Chrna7

Summary

Gene Symbol: Chrna7
Description: cholinergic receptor, nicotinic, alpha polypeptide 7
Alias: Acra7, alpha7, nAchR, neuronal acetylcholine receptor subunit alpha-7, acetylcholine receptor alpha 7 neural, alpha7 nicotinic receptor, alpha7-nAChR
Species: mouse
Products:     Chrna7

Top Publications

  1. Fernandes C, Hoyle E, Dempster E, Schalkwyk L, Collier D. Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav. 2006;5:433-40 pubmed
    ..and animal studies suggest a role for the neural nicotinic acid receptor family in cognition and specifically the alpha7-receptor subunit in schizophrenia and its endophenotypes...
  2. Laudenbach V, Medja F, Zoli M, Rossi F, Evrard P, Changeux J, et al. Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries. FASEB J. 2002;16:423-5 pubmed
    ..In contrast, activation of alpha7 nAChR, which is protective in adult animals, was deleterious in our neonatal model, whereas its blockade, either ..
  3. Chernyavsky A, Arredondo J, Marubio L, Grando S. Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes. J Cell Sci. 2004;117:5665-79 pubmed
    ..chemotaxis of keratinocytes was most pronounced towards the concentration gradient of choline, a potent agonist of alpha7 nicotinic acetylcholine receptor. The alpha7-preferring antagonist alpha-bungarotoxin significantly (P<0...
  4. Naylor C, Quarta D, Fernandes C, Stolerman I. Tolerance to nicotine in mice lacking alpha7 nicotinic receptors. Psychopharmacology (Berl). 2005;180:558-63 pubmed
    Previous studies have suggested that a knockout of the gene coding for alpha7 nicotinic receptor subunits influences the behaviour of undrugged mice but not the acute effect of nicotine on locomotor activity...
  5. Keller J, Keller A, Bowers B, Wehner J. Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task. Behav Brain Res. 2005;162:143-52 pubmed
    ..These results support a role of the alpha7 nicotinic receptor in mediating appetitive learning and suggest a potential role for the alpha7 nAChRs in the regulation of ..
  6. Franceschini D, Orr Urtreger A, Yu W, Mackey L, Bond R, Armstrong D, et al. Altered baroreflex responses in alpha7 deficient mice. Behav Brain Res. 2000;113:3-10 pubmed
    ..To investigate the role of the alpha7 nAChR subunit in cardiac autonomic function, we measured baroreflex-mediated responses in alpha7 null mice...
  7. Koval L, Zverkova A, Grailhe R, Utkin Y, Tsetlin V, Komisarenko S, et al. Nicotinic acetylcholine receptors alpha4beta2 and alpha7 regulate myelo- and erythropoiesis within the bone marrow. Int J Biochem Cell Biol. 2008;40:980-90 pubmed
    ..The presence of nicotinic receptors containing alpha4(beta2) and alpha7 subunits in the bone marrow cells of C57Bl/6 mice was shown by the binding of [125I]-alpha-bungarotoxin or [3H]-..
  8. Hijioka M, Matsushita H, Ishibashi H, Hisatsune A, Isohama Y, Katsuki H. ?7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice. Neuroscience. 2012;222:10-9 pubmed publisher
    ..Daily intraperitoneal injection of ?7 nAChR agonist PNU-282987 (3-10mg/kg) for 3 days, starting from 3h after induction of ICH, significantly increased the ..
  9. Nicolussi E, Huck S, Lassmann H, Bradl M. The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation. Neurobiol Dis. 2009;35:24-31 pubmed publisher
    Stimulation of the nicotinic alpha7 acetylcholine receptor (nAChRalpha7) by nicotine or acetylcholine initiates the cholinergic anti-inflammatory pathway, a mechanism for neural inhibition of inflammation...
  10. Orr Urtreger A, Broide R, Kasten M, Dang H, Dani J, Beaudet A, et al. Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth. J Neurochem. 2000;74:2154-66 pubmed
    ..A threonine for leucine 247 substitution in the channel domain of the chick alpha7 nAChR increases agonist affinity and decreases the rate of desensitization, creating a "gain of function" ..

Detail Information

Publications63

  1. Fernandes C, Hoyle E, Dempster E, Schalkwyk L, Collier D. Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav. 2006;5:433-40 pubmed
    ..and animal studies suggest a role for the neural nicotinic acid receptor family in cognition and specifically the alpha7-receptor subunit in schizophrenia and its endophenotypes...
