CGI 58

Summary

Gene Symbol: CGI 58
Description: abhydrolase domain containing 5
Alias: 1300003D03Rik, 2010002J10Rik, CDS, CGI-58, IECN5, NCIE2, 1-acylglycerol-3-phosphate O-acyltransferase ABHD5, abhydrolase domain-containing protein 5, lipid droplet-binding protein CGI-58
Species: mouse

Top Publications

  1. pmc CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
    J Mark Brown
    Departments of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 51:3306-15. 2010
  2. pmc CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase
    Gabriela Montero-Moran
    Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 51:709-19. 2010
  3. pmc Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)
    Franz P W Radner
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    J Biol Chem 285:7300-11. 2010
  4. pmc Functional interactions between Mldp (LSDP5) and Abhd5 in the control of intracellular lipid accumulation
    James G Granneman
    Center for Integrative Metabolic and Endocrine Research, the Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Biol Chem 284:3049-57. 2009
  5. ncbi Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 281:40236-41. 2006
  6. pmc The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
    Astrid Gruber
    Institute of Molecular Biosciences, University of Graz, Humboldtstrasse, A 8010 Graz, Austria
    J Biol Chem 285:12289-98. 2010
  7. ncbi CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome
    Tomohiro Yamaguchi
    Graduate School of Life Science, Himeji Institute of Technology, University of Hyogo, 3 2 1 Koto, Kamigori, Hyogo 678 1297, Japan
    J Biol Chem 279:30490-7. 2004
  8. ncbi Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Cell Metab 3:309-19. 2006
  9. ncbi Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes
    Vidya Subramanian
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    J Biol Chem 279:42062-71. 2004
  10. pmc CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid
    Ananda K Ghosh
    Department of Biochemistry, Indian Institute of Science, Bangalore 562, India
    J Biol Chem 283:24525-33. 2008

Research Grants

  1. Analysis of Therapeutic Adipose Tissue Remodeling
    JAMES GRANNEMAN; Fiscal Year: 2004
  2. Analysis of cellular plasticity in white adipose tissue
    JAMES GRANNEMAN; Fiscal Year: 2007
  3. Analysis of lipolytic trafficking in adipocytes
    JAMES GRANNEMAN; Fiscal Year: 2009
  4. HTS for Novel Activators of Adipocyte and Myocyte Lipolysis
    JAMES GRANNEMAN; Fiscal Year: 2007
  5. Analysis of lipolytic trafficking in adipocytes
    James G Granneman; Fiscal Year: 2010
  6. Analysis of cellular plasticity in white adipose tissue
    JAMES GRANNEMAN; Fiscal Year: 2004
  7. BETA 1 AND BETA 3 ADRENORECEPTORS
    JAMES GRANNEMAN; Fiscal Year: 2001
  8. Analysis of cellular plasticity in white adipose tissue
    James G Granneman; Fiscal Year: 2010

Scientific Experts

  • JAMES GRANNEMAN
  • Sheetal Gandotra
  • M Akiyama
  • Achim Lass
  • Robert Zimmermann
  • Rudolf Zechner
  • Martina Schweiger
  • J Mark Brown
  • Dawn L Brasaemle
  • Guenter Haemmerle
  • Caleb C Lord
  • Franz P W Radner
  • Jenna L Betters
  • Manju Kumari
  • Irina Cornaciu
  • Jorge M Caviglia
  • Tomohiro Yamaguchi
  • Astrid Gruber
  • Gabriele Schoiswohl
  • Vidya Subramanian
  • Jennifer L Cantley
  • Kathrin A Zierler
  • Pierre Marie Badin
  • Sandra Eder
  • Gerald I Shulman
  • Karina Preiss-Landl
  • Mark J Graham
  • Monika Oberer
  • Xingyuan Yang
  • Gabriela Montero-Moran
  • Ananda K Ghosh
  • Lawrence Shapiro
  • Alexis Rothenberg
  • Takashi Osumi
  • Naoto Omatsu
  • Robert C Murphy
  • Doris Jaeger
  • Gary W Cline
  • Toru Yoshimura
  • Joseph Hankin
  • Dongyan Zhang
  • Burkert Pieske
  • Naoki Kumashiro
  • Albrecht Schmidt
  • Blas A Guigni
  • Dagmar Kolb
  • Gerald N Rechberger
  • Bernd Mayer
  • Joao Paulo G Camporez
  • Gerald Woelkart
  • Vara Prasad Manchem
  • Varman T Samuel
  • Julie Serr
  • Michael J Jurczak
  • Sanjay Bhanot
  • Francois R Jornayvaz
  • Nina M Pollak
  • Fitsum Guebre-Egziabher
  • Mario Kahn
  • Camille Loubière
  • John S Parks
  • Cedric Moro
  • Stephen B Milne
  • H Alex Brown
  • Richard G Lee
  • Michael B Fessler
  • Rosanne M Crooke
  • Jennifer Madenspacher
  • Steven R Smith
  • Soonkyu Chung
  • Arild C Rustan
  • Virginie Bourlier
  • Dominique Langin
  • Maarten Coonen
  • Gwynneth Thomas
  • Mingxia Liu
  • Katie Louche
  • Matthew A Davis
  • Pavlina T Ivanova
  • David S Myers
  • Aline Mairal
  • Geneviève Tavernier
  • Harald M Nagy
  • Sean Sullivan
  • Dianne Helerie Dapito
  • Haiyan Mu
  • Barbara Salzburger
  • Andras Boeszoermenyi
  • Anna Sekowski
  • Terry Yin

