Chat

Summary

Gene Symbol: Chat
Description: choline acetyltransferase
Alias: B230380D24Rik, CHOACTase, choline O-acetyltransferase, choline acetylase
Species: mouse

Top Publications

  1. ncbi Complementary expression and regulation of cadherins 6 and 11 during specific steps of motoneuron differentiation
    Veronique Marthiens
    Signalisation et Différenciation Cellulaires dans les Systèmes Nerveux et Musculaire, INSERM U440 Université Paris 6, Institut du Fer a Moulin, Paris, France
    Mol Cell Neurosci 20:458-75. 2002
  2. pmc Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
    Baiping Wang
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:14140-5. 2007
  3. pmc DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina
    Peter G Fuerst
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Neuron 64:484-97. 2009
  4. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
  5. ncbi Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development
    Eric Dessaud
    INSERM UMR 623, Developmental Biology Institute of Marseille INSERM, CNRS, Case 907, 13288 Marseille Cedex 09, France
    Mol Cell Neurosci 31:232-42. 2006
  6. ncbi Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla
    Stephan Oberle
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 26:1823-32. 2006
  7. pmc Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
  8. pmc The vesicular acetylcholine transporter is required for neuromuscular development and function
    Braulio M de Castro
    Molecular Brain Research Group, Robarts Research Institute, University of Western Ontario, P O Box 5015, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    Mol Cell Biol 29:5238-50. 2009
  9. pmc Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure
    Aline Lara
    Department of Physiology, Institute of Biological Sciences, Federal University of Minas Gerais, Av Antonio Carlos 6627, Belo Horizonte, MG CEP 31270 901, Brazil
    Mol Cell Biol 30:1746-56. 2010
  10. ncbi Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999

Research Grants

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. ncbi Complementary expression and regulation of cadherins 6 and 11 during specific steps of motoneuron differentiation
    Veronique Marthiens
    Signalisation et Différenciation Cellulaires dans les Systèmes Nerveux et Musculaire, INSERM U440 Université Paris 6, Institut du Fer a Moulin, Paris, France
    Mol Cell Neurosci 20:458-75. 2002
    ..These results strongly implicate cadherins 6 and 11 in the control of spinal motoneuron differentiation and segregation and in axoaxonal, axoglial, and glio-glial interactions during sensory-motor nerve progression...
  2. pmc Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter
    Baiping Wang
    Huffington Center on Aging and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:14140-5. 2007
    ..These results identify a physiological activity of APP in cholinergic neurons, and our data indicate that deregulation of APP function may contribute to cholinergic impairment and AD pathogenesis...
  3. pmc DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina
    Peter G Fuerst
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Neuron 64:484-97. 2009
    ..Therefore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic specificity in the mouse retina...
  4. pmc Pet-1 is required across different stages of life to regulate serotonergic function
    Chen Liu
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio, USA
    Nat Neurosci 13:1190-8. 2010
    ..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription...
  5. ncbi Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development
    Eric Dessaud
    INSERM UMR 623, Developmental Biology Institute of Marseille INSERM, CNRS, Case 907, 13288 Marseille Cedex 09, France
    Mol Cell Neurosci 31:232-42. 2006
    ..Comparison of its spatio-temporal expression pattern with that of two other members of this family, lynx1 and ly-6h, shows that these genes are detected both in distinct and overlapping neuron populations...
  6. ncbi Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla
    Stephan Oberle
    Neuroanatomy and Interdisciplinary Center for Neurosciences, University of Heidelberg, D 69120 Heidelberg, Germany
    J Neurosci 26:1823-32. 2006
    ..Thus, both somatic motoneurons and PSNs in the spinal cord depend on LIFRbeta signaling for their development and maintenance, although PSNs seem to be overall less affected than somatic motoneurons by LIFRbeta deprivation...
  7. pmc Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
    ..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
  8. pmc The vesicular acetylcholine transporter is required for neuromuscular development and function
    Braulio M de Castro
    Molecular Brain Research Group, Robarts Research Institute, University of Western Ontario, P O Box 5015, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    Mol Cell Biol 29:5238-50. 2009
    ..The abnormalities are similar to those of mice that cannot synthesize ACh due to a lack of choline acetyltransferase. Our results indicate that VAChT is essential to the normal development of motor neurons and the release of ACh...
