Cited2

Summary

Gene Symbol: Cited2
Description: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Alias: AI835299, ER154-like, Mrg1, Msg2, p35srj, cbp/p300-interacting transactivator 2, MSG-related protein 1, melanocyte specific gene 2
Species: mouse
Products:     Cited2

Top Publications

  1. Weninger W, Lopes Floro K, Bennett M, Withington S, Preis J, Barbera J, et al. Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development. 2005;132:1337-48 pubmed
    ..The transcriptional modulator Cited2 is essential for embryonic development: Cited2-null embryos die during gestation with profound developmental ..
  2. Schneider J, Bamforth S, Farthing C, Clarke K, Neubauer S, Bhattacharya S. High-resolution imaging of normal anatomy, and neural and adrenal malformations in mouse embryos using magnetic resonance microscopy. J Anat. 2003;202:239-47 pubmed
    ..Examination of the brain in embryos lacking the transcriptional coactivator Cited2 showed cerebellar and midbrain roof agenesis, in addition to exencephaly...
  3. Dunwoodie S, Rodriguez T, Beddington R. Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. Mech Dev. 1998;72:27-40 pubmed
    Msg1 and Mrg1 are founding members of a gene family which exhibit distinct patterns of gene expression during mouse embryogenesis...
  4. Kranc K, Bamforth S, Braganca J, Norbury C, Van Lohuizen M, Bhattacharya S. Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Mol Cell Biol. 2003;23:7658-66 pubmed
    b>Cited2 (CBP/p300 interacting transactivator with ED-rich tail 2) is required for embryonic development, coactivation of transcription factor AP-2, and inhibition of hypoxia-inducible factor 1 transactivation...
  5. Sun H, Zhu Y, Yin T, Sledge G, Yang Y. MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity. Proc Natl Acad Sci U S A. 1998;95:13555-60 pubmed
    ..A cytokine-inducible gene, mrg1 [melanocyte-specific gene (msg1) related gene], was identified through mRNA differential display of interleukin (IL)..
  6. Barbera J, Rodriguez T, Greene N, Weninger W, Simeone A, Copp A, et al. Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet. 2002;11:283-93 pubmed
    Cited2 (also Mrg1/p35srj) is a member of a new conserved gene family that is expressed during mouse development and in adult tissues...
  7. Schneider J, Böse J, Bamforth S, Gruber A, Broadbent C, Clarke K, et al. Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol. 2004;4:16 pubmed
    ..The technique can be easily adapted for mouse mutagenesis screens and, thus provides an important new tool for identifying new mouse models for human congenital heart diseases. ..
  8. Schneider J, Bamforth S, Farthing C, Clarke K, Neubauer S, Bhattacharya S. Rapid identification and 3D reconstruction of complex cardiac malformations in transgenic mouse embryos using fast gradient echo sequence magnetic resonance imaging. J Mol Cell Cardiol. 2003;35:217-22 pubmed
    ..In embryos lacking Cited2 (a transcriptional co-activator required for normal heart development), we identified cardiac malformations ..
  9. Braganca J, Eloranta J, Bamforth S, Ibbitt J, Hurst H, Bhattacharya S. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J Biol Chem. 2003;278:16021-9 pubmed
    The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator...
  10. Preis J, Wise N, Solloway M, Harvey R, Sparrow D, Dunwoodie S. Generation of conditional Cited2 null alleles. Genesis. 2006;44:579-83 pubmed
    b>Cited2 is a transcriptional co-factor that is widely expressed in both embryonic and extraembryonic cells during early development...

Detail Information

Publications72

  1. Weninger W, Lopes Floro K, Bennett M, Withington S, Preis J, Barbera J, et al. Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development. Development. 2005;132:1337-48 pubmed
    ..The transcriptional modulator Cited2 is essential for embryonic development: Cited2-null embryos die during gestation with profound developmental ..
  2. Schneider J, Bamforth S, Farthing C, Clarke K, Neubauer S, Bhattacharya S. High-resolution imaging of normal anatomy, and neural and adrenal malformations in mouse embryos using magnetic resonance microscopy. J Anat. 2003;202:239-47 pubmed
    ..Examination of the brain in embryos lacking the transcriptional coactivator Cited2 showed cerebellar and midbrain roof agenesis, in addition to exencephaly...
