Gene Symbol: Chst8
Description: carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
Alias: 1500011J21Rik, AI426009, carbohydrate sulfotransferase 8, GalNAc4ST-1, N-acetylgalactosamine-4-O-sulfotransferase 1, galNAc-4-O-sulfotransferase 1, galNAc-4-ST1
Species: mouse
Products:     Chst8

Top Publications

  1. Wilson D, Phamluong K, Lin W, Barck K, Carano R, Diehl L, et al. Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning. Dev Biol. 2012;363:413-25 pubmed publisher
    ..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1. ..
  2. Okuda T, Sawada T, Nakano H, Matsubara K, Matsuda Y, Fukuta M, et al. Mouse N-acetylgalactosamine 4-sulfotransferases-1 and -2. Molecular cloning, expression, chromosomal mapping and detection of their activity with GalNAcbeta1-4GlcNAcbeta1-octyl. J Biochem. 2003;134:111-20 pubmed
    ..By fluorescence in situ hybridization, the GalNAc4ST-1 and GalNAc4ST-2 genes were localized to mouse chromosome 7B3 distal-B5 proximal and chromosome 18A2 distal-B1 proximal, respectively. ..
  3. Boregowda R, Mi Y, Bu H, Baenziger J. Differential expression and enzymatic properties of GalNAc-4-sulfotransferase-1 and GalNAc-4-sulfotransferase-2. Glycobiology. 2005;15:1349-58 pubmed
    ..Genetic ablation of both GalNAc-4-ST1 and GalNAc-4-ST2 may be necessary to alter the pattern and/or extent of sulfate addition to terminal beta1,4GalNAc in tissues such as pituitary. ..
  4. Mi Y, Fiete D, Baenziger J. Ablation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in mice. J Clin Invest. 2008;118:1815-24 pubmed publisher
    ..Thus, sulfate modification of the terminal glycosylation of LH plays a central role in regulating the hypothalamic-pituitary-gonad axis in vivo. ..
  5. Chotalia M, Smallwood S, Ruf N, Dawson C, Lucifero D, Frontera M, et al. Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev. 2009;23:105-17 pubmed publisher
  6. Xia G, Evers M, Kang H, Schachner M, Baenziger J. Molecular cloning and expression of the pituitary glycoprotein hormone N-acetylgalactosamine-4-O-sulfotransferase. J Biol Chem. 2000;275:38402-9 pubmed
    ..A single transcript of 2.4 kilobases is most highly expressed in the pituitary and other regions of the central nervous system. The GalNAc-4-ST1 gene is located on human chromosome 19q13.1. ..
  7. Martin R, Chantepie S, Chapuis J, Le Duc A, Maftah A, Papy Garcia D, et al. Variation in Chst8 gene expression level affects PrPC to PrPSc conversion efficiency in prion-infected Mov cells. Biochem Biophys Res Commun. 2011;414:587-91 pubmed publisher
    ..The present study was aimed to examine a possible link between PrP conversion efficiency and transcript level of Chst8 gene that encodes the carbohydrate N-acetylgalactosamine 4-O-sulfotransferase 8...
  8. Molyneaux B, Goff L, Brettler A, Chen H, Hrvatin S, Rinn J, et al. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 2015;85:275-288 pubmed publisher
    ..This multifaceted study generates a powerful resource and informs understanding of the transcriptional regulation underlying pyramidal neuron diversity in the neocortex. ..