Chrna7

Summary

Gene Symbol: Chrna7
Description: cholinergic receptor, nicotinic, alpha polypeptide 7
Alias: Acra7, alpha7, acetylcholine receptor alpha 7 neural, alpha7 nicotinic receptor, alpha7-nAChR, neuronal acetylcholine receptor subunit alpha-7
Species: mouse

Top Publications

  1. ncbi Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries
    Vincent Laudenbach
    Laboratoire de Neurologie du Développement, INSERM E9935, Hopital Robert Debre, Paris, France
    FASEB J 16:423-5. 2002
  2. pmc Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
    George S Portugal
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 89:106-13. 2008
  3. ncbi Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory
    C Fernandes
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 5:433-40. 2006
  4. ncbi Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task
    Jason J Keller
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Behav Brain Res 162:143-52. 2005
  5. ncbi Tolerance to nicotine in mice lacking alpha7 nicotinic receptors
    C Naylor
    Section of Behavioural Pharmacology, Institute of Psychiatry P049, King s College London, London, SE5 8AF, UK
    Psychopharmacology (Berl) 180:558-63. 2005
  6. ncbi Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
  7. ncbi Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:22768-80. 2002
  8. pmc Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice
    R Paylor
    Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Learn Mem 5:302-16. 1998
  9. pmc Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis
    Geber Peña
    Laboratory of Immunity and Infection, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Eur J Immunol 40:2580-9. 2010
  10. pmc α7-cholinergic receptor mediates vagal induction of splenic norepinephrine
    Gergely Vida
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 186:4340-6. 2011

Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. ncbi Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries
    Vincent Laudenbach
    Laboratoire de Neurologie du Développement, INSERM E9935, Hopital Robert Debre, Paris, France
    FASEB J 16:423-5. 2002
    ..In contrast, activation of alpha7 nAChR, which is protective in adult animals, was deleterious in our neonatal model, whereas its blockade, either ..
  2. pmc Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
    George S Portugal
    Department of Psychology, Neuroscience Program, Weiss Hall, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Learn Mem 89:106-13. 2008
    ..In addition, nicotine withdrawal selectively affects acquisition but not recall or expression of the learned response...
  3. ncbi Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory
    C Fernandes
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Genes Brain Behav 5:433-40. 2006
    ..Consequently, we tested mice lacking the alpha7 subunit of the neural nicotinic receptor (B6.129S7-Chrna7(tm1Bay)/J) in the delayed matching-to-place (DMP) task of the Morris water maze, a measure of working/episodic ..
  4. ncbi Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task
    Jason J Keller
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Behav Brain Res 162:143-52. 2005
    ..These results support a role of the alpha7 nicotinic receptor in mediating appetitive learning and suggest a potential role for the alpha7 nAChRs in the regulation of ..
  5. ncbi Tolerance to nicotine in mice lacking alpha7 nicotinic receptors
    C Naylor
    Section of Behavioural Pharmacology, Institute of Psychiatry P049, King s College London, London, SE5 8AF, UK
    Psychopharmacology (Berl) 180:558-63. 2005
    Previous studies have suggested that a knockout of the gene coding for alpha7 nicotinic receptor subunits influences the behaviour of undrugged mice but not the acute effect of nicotine on locomotor activity.
  6. ncbi Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Here we report that the nicotinic acetylcholine receptor alpha7 subunit is required for acetylcholine inhibition of macrophage TNF release...
  7. ncbi Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:22768-80. 2002
    ..These findings provide two robust and rapid assays for beta-amyloid-associated effects that can be performed on young animals: impaired contextual fear learning and up-regulation of alpha 7 nicotinic receptors...
  8. pmc Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice
    R Paylor
    Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Learn Mem 5:302-16. 1998
    ..There is also evidence for an association between levels of alpha7 nAChR and in sensorimotor gating impairments...
  9. pmc Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis
    Geber Peña
    Laboratory of Immunity and Infection, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Eur J Immunol 40:2580-9. 2010
    ..Stattic also prevented the production of late mediators of sepsis and improved survival in established sepsis. These results reveal the immunological implications of tyrosine-unphosphorylated STAT3 in infectious diseases...
  10. pmc α7-cholinergic receptor mediates vagal induction of splenic norepinephrine
    Gergely Vida
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 186:4340-6. 2011
    ..7nAChR represents a unique molecular link between the parasympathetic and sympathetic system to control inflammation...
  11. doi Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention
    Karine Guillem
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research CNCR, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, Netherlands
    Science 333:888-91. 2011
    ..Our findings show that β2-subunit expression in the PrL PFC is sufficient for endogenous nAChR-mediated cholinergic regulation of attentional performance...
  12. ncbi Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents
    A Orr-Urtreger
    Department of Molecular and Human Genetics, Houston, Texas 77030, USA
    J Neurosci 17:9165-71. 1997
    The alpha7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is abundantly expressed in hippocampus and is implicated in modulating neurotransmitter release and in binding alpha-bungarotoxin (alpha-BGT)...