  3. Dunwoodie S, Rodriguez T, Beddington R. Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. Mech Dev. 1998;72:27-40 pubmed
    Msg1 and Mrg1 are founding members of a gene family which exhibit distinct patterns of gene expression during mouse embryogenesis...
  4. Kranc K, Bamforth S, Braganca J, Norbury C, Van Lohuizen M, Bhattacharya S. Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF. Mol Cell Biol. 2003;23:7658-66 pubmed
    b>Cited2 (CBP/p300 interacting transactivator with ED-rich tail 2) is required for embryonic development, coactivation of transcription factor AP-2, and inhibition of hypoxia-inducible factor 1 transactivation...
  5. Sun H, Zhu Y, Yin T, Sledge G, Yang Y. MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity. Proc Natl Acad Sci U S A. 1998;95:13555-60 pubmed
    ..A cytokine-inducible gene, mrg1 [melanocyte-specific gene (msg1) related gene], was identified through mRNA differential display of interleukin (IL)..
  6. Barbera J, Rodriguez T, Greene N, Weninger W, Simeone A, Copp A, et al. Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet. 2002;11:283-93 pubmed
    Cited2 (also Mrg1/p35srj) is a member of a new conserved gene family that is expressed during mouse development and in adult tissues...
  7. Schneider J, Böse J, Bamforth S, Gruber A, Broadbent C, Clarke K, et al. Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol. 2004;4:16 pubmed
    ..The technique can be easily adapted for mouse mutagenesis screens and, thus provides an important new tool for identifying new mouse models for human congenital heart diseases. ..
  8. Schneider J, Bamforth S, Farthing C, Clarke K, Neubauer S, Bhattacharya S. Rapid identification and 3D reconstruction of complex cardiac malformations in transgenic mouse embryos using fast gradient echo sequence magnetic resonance imaging. J Mol Cell Cardiol. 2003;35:217-22 pubmed
    ..In embryos lacking Cited2 (a transcriptional co-activator required for normal heart development), we identified cardiac malformations ..
  9. Braganca J, Eloranta J, Bamforth S, Ibbitt J, Hurst H, Bhattacharya S. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J Biol Chem. 2003;278:16021-9 pubmed
    The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator...
  10. Preis J, Wise N, Solloway M, Harvey R, Sparrow D, Dunwoodie S. Generation of conditional Cited2 null alleles. Genesis. 2006;44:579-83 pubmed
    b>Cited2 is a transcriptional co-factor that is widely expressed in both embryonic and extraembryonic cells during early development...
  11. Val P, Martinez Barbera J, Swain A. Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development. 2007;134:2349-58 pubmed
    ..Here we show in mice that the transcription co-factor Cited2 is required for the specification of the adrenal cortex from the AGP...
  12. Xu B, Qu X, Gu S, Doughman Y, Watanabe M, Dunwoodie S, et al. Cited2 is required for fetal lung maturation. Dev Biol. 2008;317:95-105 pubmed publisher
    ..The Cited2-Tcfap2a/c complex has been shown to activate transcription of Erbb3 and Pitx2c during mouse development...
  13. Lopes Floro K, Artap S, Preis J, Fatkin D, Chapman G, Furtado M, et al. Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis. Hum Mol Genet. 2011;20:1097-110 pubmed publisher
    b>Cited2 is a transcriptional coactivator that is required for normal development of the embryo and placenta. Cited2-null mice die during gestation with fully penetrant heart defects and partially penetrant laterality defects...
  14. Bentham J, Michell A, Lockstone H, Andrew D, Schneider J, Brown N, et al. Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left-right patterning defects. Hum Mol Genet. 2010;19:3394-401 pubmed publisher
    Deficiency of the transcription factor Cited2 in mice results in cardiac malformation, adrenal agenesis, neural tube, placental defects and partially penetrant cardiopulmonary laterality defects resulting from an abnormal Nodal->Pitx2c ..
  15. Boyle S, Shioda T, Perantoni A, De Caestecker M. Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Dev Dyn. 2007;236:2321-30 pubmed
    ..The expression pattern of Cited2 overlaps that of Cited1, but its deletion, either alone or in combination with Cited1, does not disrupt epithelial ..
  16. Chen Y, Haviernik P, Bunting K, Yang Y. Cited2 is required for normal hematopoiesis in the murine fetal liver. Blood. 2007;110:2889-98 pubmed
    b>Cited2 (cAMP-responsive elementbinding protein [CBP]/p300-interacting transactivators with glutamic acid [E] and aspartic acid [D]-rich tail 2) is a newly identified transcriptional modulator...
