Cgn

Summary

Gene Symbol: Cgn
Description: cingulin
Alias: 6330408J11Rik, AI647528, AI987749
Species: mouse

Top Publications

  1. pmc Under construction: building the macromolecular superstructure and signaling components of an electrical synapse
    B D Lynn
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
    J Membr Biol 245:303-17. 2012
  2. doi Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    J Cell Sci 125:5005-14. 2012
  3. ncbi Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development
    T P Fleming
    Department of Biology, University of Southampton, UK
    Development 117:1135-44. 1993
  4. ncbi Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development
    Q Javed
    Department of Biology, University of Southampton, UK
    Development 117:1145-51. 1993
  5. ncbi Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction
    B Sheth
    Division of Cell Sciences, School of Biological Sciences, University of Southampton, Bassett Crescent East, SO16 7PX, Southampton, UK
    Mech Dev 97:93-104. 2000
  6. ncbi A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation
    Saadia A Karim
    Applied Neurobiology Group, Institute of Comparative Medicine, Veterinary School, United Kingdom
    Genomics 83:225-30. 2004
  7. ncbi JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin
    Hiroe Ohnishi
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:46014-22. 2004
  8. ncbi Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    J Cell Sci 117:5245-56. 2004

Detail Information

Publications9

  1. pmc Under construction: building the macromolecular superstructure and signaling components of an electrical synapse
    B D Lynn
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
    J Membr Biol 245:303-17. 2012
    ....
  2. doi Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, CH 1211 Geneva, Switzerland
    J Cell Sci 125:5005-14. 2012
    Cingulin (CGN) is a 140 kDa protein, which is localized to the cytoplasmic region of vertebrate tight junctions (TJ), and regulates gene expression and RhoA signaling in cultured cells...
  3. ncbi Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development
    T P Fleming
    Department of Biology, University of Southampton, UK
    Development 117:1135-44. 1993
    ..Collectively, our results indicate that (i) cingulin from nonjunctional sites does not contribute to tight junction assembly and (ii) the molecular maturation of the junction appears to occur progressively over at least two cell cycles...
  4. ncbi Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development
    Q Javed
    Department of Biology, University of Southampton, UK
    Development 117:1145-51. 1993
    ..Taken together, the results suggest that (i) cingulin may have a role during oogenesis and (ii) cell-cell contact patterns regulate cingulin biosynthesis during early morphogenesis, contributing to lineage-specific epithelial maturation...
  5. ncbi Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction
    B Sheth
    Division of Cell Sciences, School of Biological Sciences, University of Southampton, Bassett Crescent East, SO16 7PX, Southampton, UK
    Mech Dev 97:93-104. 2000
    ..Moreover, we propose a role for rab13 in the specification of the AJC site and the formation and segregation of the TJ...
  6. ncbi A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation
    Saadia A Karim
    Applied Neurobiology Group, Institute of Comparative Medicine, Veterinary School, United Kingdom
    Genomics 83:225-30. 2004
    ..Accordingly, our findings both map the area surrounding the hsh mutation and present important corrections to the current maps in an area rich in genes related to the nervous system...
  7. ncbi JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin
    Hiroe Ohnishi
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:46014-22. 2004
    ..These findings suggest that JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons...
  8. ncbi Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression
    Laurent Guillemot
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland
    J Cell Sci 117:5245-56. 2004
    ..Thus, lack of junctional cingulin does not prevent tight-junction formation, but gene expression and tight junction protein levels are altered by the cingulin mutation...