Gene Symbol: Chrna6
Description: cholinergic receptor, nicotinic, alpha polypeptide 6
Alias: Acra6, Nica6, neuronal acetylcholine receptor subunit alpha-6, acetylcholine receptor alpha 6 neural, alpha6 nAChR, nicotinic acetylcholine receptor subunit alpha 6
Species: mouse
Products:     Chrna6

Top Publications

  1. Champtiaux N, Han Z, Bessis A, Rossi F, Zoli M, Marubio L, et al. Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci. 2002;22:1208-17 pubmed
    ..To provide new tools to investigate this issue, we generated an alpha6 nAChR knock-out mouse...
  2. Champtiaux N, Gotti C, Cordero Erausquin M, David D, Przybylski C, Léna C, et al. Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci. 2003;23:7820-9 pubmed
  3. Drenan R, Grady S, Whiteaker P, McClure Begley T, McKinney S, Miwa J, et al. In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors. Neuron. 2008;60:123-36 pubmed publisher
    ..alpha6*-specific agonists or antagonists may, by targeting endogenous cholinergic mechanisms in midbrain or striatum, provide a method for manipulating DA transmission in neural disorders. ..
  4. Exley R, Maubourguet N, David V, Eddine R, Evrard A, Pons S, et al. Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine. Proc Natl Acad Sci U S A. 2011;108:7577-82 pubmed publisher
  5. Kamens H, Peck C, Garrity C, Gechlik A, Jenkins B, Rajan A. ?6?2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption. Alcohol. 2017;61:43-49 pubmed publisher
    ..This study provides evidence that ?6?2 nAChRs are involved in locomotor activity as well as ethanol and saccharin consumption in adolescent animals. ..
  6. Wang Y, Lee J, Oh G, Grady S, McIntosh J, Brunzell D, et al. Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function ?6* nAChRs. J Neurochem. 2014;129:315-27 pubmed publisher
    ..Western blot analysis revealed increased tyrosine hydroxylase expression in ?6L9'S NAc. Overall, these results show that enhanced ?6?2* nAChR activity in NAc can stimulate DA production and lead to increased extracellular DA levels. ..
  7. Mackey E, Engle S, Kim M, O Neill H, Wageman C, Patzlaff N, et al. ?6* nicotinic acetylcholine receptor expression and function in a visual salience circuit. J Neurosci. 2012;32:10226-37 pubmed publisher
  8. Even N, Cardona A, Soudant M, Corringer P, Changeux J, Cloëz Tayarani I. Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors. Neuroreport. 2008;19:1545-50 pubmed publisher
    ..The complex pattern of upregulation/downregulation observed in this study depends on both nAChR composition and regional distribution. ..
  9. Marks M, Wageman C, Grady S, Gopalakrishnan M, Briggs C. Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain. Biochem Pharmacol. 2009;78:795-802 pubmed publisher
    ..As one form of alpha6beta2* nAChR is sensitive to sub-muM concentrations, we propose that this receptor in particular may contribute to the enhanced cognitive performance following low doses of ABT-089. ..