  17. Shioda T, Fenner M, Isselbacher K. MSG1 and its related protein MRG1 share a transcription activating domain. Gene. 1997;204:235-41 pubmed
    ..Based on these EST sequences, we isolated a novel gene, MRG1 (MSG1-Related Gene 1), by the 5'-RACE (rapid amplification of cDNA ends) technique...
  18. Chen Y, Doughman Y, Gu S, Jarrell A, Aota S, Cvekl A, et al. Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development. 2008;135:2939-48 pubmed publisher
    b>Cited2 is a transcriptional modulator with pivotal roles in different biological processes. Cited2-deficient mouse embryos manifested two major defects in the developing eye...
  19. Bamforth S, Braganca J, Farthing C, Schneider J, Broadbent C, Michell A, et al. Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet. 2004;36:1189-96 pubmed
    ..outflow tract and aortic arch are the most common congenital cardiovascular defects and occur in mice lacking Cited2, a transcriptional coactivator of TFAP2...
  20. Bhattacharya S, Michels C, Leung M, Arany Z, Kung A, Livingston D. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 1999;13:64-75 pubmed
    ..A new p300-CH1 interacting protein, p35srj, has been identified and cloned...
  21. Glenn D, Maurer R. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J Biol Chem. 1999;274:36159-67 pubmed
    ..A yeast two-hybrid screen identified the recently described melanocyte-specific gene-related gene 1 (MRG1) as an Lhx2 LIM-interacting protein...
  22. Tien E, Davis J, Vanden Heuvel J. Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator. J Biol Chem. 2004;279:24053-63 pubmed
    ..cloning was the CREB-binding protein/p300-interacting transactivator with ED-rich tail 2 (CITED2, also called p35srj/mrg1/msg1)...
  23. Buaas F, Val P, Swain A. The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet. 2009;18:2989-3001 pubmed publisher
    ..We have previously shown that the transcription co-factor CITED2 interacts with WT1 to stimulate the expression of Sf1 in the adrenogonadal primordium to ensure adrenal ..
  24. Withington S, Scott A, Saunders D, Lopes Floro K, Preis J, Michalicek J, et al. Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta. Dev Biol. 2006;294:67-82 pubmed
    b>Cited2 is widely expressed in the developing embryo and in extraembryonic tissues including the placenta...
  25. Xu B, Doughman Y, Turakhia M, Jiang W, Landsettle C, Agani F, et al. Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity. Dev Biol. 2007;301:130-40 pubmed
    ..Evidence from in vitro and structural analyses supports a critical role for Cited2 in down-regulating HIF-1-mediated transcription by competing for binding with oxygen-sensitive HIF-1alpha to ..
  26. Kranc K, Schepers H, Rodrigues N, Bamforth S, Villadsen E, Ferry H, et al. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell. 2009;5:659-65 pubmed publisher
    ..we report a selective and cell-autonomous requirement for the p300/CBP-binding transcriptional coactivator Cited2 in adult HSC maintenance...
  27. Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, et al. The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A. 2002;99:10488-93 pubmed
    b>Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1alpha through its competitive binding with HIF-1alpha to CBP/p300...
  28. Weninger W, Mohun T. Phenotyping transgenic embryos: a rapid 3-D screening method based on episcopic fluorescence image capturing. Nat Genet. 2002;30:59-65 pubmed
    ..have used this procedure to describe the cardiac phenotype and associated blood vessels of trisomic 16 (Ts16) and Cited2-null mutant mice, as well as the expression pattern of an Myf5 enhancer/beta-galactosidase transgene...
  29. Bamforth S, Braganca J, Eloranta J, Murdoch J, Marques F, Kranc K, et al. Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet. 2001;29:469-74 pubmed
    ..The CBP/p300-interacting transactivator with ED-rich tail 2 (CITED2) binds EP300 and CREBBP with high affinity and regulates gene transcription...
  30. Qu X, Lam E, Doughman Y, Chen Y, Chou Y, Lam M, et al. Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J. 2007;26:4445-56 pubmed
    The transcriptional modulator Cited2 is induced by various biological stimuli including hypoxia, cytokines, growth factors, lipopolysaccharide (LPS) and flow shear...
