ChREBP

Summary

Gene Symbol: ChREBP
Description: MLX interacting protein-like
Alias: ChREBP, Mlx, WS-bHLH, Wbscr14, bHLHd14, carbohydrate-responsive element-binding protein, MLX interacting protein-like beta, MLX interactor, Max-like protein, Williams-Beuren syndrome chromosome region 14 homolog
Species: mouse
Products:     ChREBP

Top Publications

  1. Pashkov V, Huang J, Parameswara V, Kedzierski W, Kurrasch D, Tall G, et al. Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner. J Biol Chem. 2011;286:15116-25 pubmed publisher
    ..The transcription factor carbohydrate response element-binding protein (ChREBP), which induces fatty acid synthesis genes in response to high carbohydrate feeding, was unexpectedly required ..
  2. Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox A, et al. Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Mol Endocrinol. 2010;24:1594-604 pubmed publisher
    ..We further demonstrate that expression of carbohydrate response element-binding protein (ChREBP or Mlxipl), an important transcriptional regulator of carbohydrate metabolism, is significantly affected in ..
  3. Davies M, O Callaghan B, Towle H. Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity. J Biol Chem. 2008;283:24029-38 pubmed publisher
    Carbohydrate response element-binding protein (ChREBP) is a glucose-responsive transcription factor that activates genes involved in de novo lipogenesis in mammals...
  4. Noordeen N, Khera T, Sun G, Longbottom E, Pullen T, Da Silva Xavier G, et al. Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells. Diabetes. 2010;59:153-60 pubmed publisher
    Carbohydrate-responsive element-binding protein (ChREBP) is a transcription factor that has been shown to regulate carbohydrate metabolism in the liver and pancreatic beta-cells in response to elevated glucose concentrations...
  5. Sakiyama H, Wynn R, Lee W, Fukasawa M, Mizuguchi H, Gardner K, et al. Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation. J Biol Chem. 2008;283:24899-908 pubmed publisher
    Carbohydrate response element-binding protein (ChREBP) is a glucose-responsive transcription factor that plays a critical role in the glucose-mediated induction of gene products involved in hepatic glycolysis and lipogenesis...
  6. Cha J, Repa J. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem. 2007;282:743-51 pubmed
    ..In this report, we identify the carbohydrate response element-binding protein (ChREBP) as an LXR target that independently enhances the up-regulation of select lipogenic genes...
  7. Da Silva Xavier G, Rutter G, Diraison F, Andreolas C, Leclerc I. ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells. J Lipid Res. 2006;47:2482-91 pubmed
    ..The relative importance of the transcription factors carbohydrate-responsive element binding protein (ChREBP), sterol-responsive element binding protein-1c (SREBP-1c), and upstream stimulatory factor (USF) in the induction ..
  8. Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck J, et al. Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes. 2006;55:2159-70 pubmed
    ..We have recently demonstrated that carbohydrate responsive element-binding protein (ChREBP) plays a key role in the control of lipogenesis through the transcriptional regulation of lipogenic genes, ..
  9. Iizuka K, Miller B, Uyeda K. Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice. Am J Physiol Endocrinol Metab. 2006;291:E358-64 pubmed
    The transcription factor carbohydrate response element-binding protein (ChREBP) mediates insulin-independent, glucose-stimulated gene expression of multiple liver enzymes responsible for converting excess carbohydrate to fatty acids for ..

More Information

Publications74

  1. Ishii S, Iizuka K, Miller B, Uyeda K. Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc Natl Acad Sci U S A. 2004;101:15597-602 pubmed
    Carbohydrate response element (ChRE)-binding protein (ChREBP) is a recently discovered transcription factor that is activated in response to high glucose concentrations in liver independently of insulin...
  2. Merla G, Howald C, Antonarakis S, Reymond A. The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. Hum Mol Genet. 2004;13:1505-14 pubmed
    ..The WBSCR14 gene, one of the genes mapping to the WBS critical region, encodes a member of the basic-helix-loop-helix leucine ..
  3. Li M, Chen W, Harmancey R, Nuotio Antar A, Imamura M, Saha P, et al. Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun. 2010;395:395-400 pubmed publisher
    Carbohydrate response element binding protein (ChREBP) is a Mondo family transcription factor that activates a number of glycolytic and lipogenic genes in response to glucose stimulation...
  4. Tong X, Zhao F, Mancuso A, Gruber J, Thompson C. The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proc Natl Acad Sci U S A. 2009;106:21660-5 pubmed publisher
    ..The glucose-responsive transcription factor carbohydrate responsive element binding protein (ChREBP) was previously shown to be important for redirecting glucose metabolism in support ..