  13. doi Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus
    Mateo Vélez-Fort
    INSERM, U603, Paris, France
    Glia 57:1104-14. 2009
    ....
  14. pmc Trace eyeblink conditioning is impaired in α7 but not in β2 nicotinic acetylcholine receptor knockout mice
    Kevin L Brown
    Neuroscience Program and Department of Psychology, Temple University Philadelphia, PA, USA
    Front Behav Neurosci 4:166. 2010
    ..The prominent distribution of α7 nAChRs in the hippocampus and other forebrain regions may account for these genotype-specific acquisition effects in this hippocampus-dependent trace paradigm...
  15. doi Activation of nicotinic α(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1ΔE9 mice
    Andreas Söderman
    Department of Anatomy, University of Aarhus, Wilhelm Meyers Alle, 8000 Arhus C, Denmark
    Neurosci Lett 487:325-9. 2011
    ..These findings indicate that the α(7) nAChR is functionally blocked in the hippocampal neurons, downstream of the α(7) nAChR, and that this is likely due to an interaction between the receptor and Aβ, which leads to changes in LTP...
  16. doi Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro
    Da Wei Wang
    Emergency Department, General Hospital of Beijing Military Area Command, Beijing, People s Republic of China
    J Pharmacol Exp Ther 335:553-61. 2010
    ..7 nAChR seems to be a critical regulator for immunosuppressive function of CD4(+)CD25(+) Tregs...
  17. pmc Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA Medical Center, USA
    J Neuroinflammation 7:38. 2010
    ..Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor (nAChR) alpha7.
  18. doi Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice
    Nicola Origlia
    Neuroscience Institute National Council of Research CNR, Pisa, Italy
    Invest Ophthalmol Vis Sci 53:1211-8. 2012
    ..The impact of α7 homomeric nAChRs on visual function was investigated using mutant mice lacking the α7 nicotinic receptor subunit...
  19. doi Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis
    Valentin Galitovskiy
    Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USA
    J Immunol 187:2677-87. 2011
    ..These findings help explain the dichotomous effect of smoking in patients with UC and CD, and they underscore the potential for nicotinergic drugs in regulating colonic inflammation...
  20. pmc Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure
    Scott W Rogers
    Salt Lake City VA Geriatric Research, Education and Clinical Center, Salt Lake City, Utah, USA
    Am J Med Genet A 158:1135-44. 2012
    ..Here, we provide the first genetic delineation of cholinergic nicotinic receptor alpha7 (Chrna7) expression and link the ablation of the Chrna7 cell lineage to this condition in the mouse...
  21. doi Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice
    J W Young
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    Genes Brain Behav 10:720-33. 2011
    ....
  22. pmc Up-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder
    Leomar Y Ballester
    Department of Biology, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico
    J Biol Chem 287:3079-86. 2012
    ..In summary, CXCR4 activation induces up-regulation of α7-nAChR, causing cell death, suggesting that α7-nAChR is a previously unrecognized contributor to the neurotoxicity associated with HIV infection...
  23. pmc Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy
    Scott W Rogers
    Geriatric Research, Education and Clinical Center, Veteran s Administration, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e36467. 2012
    The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green ..
  24. doi Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, San Diego, California, USA
    Am J Pathol 181:478-86. 2012
    ....
  25. pmc Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation
    Amber V Osborne-Hereford
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, United States
    J Neuroimmunol 193:130-9. 2008
    The anti-inflammatory effects of the neuronal nicotinic receptor alpha7 (nAChRalpha7) are proposed to require acetylcholine release from vagal efferents...
  26. doi α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice
    M Hijioka
    Department of Chemico Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Chuo Ku, Kumamoto 862 0973, Japan
    Neuroscience 222:10-9. 2012
    ..These results suggest that α7 nAChR agonist can provide neuroprotective effect on ICH-induced injury, independently of its anti-inflammatory actions...
  27. pmc Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors
    Adrian F Lozada
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0357, USA
    J Neurosci 32:7651-61. 2012
    ..This ratio represents a fundamental feature of neural networks and shows for the first time that endogenous nicotinic cholinergic signaling plays a key role in network construction...
  28. ncbi Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures
    Davide Franceschini
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Brain Res Mol Brain Res 98:29-40. 2002
    ..nicotinic acetylcholine receptors (nAChRs) represent the major binding site for alpha-BTX, mice lacking the alpha7 nAChR subunit were predicted to be less sensitive to the convulsive effects of nicotine...
  29. pmc Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors
    Greg J Norman
    Department of Psychology, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 31:3446-52. 2011
    ..Furthermore, we provide evidence that pharmacological activation of α7 nicotinic acetylcholine receptors provide significant protection against ischemia-related cell death and inflammation within a clinically relevant time frame...