  2. Laudenbach V, Medja F, Zoli M, Rossi F, Evrard P, Changeux J, et al. Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries. FASEB J. 2002;16:423-5 pubmed
    ..In contrast, activation of alpha7 nAChR, which is protective in adult animals, was deleterious in our neonatal model, whereas its blockade, either ..
  3. Chernyavsky A, Arredondo J, Marubio L, Grando S. Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes. J Cell Sci. 2004;117:5665-79 pubmed
    ..chemotaxis of keratinocytes was most pronounced towards the concentration gradient of choline, a potent agonist of alpha7 nicotinic acetylcholine receptor. The alpha7-preferring antagonist alpha-bungarotoxin significantly (P<0...
  4. Naylor C, Quarta D, Fernandes C, Stolerman I. Tolerance to nicotine in mice lacking alpha7 nicotinic receptors. Psychopharmacology (Berl). 2005;180:558-63 pubmed
    Previous studies have suggested that a knockout of the gene coding for alpha7 nicotinic receptor subunits influences the behaviour of undrugged mice but not the acute effect of nicotine on locomotor activity...
  5. Keller J, Keller A, Bowers B, Wehner J. Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task. Behav Brain Res. 2005;162:143-52 pubmed
    ..These results support a role of the alpha7 nicotinic receptor in mediating appetitive learning and suggest a potential role for the alpha7 nAChRs in the regulation of ..
  6. Franceschini D, Orr Urtreger A, Yu W, Mackey L, Bond R, Armstrong D, et al. Altered baroreflex responses in alpha7 deficient mice. Behav Brain Res. 2000;113:3-10 pubmed
    ..To investigate the role of the alpha7 nAChR subunit in cardiac autonomic function, we measured baroreflex-mediated responses in alpha7 null mice...
  7. Koval L, Zverkova A, Grailhe R, Utkin Y, Tsetlin V, Komisarenko S, et al. Nicotinic acetylcholine receptors alpha4beta2 and alpha7 regulate myelo- and erythropoiesis within the bone marrow. Int J Biochem Cell Biol. 2008;40:980-90 pubmed
    ..The presence of nicotinic receptors containing alpha4(beta2) and alpha7 subunits in the bone marrow cells of C57Bl/6 mice was shown by the binding of [125I]-alpha-bungarotoxin or [3H]-..
  8. Hijioka M, Matsushita H, Ishibashi H, Hisatsune A, Isohama Y, Katsuki H. ?7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice. Neuroscience. 2012;222:10-9 pubmed publisher
    ..Daily intraperitoneal injection of ?7 nAChR agonist PNU-282987 (3-10mg/kg) for 3 days, starting from 3h after induction of ICH, significantly increased the ..
  9. Nicolussi E, Huck S, Lassmann H, Bradl M. The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation. Neurobiol Dis. 2009;35:24-31 pubmed publisher
    Stimulation of the nicotinic alpha7 acetylcholine receptor (nAChRalpha7) by nicotine or acetylcholine initiates the cholinergic anti-inflammatory pathway, a mechanism for neural inhibition of inflammation...
  10. Orr Urtreger A, Broide R, Kasten M, Dang H, Dani J, Beaudet A, et al. Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth. J Neurochem. 2000;74:2154-66 pubmed
    ..A threonine for leucine 247 substitution in the channel domain of the chick alpha7 nAChR increases agonist affinity and decreases the rate of desensitization, creating a "gain of function" ..
  11. Sadis C, Teske G, Stokman G, Kubjak C, Claessen N, Moore F, et al. Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway. PLoS ONE. 2007;2:e469 pubmed
    ..This cholinergic anti-inflammatory pathway acts via the alpha7 nicotinic acetylcholine receptor (alpha7nAChR)...
  12. Guillem K, Bloem B, Poorthuis R, Loos M, Smit A, Maskos U, et al. Nicotinic acetylcholine receptor ?2 subunits in the medial prefrontal cortex control attention. Science. 2011;333:888-91 pubmed publisher
    ..Acetylcholine (ACh) levels in the brain diminish with aging, and nicotinic ACh receptor (nAChR) stimulation is known to enhance cognitive performance...