  5. Dentin R, Pégorier J, Benhamed F, Foufelle F, Ferre P, Fauveau V, et al. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem. 2004;279:20314-26 pubmed
    ..in hGK-KO hepatocytes is associated with a decreased in the carbohydrate responsive element-binding protein (ChREBP) gene expression, a transcription factor suggested to mediate glucose signaling in liver...
  6. Denechaud P, Bossard P, Lobaccaro J, Millatt L, Staels B, Girard J, et al. ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest. 2008;118:956-64 pubmed publisher
    The transcription factor carbohydrate-responsive element-binding protein (ChREBP) has emerged as a central regulator of lipid synthesis in liver because it is required for glucose-induced expression of the glycolytic enzyme liver-pyruvate ..
  7. Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci U S A. 2001;98:13710-5 pubmed
    ..This factor was named carbohydrate responsive element binding protein (ChREBP)...
  8. Da Silva Xavier G, Sun G, Qian Q, Rutter G, Leclerc I. ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic ?-cells. Biochem Biophys Res Commun. 2010;402:252-7 pubmed publisher
    Carbohydrate responsive element-binding protein (ChREBP) is a transcription factor whose expression and activity are increased in pancreatic ?-cells maintained at elevated glucose concentrations...
  9. Stoeckman A, Ma L, Towle H. Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. J Biol Chem. 2004;279:15662-9 pubmed
    ..The carbohydrate response element-binding protein (ChREBP) is a newly identified basic helix-loop-helix/leucine zipper transcription factor proposed to regulate the ..
  10. Bricambert J, Miranda J, Benhamed F, Girard J, Postic C, Dentin R. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest. 2010;120:4316-31 pubmed publisher
    ..Carbohydrate-responsive element-binding protein (ChREBP), a transcriptional activator of glycolytic and lipogenic genes, has emerged as a major player in the development ..
  11. Iizuka K, Bruick R, Liang G, Horton J, Uyeda K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A. 2004;101:7281-6 pubmed
    ..In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for ..
  12. Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A. WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. Hum Mol Genet. 2001;10:617-27 pubmed
    ..23. Here, we report the functional characterization of WBS critical region gene 14 (WBSCR14), a gene contained in the WBS commonly deleted region...
  13. Zhang D, Tong X, VanDommelen K, Gupta N, Stamper K, Brady G, et al. Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. J Clin Invest. 2017;127:2855-2867 pubmed publisher
    ..the essential function of the lipogenic transcription factor carbohydrate response element-binding protein (ChREBP) in mediating adaptive responses to fructose and protecting against fructose-induced hepatotoxicity...
  14. Guinez C, Filhoulaud G, Rayah Benhamed F, Marmier S, Dubuquoy C, Dentin R, et al. O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver. Diabetes. 2011;60:1399-413 pubmed publisher
    Carbohydrate-responsive element-binding protein (ChREBP) is a key transcription factor that mediates the effects of glucose on glycolytic and lipogenic genes in the liver...
  15. Hanke N, Scheibe R, Manukjan G, Ewers D, Umeda P, Chang K, et al. Gene regulation mediating fiber-type transformation in skeletal muscle cells is partly glucose- and ChREBP-dependent. Biochim Biophys Acta. 2011;1813:377-89 pubmed publisher
    ..Carbohydrate response element-binding protein (ChREBP), a glucose-dependent transcription factor downstream of PP2A, partially mediated the effects of glucose on ..
  16. Kim M, Krawczyk S, Doridot L, Fowler A, Wang J, Trauger S, et al. ChREBP regulates fructose-induced glucose production independently of insulin signaling. J Clin Invest. 2016;126:4372-4386 pubmed publisher
    ..Here, we hypothesized that carbohydrate-responsive element-binding protein (ChREBP), a transcriptional activator of glycolytic and lipogenic genes, plays a central role in this paradox...
  17. Ge Q, Nakagawa T, Wynn R, Chook Y, Miller B, Uyeda K. Importin-alpha protein binding to a nuclear localization signal of carbohydrate response element-binding protein (ChREBP). J Biol Chem. 2011;286:28119-27 pubmed publisher
    Carbohydrate response element-binding protein (ChREBP) is a glucose-responsive transcription factor that plays a critical role in the glucose-mediated induction of genes involved in hepatic glycolysis and lipogenesis...