More Information


  1. Liu L, Zhao Shea R, McIntosh J, Tapper A. Nicotinic acetylcholine receptors containing the ?6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons. Biochem Pharmacol. 2013;86:1194-200 pubmed publisher
    ..In contrast, ethanol did not significantly increase activity of VTA DAergic neurons in mice that do not express CHRNA6, the gene encoding the ?6 nAChR subunit (?6 knock-out (KO) mice)...
  2. Dash B, Bhakta M, Chang Y, Lukas R. Identification of N-terminal extracellular domain determinants in nicotinic acetylcholine receptor (nAChR) ?6 subunits that influence effects of wild-type or mutant ?3 subunits on function of ?6?2*- or ?6?4*-nAChR. J Biol Chem. 2011;286:37976-89 pubmed publisher
    ..These studies illuminate the structural bases for effects of ?3 subunits on ?6*-nAChR function and suggest that unique subunit interfaces involving the complementary rather than the primary face of ?6 subunits are involved. ..
  3. Lee A, Messing R. Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens. Proc Natl Acad Sci U S A. 2011;108:16080-5 pubmed publisher
    ..Our results indicate that PKC? regulates reward signaling through ?(6)-containing nicotinic receptors and suggest that PKC? could be a target for the treatment of comorbid nicotine and alcohol addictions. ..
  4. Dash B, Lukas R. Modulation of gain-of-function ?6*-nicotinic acetylcholine receptor by ?3 subunits. J Biol Chem. 2012;287:14259-69 pubmed publisher
    ..Moreover, our findings suggest that ?3 subunit coexpression promotes function of ?6*-nAChR. ..
  5. Drenan R, Grady S, Steele A, McKinney S, Patzlaff N, McIntosh J, et al. Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors. J Neurosci. 2010;30:9877-89 pubmed publisher
    ..These results implicate alpha6alpha4beta2* nAChRs in cholinergic control of DA transmission, and strongly suggest that these receptors are candidate drug targets for disorders involving the DA system...
  6. Kuo Y, Lucero L, Michaels J, Deluca D, Lukas R. Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus. J Neuroimmunol. 2002;130:140-54 pubmed
    ..These studies suggest important roles for nAChR in immune system development and function and in the neuroimmune network. ..
  7. Grady S, Moretti M, Zoli M, Marks M, Zanardi A, Pucci L, et al. Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release. J Neurosci. 2009;29:2272-82 pubmed publisher
  8. Soll L, Grady S, Salminen O, Marks M, Tapper A. A role for ?4(non-?6)* nicotinic acetylcholine receptors in motor behavior. Neuropharmacology. 2013;73:19-30 pubmed publisher
    ..Together, these data indicate that ?4(non-?6)* nAChR have an impact on motor output and may be potential molecular targets for treatment of disorders associated with motor impairment. ..
  9. Garção P, Oliveira C, Cunha R, Agostinho P. Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. Neurosci Lett. 2014;566:106-10 pubmed publisher
  10. Bordia T, McGregor M, McIntosh J, Drenan R, Quik M. Evidence for a role for α6(∗) nAChRs in l-dopa-induced dyskinesias using Parkinsonian α6(∗) nAChR gain-of-function mice. Neuroscience. 2015;295:187-97 pubmed publisher
    ..The present data show that α6β2(∗) nAChRs are key regulators of LIDs, and may be useful therapeutic targets for their management in Parkinson's disease. ..
  11. Wieskopf J, Mathur J, Limapichat W, Post M, Al Qazzaz M, Sorge R, et al. The nicotinic ?6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Sci Transl Med. 2015;7:287ra72 pubmed publisher
    ..We identified expression levels of Chrna6, which encodes the ?6 subunit of the nicotinic acetylcholine receptor (nAChR), as highly associated with allodynia...
  12. Kamens H, Hoft N, Cox R, Miyamoto J, Ehringer M. The ?6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation. Alcohol. 2012;46:463-71 pubmed publisher
    ..The mammalian genes that code for the ?6 and ?3 subunits of the nicotinic acetylcholine receptor (Chrna6 and Chrnb3, respectively) are located adjacent to each other on human and mouse chromosome 8...
  13. Exley R, McIntosh J, Marks M, Maskos U, Cragg S. Striatal ?5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum. J Neurosci. 2012;32:2352-6 pubmed publisher
  14. Cohen B, Mackey E, Grady S, McKinney S, Patzlaff N, Wageman C, et al. Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior. Neuroscience. 2012;200:31-41 pubmed publisher
    ..This study highlights the precise control that the nicotinic cholinergic system exerts on DA transmission and provides further insights into the mechanisms and consequences of enhanced DA release. ..
  15. Berry J, Engle S, McIntosh J, Drenan R. α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity. Neuroscience. 2015;304:161-75 pubmed publisher
    ..Together, these results from in vivo studies strongly suggest that α6(∗) nAChRs expressed by VTA DA neurons are positioned to strongly influence both DA-mediated behaviors and the induction of synaptic plasticity by nicotine. ..
  16. Nuutinen S, Panula P, Salminen O. Different Hypothalamic Nicotinic α7 Receptor Expression and Response to Low Nicotine Dose in Alcohol-Preferring and Alcohol-Avoiding Rats. Alcohol Clin Exp Res. 2016;40:329-34 pubmed publisher
    ..Stronger nicotine-induced locomotor response, mediated partially via α7 receptors, and previously described high alcohol consumption in AA rats could be explained by the found difference in tuberomamillary α7 receptor levels. ..
  17. Drescher D, Khan K, Green G, Morley B, Beisel K, Kaul H, et al. Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995;112:267-73 pubmed
    ..The presence of messages corresponding to the muscle-type beta 1 and neuronal-type nAChR subunits may be correlated with the atypical cholinergic response of cochlear hair cells to agonists and antagonists. ..
  18. Chakrabarty K, von Oerthel L, Hellemons A, Clotman F, Espana A, Groot Koerkamp M, et al. Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biol Open. 2012;1:693-704 pubmed publisher the identification of novel regulatory roles of neuronal signaling through nicotinic acthylcholine receptors (Chrna6 and Chrnb3 subunits) and the identification of novel transcription factors (Oc2 and 3) involved in the generation ..
  19. Munguba G, Geisert E, Williams R, Tapia M, Lam D, Bhattacharya S, et al. Effects of glaucoma on Chrna6 expression in the retina. Curr Eye Res. 2013;38:150-7 pubmed publisher
    ..The present experiments were carried out to determine if acetylcholine receptor ? 6 subunit (Chrna6) is a reliable retinal ganglion cell (RGC) marker in adult mouse eyes and if Chrna6 expression can be used to ..
  20. Purohit P, Bruhova I, Auerbach A. Sources of energy for gating by neurotransmitters in acetylcholine receptor channels. Proc Natl Acad Sci U S A. 2012;109:9384-9 pubmed publisher
    ..Mutations of TyrC1 cause particularly large energy reductions because they remove two favorable and approximately equal interactions between the aromatic ring and the quaternary amine of the agonist and between the hydroxyl and ?Lys?7. ..