  13. Wehner J, Keller J, Keller A, Picciotto M, Paylor R, Booker T, et al. Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience. 2004;129:11-24 pubmed
    ..or co-administration of nicotine and ethanol were examined in wild type and homozygous null mutant mice from alpha7, beta2, beta3, and beta4 mouse lines at 24 h after training...
  14. Su X, Lee J, Matthay Z, Mednick G, Uchida T, Fang X, et al. Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol. 2007;37:186-92 pubmed
    ..In these studies, we tested the potential role of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) in a rodent model of acid-induced acute lung injury...
  15. Franceschini D, Paylor R, Broide R, Salas R, Bassetto L, Gotti C, et al. Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures. Brain Res Mol Brain Res. 2002;98:29-40 pubmed
    ..nicotinic acetylcholine receptors (nAChRs) represent the major binding site for alpha-BTX, mice lacking the alpha7 nAChR subunit were predicted to be less sensitive to the convulsive effects of nicotine...
  16. David R, Ciuraszkiewicz A, Simeone X, Orr Urtreger A, Papke R, McIntosh J, et al. Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur J Neurosci. 2010;31:978-93 pubmed publisher
    ..nAChRs in the mouse superior cervical ganglion (SCG), the function of distinct receptors (obtained by deletions of nAChR subunit genes) and mechanisms at the level of nAChRs that might compensate for the loss of subunits...
  17. Vida G, Peña G, Deitch E, Ulloa L. ?7-cholinergic receptor mediates vagal induction of splenic norepinephrine. J Immunol. 2011;186:4340-6 pubmed publisher
    ..7nAChR represents a unique molecular link between the parasympathetic and sympathetic system to control inflammation. ..
  18. Wang H, Yu M, Ochani M, Amella C, Tanovic M, Susarla S, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003;421:384-8 pubmed
    ..Here we report that the nicotinic acetylcholine receptor alpha7 subunit is required for acetylcholine inhibition of macrophage TNF release...
  19. Su X, Matthay M, Malik A. Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol. 2010;184:401-10 pubmed publisher
    Although activation of the alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) modulates the response to sepsis, the role of this pathway in the development of sepsis-induced acute lung injury (ALI) is not known...
  20. Arredondo J, Nguyen V, Chernyavsky A, Bercovich D, Orr Urtreger A, Vetter D, et al. Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis. Life Sci. 2003;72:2063-7 pubmed
    ..Herein, we report that cutaneous alpha7 nAChR plays a role in the physiological control of cutaneous homeostasis...
  21. Portugal G, Kenney J, Gould T. Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning. Neurobiol Learn Mem. 2008;89:106-13 pubmed
    ..However, the nicotinic acetylcholine receptors (nAChR) that are involved in nicotine withdrawal deficits in contextual fear conditioning are unknown...
  22. Maouche K, Medjber K, Zahm J, Delavoie F, Terryn C, Coraux C, et al. Contribution of ?7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure. Proc Natl Acad Sci U S A. 2013;110:4099-104 pubmed publisher
    ..Here we identify ?7 nAChR as a key regulator of CFTR in the airways...
  23. Maouche K, Polette M, Jolly T, Medjber K, Cloëz Tayarani I, Changeux J, et al. {alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation. Am J Pathol. 2009;175:1868-82 pubmed publisher
    ..Here, we have investigated the potential role of the alpha7 nAChR in the regulation of airway epithelial basal cell proliferation and the differentiation of the human airway ..
  24. Reynolds P, Hoidal J. Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development. J Biol Chem. 2005;280:32548-54 pubmed
    ..A model is also supported whereby alpha(7) is induced by the essential pulmonary transcription factor TTF-1 and suppressed by Egr-1 during pulmonary development. ..
  25. Chi F, Wang L, Zheng X, Wu C, Jong A, Sheard M, et al. Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. PLoS ONE. 2011;6:e25016 pubmed publisher
    b>Alpha7 nicotinic acetylcholine receptor (nAChR), an essential regulator of inflammation, is abundantly expressed in hippocampal neurons, which are vulnerable to bacterial meningitis...
  26. Hu J, Zhu C, Liu Y, Wang F, Huang Z, Fan W, et al. Dynamic alterations of gene expression of nicotinic acetylcholine receptor ?7, ?4 and ?2 subunits in an acute MPTP-lesioned mouse model. Neurosci Lett. 2011;494:232-6 pubmed publisher
    ..However, the alterations in gene expression of nAChR subunits using an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse PD model remain unclear...