  18. Dentin R, Benhamed F, Pégorier J, Foufelle F, Viollet B, Vaulont S, et al. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest. 2005;115:2843-54 pubmed
    ..Recently, carbohydrate-responsive element-binding protein (ChREBP) was implicated in the regulation by glucose of glycolytic and lipogenic genes, including those encoding L-..
  19. Zhang P, Kumar A, Katz L, Li L, Paulynice M, Herman M, et al. Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation. Diabetes. 2015;64:4158-70 pubmed publisher
    Carbohydrate-responsive element-binding protein (ChREBP) is a glucose-sensing transcription factor required for glucose-stimulated proliferation of pancreatic β-cells in rodents and humans...
  20. Poungvarin N, Lee J, Yechoor V, Li M, Assavapokee T, Suksaranjit P, et al. Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity. Diabetologia. 2012;55:1783-96 pubmed publisher
    ..Carbohydrate response element-binding protein (ChREBP), a transcription factor that regulates the expression of multiple hyperglycaemia-induced genes, is produced in ..
  21. Huo M, Zang H, Zhang D, Wang B, Wu J, Zhang X, et al. [Role of increased activity of carbohydrate response element binding protein in excessive lipid accumulation in the liver of type 2 diabetic db/db mouse]. Beijing Da Xue Xue Bao Yi Xue Ban. 2009;41:307-12 pubmed
    To study the role of the carbohydrate response element binding protein (ChREBP) in excessive lipid deposition in the liver of db/db mouse. The deposition of neutral lipids in the liver was evaluated by Oil Red O staining...
  22. Hashimoto K, Ishida E, Matsumoto S, Okada S, Yamada M, Satoh T, et al. Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone. Endocrinology. 2009;150:3417-24 pubmed publisher
    ..The carbohydrate response element-binding protein (ChREBP) as well as sterol response element-binding protein (SREBP)-1c plays a pivotal role in hepatic lipogenesis...
  23. Dubuquoy C, Robichon C, Lasnier F, Langlois C, Dugail I, Foufelle F, et al. Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes. J Hepatol. 2011;55:145-53 pubmed publisher
    ..in vivo in the mouse liver and in vitro in murine hepatocytes and human hepatocyte cell lines infected with ChREBP or SREBP1c-expressing adenoviruses...
  24. Tang Y, Wallace M, Sanchez Gurmaches J, Hsiao W, Li H, Lee P, et al. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Nat Commun. 2016;7:11365 pubmed publisher
    ..2 (mTORC2) functions in white adipose tissue (WAT) to control expression of the lipogenic transcription factor ChREBP?...
  25. Kahraman S, Dirice E, De Jesus D, Hu J, Kulkarni R. Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. Am J Physiol Endocrinol Metab. 2014;307:E906-18 pubmed publisher
    ..The relatively smaller β-cell mass/area and β-cell proliferation in these control offspring suggest cell-autonomous epigenetic mechanisms in the regulation of islet growth and development. ..
  26. Gauthier K, Billon C, Bissler M, Beylot M, Lobaccaro J, Vanacker J, et al. Thyroid hormone receptor beta (TRbeta) and liver X receptor (LXR) regulate carbohydrate-response element-binding protein (ChREBP) expression in a tissue-selective manner. J Biol Chem. 2010;285:28156-63 pubmed publisher
    ..In the present study, carbohydrate-response element-binding protein (ChREBP), a major transcription factor controlling the activation of glucose-induced lipogenesis in liver, is ..
  27. Stamatikos A, da Silva R, Lewis J, Douglas D, Kneteman N, Jacobs R, et al. Tissue Specific Effects of Dietary Carbohydrates and Obesity on ChREBPα and ChREBPβ Expression. Lipids. 2016;51:95-104 pubmed publisher
    Carbohydrate response element binding protein (ChREBP) regulates insulin-independent de novo lipogenesis. Recently, a novel ChREBPβ isoform was identified...
  28. Hall A, Finck B. ChREBP refines the hepatic response to fructose to protect the liver from injury. J Clin Invest. 2017;127:2533-2535 pubmed publisher
    ..In this issue of the JCI, Zhang and colleagues show that the carbohydrate response element-binding protein (ChREBP) coordinates an adaptive response to a high-fructose diet in mice and that loss of this transcription factor leads ..
  29. Noordeen N, Meur G, Rutter G, Leclerc I. Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells. Diabetes. 2012;61:574-85 pubmed publisher
    Carbohydrate-responsive element-binding protein (ChREBP) is a regulator of pancreatic β-cell gene expression and an important mediator of glucotoxicity...