  9. pmc Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure
    Aline Lara
    Department of Physiology, Institute of Biological Sciences, Federal University of Minas Gerais, Av Antonio Carlos 6627, Belo Horizonte, MG CEP 31270 901, Brazil
    Mol Cell Biol 30:1746-56. 2010
    ..Our findings provide direct evidence that decreased cholinergic neurotransmission and underlying autonomic imbalance cause plastic alterations that contribute to heart dysfunction...
  10. ncbi Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999
    ..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs...
  11. doi Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate
    Juan Antonio Moreno-Bravo
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Dev Dyn 239:2094-101. 2010
    ..The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei...
  12. ncbi The cholinergic gene locus
    L E Eiden
    Section of Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4090, USA
    J Neurochem 70:2227-40. 1998
    Messenger RNAs and the cognate gene(s) encoding choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT) have been cloned from mammals and several other animal classes in the last decade...
  13. pmc Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain
    John Jacob
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 136:2477-85. 2009
    ..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
  14. pmc Novel strains of mice deficient for the vesicular acetylcholine transporter: insights on transcriptional regulation and control of locomotor behavior
    Cristina Martins-Silva
    Molecular Brain Research Group, Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 6:e17611. 2011
    ..VAChT gene is embedded within the first intron of the choline acetyltransferase (ChAT) gene, which provides a unique arrangement and regulation for these two genes...
  15. doi Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels
    Roberto Buccafusca
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA
    Mol Genet Metab 95:81-95. 2008
    ..In conclusion, in neonatal brain tissue, Mrps6 gene expression may not be contingent on function of its embedded Slc5a3 gene, while inositide deficiency may not be the mechanism of lethal apnea in null Slc5a3 mice...
  16. ncbi c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice
    K Burau
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Eur J Neurosci 20:353-62. 2004
    ..of the c-ret receptor in mice dramatically reduces numbers of cells positive for choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT) in stellate ganglia of homozygous newborn animals...
  17. ncbi Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency
    Eugene P Brandon
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 24:5459-66. 2004
    Choline acetyltransferase (ChAT), the enzyme that synthesizes the neurotransmitter acetylcholine (ACh), is thought to be present in kinetic excess in cholinergic neurons...
  18. doi Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome
    Chantal F Medina
    Regenerative Medicine, Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8L6
    Hum Mol Genet 18:966-77. 2009
    ..These results implicate a role for Atrx in interneuron survival and differentiation...
  19. ncbi Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism
    Weichun Lin
    The Salk Institute, La Jolla, California 92037, USA
    Neuron 46:569-79. 2005
    ..Genetic elimination of Cdk5 or blocking ACh production prevents the dispersion of AChR clusters in agrin mutants. Therefore, we propose that ACh negatively regulates neuromuscular synapse formation through a Cdk5-dependent mechanism...
  20. pmc Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology
    Thomas Rotolo
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    PLoS ONE 3:e4099. 2008
    ....
  21. ncbi Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice
    Eugene P Brandon
    Laboratory of Genetics and Peptide Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:539-49. 2003
    ..developmental roles of acetylcholine (ACh) by establishing and analyzing mice lacking choline acetyltransferase (ChAT), the biosynthetic enzyme for ACh...
  22. pmc Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter
    Thomas Misgeld
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:11088-93. 2005
    ..Similar interactions between neurotransmitters and synaptic organizing molecules may operate at synapses in the central nervous system...
  23. pmc Single-neuron labeling with inducible Cre-mediated knockout in transgenic mice
    Paul Young
    Department of Neurobiology, Duke University Medical Center, Research Drive, Durham, North Carolina 27710, USA
    Nat Neurosci 11:721-8. 2008
    ..Our results provide evidence for the long-term stability of inactive neuromuscular synapses in adult animals and demonstrate a Cre-loxP compatible system for dissecting gene functions in single identifiable neurons...
