Gene Symbol: Chn2
Description: chimerin 2
Alias: 1700026N20Rik, 4930557O16Rik, ARHGAP3, Bch, beta-chimaerin, Rho GTPase-activating protein 3, chimerin (chimaerin) 2
Yasuda S, Kai M, Imai S, Kanoh H, Sakane F. Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor. FEBS Lett. 2007;581:551-7 pubmed
..These results indicate that DGKgamma is a novel regulator of beta2-chimaerin, and thus suggest that beta2-chimaerin is an effector molecule, linking DGKgamma functionally with Rac1. ..
Griner E, Caino M, Sosa M, Colon Gonzalez F, Chalmers M, Mischak H, et al
. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2010;285:16931-41 pubmed publisher
Ip J, Shi L, Chen Y, Itoh Y, Fu W, Betz A, et al
. ?2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2. Nat Neurosci. 2011;15:39-47 pubmed publisher
..These findings establish a new ?2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders. ..
Fame R, Dehay C, Kennedy H, Macklis J. Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex. Cereb Cortex. 2017;27:1817-1830 pubmed publisher
..g., epha3, chn2)...
Casado Medrano V, Barrio Real L, Garcia Rostan G, Baumann M, Rocks O, Caloca M. A new role of the Rac-GAP ?2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression. Oncotarget. 2016;7:28301-19 pubmed publisher
..Overall, our data redefine the role of ?2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression. ..
Wegmeyer H, Egea J, Rabe N, Gezelius H, Filosa A, Enjin A, et al
. EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin. Neuron. 2007;55:756-67 pubmed
..Our results reveal an alpha-chimaerin-dependent signaling pathway downstream of EphA4, which is essential for axon guidance decisions and neuronal circuit formation in vivo. ..
Beg A, Sommer J, Martin J, Scheiffele P. alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron. 2007;55:768-78 pubmed
..These findings identify alpha2-chimaerin as an indispensable effector for EphA4 in cortical and spinal motor circuits. ..
Takeuchi S, Yamaki N, Iwasato T, Negishi M, Katoh H. Beta2-chimaerin binds to EphA receptors and regulates cell migration. FEBS Lett. 2009;583:1237-42 pubmed publisher
..These results suggest that beta2-chimaerin is activated by EphA receptors and mediates the EphA receptor-dependent regulation of cell migration. ..
Riccomagno M, Hurtado A, Wang H, Macopson J, Griner E, Betz A, et al
. The RacGAP ?2-Chimaerin selectively mediates axonal pruning in the hippocampus. Cell. 2012;149:1594-606 pubmed publisher
..Therefore, a Npn2/?2Chn/Rac1 signaling axis distinguishes DG axon pruning from the effects of Sema3F on repulsion and dendritic spine remodeling...