  30. Bae J, Oh A, Lee H, Ahn Y, Cha J. Hepatic Elovl6 gene expression is regulated by the synergistic action of ChREBP and SREBP-1c. Biochem Biophys Res Commun. 2016;478:1060-6 pubmed publisher
    ..Elovl6 expression is under the direct transcriptional control of carbohydrate response element binding protein (ChREBP), a mediator of glucose-induced gene expression...
  31. Witte N, Muenzner M, Rietscher J, Knauer M, Heidenreich S, Nuotio Antar A, et al. The Glucose Sensor ChREBP Links De Novo Lipogenesis to PPARγ Activity and Adipocyte Differentiation. Endocrinology. 2015;156:4008-19 pubmed publisher
    ..Here, we report that carbohydrate-response element-binding protein (ChREBP), a transcriptional inducer of glucose use and de novo lipogenesis, controls the activity of the adipogenic master ..
  32. Boergesen M, Poulsen L, Schmidt S, Frigerio F, Maechler P, Mandrup S. ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells. J Biol Chem. 2011;286:13214-25 pubmed publisher
    ..very similar to those of glucose activation of target genes by the carbohydrate response element-binding protein (ChREBP) prompted us to investigate the potential role of ChREBP in the regulation of PPAR? expression...
  33. Wu W, Tsuchida H, Kato T, Niwa H, Horikawa Y, Takeda J, et al. Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation. Biochem Biophys Res Commun. 2015;461:681-6 pubmed publisher
    ..Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP(-/-) mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and ..
  34. Wei J, Shimazu J, Makinistoglu M, Maurizi A, Kajimura D, Zong H, et al. Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell. 2015;161:1576-1591 pubmed publisher
    ..These results reveal an unexpected intricacy between bone and glucose metabolism. ..
  35. Metukuri M, Zhang P, Basantani M, Chin C, Stamateris R, Alonso L, et al. ChREBP mediates glucose-stimulated pancreatic ?-cell proliferation. Diabetes. 2012;61:2004-15 pubmed publisher
    ..Carbohydrate response element-binding protein (ChREBP) is a lipogenic glucose-sensing transcription factor with unknown functions in pancreatic ?-cells...
  36. Singh P, Irwin D. Contrasting Patterns in the Evolution of Vertebrate MLX Interacting Protein (MLXIP) and MLX Interacting Protein-Like (MLXIPL) Genes. PLoS ONE. 2016;11:e0149682 pubmed publisher
    b>ChREBP and MondoA are glucose-sensitive transcription factors that regulate aspects of energy metabolism. Here we performed a phylogenomic analysis of Mlxip (encoding MondoA) and Mlxipl (encoding ChREBP) genes across vertebrates...
  37. Fonseca T, Fernandes G, McAninch E, Bocco B, Abdalla S, Ribeiro M, et al. Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proc Natl Acad Sci U S A. 2015;112:14018-23 pubmed publisher
    ..The resulting phenotype of the adult ALB-D2KO mouse is dramatic, with greatly reduced susceptibility to diet-induced steatosis, hypertriglyceridemia, and obesity. ..
  38. Chau G, Im D, Kang T, Bae J, Kim W, Pyo S, et al. mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress. J Cell Biol. 2017;216:2091-2105 pubmed publisher
    ..Mechanistically, we find that mTOR associates with the carbohydrate-response element-binding protein (ChREBP)-Max-like protein complex and inhibits its transcriptional activity, leading to decreased expression of ..
  39. Sarrazy V, Sore S, Viaud M, Rignol G, Westerterp M, Ceppo F, et al. Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation. Cell Rep. 2015;13:132-144 pubmed publisher
    ..We observe that the activity of the carbohydrate-responsive element binding protein ChREBP is rapidly downregulated upon TLR4 activation in macrophages...
  40. Huang L, Yang X, Zhang X, Wang L. [The hepatic ChREBP expression and hyperinsulinemia in mice]. Yao Xue Xue Bao. 2014;49:882-7 pubmed
    To explore the effects of serum insulin on the expression of ChREBP, ACC and FAS in vivo, KKAy mice which were characterized with high levels of both serum insulin and glucose and DIO mice which were characterized with high serum insulin ..
  41. Nuotio Antar A, Poungvarin N, Li M, Schupp M, Mohammad M, Gerard S, et al. FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance. Endocrinology. 2015;156:4020-32 pubmed publisher
    Carbohydrate response element binding protein (ChREBP) regulates cellular glucose and lipid homeostasis...
