cig5

Summary

Gene Symbol: cig5
Description: radical S-adenosyl methionine domain containing 2
Alias: 2510004L01Rik, Vig1, cig5, radical S-adenosyl methionine domain-containing protein 2, VHSV-induced-like protein, rsad2, viperin, viral hemorrhagic septicemia virus (VHSV)-induced gene 1, virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Species: mouse
Products:     cig5

Top Publications

  1. Hinson E, Cresswell P. The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix. Proc Natl Acad Sci U S A. 2009;106:20452-7 pubmed publisher
    ..Here we show that the IFN-induced antiviral protein viperin, which localizes to the cytosolic face of the ER and inhibits HCV, localizes to lipid droplets...
  2. Chin K, Cresswell P. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc Natl Acad Sci U S A. 2001;98:15125-30 pubmed
    ..We have named the protein viperin (for virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)...
  3. Qiu L, Cresswell P, Chin K. Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1. Blood. 2009;113:3520-9 pubmed publisher
    b>Viperin (virus inhibitory protein, endoplasmic reticulum [ER]-associated, interferon-inducible) has been identified as a highly inducible ER protein that has antiviral activity...
  4. Seo J, Yaneva R, Hinson E, Cresswell P. Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity. Science. 2011;332:1093-7 pubmed publisher
    b>Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV) infection. Why HCMV would induce viperin, which has antiviral activity, is unknown...
  5. Tang H, Lu Z, Wei X, Zhong T, Zhong Y, Ouyang L, et al. Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. Sci Rep. 2016;6:30529 pubmed publisher
    b>Viperin (virus inhibitory protein, endoplasmic reticulum-associated, IFN-inducible) is an interferon-inducible protein that mediates antiviral activity...
  6. Stirnweiss A, Ksienzyk A, Klages K, Rand U, Grashoff M, Hauser H, et al. IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction. J Immunol. 2010;184:5179-85 pubmed publisher
    b>Viperin is an antiviral protein whose expression is highly upregulated during viral infections via IFN-dependent and/or IFN-independent pathways...
  7. Boudinot P, Massin P, Blanco M, Riffault S, Benmansour A. vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA family. J Virol. 1999;73:1846-52 pubmed
    ..This suggests that the function of vig-1 may be involved in the nonspecific virus-induced synthesis of enzymatic cofactors of the nitric oxide pathway...
  8. Tan K, Olfat F, Phoon M, Hsu J, Howe J, Seet J, et al. In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection. J Gen Virol. 2012;93:1269-77 pubmed publisher
    Influenza A virus has caused a number of pandemics in past decades, including the recent H1N1-2009 pandemic. Viperin is an interferon (IFN)-inducible protein of innate immunity, and acts as a broad-spectrum antiviral protein...
  9. Olofsson P, Jatta K, Wågsäter D, Gredmark S, Hedin U, Paulsson Berne G, et al. The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. Arterioscler Thromb Vasc Biol. 2005;25:e113-6 pubmed
    ..Gene arrays identified the cytomegalovirus-inducible gene 5 (cig5)/viperin among the genes most potently induced by LPS in human vascular biopsies...

More Information

Publications20

  1. Zhang Y, Burke C, Ryman K, Klimstra W. Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J Virol. 2007;81:11246-55 pubmed
    ..to affect virus genome translation and included murine ISG20, ISG15, the zinc finger antiviral protein (ZAP), viperin, p56, p54, and p49...
  2. Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, et al. Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity. 2011;34:352-63 pubmed publisher
    ..We showed that the IFN-inducible antiviral protein Viperin promoted TLR7- and TLR9-mediated production of type I IFN by pDCs...
  3. Hee J, Cresswell P. Viperin interaction with mitochondrial antiviral signaling protein (MAVS) limits viperin-mediated inhibition of the interferon response in macrophages. PLoS ONE. 2017;12:e0172236 pubmed publisher
    b>Viperin is an antiviral protein that is upregulated by interferons and by ligands for a variety of innate immune receptors. It possesses diverse capabilities and functions in an array of viral infections...
  4. Jumat M, Huong T, Ravi L, Stanford R, Tan B, Sugrue R. Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis. Antiviral Res. 2015;114:11-20 pubmed publisher
    We examined the effect of respiratory syncytial virus (RSV) infection on viperin protein expression in the permissive HEp2 and non-permissive RAW 264.7 macrophage cell lines...
  5. Teng T, Foo S, Simamarta D, Lum F, Teo T, Lulla A, et al. Viperin restricts chikungunya virus replication and pathology. J Clin Invest. 2012;122:4447-60 pubmed publisher
    ..a cohort of CHIKV-infected patients revealed that type I IFNs controlled CHIKV infection via RSAD2 (which encodes viperin), an enigmatic multifunctional IFN-stimulated gene (ISG)...
  6. Szretter K, Brien J, Thackray L, Virgin H, Cresswell P, Diamond M. The interferon-inducible gene viperin restricts West Nile virus pathogenesis. J Virol. 2011;85:11557-66 pubmed publisher
    ..Here, we examined the contribution of the ISG viperin to the control of West Nile virus (WNV) in genetically deficient cells and mice...
  7. Hinson E, Joshi N, Chen J, Rahner C, Jung Y, Wang X, et al. Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection. J Immunol. 2010;184:5723-31 pubmed publisher
    ..b>Viperin is an IFN-induced antiviral protein and, therefore, is an excellent marker for IFN-responsive cells...
  8. Petri A, Ahnfelt Rønne J, Frederiksen K, Edwards D, Madsen D, Serup P, et al. The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol. 2006;37:301-16 pubmed
    ..These data suggest that Irx1 and Irx2 serve an evolutionary conserved role in the regulation of alpha-cell-specific gene expression. ..
  9. Boudinot P, Riffault S, Salhi S, Carrat C, Sedlik C, Mahmoudi N, et al. Vesicular stomatitis virus and pseudorabies virus induce a vig1/cig5 homologue in mouse dendritic cells via different pathways. J Gen Virol. 2000;81:2675-82 pubmed
    The homologous genes vig1 and cig5 were identified by differential display PCR as virus-induced genes in rainbow trout and humans, respectively...
  10. Li Z, Yin H, Hao S, Wang L, Gao J, Tan X, et al. miR-200 family promotes podocyte differentiation through repression of RSAD2. Sci Rep. 2016;6:27105 pubmed publisher
    ..Moreover, further upregulation of RSAD2 combining with restraint of miR-200 family revealed a promotion of podocyte dedifferentiation and proliferation...
  11. Seo J, Cresswell P. Viperin regulates cellular lipid metabolism during human cytomegalovirus infection. PLoS Pathog. 2013;9:e1003497 pubmed publisher
    ..We show here that this increase is a consequence of the virus-induced redistribution of the host protein viperin to mitochondria and its capacity to interact with and block the function of the mitochondrial trifunctional ..