  24. pmc The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons
    Yasser Elshatory
    Medical Scientist Training Program, Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 28:3291-7. 2008
    ..Together, these results demonstrate the requirement for Isl1 in the development of restricted telencephalic cholinergic neurons and link the development of cholinergic neurons in anatomically disparate sites to Isl1 function...
  25. pmc Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy
    Shingo Kariya
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Hum Mol Genet 17:2552-69. 2008
    ..We suggest that SMA might best be described as a NMJ synaptopathy and that one promising means of treating it could involve maintaining function at the NMJ...
  26. ncbi Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase
    Thomas Misgeld
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 36:635-48. 2002
    ..At subsequent stages, neurotransmission delays some steps in synaptic maturation but accelerates others. Thus, neurotransmission affects synaptogenesis from early stages and coordinates rather than drives synaptic maturation...
  27. pmc Genetic dissection of midbrain dopamine neuron development in vivo
    Debra Ellisor
    Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, 70 Ship St, Providence, RI 02903, USA
    Dev Biol 372:249-62. 2012
    ..By placing Wnt1, Fgf8, and En1/2 in the context of their temporal requirement for MbDA neuron development, we further deciphered the developmental program underpinning MbDA neuron progenitors...
  28. doi ChAT-ChR2-EYFP mice have enhanced motor endurance but show deficits in attention and several additional cognitive domains
    Benjamin Kolisnyk
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5K8
    J Neurosci 33:10427-38. 2013
    ..transgenic mice expressing channelrhodopsin-2 (ChR2) protein under the control of the choline acetyltransferase (ChAT) promoter (ChAT-ChR2-EYFP) to dissect cholinergic circuit connectivity and function using optogenetic approaches...
  29. pmc Wnt7A identifies embryonic γ-motor neurons and reveals early postnatal dependence of γ-motor neurons on a muscle spindle-derived signal
    Soha Ashrafi
    Neuroscience Program, Weill Cornell Medical College, New York, New York 10065, USA
    J Neurosci 32:8725-31. 2012
    ..Furthermore, using Wnt7a expression as an early marker of γ-MN identity, we demonstrate a previously unknown dependence of γ-MNs on a muscle spindle-derived, GDNF-independent signal during the first postnatal week...
  30. pmc Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy
    Tara L Martinez
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 32:8703-15. 2012
    ..Our data suggest that SMN plays distinct roles in muscle, NMJs, and motor neuron somal synapses and that restored function of SMN at all three sites will be necessary for full recovery of muscle power...
  31. pmc A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
    Linda Madisen
    Allen Institute for Brain Science, Seattle, Washington, USA
    Nat Neurosci 15:793-802. 2012
    ..When combined with the hundreds of available Cre driver lines, this optimized toolbox of reporter mice will enable widespread investigations of neural circuit function with unprecedented reliability and accuracy...
  32. pmc Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum
    Rita Lopes
    Division of Molecular Neurobiology, Medical Research Council, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 109:3119-24. 2012
    ....
  33. pmc Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation
    Amanda C Martyn
    Molecular Brain Research Group, Robarts Research Institute, and Department of Anatomy and Cell Biology and Physiology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada N6A 5K8
    Proc Natl Acad Sci U S A 109:17651-6. 2012
    ..These data uncover the specific contribution of forebrain cholinergic tone for synaptic plasticity and behavior. Moreover, these experiments define specific cognitive functions that could be targeted by cholinergic replacement therapy...
  34. doi Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit
    Mauricio Rosas-Ballina
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Science 334:98-101. 2011
    ..Thus, action potentials originating in the vagus nerve regulate T cells, which in turn produce the neurotransmitter, acetylcholine, required to control innate immune responses...
  35. pmc Sustained Hox5 gene activity is required for respiratory motor neuron development
    Polyxeni Philippidou
    Howard Hughes Medical Institute, New York University School of Medicine, Smilow Neuroscience Program, Department of Physiology and Neuroscience, New York, New York, USA
    Nat Neurosci 15:1636-44. 2012
    ..These findings indicate that Hox5 genes orchestrate PMC development through deployment of temporally distinct wiring programs...