Detail Information

Publications21

  1. pmc CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
    J Mark Brown
    Departments of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 51:3306-15. 2010
    ....
  2. pmc CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase
    Gabriela Montero-Moran
    Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 51:709-19. 2010
    Mutations in human CGI-58/ABHD5 cause Chanarin-Dorfman syndrome (CDS), characterized by excessive storage of triacylglycerol in tissues. CGI-58 is an alpha/beta-hydrolase fold enzyme expressed in all vertebrates...
  3. pmc Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)
    Franz P W Radner
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    J Biol Chem 285:7300-11. 2010
    ..This mechanism may also underlie the pathogenesis of ichthyosis in neutral lipid storage disease patients lacking functional CGI-58...
  4. pmc Functional interactions between Mldp (LSDP5) and Abhd5 in the control of intracellular lipid accumulation
    James G Granneman
    Center for Integrative Metabolic and Endocrine Research, the Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Biol Chem 284:3049-57. 2009
    ..These results indicate that the interaction between Abhd5 and Mldp is dynamic and essential for regulating the activity of Atgl at lipid droplets containing Mldp...
  5. ncbi Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 281:40236-41. 2006
    ..Together, ATGL and HSL are responsible for more than 95% of the TG hydrolase activity present in murine WAT. Additional known or unknown lipases appear to play only a quantitatively minor role in fat cell lipolysis...
  6. pmc The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase
    Astrid Gruber
    Institute of Molecular Biosciences, University of Graz, Humboldtstrasse, A 8010 Graz, Austria
    J Biol Chem 285:12289-98. 2010
    ..In summary, our study shows that the N-terminal, Trp-rich region of CGI-58 is essential for correct localization and ATGL-activating function of CGI-58...
  7. ncbi CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome
    Tomohiro Yamaguchi
    Graduate School of Life Science, Himeji Institute of Technology, University of Hyogo, 3 2 1 Koto, Kamigori, Hyogo 678 1297, Japan
    J Biol Chem 279:30490-7. 2004
    ..between perilipin and CGI-58, a deficiency of which correlated with the pathogenesis of Chanarin-Dorfman syndrome (CDS)...
  8. ncbi Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Cell Metab 3:309-19. 2006
    ..Mutations in the human CGI-58 gene are associated with Chanarin-Dorfman Syndrome (CDS), a rare genetic disease where TG accumulates excessively in multiple tissues...
  9. ncbi Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes
    Vidya Subramanian
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    J Biol Chem 279:42062-71. 2004
    ..Thus, CGI-58 binds to perilipin A-coated lipid droplets in a manner that is dependent upon the metabolic status of the adipocyte and the activity of cAMP-dependent protein kinase...
  10. pmc CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid
    Ananda K Ghosh
    Department of Biochemistry, Indian Institute of Science, Bangalore 562, India
    J Biol Chem 283:24525-33. 2008
    ..These observations suggest the existence of an alternate cytosolic phosphatidic acid biosynthetic pathway in the white adipose tissue. Collectively, these results reveal the role of cgi-58 as an acyltransferase...
  11. pmc Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity
    Jorge M Caviglia
    Rutgers Center for Lipid Research and Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 52:2032-42. 2011
    ..The expression of ABHD5 in mouse adipose tissue is not limiting for either basal or stimulated lipolysis...
  12. pmc CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action
    Caleb C Lord
    Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 61:355-63. 2012
    ..Collectively, these findings establish that CGI-58 provides a novel source of signaling lipids. These findings contribute insight into the basic mechanisms linking TH1 cytokine signaling to nutrient metabolism...
  13. pmc Functional cardiac lipolysis in mice critically depends on comparative gene identification-58
    Kathrin A Zierler
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Biol Chem 288:9892-904. 2013
    ..In summary, this study demonstrates that functional muscle lipolysis depends on both CGI-58 and ATGL...
  14. pmc Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58
    Pierre Marie Badin
    Inserm 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, Toulouse, France
    J Lipid Res 53:839-48. 2012
    ....
  15. pmc CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
    Jennifer L Cantley
    Howard Hughes Medical Institute and Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 110:1869-74. 2013
    ....
  16. pmc Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl)
    James G Granneman
    Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 284:34538-44. 2009
    ..Imaging experiments demonstrated that the Plin-dependent interaction of Abhd5 and Atgl occurs mainly, but not exclusively, on lipid droplets that contain Plin...
  17. pmc The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively
    Irina Cornaciu
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    PLoS ONE 6:e26349. 2011
    ....
  18. pmc Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5)
    Sheetal Gandotra
    Institute of Metabolic Science Metabolic Research Laboratories and the Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    J Biol Chem 286:34998-5006. 2011
    ..The data also suggest that pharmacological inhibition of ATGL could have therapeutic potential in patients with this rare but metabolically serious disorder...
  19. pmc Identification of a novel splicing isoform of murine CGI-58
    Xingyuan Yang
    Department of Pediatrics, University of Kentucky, Lexington, KY 40536 0509, USA
    FEBS Lett 584:903-10. 2010
    ..Overexpression of mCGI-58S failed to promote lipid droplet turnover and loss of intracellular triacylglycerols. These results suggest that this splicing event may be involved in the regulation of lipid homeostasis...
  20. ncbi CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation
    Tomohiro Yamaguchi
    Graduate School of Life Science, University of Hyogo, 3 2 1, Koto, Kamigori, Hyogo 678 1297, Japan
    J Lipid Res 48:1078-89. 2007
    ..CGI-58 is not required for this process. Thus, CGI-58 facilitates lipolysis in cooperation with perilipin and other factors, including lipases...
  21. pmc CGI-58 is an alpha/beta-hydrolase within lipid transporting lamellar granules of differentiated keratinocytes
    Masashi Akiyama
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Am J Pathol 173:1349-60. 2008
    ..Our results indicate that CGI-58 is expressed and packaged into LGs during keratinization and likely plays crucial role(s) in keratinocyte differentiation and LG lipid metabolism, contributing to skin lipid barrier formation...