  30. ncbi Nicotinic acetylcholine receptors alpha4beta2 and alpha7 regulate myelo- and erythropoiesis within the bone marrow
    Lyudmyla M Koval
    Palladin Institute of Biochemistry, 9 Leontovicha Str, 10601 Kyiv, Ukraine
    Int J Biochem Cell Biol 40:980-90. 2008
    ..The presence of nicotinic receptors containing alpha4(beta2) and alpha7 subunits in the bone marrow cells of C57Bl/6 mice was shown by the binding of [125I]-alpha-bungarotoxin or [3H]-..
  31. doi Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia
    Najla Taslim
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Behav Brain Res 217:282-92. 2011
    ..Our results support a role for α(4)β(2) and α(7) nAChR subtypes in the development of cross-tolerance between nicotine and ethanol with the NO signaling pathway as a potential mechanism...
  32. doi Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis
    Ilona A J Giebelen
    Center for Infection and Immunity Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 198:750-7. 2008
    The efferent vagus nerve can inhibit inflammation via interaction between acetylcholine and alpha7 cholinergic receptors.
  33. doi Macrophages from alpha 7 nicotinic acetylcholine receptor knockout mice demonstrate increased cholesterol accumulation and decreased cellular paraoxonase expression: a possible link between the nervous system and atherosclerosis development
    Kenneth R Wilund
    Department of Kinesiology and Community Health, University of Illinois, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 390:148-54. 2009
    ..Mice deficient in the alpha 7 nicotinic acetylcholine receptor (alpha7(-/-)) have an impaired CAIR due to decreased signaling through this pathway...
  34. pmc α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex
    Peder S Olofsson
    The Feinstein Institute for Medical Research, Laboratory of Biomedical Science, Manhasset, New York 11030, USA
    Mol Med 18:539-43. 2012
    ..Together, these results indicate that α7nAChR expression in bone marrow-derived non-T cells is required for the integrity of the inflammatory reflex...
  35. doi Dynamic alterations of gene expression of nicotinic acetylcholine receptor α7, α4 and β2 subunits in an acute MPTP-lesioned mouse model
    Jun Hu
    Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Guang Zhou Road 300, Nanjing 210029, China
    Neurosci Lett 494:232-6. 2011
    ..These data suggest that therapeutic strategies targeted toward nAChR α7, α4 and β2 subunits may have potential for developing new treatments for PD...
  36. ncbi The role of nicotinic acetylcholine receptors in lymphocyte development
    Marina Skok
    Department of Molecular Immunology, Palladin Institute of Biochemistry, 01601 Kiev, Ukraine
    J Neuroimmunol 171:86-98. 2006
    ..In chimera mice, either beta2 or alpha7 subunits influenced lymphocyte populations in primary lymphoid organs, while in the spleen, only alpha7 receptors ..
  37. pmc Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expression
    Jennifer L Hellier
    Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Brain Res 1358:140-50. 2010
    ..These data suggest that α7-nicotinic-receptors contribute strongly to olfactory discrimination and detection in mice and may be one of the mechanisms producing olfactory dysfunction in schizophrenics...
  38. pmc Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease
    Gustavo Dziewczapolski
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 29:8805-15. 2009
    ..recently shown that the Alzheimer's disease (AD) pathogenic peptide amyloid beta(1-42) (Abeta(1-42)) binds to the alpha7 nicotinic acetylcholine receptor (alpha7nAChR) with high affinity and the alpha7nAChR and Abeta(1-42) are both ..
  39. pmc Presynaptic type III neuregulin1-ErbB signaling targets {alpha}7 nicotinic acetylcholine receptors to axons
    Melissa L Hancock
    Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University, New York, NY 10032, USA
    J Cell Biol 181:511-21. 2008
    ..We demonstrate that Type III Nrg1 back signaling regulates the surface expression of alpha7 nAChRs along axons of sensory neurons...
  40. pmc {alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation
    Kamel Maouche
    INSERM UMRS, Universite de Reims Champagne Ardenne, Reims, France
    Am J Pathol 175:1868-82. 2009
    ..Here, we have investigated the potential role of the alpha7 nAChR in the regulation of airway epithelial basal cell proliferation and the differentiation of the human airway ..
  41. ncbi Altered baroreflex responses in alpha7 deficient mice
    D Franceschini
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 113:3-10. 2000
    ..To investigate the role of the alpha7 nAChR subunit in cardiac autonomic function, we measured baroreflex-mediated responses in alpha7 null mice...
  42. ncbi NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor
    Leonard Moise
    Department of Molecular Pharmacology, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 277:12406-17. 2002
    ..alpha-bungarotoxin and a recombinantly expressed 19-mer peptide ((178)IPGKRTESFYECCKEPYPD(196)) derived from the alpha7 subunit of the chick neuronal nicotinic acetylcholine receptor...
  43. ncbi Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus
    Manickavasagon Alkondon
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 24:4635-48. 2004
    It has been postulated that endogenous kynurenic acid (KYNA) modulates alpha7* nicotinic acetylcholine receptor (nAChR) and NMDA receptor activities in the brain...
  44. pmc Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
    Xiao Su
    Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Am J Respir Cell Mol Biol 37:186-92. 2007
    ..In these studies, we tested the potential role of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) in a rodent model of acid-induced acute lung injury...
