Gene Symbol: Chrna10
Description: cholinergic receptor, nicotinic, alpha polypeptide 10
Alias: neuronal acetylcholine receptor subunit alpha-10
Elgoyhen A, Vetter D, Katz E, Rothlin C, Heinemann S, Boulter J. alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc Natl Acad Sci U S A. 2001;98:3501-6 pubmed
..Our data suggest that efferent modulation of hair cell function occurs, at least in part, through heteromeric nAChRs assembled from both alpha9 and alpha10 subunits. ..
Vetter D, Katz E, Maison S, Taranda J, Turcan S, Ballestero J, et al
. The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc Natl Acad Sci U S A. 2007;104:20594-9 pubmed
..Moreover, alpha10 nAChR subunits are required for normal olivocochlear activity because alpha9 homomeric nAChRs do not support maintenance of normal olivocochlear innervation or function in alpha10(-/-) mutant mice. ..
Smith M, Souza F, Bruce K, Strang C, Morley B, Keyser K. Acetylcholine receptors in the retinas of the Î±7 nicotinic acetylcholine receptor knockout mouse. Mol Vis. 2014;20:1328-56 pubmed
..Rather than a simple upregulation of a single AChR subunit or subtype, the absence of the Î±7 nAChR in the KO mice was associated with complex layer-specific changes in the expression of AChR subunits and subtypes. ..
Osman A, Schrader A, Hawkes A, Akil O, Bergeron A, Lustig L, et al
. Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Mol Cell Neurosci. 2008;38:153-69 pubmed publisher
..Our data suggest that RIC-3 facilitates receptor function, while rapsyn enhances receptor clustering at the cell surface. ..
Murthy V, Maison S, Taranda J, Haque N, Bond C, Elgoyhen A, et al
. SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells. Mol Cell Neurosci. 2009;40:39-49 pubmed publisher
..The data suggest a hierarchy of activity necessary to maintain early olivocochlear synapses at their targets, with SK2 serving an epistatic, upstream, role to the nAChRs. ..
Taranda J, Ballestero J, Hiel H, de Souza F, Wedemeyer C, Gómez Casati M, et al
. Constitutive expression of the alpha10 nicotinic acetylcholine receptor subunit fails to maintain cholinergic responses in inner hair cells after the onset of hearing. J Assoc Res Otolaryngol. 2009;10:397-406 pubmed publisher
..The retraction of these fibers after the onset of hearing correlates with the cessation of transcription of the Chrna10 (but not the Chrna9) gene in IHCs...
Morley B, Lysakowski A, Vijayakumar S, Menapace D, Jones T. Nicotinic acetylcholine receptors regulate vestibular afferent gain and activation timing. J Comp Neurol. 2017;525:1216-1233 pubmed publisher
..J. Comp. Neurol. 525:1216-1233, 2017. Â© 2016 Wiley Periodicals, Inc. ..
Purohit P, Bruhova I, Auerbach A. Sources of energy for gating by neurotransmitters in acetylcholine receptor channels. Proc Natl Acad Sci U S A. 2012;109:9384-9 pubmed publisher
..Mutations of TyrC1 cause particularly large energy reductions because they remove two favorable and approximately equal interactions between the aromatic ring and the quaternary amine of the agonist and between the hydroxyl and ?Lys?7. ..
Romero H, Christensen S, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie K, et al
. Inhibition of Î±9Î±10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proc Natl Acad Sci U S A. 2017;114:E1825-E1832 pubmed publisher
..These findings establish blockade of Î±9-containing nAChRs as the basis for the efficacy of RgIA4, and that Î±9-containing nAChRs are a critical target for prevention of chronic cancer chemotherapy-induced neuropathic pain. ..