  31. Michell A, Braganca J, Broadbent C, Joyce B, Franklyn A, Schneider J, et al. A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2. Dev Dyn. 2010;239:1988-94 pubmed publisher
    Deletion of the transcriptional modulator Cited2 in the mouse results in embryonic lethality, cardiovascular malformations, adrenal agenesis, cranial ganglia fusion, exencephaly, and left-right patterning defects, all seen with a varying ..
  32. MacDonald S, Bamforth S, Chen C, Farthing C, Franklyn A, Broadbent C, et al. Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res. 2008;79:448-57 pubmed publisher
    Deletion of the transcription factor Cited2 causes penetrant and phenotypically heterogenous cardiovascular and laterality defects and adrenal agenesis...
  33. Chou Y, Wang H, Chen Y, Danielpour D, Yang Y. Cited2 modulates TGF-beta-mediated upregulation of MMP9. Oncogene. 2006;25:5547-60 pubmed
    ..In this report, we provide evidence that Cited2 is an important regulator of transforming growth factor (TGF)-beta signaling...
  34. Pacheco Leyva I, Matias A, Oliveira D, Santos J, Nascimento R, Guerreiro E, et al. CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells. Stem Cell Reports. 2016;7:1037-1049 pubmed publisher
    The transcriptional regulator CITED2 is essential for heart development. Here, we investigated the role of CITED2 in the specification of cardiac cell fate from mouse embryonic stem cells (ESC)...
  35. Yoo J, Kim T, Lee J, Dunwoodie S, Ku B, Jeong J. Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling. Biochem Biophys Res Commun. 2015;462:409-14 pubmed publisher
    ..This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2, the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis...
  36. Fame R, MacDonald J, Dunwoodie S, Takahashi E, Macklis J. Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity. J Neurosci. 2016;36:6403-19 pubmed publisher
    ..We have found that the transcriptional coregulator Cited2 regulates and refines two stages of CPN development...
  37. Bhattacherjee V, Horn K, Singh S, Webb C, Pisano M, Greene R. CBP/p300 and associated transcriptional co-activators exhibit distinct expression patterns during murine craniofacial and neural tube development. Int J Dev Biol. 2009;53:1097-104 pubmed publisher
    Mutations in each of the transcriptional co-activator genes - CBP, p300, Cited2, Cart1 and Carm1 - result in neural tube defects in mice...
  38. Bakker W, van Dijk T, Parren van Amelsvoort M, Kolbus A, Yamamoto K, Steinlein P, et al. Differential regulation of Foxo3a target genes in erythropoiesis. Mol Cell Biol. 2007;27:3839-3854 pubmed
    ..One of these genes was Cited2. Transcriptional control of Epo/Foxo3a-induced Cited2 was studied and compared with that of the Epo-repressed ..
  39. Gu H, Yu J, Dong D, Zhou Q, Wang J, Fang S, et al. High Glucose-Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress. Diabetes. 2016;65:149-63 pubmed publisher
    High glucose in vivo and in vitro induces neural tube defects (NTDs). CITED2 (CBP/p300-interacting transactivator with ED-rich tail 2) is essential for neural tube closure...
  40. MacDonald S, Bamforth S, Braganca J, Chen C, Broadbent C, Schneider J, et al. A cell-autonomous role of Cited2 in controlling myocardial and coronary vascular development. Eur Heart J. 2013;34:2557-65 pubmed publisher
    ..We examined the cardiomyocyte specific role of the transcriptional co-activator Cited2 on myocardial microstructure and vessel growth, in relation to Vegfa expression...
  41. Gonzalez Y, Zhang Y, Behzadpoor D, Cregan S, Bamforth S, Slack R, et al. CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage. J Neurosci. 2008;28:5559-69 pubmed publisher
    ..With gene array analyses, we detected upregulation of Cited2, a CBP (cAMP response element-binding protein-binding protein)/p300 interacting transactivator, in response to DNA ..
  42. Lin W, Zhang Z, Srajer G, Chen Y, Huang M, Phan H, et al. Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. Dev Dyn. 2008;237:928-40 pubmed publisher
    ..These results indicate that normal levels of Gcn5 expression are critical for neural tube closure in mice and predict that mutations in this HAT may be associated with increased risk of NTDs in humans. ..
  43. Schlange T, Andree B, Arnold H, Brand T. Expression analysis of the chicken homologue of CITED2 during early stages of embryonic development. Mech Dev. 2000;98:157-60 pubmed
    ..While Cited1 also binds to the TGFbeta signal transducer Smad4, this has not been shown for Cited2. We isolated a chicken homologue of Cited2 from a HH stage 3-6 cDNA library and examined its expression pattern ..
