Gene Symbol: Clast4
Description: eukaryotic translation initiation factor 4E nuclear import factor 1
Alias: 2610509L04Rik, A930019J01Rik, AA410001, AU021239, Clast4, D11Ertd166e, eukaryotic translation initiation factor 4E transporter, 4E-T, eIF4E transporter
Warner D, Roberts E, Greene R, Pisano M. Identification of novel Smad binding proteins. Biochem Biophys Res Commun. 2003;312:1185-90 pubmed
..The identification of these proteins as Smad binding partners allows exploration of new mechanisms whereby TGFbeta signaling may be regulated, and reveals additional potential interactions with other signaling pathways. ..
Amadei G, Zander M, Yang G, Dumelie J, Vessey J, Lipshitz H, et al
. A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis. J Neurosci. 2015;35:15666-81 pubmed publisher
Villaescusa J, Allard P, Carminati E, Kontogiannea M, Talarico D, Blasi F, et al
. Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation. Gene. 2006;367:101-9 pubmed
..Cup protein, a translational repressor during female germ-line development, identified the product of the Clast4 gene...
Park C, Rehrauer H, Mansuy I. Genome-wide analysis of H4K5 acetylation associated with fear memory in mice. BMC Genomics. 2013;14:539 pubmed publisher
..More broadly, this study strengthens the importance of histone posttranslational modifications for the differential regulation of transcriptional programs in cognitive processes. ..
Yang G, Smibert C, Kaplan D, Miller F. An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014;84:723-39 pubmed publisher
..Thus, neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. ..
MartÃnez A, SesÃ© M, Losa J, Robichaud N, Sonenberg N, Aasen T, et al
. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. PLoS ONE. 2015;10:e0123352 pubmed publisher
..Further delineation of this process may identify novel therapeutic avenues for cancer treatment, and these results support the use of modern Mnk1/2 inhibitors in conjunction with standard therapy. ..