Gene Symbol: Cic
Description: capicua transcriptional repressor
Alias: 1200010B10Rik, mKIAA0306, protein capicua homolog, capicua homolog
Species: mouse
Products:     Cic

Top Publications

  1. Lim J, Crespo Barreto J, Jafar Nejad P, Bowman A, Richman R, Hill D, et al. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature. 2008;452:713-8 pubmed publisher
    ..This model provides mechanistic insight into the molecular pathogenesis of SCA1 as well as other polyglutamine diseases. ..
  2. Fryer J, Yu P, Kang H, Mandel Brehm C, Carter A, Crespo Barreto J, et al. Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua. Science. 2011;334:690-3 pubmed publisher
    ..Thus, exercise might have long-term beneficial effects in other ataxias and neurodegenerative diseases...
  3. Lam Y, Bowman A, Jafar Nejad P, Lim J, Richman R, Fryer J, et al. ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Cell. 2006;127:1335-47 pubmed
    ..These data provide insight into the function of ATXN1 and suggest that SCA1 neuropathology depends on native, not novel, protein interactions. ..
  4. Lee Y, Fryer J, Kang H, Crespo Barreto J, Bowman A, Gao Y, et al. ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev Cell. 2011;21:746-57 pubmed publisher
    ..that several Matrix metalloproteinase (Mmp) genes are overexpressed and that the transcriptional repressor Capicua (CIC) is destabilized in Atxn1L(-/-) lungs. Consistent with this, Cic deficiency causes lung alveolarization defect...
  5. Park S, Lee S, Lee C, Park G, Hong H, Lee J, et al. Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5. Nat Commun. 2017;8:16037 pubmed publisher
    ..Here we show the transcriptional repressor Capicua/CIC maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity...
  6. Lee C, Chan W, Cheung M, Cheng Y, Appleby V, Orme A, et al. CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons. Brain Res Mol Brain Res. 2002;106:151-6 pubmed
    We describe here the identification and characterization of a new gene, Cic, in both human and mouse genomes. These are orthologs of the Drosophila gene capicua, and represent a new subfamily of the HMG-box superfamily...
  7. Lee C, Chan W, Scotting P. CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas. J Neurooncol. 2005;73:101-8 pubmed
    ..We have recently identified a mammalian gene, capicua (Cic), the ortholog of a Drosophila gene implicated in c-erbB (Egfr) signaling, which is predominantly expressed during ..
  8. Crespo Barreto J, Fryer J, Shaw C, Orr H, Zoghbi H. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis. PLoS Genet. 2010;6:e1001021 pubmed publisher
    ..Altogether, these data provide evidence that partial loss of Atxn1 function contributes to SCA1 pathogenesis and raise the possibility that loss-of-function mechanisms contribute to other dominantly inherited neurodegenerative diseases. ..
  9. Kim E, Park S, Choi N, Lee J, Yoe J, Kim S, et al. Deficiency of Capicua disrupts bile acid homeostasis. Sci Rep. 2015;5:8272 pubmed publisher
    Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown...

More Information


  1. Simón Carrasco L, Grana O, Salmón M, Jacob H, Gutierrez A, Jiménez G, et al. Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev. 2017;31:1456-1468 pubmed publisher
    b>CIC (also known as Capicua) is a transcriptional repressor negatively regulated by RAS/MAPK signaling. Whereas the functions of Cic have been well characterized in Drosophila, little is known about its role in mammals...
  2. Yang R, Chen L, Hansen L, Carpenter A, Moure C, Liu H, et al. Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. Cancer Res. 2017;77:6097-6108 pubmed publisher
    Inactivating mutations in the transcriptional repression factor Capicua (CIC) occur in approximately 50% of human oligodendrogliomas, but mechanistic links to pathogenesis are unclear...
  3. Neutzsky Wulff A, Sims N, Supanchart C, Kornak U, Felsenberg D, Poulton I, et al. Severe developmental bone phenotype in ClC-7 deficient mice. Dev Biol. 2010;344:1001-10 pubmed publisher
    ..Bone formation paremeters were reduced; however, bone formation and mineralization were found to be heterogenous and continuing. ..
  4. Lasagna Reeves C, Rousseaux M, Guerrero Muñoz M, Park J, Jafar Nejad P, Richman R, et al. A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1. elife. 2015;4: pubmed publisher
    ..Identifying interactors that stabilize toxic oligomeric complexes could answer longstanding questions about the pathogenesis of other proteinopathies. ..
  5. Tan Q, Brunetti L, Rousseaux M, Lu H, Wan Y, Revelli J, et al. Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. Proc Natl Acad Sci U S A. 2018;115:E1511-E1519 pubmed publisher
    Capicua (CIC) regulates a transcriptional network downstream of the RAS/MAPK signaling cascade. In Drosophila, CIC is important for many developmental processes, including embryonic patterning and specification of wing veins...