  27. Söderman A, Mikkelsen J, West M, Christensen D, Jensen M. Activation of nicotinic ?(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1?E9 mice. Neurosci Lett. 2011;487:325-9 pubmed publisher
    Amyloid ? (A?) plays a central role in Alzheimer's disease (AD) and binds to the nicotinic ?(7) receptor (?(7) nAChR)...
  28. Parrish W, Rosas Ballina M, Gallowitsch Puerta M, Ochani M, Ochani K, Yang L, et al. Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling. Mol Med. 2008;14:567-74 pubmed publisher
    The alpha7 subunit-containing nicotinic acetylcholine receptor (alpha7nAChR) is an essential component in the vagus nerve-based cholinergic anti-inflammatory pathway that regulates the levels of TNF, high mobility group box 1 (HMGB1), and ..
  29. Orr Urtreger A, Göldner F, Saeki M, Lorenzo I, Goldberg L, De Biasi M, et al. Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J Neurosci. 1997;17:9165-71 pubmed
    The alpha7 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) is abundantly expressed in hippocampus and is implicated in modulating neurotransmitter release and in binding alpha-bungarotoxin (alpha-BGT)...
  30. Arredondo J, Nguyen V, Chernyavsky A, Bercovich D, Orr Urtreger A, Kummer W, et al. Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium. J Cell Biol. 2002;159:325-36 pubmed
    ..We found that keratinocyte alpha7 nAChR controls homeostasis and terminal differentiation of epidermal keratinocytes required for formation of the skin ..
  31. Gahring L, Osborne A, Reed M, Rogers S. Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation. J Neuroinflammation. 2010;7:38 pubmed publisher
    ..Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor (nAChR) alpha7. To further investigate the role of alpha7 in skin inflammatory responses, a local inflammatory response was ..
  32. Huston J, Ochani M, Rosas Ballina M, Liao H, Ochani K, Pavlov V, et al. Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med. 2006;203:1623-8 pubmed
    ..Vagus nerve stimulation inhibits proinflammatory cytokine production by signaling through the alpha7 nicotinic acetylcholine receptor subunit...
  33. Jaldety Y, Glick Y, Orr Urtreger A, Ickowicz D, Gerber D, Breitbart H. Sperm epidermal growth factor receptor (EGFR) mediates ?7 acetylcholine receptor (AChR) activation to promote fertilization. J Biol Chem. 2012;287:22328-40 pubmed publisher
    ..In conclusion we suggest that activation of ?7 by ZP leads to SFK-dependent EGFR activation, Ca(2+) influx, and the acrosome reaction. ..
  34. Brooks N, Mexal S, Stitzel J. Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels. Brain Res. 2009;1263:1-9 pubmed publisher
    ..but not alpha7 RNA levels, suggests that the observed linkage between Chrna7 genotype and alpha-bungarotoxin levels may be due to genetic influences on the post-transcriptional regulation of alpha7 nicotinic receptor expression.
  35. Alkondon M, Pereira E, Yu P, Arruda E, Almeida L, Guidetti P, et al. Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus. J Neurosci. 2004;24:4635-48 pubmed
    It has been postulated that endogenous kynurenic acid (KYNA) modulates alpha7* nicotinic acetylcholine receptor (nAChR) and NMDA receptor activities in the brain...
  36. Rogers S, Tvrdik P, Capecchi M, Gahring L. Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure. Am J Med Genet A. 2012;158A:1135-44 pubmed publisher
    ..Here, we provide the first genetic delineation of cholinergic nicotinic receptor alpha7 (Chrna7) expression and link the ablation of the Chrna7 cell lineage to this condition in the mouse...
  37. Ballester L, Capó Vélez C, Garcia Beltran W, Ramos F, Vázquez Rosa E, Ríos R, et al. Up-regulation of the neuronal nicotinic receptor ?7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder. J Biol Chem. 2012;287:3079-86 pubmed publisher
    ..We studied the effects of gp120(IIIB) on the expression and function of the nicotinic receptor ?7 (?7-nAChR)...
  38. Gahring L, Enioutina E, Myers E, Spangrude G, Efimova O, Kelley T, et al. Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage. PLoS ONE. 2013;8:e57481 pubmed publisher
    ..are mechanistically modulated by nicotinic acetylcholine receptors (nAChR), especially by receptors composed of alpha7 (?7) subunits, is poorly defined...
