Gene Symbol: Chmp4b
Description: charged multivesicular body protein 4B
Alias: 2010012F05Rik, C76846, Snf7-2, charged multivesicular body protein 4b, chromatin modifying protein 4B, chromatin-modifying protein 4b
Species: mouse
Products:     Chmp4b

Top Publications

  1. Murrow L, Malhotra R, Debnath J. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol. 2015;17:300-10 pubmed publisher
    ..Overall, these results identify a link between the core autophagy and ESCRT machineries and uncover a role for ATG12-ATG3 in late endosome function that is distinct from the canonical role of either ATG in autophagosome formation. ..
  2. Chassefeyre R, Martínez Hernández J, Bertaso F, Bouquier N, Blot B, Laporte M, et al. Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B. J Neurosci. 2015;35:3155-73 pubmed publisher
    ..We propose that synaptic ESCRT-III filaments may function as a novel element of the submembrane cytoskeleton of spines. ..
  3. Lee J, Beigneux A, Ahmad S, Young S, Gao F. ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr Biol. 2007;17:1561-7 pubmed
  4. Lee J, Gao F. Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia. J Neurosci. 2009;29:8506-11 pubmed publisher
    ..These findings show that autophagic stress by excess accumulation of autophagosomes is detrimental to neuronal survival under certain neurodegenerative conditions. ..
  5. Sagona A, Nezis I, Stenmark H. Association of CHMP4B and autophagy with micronuclei: implications for cataract formation. Biomed Res Int. 2014;2014:974393 pubmed publisher
    ..Here we show that the ESCRT-III subunit CHMP4B not only localizes to normal cytokinetic bridges but also to chromosome bridges and micronuclei, the latter ..