  36. pmc Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1α-related defense mechanisms
    Yoshihiko Kakinuma
    Department of Cardiovascular Control, Kochi Medical School, Nankoku, Japan
    J Am Heart Assoc 2:e004887. 2013
    ..Such a mismatch and missing link suggest the existence of a nonneuronal cholinergic system in ventricular myocardium...
  37. pmc Egr2::cre mediated conditional ablation of dicer disrupts histogenesis of mammalian central auditory nuclei
    Elena Rosengauer
    Department of Neurogenetics, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
    PLoS ONE 7:e49503. 2012
    ..Together our data identify a critical role of Dicer activity during embryonic development of the auditory brainstem...
  38. pmc Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons
    Erik Keimpema
    European Neuroscience Institute at Aberdeen, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Proc Natl Acad Sci U S A 110:1935-40. 2013
    ..These data indicate that NGF can orchestrate endocannabinoid signaling to promote cholinergic differentiation and implicate BRCA1 in determining neuronal morphology...
  39. pmc The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification
    Alessandro Furlan
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden
    EMBO J 32:1613-25. 2013
    ....
  40. ncbi Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina
    Keely M Bumsted-O'Brien
    Department of Neuroanatomy, Max Planck Institute for Brain Research, Deutschordenst 46, 60218 Frankfurt, Germany
    J Comp Neurol 505:58-72. 2007
    ....
  41. ncbi Disruption and recovery of patterned retinal activity in the absence of acetylcholine
    Rebecca C Stacy
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9347-57. 2005
    ..of cholinergic transmission by using a conditional mutant in which the gene encoding choline acetyltransferase (ChAT), the sole synthetic enzyme for acetylcholine (ACh), was deleted from large retinal regions...
  42. ncbi Spatiotemporal definition of neurite outgrowth, refinement and retraction in the developing mouse cochlea
    Lin Chien Huang
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Development 134:2925-33. 2007
    ..This reorganization also establishes the cochlea as a model system for studying CNS synapse development, plasticity and elimination...
  43. pmc TrkB receptor controls striatal formation by regulating the number of newborn striatal neurons
    Maryna Baydyuk
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20057, USA
    Proc Natl Acad Sci U S A 108:1669-74. 2011
    ..These findings suggest that neurotrophins can control the size of neuronal populations in the brain by promoting the survival of newborn neurons before they migrate to their final destinations...
  44. ncbi Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development
    Margarita García-López
    Department of Human Anatomy, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
    J Comp Neurol 506:46-74. 2008
    ..Our study provides a molecular and morphological foundation for understanding the complex embryonic origins and adult organization of the centromedial and extended amygdala...
  45. doi Mice lacking the transcription factor Ikaros display behavioral alterations of an anti-depressive phenotype
    Tim Rasmus Kiehl
    Department of Pathology, University Health Network, 610 University Avenue, Toronto, Ontario, Canada
    Exp Neurol 211:107-14. 2008
    ....
  46. doi Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy
    Hsin Lan Wen
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Hum Mol Genet 19:1766-78. 2010
    ..We conclude that aberrant stathmin levels may play a detrimental role in SMA; this finding suggests a novel approach to treating SMA by enhancing microtubule stability...
  47. doi A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei
    Fernando García-Moreno
    Instituto Cajal Consejo Superior de Investigaciones Cientificas, Laboratory of Telencephalic Development, Molecular, Cellular and Developmental Neurobiology Department, Madrid, Spain
    Nat Neurosci 13:680-9. 2010
    ..The diencephalic transcription factor OTP was necessary for this migratory behavior...
  48. pmc Loss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits
    Philippe M Duquette
    Centre for Stroke Recovery, Neuroscience, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    PLoS ONE 5:e13232. 2010
    ..However, the significance of LMO4 in mammalian eye development and function remained unknown since LMO4 null mice die prior to birth...