  39. Stolerman I, Chamberlain S, Bizarro L, Fernandes C, Schalkwyk L. The role of nicotinic receptor alpha 7 subunits in nicotine discrimination. Neuropharmacology. 2004;46:363-71 pubmed
    ..The experiments described here use mice lacking the alpha7 subunit of nicotinic receptors to investigate the role of alpha7-containing receptors in nicotine discrimination...
  40. Nakauchi S, Sumikawa K. Endogenously released ACh and exogenous nicotine differentially facilitate long-term potentiation induction in the hippocampal CA1 region of mice. Eur J Neurosci. 2012;35:1381-95 pubmed publisher
    ..Thus, our study demonstrates that the activation of ?7- and ?2-containing nAChRs differentially facilitates LTP induction via endogenously released ACh and exogenous nicotine, respectively, in the hippocampal CA1 region of mice. ..
  41. de Jonge W, van der Zanden E, The F, Bijlsma M, van Westerloo D, Bennink R, et al. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol. 2005;6:844-51 pubmed
    ..STAT3 was phosphorylated by the tyrosine kinase Jak2 that was recruited to the alpha7 subunit of the nicotinic acetylcholine receptor...
  42. Rogers S, Gahring L. Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy. PLoS ONE. 2012;7:e36467 pubmed publisher
    The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green ..
  43. Osborne Hereford A, Rogers S, Gahring L. Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation. J Neuroimmunol. 2008;193:130-9 pubmed
    The anti-inflammatory effects of the neuronal nicotinic receptor alpha7 (nAChRalpha7) are proposed to require acetylcholine release from vagal efferents...
  44. Nizri E, Irony Tur Sinai M, Lory O, Orr Urtreger A, Lavi E, Brenner T. Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses. J Immunol. 2009;183:6681-8 pubmed publisher
    ..In this study, we determined the immunological effects of alpha7 nAChR activation by nicotine...
  45. Origlia N, Valenzano D, Moretti M, Gotti C, Domenici L. Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice. Invest Ophthalmol Vis Sci. 2012;53:1211-8 pubmed publisher
    ..Because the cortical output has an abnormal spatial resolution but retinal output is preserved, it can be concluded that the low visual acuity was due to a deficit specifically present in the visual cortex. ..
  46. Huang S, Wang L, Chi F, Wu C, Cao H, Zhang A, et al. Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors. PLoS ONE. 2013;8:e62164 pubmed publisher
    ..leukocyte migration across the BBB and albumin extravasation into the brain were significantly reduced in alpha7 nAChR knockout mice, suggesting that this inflammatory regulator plays an important role in CNS inflammation and BBB ..
  47. Paylor R, Nguyen M, Crawley J, Patrick J, Beaudet A, Orr Urtreger A. Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice. Learn Mem. 1998;5:302-16 pubmed
    ..There is also evidence for an association between levels of alpha7 nAChR and in sensorimotor gating impairments...
  48. Kume T, Sugimoto M, Takada Y, Yamaguchi T, Yonezawa A, Katsuki H, et al. Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons. Eur J Pharmacol. 2005;527:77-85 pubmed
    ..that donepezil, a central-type acetylcholinesterase inhibitor, showed neuroprotective action via alpha4-and alpha7-nicotinic acetylcholine receptors against glutamate neurotoxicity in rat cortical culture...
  49. Peña G, Cai B, Liu J, van der Zanden E, Deitch E, de Jonge W, et al. Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis. Eur J Immunol. 2010;40:2580-9 pubmed publisher
    ..Stattic also prevented the production of late mediators of sepsis and improved survival in established sepsis. These results reveal the immunological implications of tyrosine-unphosphorylated STAT3 in infectious diseases. ..
  50. Wongtrakool C, Wang N, Hyde D, Roman J, Spindel E. Prenatal nicotine exposure alters lung function and airway geometry through ?7 nicotinic receptors. Am J Respir Cell Mol Biol. 2012;46:695-702 pubmed publisher
    ..Prenatal nicotine exposure decreases forced expiratory flows in offspring through ?7 nAChR-mediated signals, and the critical period of nicotine exposure was between Prenatal Day 14 and Postnatal Day 7...