  45. ncbi Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth
    A Orr-Urtreger
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurochem 74:2154-66. 2000
    ..A threonine for leucine 247 substitution in the channel domain of the chick alpha7 nAChR increases agonist affinity and decreases the rate of desensitization, creating a "gain of function" model for ..
  46. ncbi Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor
    Jared W Young
    Fujisawa Institute of Neuroscience, Division of Neuroscience, University of Edinburgh, Edinburgh, UK
    Neuropsychopharmacology 29:891-900. 2004
    ..which nicotinic acetylcholine receptor (nAChR) subtype(s) mediate this effect, we examined the performance of alpha7 nAChR knockout (KO) mice in the 5-CSR task...
  47. pmc Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium
    Juan Arredondo
    Department of Dermatology, UC Davis Medical Center, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
    J Cell Biol 159:325-36. 2002
    ..We found that keratinocyte alpha7 nAChR controls homeostasis and terminal differentiation of epidermal keratinocytes required for formation of the skin ..
  48. ncbi Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development
    Paul R Reynolds
    Department of Internal Medicine, Pulmonary Division, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    J Biol Chem 280:32548-54. 2005
    ..A model is also supported whereby alpha(7) is induced by the essential pulmonary transcription factor TTF-1 and suppressed by Egr-1 during pulmonary development...
  49. pmc Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons
    Jingming Zhang
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Physiol 579:753-63. 2007
    ..A major species of neuronal nAChRs contains the alpha7 gene product and has a high relative permeability to calcium...
  50. ncbi Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning
    J M Wehner
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309 0447, USA
    Neuroscience 129:11-24. 2004
    ..or co-administration of nicotine and ethanol were examined in wild type and homozygous null mutant mice from alpha7, beta2, beta3, and beta4 mouse lines at 24 h after training...
  51. ncbi Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis
    Juan Arredondo
    Department of Dermatology, University of California, Davis, 4860 Y Street, 3400, Sacramento, CA 95817, USA
    Life Sci 72:2063-7. 2003
    ..Herein, we report that cutaneous alpha7 nAChR plays a role in the physiological control of cutaneous homeostasis...
  52. ncbi Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice
    Jared W Young
    Astellas CNS Research in Edinburgh, The University of Edinburgh, The Chancellor s Building, 49 Little France Crescent, EH16 4SB, UK
    Eur Neuropsychopharmacol 17:145-55. 2007
    b>alpha7-Nicotinic acetylcholine receptors (alpha7-nAChR) have been implicated in a range of cognitive deficits in schizophrenia...
  53. ncbi Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes
    Alex I Chernyavsky
    Department of Dermatology, University of California Davis, 4860 Y Street, Sacramento, CA 95817, USA
    J Cell Sci 117:5665-79. 2004
    ..chemotaxis of keratinocytes was most pronounced towards the concentration gradient of choline, a potent agonist of alpha7 nicotinic acetylcholine receptor. The alpha7-preferring antagonist alpha-bungarotoxin significantly (P<0...
  54. ncbi Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes
    J A Stitzel
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA
    J Pharmacol Exp Ther 284:1104-11. 1998
    ..Levels of alpha-BTX binding did not correlate with nicotine-induced seizure sensitivity or overall nicotine sensitivity score in any of the four brain regions examined...
  55. ncbi A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant
    Barbara J Morley
    Boys Town National Research Hospital, 555 North 30th St, Omaha, NE 68131, USA
    Brain Res 1023:41-7. 2004
    ..On a molecular level, the alpha7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes...
  56. ncbi The role of nicotinic receptor alpha 7 subunits in nicotine discrimination
    I P Stolerman
    Section of Behavioural Pharmacology, Institute of Psychiatry P049, King s College London, De Crespigny Park, London SE5 8AF, UK
    Neuropharmacology 46:363-71. 2004
    ..The experiments described here use mice lacking the alpha7 subunit of nicotinic receptors to investigate the role of alpha7-containing receptors in nicotine discrimination...
  57. pmc Mitochondria express α7 nicotinic acetylcholine receptors to regulate Ca2+ accumulation and cytochrome c release: study on isolated mitochondria
    Galyna Gergalova
    Department of Molecular Immunology, Palladin Institute of Biochemistry, Kyiv, Ukraine
    PLoS ONE 7:e31361. 2012
    ..It is concluded that α7 nAChRs are expressed in mitochondria outer membrane to regulate the VDAC-mediated Ca(2+) transport and mitochondrial permeability transition...
  58. ncbi Mapping of putative ether-anesthesia resistance gene using C57BL/6J and MSM/Ms mouse strains
    Tsuneo Megumi
    Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai, Japan
    J Anesth 18:267-76. 2004
    ..We attempted to identify the locations of major mouse genes responsible for sensitivity to diethylether (ether) anesthesia, using microsatellite linkage analyses including Quantitative Trait Locus (QTL) analysis...