  49. pmc Seizure-related gene 6 (Sez-6) in amacrine cells of the rodent retina and the consequence of gene deletion
    Jenny M Gunnersen
    Brain Development, Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 4:e6546. 2009
    ..Seizure-related gene 6 (Sez-6) is expressed in neurons of the mouse brain, retina and spinal cord. In the cortex, Sez-6 plays a role in specifying dendritic branching patterns and excitatory synapse numbers during development...
  50. doi Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome
    Eva K Wirth
    Neuroscience Research Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Neurosci 29:9439-49. 2009
    ....
  51. pmc The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum
    Li Chen
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 6403, USA
    J Neurosci 30:14824-34. 2010
    ..Together, our data demonstrate that Gbx2 is required for the development of striatal cholinergic interneurons, perhaps by regulating tangential migration of the striatal cholinergic precursors...
  52. pmc Developmental origin of preBötzinger complex respiratory neurons
    Paul A Gray
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:14883-95. 2010
    ..These data indicate that Dbx1-derived neurons are essential for the expression and, we hypothesize, are responsible for the generation of respiratory behavior both in vitro and in vivo...
  53. pmc MSC p43 required for axonal development in motor neurons
    Xiaodong Zhu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 106:15944-9. 2009
    ..Thus, MSC p43 is indispensable in maintaining axonal integrity. Its dysfunction may underlie the NF disorganization and axon degeneration associated with motor neuron degenerative diseases...
  54. pmc LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons
    Apostolia Fragkouli
    MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 136:3841-51. 2009
    ..These studies suggest that a LIM homeodomain transcriptional code confers cell-fate specification and neurotransmitter identity in neuronal subpopulations of the ventral forebrain...
  55. pmc Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits
    Olga Penagarikano
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell 147:235-46. 2011
    ..These data demonstrate a functional role for CNTNAP2 in brain development and provide a new tool for mechanistic and therapeutic research in ASD...
  56. pmc Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy
    Dirk Bäumer
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000773. 2009
    ....
  57. ncbi V1 spinal neurons regulate the speed of vertebrate locomotor outputs
    Simon Gosgnach
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 440:215-9. 2006
    ....
  58. ncbi NCAM in the organ of Corti of the developing mouse
    D S Whitlon
    Department of Neurology, University of Wisconsin, Madison
    J Neurocytol 19:970-7. 1990
    ..NCAM is also present along the growth path of the nerve fibres. These studies suggest that NCAM is properly positioned in the cochlea for possible roles in axon guidance and nerve-target interactions...
  59. pmc Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3
    Y Qian
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 15:2533-45. 2001
    ....
  60. pmc FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals
    Ras Trokovic
    Institute of Biotechnology, Viikki Biocenter, PO Box 56, 00014 University of Helsinki, Finland
    EMBO J 22:1811-23. 2003
    ..In addition, FGFR1 appears to modify cell adhesion properties critical for maintaining a coherent organizing center. This may be achieved by regulating expression of specific cell-adhesion molecules at the midbrain-hindbrain border...
  61. ncbi Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    J Neurosci 22:4036-44. 2002
    ..These results indicate that Cdk5/p35 and Reelin signaling regulates the selective mode of neuronal migration in the developing mouse hindbrain...
  62. ncbi Developmental timing of hair follicle and dorsal skin innervation in mice
    Eva M J Peters
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg D 20246, Germany
    J Comp Neurol 448:28-52. 2002
    ..This sequence of developing innervation consistently correlates with hair follicle development, indicating a close interdependence of neuronal and epithelial morphogenesis...
  63. ncbi Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression
    Tiffany Mellott
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Eur J Biochem 269:850-8. 2002
    The expression of the choline acetyltransferase (ChAT) enzyme that synthesizes the neurotransmitter acetylcholine (ACh) is upregulated by ciliary neurotrophic factor (CNTF)...
  64. ncbi Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genes
    H Usui
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Japan
    Gene 248:127-35. 2000
    ..Northern blot analysis showed that the Sfmbt mRNAs were expressed most abundantly in the adult testis, and less intensively in all other tissues examined...