  51. Dineley K, Westerman M, Bui D, Bell K, Ashe K, Sweatt J. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci. 2001;21:4125-33 pubmed
    ..In vivo elevation of Abeta, such as that exhibited in an animal model for AD, leads to the upregulation of alpha7 nAChR protein...
  52. Morley B, Rodriguez Sierra J. A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant. Brain Res. 2004;1023:41-7 pubmed
    ..On a molecular level, the alpha7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes...
  53. Egea J, Rosa A, Sobrado M, Gandia L, Lopez M, Garcia A. Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice. Neuroscience. 2007;145:866-72 pubmed
    Although alpha7-receptors are considered the main target for neuroprotection, other receptor subtypes (alpha4beta2 or alpha3beta4) have also been implicated...
  54. Young J, Crawford N, Kelly J, Kerr L, Marston H, Spratt C, et al. Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice. Eur Neuropsychopharmacol. 2007;17:145-55 pubmed
    b>alpha7-Nicotinic acetylcholine receptors (alpha7-nAChR) have been implicated in a range of cognitive deficits in schizophrenia...
  55. Galitovskiy V, Qian J, Chernyavsky A, Marchenko S, Gindi V, Edwards R, et al. Cytokine-induced alterations of ?7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis. J Immunol. 2011;187:2677-87 pubmed publisher
    ..The dichotomous action of nicotine resulted from the up- and downregulation of anti-inflammatory ?7 nAChR on colonic CD4 T cells induced by cytokines characteristic of the inflammatory milieu in oxazolone (IL-4) and TNBS ..
  56. Skok M, Grailhe R, Agenes F, Changeux J. The role of nicotinic acetylcholine receptors in lymphocyte development. J Neuroimmunol. 2006;171:86-98 pubmed
    ..In chimera mice, either beta2 or alpha7 subunits influenced lymphocyte populations in primary lymphoid organs, while in the spleen, only alpha7 receptors ..
  57. Zhang J, Berg D. Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons. J Physiol. 2007;579:753-63 pubmed
    ..A major species of neuronal nAChRs contains the alpha7 gene product and has a high relative permeability to calcium...
  58. Giebelen I, Le Moine A, van den Pangaart P, Sadis C, Goldman M, Florquin S, et al. Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis. J Infect Dis. 2008;198:750-7 pubmed publisher
    The efferent vagus nerve can inhibit inflammation via interaction between acetylcholine and alpha7 cholinergic receptors...
  59. Kageyama Yahara N, Suehiro Y, Yamamoto T, Kadowaki M. IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors. Biochem Biophys Res Commun. 2008;377:321-5 pubmed publisher
    ..Expression of mRNA of nAChR alpha4, alpha7, and beta2 subunits were detected in specially differentiated mucosal-type murine bone marrow-derived mast cells (..
  60. Young J, Finlayson K, Spratt C, Marston H, Crawford N, Kelly J, et al. Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor. Neuropsychopharmacology. 2004;29:891-900 pubmed
    ..which nicotinic acetylcholine receptor (nAChR) subtype(s) mediate this effect, we examined the performance of alpha7 nAChR knockout (KO) mice in the 5-CSR task...
  61. Lee S. Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model. Neurosci Lett. 2013;548:291-5 pubmed publisher
    It has been suggested that activation of alpha7 nicotinic acetylcholine receptors (?7nAChR) could alleviate acute and chronic pain in various abnormal pain models...
  62. Wang C, Chen H, Zhu W, Xu Y, Liu M, Zhu L, et al. Nicotine Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice by Activating ?7 Nicotinic Acetylcholine Receptor on Mast Cells. Arterioscler Thromb Vasc Biol. 2017;37:53-65 pubmed publisher
    ..Activation of ?7 nicotinic acetylcholine receptor on MCs is a mechanism by which nicotine enhances atherosclerosis. ..
  63. Caffery P, Krishnaswamy A, Sanders T, Liu J, Hartlaub H, Klysik J, et al. Engineering neuronal nicotinic acetylcholine receptors with functional sensitivity to alpha-bungarotoxin: a novel alpha3-knock-in mouse. Eur J Neurosci. 2009;30:2064-76 pubmed publisher
    ..potentials recorded from SCG of mice homozygous for alpha3[5] were abolished by 100 nmalphaBTX, even in an alpha7 null background, demonstrating that synaptic throughput in the SCG is completely dependent on the alpha3-subunit...