  59. doi Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes
    Simon Sydserff
    Neuroscience Department, AstraZeneca Pharmaceuticals LP, FRC B1129B, Wilmington, DE 19850, USA
    Biochem Pharmacol 78:880-8. 2009
    AZD0328, a novel spirofuropyridine neuronal nicotinic receptor partial agonist, was used to investigate the role of alpha7 neuronal nicotinic receptor (NNR) activation in the modulation of midbrain dopamine neuron function, cortical ..
  60. ncbi Functional nicotinic acetylcholine receptor expression on stem and progenitor cells of the early embryonic nervous system
    A S Schneider
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Ann N Y Acad Sci 971:135-8. 2002
    ..We now report the first evidence of functional nicotinic ACh receptors on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10...
  61. pmc Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses
    Yi Fan Li
    Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069, USA
    Neurosci Lett 462:20-3. 2009
    ..These data suggest that specific subtypes of nicotinic receptors at the level of the ganglia may play distinct roles in mediating sympathetic or parasympathetic activation...
  62. ncbi Developmental changes in nicotinic receptor mRNAs and responses to nicotine in the suprachiasmatic nucleus and other brain regions
    B F O'Hara
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Brain Res Mol Brain Res 66:71-82. 1999
    ..b>alpha7 mRNA increases substantially while beta2 mRNA is relatively abundant throughout development...
  63. pmc Role of key aromatic residues in the ligand-binding domain of alpha7 nicotinic receptors in the agonist action of beta-amyloid
    Mei Tong
    Department of Cell and Molecular Biology, University of Hawai i at Manoa, Honolulu, HI 96813, USA
    J Biol Chem 286:34373-81. 2011
    ..Together, these results directly demonstrate an essential role for the aromatic residue Tyr-188 as a key component in the agonist binding domain for the activation of α7-nAChRs by Aβ...
  64. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ..Vagus nerve stimulation inhibits proinflammatory cytokine production by signaling through the alpha7 nicotinic acetylcholine receptor subunit...
  65. ncbi Identification of an alternatively processed nicotinic receptor alpha7 subunit RNA in mouse brain
    Philip A Saragoza
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109 0930, USA
    Brain Res Mol Brain Res 117:15-26. 2003
    ..and characterization of a previously unidentified alternatively processed RNA for the neuronal nicotinic receptor alpha7 subunit...
  66. pmc Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells
    Ingrid U Schraufstatter
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    J Stem Cells 4:203-15. 2009
    ..These findings reveal an involvement of the non-neural cholinergic system in regulation of hMSC migration...
  67. pmc TTF-1 regulates α5 nicotinic acetylcholine receptor (nAChR) subunits in proximal and distal lung epithelium
    Paul R Reynolds
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Respir Res 11:175. 2010
    ..5 is a structural subunit detected in many non-neuronal tissues; however, its function during pulmonary development is unknown...
  68. doi Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice
    Paulo Emilio Correa Leite
    Laboratorio de Patologia Celular, Instituto de Biologia, Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil
    J Neuroimmunol 227:44-51. 2010
    ..Our data indicate that nAChR activation influences local inflammatory responses in the muscular lesion of mdx mice...
  69. ncbi Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado at Boulder, 447 UCB, Boulder, CO 80309, USA
    Alcohol Clin Exp Res 29:295-302. 2005
    ..indicate that physiologically relevant concentrations of ethanol inhibit the functional activation of homomeric alpha7 nAChRs, which are one of the most abundant nAChR subtypes expressed in the mammalian brain...
  70. pmc Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease
    Caterina M Hernandez
    Department of Neurology, Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Neurosci 30:2442-53. 2010
    ..We tested the role that alpha7 nAChRs perform in the etiology of early AD by genetically deleting the alpha7 nAChR subunit from the Tg2576 mouse model for AD and assessing animals for cognitive function and septohippocampal ..
  71. doi Influenza virus infection aggravates stroke outcome
    Sajjad Muhammad
    Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Stroke 42:783-91. 2011
    ..Stroke is triggered by several risk factors, including influenza and other respiratory tract infections. However, it is unknown how and in which way influenza infection affects stroke outcome...
  72. doi Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension
    Dong Jie Li
    Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
    Hypertension 57:298-307. 2011
    ..This pathway may provide a new target for preventing cardiovascular disease resulting from hypertension...
  73. doi Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro
    M Mousavi
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    Neurochem Int 54:237-44. 2009
    ..and at the same time lowered Abeta levels in both SH-SY5Y and SH-SY5Y/APPsw cells expressing alpha3 and alpha7 nAChR subtypes...
  74. ncbi Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1
    Ines Ibanez-Tallon
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, New York, NY 10021, USA
    Neuron 33:893-903. 2002
    ....
  75. ncbi Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice
    Yoshihito X Fujii
    Department of Pharmacology, Kyoritsu College of Pharmacy, Minato ku, Tokyo 105 8512, Japan
    J Neuroimmunol 189:69-74. 2007
    ..that immune cell function is regulated by its own non-neuronal cholinergic system, at least in part, via alpha7 nAChR-mediated pathways...