  65. ncbi Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14
    E Rasmussen
    Department of Psychiatry and Psychology, State University of New York at Stony Brook, Stony Brook, New York, USA
    J Pharmacol Exp Ther 290:1337-46. 1999
    ..A second QTL was detected on chromosome 14 (peak LOD = 6.9), which was located more proximally and included the Chat locus...
  66. ncbi Impaired extrapyramidal function caused by the targeted disruption of retinoid X receptor RXRgamma1 isoform
    Y Saga
    Banyu Tsukuba Research Institute Merck Tsukuba, Ibaraki, 300 33 Japan
    Genes Cells 4:219-28. 1999
    ..In contrast to the widespread expression of RXRalpha and RXRbeta, the expression of RXRgamma is restricted to particular tissues in which RXRgamma1 is the major isoform expressed in the mouse corpus striatum...
  67. ncbi The origin and development of the vagal and spinal innervation of the external muscle of the mouse esophagus
    Q Sang
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia
    Brain Res 809:253-68. 1998
    ....
  68. ncbi Molecular characterization of the mouse vesicular acetylcholine transporter gene
    J M Naciff
    Department of Molecular and Cellular Physiology, University of Cincinnati, College of Medicine, OH 45267 0576, USA
    Neuroreport 8:3467-73. 1997
    The organization of the mouse choline acetyltransferase (ChAT) gene has been previously analyzed. Here we show that the first intron of the mouse ChAT gene contains an uninterrupted open reading frame...
  69. pmc Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration
    C Andres
    Department of Biological Chemistry, The Hebrew University of Jerusalem, 91904 Israel
    Proc Natl Acad Sci U S A 94:8173-8. 1997
    ....
  70. ncbi Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Development 124:1215-26. 1997
    ..This navigational error could explain the disappearance, at around 17.5 dpc, of the trigeminal motor nucleus in Krox-20(-/-) embryos by inadequate supply of essential, possibly arch-specific survival factors...
  71. ncbi The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system
    M C Tiveron
    Institut de Biologie du Developpement de Marseille, Centre National dela Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de la Mediterranée, Marseille, France
    J Neurosci 16:7649-60. 1996
    ..e., that of the medullary control reflexes of autonomic functions. This suggests that Phox2 could be involved in the establishment of these circuits...
  72. ncbi Analysis of CAG trinucleotide repeats from mouse cDNA sequences
    C Abbott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Ann Hum Genet 58:87-94. 1994
    ..containing variable length CAG repeats, seven in absentia homologue 1b (Sinh1b), and choline acetyl transferase (Chat), which had not previously been mapped in the mouse genome, were mapped by linkage analysis in an interspecific ..
  73. pmc The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain
    Yangu Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:9005-10. 2003
    ..These results provide genetic evidence supporting an important role for Lhx8 in development of cholinergic neurons in the forebrain...
  74. pmc Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin
    Silvia Pagliardini
    Department of Physiology, Centre of Neuroscience, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Am J Pathol 167:175-91. 2005
    ....
  75. ncbi Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2
    M I Ransome
    Neural Regeneration Laboratory, Centre for Neuroscience, University of Melbourne, Melbourne, Victoria 3010, Australia
    Neuroscience 132:673-87. 2005
    ..Therefore, over-expression of SOCS2 variably affects different cortical regions and neuronal populations, with the predominant effect appearing to be on interneurons and neuronal connectivity in the cortex...
  76. pmc Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice
    Shawn M Ferguson
    Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 101:8762-7. 2004
    ..Our results demonstrate that CHT is an essential and regulated presynaptic component of cholinergic signaling and indicate that CHT warrants consideration as a candidate gene for disorders characterized by cholinergic hypofunction...
  77. ncbi Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice
    Apostolia Fragkouli
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Eur J Neurosci 21:2923-38. 2005
    ..Overall our experiments demonstrate that Lhx7 expression is required for the specification or differentiation of cholinergic forebrain neurons involved in the processing of spatial information...
  78. ncbi Evidence for a cell-specific action of Reelin in the spinal cord
    Patricia E Phelps
    Department of Physiological Science, UCLA, Los Angeles, California 90095 1527, USA
    Dev Biol 244:180-98. 2002
    ..These results suggest that Reelin acts in a cell-specific manner on the migration of cholinergic spinal cord neurons...