Research Grants20

  1. Analysis of Therapeutic Adipose Tissue Remodeling
    JAMES GRANNEMAN; Fiscal Year: 2004
    ..2) To examine adipose tissue cellular dynamics during therapeutic remodeling induced by agonist activation of beta3-adrenergic receptors and PPAR-gamma. ..
  2. Analysis of cellular plasticity in white adipose tissue
    JAMES GRANNEMAN; Fiscal Year: 2007
    ..2) To determine the origin and fate of multilocular white adipocytes. 3) To examine mechanisms by which Adrb3 activation induces mitochondrial biogenesis in white adipocytes in vivo. ..
  3. Analysis of lipolytic trafficking in adipocytes
    JAMES GRANNEMAN; Fiscal Year: 2009
    ....
  4. HTS for Novel Activators of Adipocyte and Myocyte Lipolysis
    JAMES GRANNEMAN; Fiscal Year: 2007
    ..Our long term goal is to identify lead compounds that will reduce lipid accumulation specifically in fat and muscle and thus would be potential novel treatments of obesity-related disorders including diabetes and cardiovascular disease. ..
  5. Analysis of lipolytic trafficking in adipocytes
    James G Granneman; Fiscal Year: 2010
    ....
  6. Analysis of cellular plasticity in white adipose tissue
    JAMES GRANNEMAN; Fiscal Year: 2004
    ..2) To examine the function of novel multilocular white adipocytes in vivo and in vitro. 3) To test the involvement of PPAR-alpha and TLR4 in mediating adipocyte plasticity in vivo. ..
  7. BETA 1 AND BETA 3 ADRENORECEPTORS
    JAMES GRANNEMAN; Fiscal Year: 2001
    ..Aim 2. To further characterize the differential signaling properties of beta1- beta3-AR and to examine the cellular and molecular basis. Specific Aim 3. To examine the molecular pharmacology of beta3-AR-selective agonists. ..
  8. Analysis of cellular plasticity in white adipose tissue
    James G Granneman; Fiscal Year: 2010
    ..2) To determine the origin and fate of multilocular white adipocytes. 3) To examine mechanisms by which Adrb3 activation induces mitochondrial biogenesis in white adipocytes in vivo. ..