  76. ncbi The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice
    K Ren
    Department of Pharmaceutics, 1600 Southwest Archer Drive, Box 100494, University of Florida, Gainesville, FL 32610, USA
    Neuroscience 148:230-7. 2007
    ..Hippocampal amyloid deposition was not affected by FFX lesions or treatment with this alpha7 nicotinic receptor agonist in APP/PS1 mice under these conditions...
  77. pmc Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice
    Corentin Le Magueresse
    Neurobiology Department, International School for Advanced Studies, Via Beirut 2 4, 34014 Trieste, Italy
    J Physiol 576:533-46. 2006
    ..Here, the patch-clamp technique was used to assess the contribution of alpha7 and beta2-containing (alpha7* and beta2*) nAChRs to nicotine-elicited modulation of GABAergic and glutamatergic ..
  78. ncbi Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms
    S Fitter
    The Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Post Office Box 14, Rundle Mall, Adelaide, South Australia 5000, Australia
    Biochim Biophys Acta 1398:75-85. 1998
    ..Cd151 maps to chromosome 7, in close linkage to the p gene (OCA2 in humans), and helps define a boundary in the human/mouse homology relationships...
  79. ncbi Development of hippocampal alpha7 nicotinic receptors in C3H and DBA/2 congenic mice
    Catherine E Adams
    Department of Psychiatry, Veterans Affairs Medical Center, Denver, CO 80220, and University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Brain Res 1122:27-35. 2006
    ..these developmental differences occur solely as a result of the different alleles of the alpha7 receptor gene (Chrna7) expressed by the two strains or whether strain-specific background factors also play a role...
  80. ncbi alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation
    K Ren
    Department of Pharmaceutics, Box 100494, University of Florida, Gainesville, FL 32610, USA
    Neuroscience 145:314-22. 2007
    Brain alpha7 nicotinic receptors have become therapeutic targets for Alzheimer's disease (AD) based on their memory-enhancing and neuroprotective actions...
  81. doi beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts
    Ghous M Khan
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Eur J Neurosci 31:788-96. 2010
    ..However, conflicting data exist as to the nature of the Abeta-alpha7 nAChR interaction, and whether it is the result of specific binding...
  82. pmc beta2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice
    Jennifer A Davis
    Department of Psychology, Weiss Hall, Temple University, Philadelphia, PA, 19122, USA
    Psychopharmacology (Berl) 190:343-52. 2007
    ..Similarly, genetic deletion of the beta2 nAChR subunit but not the alpha7 nAChR subunit blocked the enhancing effect of nicotine on contextual fear conditioning.
  83. ncbi Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity
    Khosrow Rezvani
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:10508-19. 2007
    ..In particular, a 24 h exposure to nicotine decreased proteasome-dependent degradation of the alpha7 nicotinic acetylcholine receptor (nAChR) subunit, as indicated by the accumulation of ubiquitinated alpha7...
  84. ncbi Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3
    Rosa Andres
    Life Sciences Building, School of Biosciences, Museum Avenue, Cardiff CF10 3US, Wales, United Kingdom
    Neurosci Lett 431:241-6. 2008
    ....
  85. ncbi The pathophysiology of traumatic brain injury in alpha7 nicotinic cholinergic receptor knockout mice
    Matthew L Kelso
    College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Brain Res 1083:204-10. 2006
    The alpha7 nicotinic cholinergic receptor is a ligand-gated ion channel with calcium permeability similar to that of ionotrophic glutamate receptors...
  86. pmc Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice
    C E Adams
    Medical Research, Veterans Affairs Medical Center, Denver, CO 80220, USA
    Brain Res 1194:138-45. 2008
    The alpha7 subtype of nicotinic receptor is highly expressed in the hippocampus where it is purported to modulate release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)...
  87. pmc PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity
    Fiana Levitin
    Department of Cell Research and Immunology, Tel Aviv University, Ramat Aviv, 69978 Israel
    J Biol Chem 283:16928-39. 2008
    ..Taken together, our findings indicate that in addition to participation of the PATE (Pate)-like genes in functions related to fertility and reproduction, some of them likely act as important modulators of neural transmission...
  88. pmc Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo
    Corey M McCann
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Ave, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 11:807-15. 2008
    ..Therefore, neurotransmitter receptor dynamism associated with rapid changes in synaptic efficacy precedes long-lasting structural changes in synaptic connectivity...
  89. ncbi Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    Wouter J de Jonge
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Nat Immunol 6:844-51. 2005
    ..STAT3 was phosphorylated by the tyrosine kinase Jak2 that was recruited to the alpha7 subunit of the nicotinic acetylcholine receptor...
  90. ncbi Evolution of nicotinic acetylcholine receptor subunits
    K Tsunoyama
    Department of Genetics, Graduate University for Advanced Studies, Mishima, Japan
    Mol Biol Evol 15:518-27. 1998
    ..Thus, the window analysis of the f values is useful for evaluating the degree of functional constraints in not only the entire gene region, but also the within-gene subregion...