  79. pmc Genetic dissection of the function of hindbrain axonal commissures
    Nicolas Renier
    INSERM, U968, Paris, F 75012, France
    PLoS Biol 8:e1000325. 2010
    ..To our knowledge, this study is one of the first to link defects in commissural axon guidance with specific cellular and behavioral phenotypes...
  80. ncbi Developmental expression of ascidian neurotransmitter synthesis genes. I. Choline acetyltransferase and acetylcholine transporter genes
    Katsumi Takamura
    Department of Marine Biotechnology, Faculty of Engineering, Fukuyama University, 729 0292, Japan
    Dev Genes Evol 212:50-3. 2002
    To identify cholinergic neurons, we isolated a choline acetyltransferase (Ci-ChAT) gene from Ciona intestinalis by PCR methods. In the cloning process, we also obtained the gene encoding the vesicular acetylcholine transporter (Ci-vAChTP)...
  81. pmc Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling
    Ekim Ozkaynak
    Department of Cell Biology and Genetics, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    J Neurosci 30:3857-64. 2010
    ..Our results thus reveal a novel paracrine signaling axis in peripheral nerve myelination in which Schwann cell secreted Lgi4 functions through binding of axonal Adam22 to drive the differentiation of Schwann cells...
  82. pmc FSH regulates acetycholine production by ovarian granulosa cells
    Artur Mayerhofer
    Anatomisches Institut der Universität München, Deutschland
    Reprod Biol Endocrinol 4:37. 2006
    ..cultured granulosa cells (GCs) derived from human ovarian preovulatory follicles contain choline acetyltransferase (ChAT), the enzyme responsible for acetylcholine (ACh) synthesis...
  83. ncbi Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem
    A Wallén A
    Ludwig Institute for Cancer Research, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Mol Cell Neurosci 18:649-63. 2001
    ..In conclusion, regulation of Ret by Nurr1 in midbrain DA neurons and in the DMN has implications for both embryonal development and adult physiology in which signaling by neurotrophic factors plays important roles...
  84. pmc A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
    Linda Madisen
    Allen Institute for Brain Science, Seattle, Washington, USA
    Nat Neurosci 13:133-40. 2010
    ..Our expression data are displayed in a public online database to help researchers assess the utility of various Cre-driver lines for cell-type-specific genetic manipulation...
  85. ncbi Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS
    S Sakakibara
    Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Neurosci 21:8091-107. 2001
    ..These two RNA-binding proteins may exert common functions in neural precursor cells by regulating gene expression at the post-transcriptional level...
  86. ncbi Generation of a novel functional neuronal circuit in Hoxa1 mutant mice
    E D del Toro
    Neurobiologie Genetique et Integrative, Unité Propre de Recherche 2216, Centre National de la Recherche Scientifique CNRS, 91198 Gif sur Yvette, France
    J Neurosci 21:5637-42. 2001
    ..This is the first demonstration that changes in Hox expression patterns allow the selection of novel neuronal circuits regulating vital adaptive behaviors. The implications for the evolution of brainstem neural networks are discussed...
  87. doi TGIF, a homeodomain transcription factor, regulates retinal progenitor cell differentiation
    Shinya Satoh
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Exp Eye Res 87:571-9. 2008
    ....
  88. ncbi Defects in enteric innervation and kidney development in mice lacking GDNF
    J G Pichel
    Laboratory of Mammalian Genes and Development, National Institutes of Health, Bethesda 20892, USA
    Nature 382:73-6. 1996
    ..We demonstrate that GDNF induces ureter bud formation and branching during metanephros development, and is essential for proper innervation of the gastrointestinal tract...
  89. pmc BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons
    Qian Ding
    University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 29:3992-4003. 2009
    ..Thus, BARHL2 appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival...
  90. ncbi Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
    R J McEvilly
    Howard Hughes Medical Institute, University of California, San Diego, USA
    Nature 384:574-7. 1996
    ..Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations...
