Chn2

Summary

Gene Symbol: Chn2
Description: chimerin 2
Alias: 1700026N20Rik, 4930557O16Rik, ARHGAP3, Bch, beta-chimaerin, Rho GTPase-activating protein 3, chimerin (chimaerin) 2
Species: mouse
Products:     Chn2

Top Publications

  1. Yasuda S, Kai M, Imai S, Kanoh H, Sakane F. Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor. FEBS Lett. 2007;581:551-7 pubmed
    ..These results indicate that DGKgamma is a novel regulator of beta2-chimaerin, and thus suggest that beta2-chimaerin is an effector molecule, linking DGKgamma functionally with Rac1. ..
  2. Griner E, Caino M, Sosa M, Colon Gonzalez F, Chalmers M, Mischak H, et al. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2010;285:16931-41 pubmed publisher
  3. Ip J, Shi L, Chen Y, Itoh Y, Fu W, Betz A, et al. ?2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2. Nat Neurosci. 2011;15:39-47 pubmed publisher
    ..These findings establish a new ?2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders. ..
  4. Fame R, Dehay C, Kennedy H, Macklis J. Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex. Cereb Cortex. 2017;27:1817-1830 pubmed publisher
    ..g., epha3, chn2)...
  5. Casado Medrano V, Barrio Real L, Garcia Rostan G, Baumann M, Rocks O, Caloca M. A new role of the Rac-GAP ?2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression. Oncotarget. 2016;7:28301-19 pubmed publisher
    ..Overall, our data redefine the role of ?2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression. ..
  6. Wegmeyer H, Egea J, Rabe N, Gezelius H, Filosa A, Enjin A, et al. EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin. Neuron. 2007;55:756-67 pubmed
    ..Our results reveal an alpha-chimaerin-dependent signaling pathway downstream of EphA4, which is essential for axon guidance decisions and neuronal circuit formation in vivo. ..
  7. Beg A, Sommer J, Martin J, Scheiffele P. alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron. 2007;55:768-78 pubmed
    ..These findings identify alpha2-chimaerin as an indispensable effector for EphA4 in cortical and spinal motor circuits. ..
  8. Takeuchi S, Yamaki N, Iwasato T, Negishi M, Katoh H. Beta2-chimaerin binds to EphA receptors and regulates cell migration. FEBS Lett. 2009;583:1237-42 pubmed publisher
    ..These results suggest that beta2-chimaerin is activated by EphA receptors and mediates the EphA receptor-dependent regulation of cell migration. ..
  9. Riccomagno M, Hurtado A, Wang H, Macopson J, Griner E, Betz A, et al. The RacGAP ?2-Chimaerin selectively mediates axonal pruning in the hippocampus. Cell. 2012;149:1594-606 pubmed publisher
    ..Therefore, a Npn2/?2Chn/Rac1 signaling axis distinguishes DG axon pruning from the effects of Sema3F on repulsion and dendritic spine remodeling...
  10. Wang Q, Chiu S, Koropouli E, Hong I, Mitchell S, Easwaran T, et al. Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron. 2017;96:1084-1098.e7 pubmed publisher
    ..Therefore, Sema3F-Npn-2/PlexA3 signaling controls both synapse development and synaptic plasticity. ..

Detail Information

Publications10

  1. Yasuda S, Kai M, Imai S, Kanoh H, Sakane F. Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor. FEBS Lett. 2007;581:551-7 pubmed
    ..These results indicate that DGKgamma is a novel regulator of beta2-chimaerin, and thus suggest that beta2-chimaerin is an effector molecule, linking DGKgamma functionally with Rac1. ..
  2. Griner E, Caino M, Sosa M, Colon Gonzalez F, Chalmers M, Mischak H, et al. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2010;285:16931-41 pubmed publisher
  3. Ip J, Shi L, Chen Y, Itoh Y, Fu W, Betz A, et al. ?2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2. Nat Neurosci. 2011;15:39-47 pubmed publisher
    ..These findings establish a new ?2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders. ..
  4. Fame R, Dehay C, Kennedy H, Macklis J. Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex. Cereb Cortex. 2017;27:1817-1830 pubmed publisher
    ..g., epha3, chn2)...
  5. Casado Medrano V, Barrio Real L, Garcia Rostan G, Baumann M, Rocks O, Caloca M. A new role of the Rac-GAP ?2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression. Oncotarget. 2016;7:28301-19 pubmed publisher
    ..Overall, our data redefine the role of ?2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression. ..
  6. Wegmeyer H, Egea J, Rabe N, Gezelius H, Filosa A, Enjin A, et al. EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin. Neuron. 2007;55:756-67 pubmed
    ..Our results reveal an alpha-chimaerin-dependent signaling pathway downstream of EphA4, which is essential for axon guidance decisions and neuronal circuit formation in vivo. ..
  7. Beg A, Sommer J, Martin J, Scheiffele P. alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron. 2007;55:768-78 pubmed
    ..These findings identify alpha2-chimaerin as an indispensable effector for EphA4 in cortical and spinal motor circuits. ..
  8. Takeuchi S, Yamaki N, Iwasato T, Negishi M, Katoh H. Beta2-chimaerin binds to EphA receptors and regulates cell migration. FEBS Lett. 2009;583:1237-42 pubmed publisher
    ..These results suggest that beta2-chimaerin is activated by EphA receptors and mediates the EphA receptor-dependent regulation of cell migration. ..
  9. Riccomagno M, Hurtado A, Wang H, Macopson J, Griner E, Betz A, et al. The RacGAP ?2-Chimaerin selectively mediates axonal pruning in the hippocampus. Cell. 2012;149:1594-606 pubmed publisher
    ..Therefore, a Npn2/?2Chn/Rac1 signaling axis distinguishes DG axon pruning from the effects of Sema3F on repulsion and dendritic spine remodeling...
  10. Wang Q, Chiu S, Koropouli E, Hong I, Mitchell S, Easwaran T, et al. Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons. Neuron. 2017;96:1084-1098.e7 pubmed publisher
    ..Therefore, Sema3F-Npn-2/PlexA3 signaling controls both synapse development and synaptic plasticity. ..