Gene Symbol: Chpf
Description: chondroitin polymerizing factor
Alias: 1700028N03Rik, AI414328, D1Bwg1363e, chondroitin sulfate synthase 2, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II, N-acetylgalactosaminyltransferase 2, chondroitin glucuronyltransferase 2, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
Species: mouse
Products:     Chpf

Top Publications

  1. Wilson D, Phamluong K, Lin W, Barck K, Carano R, Diehl L, et al. Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning. Dev Biol. 2012;363:413-25 pubmed publisher
    ..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1. ..
  2. Ogawa H, Shionyu M, Sugiura N, Hatano S, Nagai N, Kubota Y, et al. Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function. J Biol Chem. 2010;285:34155-67 pubmed publisher
    ..Molecular modeling of CSS2A and CSS2B provided support for their properties. These findings, implicating regulation of CS chain polymerization by CSS2 variants, provide insight in elucidating the mechanisms of CS biosynthesis...
  3. Ogawa H, Hatano S, Sugiura N, Nagai N, Sato T, Shimizu K, et al. Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development. PLoS ONE. 2012;7:e43806 pubmed publisher
    ..Our study demonstrates the distinct function of CSS1 and CSS2, providing a clue in the elucidation of the mechanism of CS biosynthesis. ..
  4. Dorval V, Smith P, Delay C, Calvo E, Planel E, Zommer N, et al. Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons. PLoS ONE. 2012;7:e44060 pubmed publisher
    ..Taken together, these results provide new clues into the role of specific miRNA pathways in the regulation of brain identity and maintenance in adult mice. ..
  5. Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K, et al. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. J Biol Chem. 2007;282:4152-61 pubmed
    ..Our studies may lead to a new therapeutic intervention, ameliorating the outcome of cartilage degenerative diseases. ..
  6. Kuroda Y, Sako W, Goto S, Sawada T, Uchida D, Izumi Y, et al. Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential. Hum Mol Genet. 2012;21:991-1003 pubmed publisher
    ..Our findings indicate that mitochondrial Parkin prevents mitochondrial depolarization and that Klokin 1 may compensate for Parkin deficiency. ..