  91. ncbi Distribution of neuronal nicotinic acetylcholine receptor gene restriction fragment length polymorphisms in inbred and partially inbred mice
    U Nagavarapu
    Department of Pharmacology, Ohio State University College of Medicine, Columbus 43210, USA
    Pharmacogenetics 5:326-31. 1995
  92. pmc Long-term effects of chronic nicotine exposure on brain nicotinic receptors
    Morgane Besson
    Recepteurs et Cognition, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182, Unité de Neurobiologie Intégrative des Systémes Cholinergiques, Institut Pasteur, 75724 Paris, France
    Proc Natl Acad Sci U S A 104:8155-60. 2007
    ..b>alpha7*nAChRs...
  93. ncbi ST/b and DBA/2 mice differ in brain alpha-bungarotoxin binding and alpha 7 nicotinic receptor subunit mRNA levels: a quantitative autoradiographic analysis
    M J Marks
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Brain Res Mol Brain Res 39:207-22. 1996
    ..The alpha 7 mRNA levels were significantly correlated with alpha BTX binding in both mouse strains which suggests that the strain differences in binding are related, in part, to the levels of alpha 7 mRNA...
  94. ncbi Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse
    D G Drescher
    Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 112:267-73. 1995
    ..The presence of messages corresponding to the muscle-type beta 1 and neuronal-type nAChR subunits may be correlated with the atypical cholinergic response of cochlear hair cells to agonists and antagonists...
  95. ncbi Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus
    Yen Kuo
    Division of Neurobiology, Barrow Neurological Institute, 350 West Thomas Road, 85013, Phoenix, AZ, USA
    J Neuroimmunol 130:140-54. 2002
    ..Reported here are reverse transcription-polymerase chain reactions (RT-PCR) studies of nAChR alpha2-alpha7 and beta2-beta4 subunit gene expression using fetal or neonatal regular or scid/scid C57BL/6 mouse thymus...
  96. ncbi Linkage of strain-specific nicotinic receptor alpha 7 subunit restriction fragment length polymorphisms with levels of alpha-bungarotoxin binding in brain
    J A Stitzel
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Brain Res Mol Brain Res 43:30-40. 1996
    ..A significant association between genotype and receptor levels was observed in both, the F2 and backcross generations. These results indicate that alpha 7 genotype is an important determinant of alpha-bungarotoxin receptor levels...
  97. ncbi The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice
    R L Rabenstein
    Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 189:395-401. 2006
    ..We therefore examined the effect of decreasing nicotinic acetylcholine receptor (nAChR) activity in tests of antidepressant efficacy using C57BL/6J mice...
  98. ncbi Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice
    J Egea
    Instituto Teófilo Hernando and Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo, 4, 28029 Madrid, Spain
    Neuroscience 145:866-72. 2007
    Although alpha7-receptors are considered the main target for neuroprotection, other receptor subtypes (alpha4beta2 or alpha3beta4) have also been implicated...
  99. ncbi Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice
    W F Yu
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Neuroscience 146:1618-28. 2007
    ..The alpha7 nicotinic receptors which have high Ca2+ permeability are important for cognitive, neuroprotective and trophic ..
  100. ncbi Evidence that alpha7 nicotinic receptor modulates glutamate release from mouse neocortical gliosomes
    Laura Patti
    Sezione di Farmacologia e Tossicologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Viale Cembrano 4, 16148 Genoa, Italy
    Neurochem Int 51:1-7. 2007
    ..The present results indicate that alpha7 nicotinic receptors exist on mouse cortical glial particles and stimulate glutamate release.
  101. ncbi Naturally occurring genetic variability in the nicotinic acetylcholine receptor alpha4 and alpha7 subunit genes and phenotypic diversity in humans and mice
    Jerry A Stitzel
    Institute for Behavioral Genetics and Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80303, USA
    Front Biosci 13:477-91. 2008
    ..review, current evidence for the role of variability in the genes that encode the two major brain-expressed alpha subunits, alpha4 and alpha7, in modulating behavior, physiology and disease risk in both humans and mice will be discussed.

Research Grants78

  1. COMPREHENSIVE DATABASE OF DRUG DISCRIMINATION RESEARCH
    Ian Stolerman; Fiscal Year: 1993
    ..The present database covers the years 1951-1991 and it con- tains about 1600 citations; it is estimated this will be increased to about 2100 in the next three years...
  2. COMPREHENSIVE DATABASE OF DRUG DISCRIMINATION RESEARCH
    Ian Stolerman; Fiscal Year: 2001
    ..The database now covers year 1951-1997 (2,585 citations); it is estimated this will increase to over 3,000 in the next three years. ..
  3. CNS DISEASE AND AUTOIMMUNITY TO GLUTAMATE RECEPTORS
    Scott Rogers; Fiscal Year: 2001
    ..The relevance of these findings will be tested by measuring the neurotoxic effect of GluR autoantibodies on cultured cells that express GluRs of defined subunit composition. ..