  91. pmc AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons
    Francesca M Theriault
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 101:10343-8. 2004
    ..Runx1 inactivation also leads to a loss of selected sensory neurons in trigeminal and vestibulocochlear ganglia. These findings uncover previously unrecognized roles for Runx1 in the regulation of mammalian neuronal subtype development...
  92. pmc Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center and Graduate Training Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:6942-7. 2008
    ..They also reveal that identical RGC expression patterns are achieved by different combinations of divergent inputs from upstream transcription factors...
  93. ncbi Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Cell 75:1199-214. 1993
    ..We conclude that Krox-20, although not required for the initial delimitation of r3 and r5, plays an important role in the process of segmentation governing hindbrain development...
  94. ncbi Calcium-independent release of acetylcholine from stable cell lines expressing mouse choline acetyltransferase cDNA
    H Misawa
    Department of Neurology, Tokyo Metropolitan Institute for Neuroscience, Japan
    J Neurochem 62:465-70. 1994
    Stably transfected cells expressing mouse choline acetyltransferase (ChAT) cDNA were established, and the synthesis and release of acetylcholine (ACh) were examined...
  95. ncbi Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism
    Malgorzata Chalimoniuk
    Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 90:629-36. 2004
    ..To test this hypothesis, mRNA expression and activity of choline acetyltransferase (ChAT) was measured in cultured spinal cord neurons treated with increasing concentrations (0.1-10 microm) of AA...
  96. ncbi The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons
    Tetsuji Mori
    Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295 Japan
    Eur J Neurosci 19:3129-41. 2004
    ..Neurotransmitter phenotypes other than cholinergic in the basal forebrain appeared intact. From these results, we suggested that L3/Lhx8 has a pivotal and specific role in the development and/or maintenance of BFCNs...
  97. ncbi Prenatal development of peptidergic primary afferent projections to mouse lumbosacral autonomic preganglionic cell columns
    Kengo Funakoshi
    Department of Neuroanatomy, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Brain Res Dev Brain Res 144:107-19. 2003
    ..The potential direct connections between the peptidergic primary sensory fibers and preganglionic neurons innervating the pelvic viscera might provide a circuit for spinal visceral reflexes active in embryos...
  98. ncbi Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains
    D M Chambers
    Medical Research Council MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Genome Res 6:715-23. 1996
    ..However, two of the repeats were shown to have undergone size changes during the establishment of a number of recombinant inbred strains, suggesting that these repeats are at least moderately unstable...
  99. ncbi Altered forebrain and hindbrain development in mice mutant for the Gsh-2 homeobox gene
    J C Szucsik
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Dev Biol 191:230-42. 1997
    ....
  100. ncbi Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, France
    Development 124:4065-75. 1997
    ..This suggests that Phox2b links early patterning events to the differentiation of defined neuronal populations in the hindbrain...
  101. ncbi Mouse surfactant protein-D. cDNA cloning, characterization, and gene localization to chromosome 14
    M Motwani
    Department of Pathology, Boston University School of Medicine, MA 02118, USA
    J Immunol 155:5671-7. 1995
    ..The mouse SP-D gene (Sftp4) has been localized to chromosome 14 (to a region syntenic to human chromosome 10), closely linked to the genes for other collagenous lectins, mannose-binding protein-A (MbI1), and SP-A (Sftp1)...

Research Grants4

  1. Does cortex kill striatum in HD?
    CHRISTOPHER MEADE; Fiscal Year: 2004
    ..These studies will validate the in oculo technique as an effective HD model system, which might be useful in further testing hypotheses of mutant Ht mechanism of action and in testing possible drug therapies. ..
  2. GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEM
    Paul Gray; Fiscal Year: 2010
    ..Understanding the genetic organization of the brainstem neurons that generate breathing is essential for the diagnosis and treatment of breathing disorders. ..
  3. GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEM
    Paul Gray; Fiscal Year: 2009
    ..Understanding the genetic organization of the brainstem neurons that generate breathing is essential for the diagnosis and treatment of breathing disorders. ..