  42. Liu A, Wang Y, Zhang D, Wang X, Song H, Dang C, et al. Classification and evolutionary analysis of the basic helix-loop-helix gene family in the green anole lizard, Anolis carolinensis. Mol Genet Genomics. 2013;288:365-80 pubmed publisher
    ..Our classification and evolutionary analysis has provided insights into the evolutionary diversification of animal bHLH genes, and should aid future studies on bHLH protein regulation of key growth and developmental processes. ..
  43. Meng J, Feng M, Dong W, Zhu Y, Li Y, Zhang P, et al. Identification of HNF-4? as a key transcription factor to promote ChREBP expression in response to glucose. Sci Rep. 2016;6:23944 pubmed publisher
    Transcription factor carbohydrate responsive element binding protein (ChREBP) promotes glycolysis and lipogenesis in metabolic tissues and cancer cells...
  44. Richards P, Rachdi L, Oshima M, Marchetti P, Bugliani M, Armanet M, et al. MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic ?-Cells. Diabetes. 2018;67:461-472 pubmed publisher
    ..Furthermore, we demonstrate that silencing MondoA expression improves glucose uptake in EndoC-?H1 cells. These results highlight MondoA as a novel target in ?-cells that coordinates transcriptional response to elevated glucose levels. ..
  45. Billin A, Eilers A, Queva C, Ayer D. Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. J Biol Chem. 1999;274:36344-50 pubmed
    ..Here we present the identification and characterization of the novel basic-helix-loop-helix zipper protein Mlx (Max-like protein x), which is structurally and functionally related to Max...
  46. Katz L, Xu S, Ge K, Scott D, Gershengorn M. T3 and Glucose Coordinately Stimulate ChREBP-Mediated Ucp1 Expression in Brown Adipocytes From Male Mice. Endocrinology. 2018;159:557-569 pubmed publisher
    ..We identified carbohydrate response element binding protein (ChREBP) as a T3 target gene in BAT by RNA sequencing and studied its effects in brown adipocytes...
  47. de Luis O, Valero M, Jurado L. WBSCR14, a putative transcription factor gene deleted in Williams-Beuren syndrome: complete characterisation of the human gene and the mouse ortholog. Eur J Hum Genet. 2000;8:215-22 pubmed
    ..We have fully characterised a gene commonly deleted in WBS, WBSCR14, previously reported in a truncated form as WS-bHLH...
  48. Liangpunsakul S, Ross R, Crabb D. Activation of carbohydrate response element-binding protein by ethanol. J Investig Med. 2013;61:270-7 pubmed publisher
    Carbohydrate response element-binding protein (ChREBP) is a transcription factor involved in hepatic lipogenesis. Its function is in part under the control of AMP-activated protein kinase (AMPK) and protein phosphatase 2A (PP2A)...
  49. Ge Q, Huang N, Wynn R, Li Y, Du X, Miller B, et al. Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3? protein. J Biol Chem. 2012;287:41914-21 pubmed publisher
    Carbohydrate response element-binding protein (ChREBP) is an insulin-independent, glucose-responsive transcription factor that is expressed at high levels in liver hepatocytes where it plays a critical role in converting excess ..
  50. Iizuka K, Horikawa Y. ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome. Endocr J. 2008;55:617-24 pubmed
    ..Recently, a carbohydrate response element binding protein (ChREBP), which binds to the carbohydrate response element (ChoRE) in the promoter of rat liver type pyruvate kinase (LPK),..
  51. He Z, Jiang T, Wang Z, Levi M, Li J. Modulation of carbohydrate response element-binding protein gene expression in 3T3-L1 adipocytes and rat adipose tissue. Am J Physiol Endocrinol Metab. 2004;287:E424-30 pubmed
    Carbohydrate response element-binding protein (ChREBP) is a rat homolog of human Williams-Beuren syndrome region 14 and a member of the basic helix-loop-helix leucine zipper transcription factor family...
  52. Clar J, Gri B, Calderaro J, Birling M, Hérault Y, Smit G, et al. Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy. Kidney Int. 2014;86:747-56 pubmed publisher
    ..The K-G6pc(-/-) mouse model is a unique tool to decipher the molecular mechanisms underlying renal failure and to evaluate potential therapeutic strategies. ..
  53. Qiao L, Yoo H, Madon A, Kinney B, Hay W, Shao J. Adiponectin enhances mouse fetal fat deposition. Diabetes. 2012;61:3199-207 pubmed publisher
    ..Together, our study indicates that adiponectin enhances fetal fat deposition and plays an important role in maternal obesity-induced high birth weight. ..
