisherTight junctions are important for skin barrier function. The tight junction protein claudin 1 (Cldn-1) has been reported to be down-regulated in nonlesional skin of atopic dermatitis (AD) patients...
- Mahati S, Xiao L, Yang Y, Mao R, Bao Y. miR-29a suppresses growth and migration of hepatocellular carcinoma by regulating CLDN1. Biochem Biophys Res Commun. 2017;486:732-737 pubmed publisherb>CLDN1 (claudin1) is essential for intercellular junctions and has been reported to be involving in cell migration and metastasis, making it as an oncogene in various cancer types...
- Pope J, Bhat A, Sharma A, Ahmad R, Krishnan M, Washington M, et al. Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling. Gut. 2014;63:622-34 pubmed publisher..Claudin-1 expression also induces colonic epithelial proliferation in a Notch-dependent manner. Our findings may help understand the role of claudin-1 in the regulation of inflammatory bowel diseases and CRC. ..
- Guttman J, Samji F, Li Y, Vogl A, Finlay B. Evidence that tight junctions are disrupted due to intimate bacterial contact and not inflammation during attaching and effacing pathogen infection in vivo. Infect Immun. 2006;74:6075-84 pubmed
- Alshbool F, Mohan S. Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis. PLoS ONE. 2014;9:e114357 pubmed publisher..In addition, Cldn-1 is a positive regulator of osteoblast proliferation and differentiation. ..
- Kopecki Z, Yang G, Arkell R, Jackson J, Melville E, Iwata H, et al. Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering. J Pathol. 2014;232:541-52 pubmed publisher..These results therefore demonstrate an important role for Flii in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of EB patients. ..
- Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S. Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem. 2002;277:455-61 pubmed