  44. Combes A, Spiller C, Harley V, Sinclair A, Dunwoodie S, Wilhelm D, et al. Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation. Int J Dev Biol. 2010;54:683-9 pubmed publisher
    ..In the gonad, Sf1 expression is enhanced by the transcriptional co-factor Cited2. We have used the reduced levels of Sf1 expression in Cited2(-/-) mice as a hypomorphic model to gain insight into ..
  45. Lakhwani S, García Sanz P, Vallejo M. Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects. Dev Biol. 2010;344:869-80 pubmed publisher
    ..Thus, Alx3 emerges as a candidate gene for human neural tube defects and reveals the existence of induced transcription factor gene expression as a previously unknown mechanism by which folic acid prevents neural tube closure defects. ..
  46. Parmentier Batteur S, Jin K, Xie L, Mao X, Greenberg D. DNA microarray analysis of cannabinoid signaling in mouse brain in vivo. Mol Pharmacol. 2002;62:828-35 pubmed
    ..of two such genes not previously implicated in cannabinoid signaling-melanocyte-specific gene-related gene 1 (MRG1) and hexokinase 4 (glucokinase, GK)-was measured by Western blotting and immunohistochemistry...
  47. Kashimada K, Svingen T, Feng C, Pelosi E, Bagheri Fam S, Harley V, et al. Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J. 2011;25:3561-9 pubmed publisher
    ..These data support the hypothesis that SOX9 and SF1 ensure the male fate of germ cells by up-regulating Cyp26b1 and that FOXL2 acts to antagonize Cyp26b1 expression in ovaries. ..
  48. Bort R, Martinez Barbera J, Beddington R, Zaret K. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development. 2004;131:797-806 pubmed
    ..Other endodermal transcription factors may also function morphogenetically rather than by directly regulating tissue-specific programs. ..
  49. Li Q, Hakimi P, Liu X, Yu W, Ye F, Fujioka H, et al. Cited2, a transcriptional modulator protein, regulates metabolism in murine embryonic stem cells. J Biol Chem. 2014;289:251-63 pubmed publisher
    CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse...
  50. Huang T, Wang Y, Ebrahem Q, Chen Y, Cheng C, Doughman Y, et al. Deletion of HIF-1? partially rescues the abnormal hyaloid vascular system in Cited2 conditional knockout mouse eyes. Mol Vis. 2012;18:1260-70 pubmed
    b>Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a member of a new family of transcriptional modulators...
  51. Charneca J, Matias A, Escapa A, Fernandes C, Alves A, Santos J, et al. Ectopic expression of CITED2 prior to reprogramming, promotes and homogenises the conversion of somatic cells into induced pluripotent stem cells. Exp Cell Res. 2017;358:290-300 pubmed publisher
    b>Cited2 plays crucial roles in mouse embryonic stem cells self-renewal, the initiation of the somatic reprogramming process into induced pluripotent stem cells (iPSC) and the suppression of cell senescence...
  52. Chen Y, Carlson E, Chen Z, Hamik A, Jain M, Dunwoodie S, et al. Conditional deletion of Cited2 results in defective corneal epithelial morphogenesis and maintenance. Dev Biol. 2009;334:243-52 pubmed publisher
    b>Cited2 is an important transcriptional cofactor involved in multiple organ development. Gene profile analysis has identified Cited2 as one of the transcription factors expressed at high levels in adult mouse cornea...
  53. Liu Y, Chang P, Chao C. CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene. Nucleic Acids Res. 2015;43:10760-81 pubmed publisher
    In this study, we show that silencing of CITED2 using small-hairpin RNA (shCITED2) induced DNA damage and reduction of ERCC1 gene expression in HEK293, HeLa and H1299 cells, even in the absence of cisplatin...
  54. Kranc K, Oliveira D, Armesilla Diaz A, Pacheco Leyva I, Catarina Matias A, Luisa Escapa A, et al. Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells. 2015;33:699-712 pubmed publisher
    ..While overexpression of the transcriptional regulator Cited2 sustains ESC pluripotency, its role in ESC functions remains unclear...
  55. Moreau J, Artap S, Shi H, Chapman G, Leone G, Sparrow D, et al. Cited2 is required in trophoblasts for correct placental capillary patterning. Dev Biol. 2014;392:62-79 pubmed publisher
    b>CITED2 is a transcriptional co-factor with important roles in many organs of the developing mammalian embryo...