  54. Jois T, Howard V, Youngs K, Cowley M, Sleeman M. Dietary Macronutrient Composition Directs ChREBP Isoform Expression and Glucose Metabolism in Mice. PLoS ONE. 2016;11:e0168797 pubmed publisher
    Carbohydrate response element binding protein (ChREBP) is a lipogenic transcription factor that is thought to be involved in the development of hepatic steatosis and insulin resistance...
  55. Kitsunai H, Makino Y, Sakagami H, Mizumoto K, Yanagimachi T, Atageldiyeva K, et al. High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells. Physiol Rep. 2016;4: pubmed publisher
    ..A glucose-responsive transcription factor carbohydrate response element-binding protein (ChREBP) is a key mediator for such perturbation of gene regulation...
  56. Banks A, Kim Muller J, Mastracci T, Kofler N, Qiang L, Haeusler R, et al. Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab. 2011;14:587-97 pubmed publisher
    ..Thus, acetylation inactivates FoxO1 during nutrient excess whereas deacetylation selectively potentiates FoxO1 activity, protecting against excessive catabolism during nutrient deprivation. ..
  57. Wang R, Li C, Deng C. Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci. 2010;6:682-90 pubmed
    ..that the steatosis is accompanied by altered expression of a number of genes, including increased expression of ChREBP, which acts as one of the central determinants of lipid synthesis in the liver...
  58. Benhamed F, Denechaud P, Lemoine M, Robichon C, Moldes M, Bertrand Michel J, et al. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J Clin Invest. 2012;122:2176-94 pubmed publisher
    ..We have explored this in mice overexpressing carbohydrate responsive element-binding protein (ChREBP)...
  59. Bindesbøll C, Fan Q, Nørgaard R, MacPherson L, Ruan H, Wu J, et al. Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity. J Lipid Res. 2015;56:771-85 pubmed publisher
    ..sterol regulatory element-binding protein (SREBP)-1c and carbohydrate responsive element-binding protein (ChREBP). LXRs activate lipogenic gene transcription in response to feeding, which is believed to be mediated by insulin...
  60. Yang A, Li D, Chi L, Ye X. Validation, Identification, and Biological Consequences of the Site-specific O-GlcNAcylation Dynamics of Carbohydrate-responsive Element-binding Protein (ChREBP). Mol Cell Proteomics. 2017;16:1233-1243 pubmed publisher
    i>O-GlcNAcylation of carbohydrate-responsive element-binding protein (ChREBP) is believed as an important modulator of ChREBP activities, however little direct evidence of O-GlcNAcylation on ChREBP and no exact O-..
  61. Robichon C, Girard J, Postic C. [Can the hyperactivity of lipogenesis cause hepatic steatosis? A role for ChREBP]. Med Sci (Paris). 2008;24:841-6 pubmed publisher
    ..Although its implication in human disease has not yet been demonstrated, ChRepsilonBP could be an interesting therapeutic target against metabolic syndrome components. ..
  62. Herman M, Peroni O, Villoria J, Schön M, Abumrad N, Blüher M, et al. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature. 2012;484:333-8 pubmed publisher
    ..we report that adipose tissue GLUT4 regulates the expression of carbohydrate-responsive-element-binding protein (ChREBP; also known as MLXIPL), a transcriptional regulator of lipogenic and glycolytic genes...
  63. Grefhorst A, Schreurs M, Oosterveer M, Cortés V, Havinga R, Herling A, et al. Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor ? (LXR?) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1. Biochem J. 2010;432:249-54 pubmed publisher
    ..of the transcription factors SREBP (sterol-regulatory-element-binding protein)-1c, LXR? (liver X receptor ?) and ChREBP (carbohydrate-response-element-binding protein)...
  64. von Holstein Rathlou S, BonDurant L, Peltekian L, Naber M, Yin T, Claflin K, et al. FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. Cell Metab. 2016;23:335-43 pubmed publisher
    ..We conclude that the liver functions to regulate macronutrient-specific intake by producing an endocrine satiety signal that acts centrally to suppress the intake of "sweets." ..
  65. Yore M, Syed I, Moraes Vieira P, Zhang T, Herman M, Homan E, et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014;159:318-32 pubmed publisher
    ..PAHSAs also reduce adipose tissue inflammation. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake. Thus, FAHFAs are endogenous lipids with the potential to treat type 2 diabetes. ..