Gene Symbol: Chst8
Description: carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
Alias: 1500011J21Rik, AI426009, carbohydrate sulfotransferase 8, GalNAc4ST-1, N-acetylgalactosamine-4-O-sulfotransferase 1, galNAc-4-O-sulfotransferase 1, galNAc-4-ST1
Wilson D, Phamluong K, Lin W, Barck K, Carano R, Diehl L, et al
. Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning. Dev Biol. 2012;363:413-25 pubmed publisher
..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1. ..
Okuda T, Sawada T, Nakano H, Matsubara K, Matsuda Y, Fukuta M, et al
. Mouse N-acetylgalactosamine 4-sulfotransferases-1 and -2. Molecular cloning, expression, chromosomal mapping and detection of their activity with GalNAcbeta1-4GlcNAcbeta1-octyl. J Biochem. 2003;134:111-20 pubmed
..By fluorescence in situ hybridization, the GalNAc4ST-1 and GalNAc4ST-2 genes were localized to mouse chromosome 7B3 distal-B5 proximal and chromosome 18A2 distal-B1 proximal, respectively. ..
Boregowda R, Mi Y, Bu H, Baenziger J. Differential expression and enzymatic properties of GalNAc-4-sulfotransferase-1 and GalNAc-4-sulfotransferase-2. Glycobiology. 2005;15:1349-58 pubmed
..Genetic ablation of both GalNAc-4-ST1 and GalNAc-4-ST2 may be necessary to alter the pattern and/or extent of sulfate addition to terminal beta1,4GalNAc in tissues such as pituitary. ..
Mi Y, Fiete D, Baenziger J. Ablation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in mice. J Clin Invest. 2008;118:1815-24 pubmed publisher
..Thus, sulfate modification of the terminal glycosylation of LH plays a central role in regulating the hypothalamic-pituitary-gonad axis in vivo. ..
Chotalia M, Smallwood S, Ruf N, Dawson C, Lucifero D, Frontera M, et al
. Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev. 2009;23:105-17 pubmed publisher
Xia G, Evers M, Kang H, Schachner M, Baenziger J. Molecular cloning and expression of the pituitary glycoprotein hormone N-acetylgalactosamine-4-O-sulfotransferase. J Biol Chem. 2000;275:38402-9 pubmed
..A single transcript of 2.4 kilobases is most highly expressed in the pituitary and other regions of the central nervous system. The GalNAc-4-ST1 gene is located on human chromosome 19q13.1. ..
Martin R, Chantepie S, Chapuis J, Le Duc A, Maftah A, Papy Garcia D, et al
. Variation in Chst8 gene expression level affects PrPC to PrPSc conversion efficiency in prion-infected Mov cells. Biochem Biophys Res Commun. 2011;414:587-91 pubmed publisher
..The present study was aimed to examine a possible link between PrP conversion efficiency and transcript level of Chst8 gene that encodes the carbohydrate N-acetylgalactosamine 4-O-sulfotransferase 8...
Molyneaux B, Goff L, Brettler A, Chen H, Hrvatin S, Rinn J, et al
. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 2015;85:275-288 pubmed publisher
..This multifaceted study generates a powerful resource and informs understanding of the transcriptional regulation underlying pyramidal neuron diversity in the neocortex. ..