  4. Mechanisms of TNFa Enhancement of Nicotinic Receptor Upregulation
    LORISE GAHRING; Fiscal Year: 2009
    ..Understanding how the inflammatory system and response to nicotine interact will impact upon how we approach these problems with therapeutic agents. ..
  5. Peripheral Nicotinic Cholinergic and Inflammatory Dysfunction in Aging
    LORISE GAHRING; Fiscal Year: 2009
    ..Further, we will determine if changes in nAChR expression shape the progression of normal aging of the skin through altering the important balance between normal and excessive inflammation. ..
  6. Peripheral Nicotinic Cholinergic and Inflammatory Dysfunction in Aging
    Lorise C Gahring; Fiscal Year: 2010
    ..Further, we will determine if changes in nAChR expression shape the progression of normal aging of the skin through altering the important balance between normal and excessive inflammation. ..
  7. Nicotine Receptors and COX2 in the Aging Brain
    Scott Rogers; Fiscal Year: 2007
    ....
  8. Cholinergic Modulation of Inflammatory CNS Cytokines
    LORISE GAHRING; Fiscal Year: 2006
    ..abstract_text> ..
  9. Cholinergic Modulation of Inflammatory CNS Cytokines
    LORISE GAHRING; Fiscal Year: 2003
    ....
  10. Nicotine Modulation of Caspases in Non-Neuronal Cells
    LORISE GAHRING; Fiscal Year: 2006
    ....
  11. CNS Disease and Autoimmunity of Glutamate Receptors
    Scott Rogers; Fiscal Year: 2005
    ..abstract_text> ..
  12. Nicotinic Receptors and COX2 in the Aging Brain
    Scott Rogers; Fiscal Year: 2003
    ..many cellular functions including the ability to respond to inflammatory agents, we will ask in Specific Aim 3 using microarray chip analysis; Do these treatments contribute to maintaining normal transcriptional responses by the brain? ..
  13. Nicotine Receptors and COX2 in the Aging Brain
    SCOTT WARREN ROGERS; Fiscal Year: 2010
    ....
  14. Peripheral Nicotinic Cholinergic and Inflammatory Dysfunction in Aging
    LORISE GAHRING; Fiscal Year: 2009
    ..Further, we will determine if changes in nAChR expression shape the progression of normal aging of the skin through altering the important balance between normal and excessive inflammation. ..
  15. Mechanisms of TNFa Enhancement of Nicotinic Receptor Upregulation
    SCOTT WARREN ROGERS; Fiscal Year: 2010
    ..Understanding how the inflammatory system and response to nicotine interact will impact upon how we approach these problems with therapeutic agents. ..
  16. TRANSIENT EXPRESSION OF CHOLINERGIC MARKERS IN THE PVCN
    Barbara J Morley; Fiscal Year: 2010
    ..abstract_text> ..
  17. SPERM GLYCINE RECEPTORS AND ZONA-INITIATED EXOCYTOSIS
    Stanley Meizel; Fiscal Year: 2006
    ..abstract_text> ..
  18. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  19. COMPREHENSIVE DATABASE OF DRUG DISCRIMINATION RESEARCH
    Ian Stolerman; Fiscal Year: 2006
    ..The database now covers years 1951-2000 (3,314 citations); from the recent rate of growth, it is estimated this will increase to over 4,300 in the next five years. ..
  20. TRANSIENT EXPRESSION OF CHOLINERGIC MARKERS IN THE PVCN
    BARBARA MORLEY; Fiscal Year: 2007
    ....
  21. TRANSIENT EXPRESSION OF CHOLINERGIC MARKERS IN THE PVCN
    BARBARA MORLEY; Fiscal Year: 2009
    ..abstract_text> ..
  22. Circadian Variations in Nicotine Sensitivity in Mice
    Jerry Stitzel; Fiscal Year: 2007
    ..This knowledge would be extremely useful for the development of better methods to treat nicotine addiction. ..
  23. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2007
    ....
  24. Comprehensive database of drug discrimination and self-administration research
    Ian Stolerman; Fiscal Year: 2007
    ....
  25. SPERM GLYCINE RECEPTOR AND ZONA-INITIATED EXOCYTOSIS
    Stanley Meizel; Fiscal Year: 2000
    ..In Aim 5, the P.I. will solubilze boar sperm membranes and isolate the receptor by affinity chromatography. Biochemical characterization of the isolated receptor will be performed. ..
  26. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....
  27. Identification of Functional nAChR Variants in Mice
    Jerry Stitzel; Fiscal Year: 2005
    ..that express functionally distinct isoforms of the neuronal nicotinic receptor subunits alpha3, alpha4, alpha6, alpha7, and beta2...
  28. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  29. NICOTINIC RECEPTORS IN CEREBRAL CORTICAL DEVELOPMENT
    ALLAN SCHNEIDER; Fiscal Year: 2002
    ..The results of this project will lay the groundwork for further exploration of the role of nicotinic receptors in normal development and that of nicotine as a neuroteratogen. ..