Gene Symbol: Clasp2
Description: CLIP associating protein 2
Alias: 1500004F14Rik, 8030404L10Rik, C77448, CLASP2beta, mKIAA0627, CLIP-associating protein 2, CLASP2alpha, CLASP2gamma, CLIP-associating protein CLASP2, cytoplasmic linker-associated protein 2
Species: mouse
Products:     Clasp2

Top Publications

  1. Akhmanova A, Hoogenraad C, Drabek K, Stepanova T, Dortland B, Verkerk T, et al. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell. 2001;104:923-35 pubmed
    ..Antibody injections suggest that CLASP2 is required for the orientation of stabilized microtubules toward the leading edge...
  2. Drabek K, van Ham M, Stepanova T, Draegestein K, van Horssen R, Sayas C, et al. Role of CLASP2 in microtubule stabilization and the regulation of persistent motility. Curr Biol. 2006;16:2259-64 pubmed
    ..By using mouse embryonic fibroblasts (MEFs) in a wound-healing assay, we show here that CLASP2 is required for the formation of a stable, polarized MT array but that CLIP-170 and an APC-EB1 interaction are not ..
  3. Moore C, Zernicka Goetz M. PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles. Reproduction. 2005;130:311-20 pubmed
    ..In addition, the microtubule-associated proteins CLASP2 (a CLIP associating protein) and dynactin-p50 are found on kinetochores and a subset of microtubule-organising ..
  4. Beffert U, Dillon G, Sullivan J, Stuart C, Gilbert J, Kambouris J, et al. Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function. J Neurosci. 2012;32:13906-16 pubmed publisher
    ..Here, we present evidence that the microtubule plus-end tracking protein CLASP2 (cytoplasmic linker associated protein 2) is a key regulator of axon and dendrite outgrowth that leads to functional alterations in ..
  5. Schmidt N, Basu S, Sladecek S, Gatti S, van Haren J, Treves S, et al. Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane. J Cell Biol. 2012;198:421-37 pubmed publisher
    ..acetylcholine receptor (AChR) clusters, mediated to a large extent by the microtubule plus-end tracking proteins CLASP2 and CLIP-170...
  6. Langlais P, Dillon J, Mengos A, Baluch D, Ardebili R, Miranda D, et al. Identification of a role for CLASP2 in insulin action. J Biol Chem. 2012;287:39245-53 pubmed publisher
    ..We present evidence that CLIP-associating protein 2 (CLASP2), a protein previously unassociated with insulin action, is responsive to insulin stimulation...
  7. Drabek K, Gutierrez L, Vermeij M, Clapes T, Patel S, Boisset J, et al. The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance. Cell Rep. 2012;2:781-8 pubmed publisher
    ..We show here that absence of murine CLASP2 in vivo results in thrombocytopenia, progressive anemia, and pancytopenia, due to defects in megakaryopoiesis, in ..
  8. Shahbazi M, Megias D, Epifano C, Akhmanova A, Gundersen G, Fuchs E, et al. CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions. J Cell Biol. 2013;203:1043-61 pubmed publisher
    ..In this paper, we report that the MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse ..
  9. Shahbazi M, Peña Jimenez D, Antonucci F, Drosten M, Perez Moreno M. Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes. J Cell Sci. 2017;130:683-688 pubmed publisher
    ..keratinocytes, here we report that the expression of the mammalian microtubule and kinetochore-associated protein Clasp2 is intimately associated with the basal proliferative makeup of keratinocytes, and its deficiency leads to ..

More Information


  1. Dillon G, Tyler W, Omuro K, Kambouris J, Tyminski C, Henry S, et al. CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development. Neuron. 2017;93:1344-1358.e5 pubmed publisher
    ..However, little is known about how Reelin controls the cytoskeleton during neuronal migration. Here, we identify CLASP2 as a key cytoskeletal effector in the Reelin signaling pathway...
  2. Pereira A, Pereira A, Maia A, Drabek K, Sayas C, Hergert P, et al. Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function. Mol Biol Cell. 2006;17:4526-42 pubmed
    ..however, only CLASP1 has been directly implicated in cell division, despite the existence of a second paralogue, CLASP2, whose mitotic roles remain unknown...
  3. Wu X, Kodama A, Fuchs E. ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell. 2008;135:137-48 pubmed publisher
    ..Our findings provide insight into the functions of this important cytoskeletal crosslinking protein in regulating dynamic interactions between MTs and F-actin to sustain directional cell movement. ..
  4. Ota H, Hikita T, Nishioka T, Matsumoto M, Ito J, Asai N, et al. Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain. Biochem Biophys Res Commun. 2013;442:16-21 pubmed publisher
    ..Our results suggest that Girdin and Girdin-interacting proteins control neuronal migration by regulating actin and/or microtubule dynamics. ..
  5. Engel U, Zhan Y, Long J, Boyle S, Ballif B, Dorey K, et al. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. Cytoskeleton (Hoboken). 2014;71:195-209 pubmed publisher
    ..Using purified proteins, we find that Abl phosphorylation modulates direct binding between purified CLASP2 with both MTs and actin...
  6. Basu S, Sladecek S, Martinez de la Peña y Valenzuela I, Akaaboune M, Smal I, Martin K, et al. CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles. Mol Biol Cell. 2015;26:938-51 pubmed publisher
    ..We previously showed that microtubule (MT) capture by the plus end-tracking protein CLASP2 regulates AChR density at agrin-induced AChR clusters in cultured myotubes via PI3 kinase acting through GSK3β...
  7. Berg J, Lee C, Chen L, Galvan L, Cepeda C, Chen J, et al. JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron. 2015;88:1173-1191 pubmed publisher
    ..These findings define an important and novel role for JAKMIP1 in neural development and further highlight pathways regulating mRNA translation during synaptogenesis in the genesis of neurodevelopmental disorders. ..