  56. Du J, Li Q, Tang F, Puchowitz M, Fujioka H, Dunwoodie S, et al. Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells. Stem Cells Dev. 2014;23:83-94 pubmed publisher
    ..b>Cited2 is an essential regulator for HSC quiescence, apoptosis, and function...
  57. Chen C, Bentham J, Cosgrove C, Braganca J, Cuenda A, Bamforth S, et al. Functional significance of SRJ domain mutations in CITED2. PLoS ONE. 2012;7:e46256 pubmed publisher
    b>CITED2 is a transcriptional co-activator with 3 conserved domains shared with other CITED family members and a unique Serine-Glycine Rich Junction (SRJ) that is highly conserved in placental mammals...
  58. Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung W, et al. Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet. 2012;8:e1002728 pubmed publisher
    ..These data clearly establish the three HEY bHLH factors as highly redundant transcriptional repressors in vitro and in vivo, which explains the combinatorial action observed in different tissues with overlapping expression. ..
  59. Sakai M, Matsumoto M, Tujimura T, Yongheng C, Noguchi T, Inagaki K, et al. CITED2 links hormonal signaling to PGC-1? acetylation in the regulation of gluconeogenesis. Nat Med. 2012;18:612-7 pubmed publisher
    ..Although CITED2 (CBP- and p300-interacting transactivator with glutamic acid- and aspartic acid-rich COOH-terminal domain 2) ..
  60. Lou X, Sun S, Chen W, Zhou Y, Huang Y, Liu X, et al. Negative feedback regulation of NF-?B action by CITED2 in the nucleus. J Immunol. 2011;186:539-48 pubmed publisher
    ..Bioinformatics analysis predicts that CITED2 is topologically close to NF-?B in the protein interaction networks...
  61. Vigano M, Lamartine J, Testoni B, Merico D, Alotto D, Castagnoli C, et al. New p63 targets in keratinocytes identified by a genome-wide approach. EMBO J. 2006;25:5105-16 pubmed
    ..We discovered several new specific targets whose functional categorization links p63 to cell growth and differentiation. ..
  62. Tobimatsu K, Noguchi T, Hosooka T, Sakai M, Inagaki K, Matsuki Y, et al. Overexpression of the transcriptional coregulator Cited2 protects against glucocorticoid-induced atrophy of C2C12 myotubes. Biochem Biophys Res Commun. 2009;378:399-403 pubmed publisher
    ..Here we show that CREB-binding protein (CBP)/p300-interacting transactivator with ED-rich tail 2 (Cited2), which binds to the cysteine-histidine-rich region 1 of p300 and CBP, regulates muscle mass in vitro...
  63. Chassot A, Bradford S, Auguste A, Gregoire E, Pailhoux E, de Rooij D, et al. WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad. Development. 2012;139:4461-72 pubmed publisher
    ..Hence, this study identifies Rspo1 and Wnt4 as two new regulators of cell proliferation in the early gonad regardless of its sex, in addition to the specific role of these genes in ovarian differentiation. ..
  64. Wainwright E, Jorgensen J, Kim Y, Truong V, Bagheri Fam S, Davidson T, et al. SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation. Biol Reprod. 2013;89:34 pubmed publisher
    ..Our findings indicate that expression of the conserved gonad microRNA, miR-202-5p/3p, is downstream of the testis-determining factor SOX9, suggesting an early role in testis development. ..
  65. Li Q, Ramirez Bergeron D, Dunwoodie S, Yang Y. Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene. J Biol Chem. 2012;287:29088-100 pubmed publisher
    b>Cited2 (CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail 2) is a transcriptional modulator critical for the development of multiple organs...
  66. Du J, Chen Y, Li Q, Han X, Cheng C, Wang Z, et al. HIF-1? deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood. 2012;119:2789-98 pubmed publisher
    b>Cited2 is a transcriptional modulator involved in various biologic processes including fetal liver hematopoiesis. In the present study, the function of Cited2 in adult hematopoiesis was investigated in conditional knockout mice...
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    ..Instead, these miRNAs targeted Cited2, a coactivator required for proper cardiac development...
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    ..g., Ptn, Nnmt, Cited2, Dkk3), in contrast, the examined genes expressed by superficial layer CPN show more variable levels of ..
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