Cfh

Summary

Gene Symbol: Cfh
Description: complement component factor h
Alias: Mud-1, NOM, Sas-1, Sas1, complement factor H, complement factor H related protein 3A4/5G4, protein beta-1-H
Species: mouse
Products:     Cfh

Top Publications

  1. Moseley W, Seldin M. Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1. Genomics. 1989;5:899-905 pubmed
    ..These studies provide a model for examination of specific evolutionary events. ..
  2. Joyner A, Martin G. En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis. Genes Dev. 1987;1:29-38 pubmed
    ..Both genes map in the vicinity of mutations that are known to cause abnormalities during development. ..
  3. Elliott R, Barlow D, Hogan B. Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985;21:477-84 pubmed
    ..4 +/- 3.2 cM distal to the Pep-3 locus. There is no evidence in the mouse for pseudogenes for these proteins. ..
  4. Turnberg D, Botto M. The regulation of the complement system: insights from genetically-engineered mice. Mol Immunol. 2003;40:145-53 pubmed
    ..The advantages and disadvantages of this type of approach are discussed and the insights gained from the investigation of these animals are reviewed. ..
  5. Bao L, Haas M, Quigg R. Complement factor H deficiency accelerates development of lupus nephritis. J Am Soc Nephrol. 2011;22:285-95 pubmed publisher
    b>Complement factor H (CfH) is a key regulator of the alternative pathway, and its presence on mouse platelets and podocytes allows the processing of immune complexes...
  6. Lyzogubov V, Tytarenko R, Jha P, Liu J, Bora N, Bora P. Role of ocular complement factor H in a murine model of choroidal neovascularization. Am J Pathol. 2010;177:1870-80 pubmed publisher
    The objective of this study was to explore the relationship between local (ie, ocular) complement factor H (CFH) and choroidal neovascularization (CNV) associated with wet age-related macular degeneration (AMD), a leading cause of ..
  7. Coffey P, Gias C, McDermott C, Lundh P, Pickering M, Sethi C, et al. Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction. Proc Natl Acad Sci U S A. 2007;104:16651-6 pubmed
    ..is the most common form of legal blindness in westernized societies, and polymorphisms in the gene encoding complement factor H (CFH) are associated with susceptibility to age-related macular degeneration in more than half of affected ..
  8. Ruseva M, Vernon K, Lesher A, Schwaeble W, Ali Y, Botto M, et al. Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency. J Am Soc Nephrol. 2013;24:43-52 pubmed publisher
    b>Complement factor H (CFH) is a negative regulator of the alternative pathway of complement, and properdin is the sole positive regulator...
  9. Alexander J, Aneziokoro O, Chang A, Hack B, Markaryan A, Jacob A, et al. Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease. J Am Soc Nephrol. 2006;17:1354-61 pubmed
    Plasma complement factor H (Cfh) is a potent complement regulator, whereas Cfh on the surface of rodent platelets is responsible for immune complex processing...

More Information

Publications83

  1. Ufret Vincenty R, Aredo B, Liu X, McMahon A, Chen P, Sun H, et al. Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings. Invest Ophthalmol Vis Sci. 2010;51:5878-87 pubmed publisher
    b>Complement factor H (Cfh) is a key regulator of the alternative complement pathway. A Cfh variant (Y402H) increases the risk for AMD...
  2. Rose K, Paixao Cavalcante D, Fish J, Manderson A, Malik T, Bygrave A, et al. Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. J Clin Invest. 2008;118:608-18 pubmed publisher
  3. Alexander J, Pickering M, Haas M, Osawe I, Quigg R. Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness. J Am Soc Nephrol. 2005;16:52-7 pubmed
    ..C57BL/6 factor H-deficient mice (Cfh(-/-)) and wild-type (wt) controls were immunized daily for 5 wk with heterologous apoferritin to study the chronic ..
  4. Shaw P, Zhang L, Zhang M, Du H, Zhao L, Lee C, et al. Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids. Proc Natl Acad Sci U S A. 2012;109:13757-62 pubmed publisher
    The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD)...
  5. Vik D, Munoz Canoves P, Kozono H, Martin L, Tack B, Chaplin D. Identification and sequence analysis of four complement factor H-related transcripts in mouse liver. J Biol Chem. 1990;265:3193-201 pubmed
    Mouse liver RNA analyzed by Northern blotting with a full-length complement factor H cDNA probe demonstrates the 4.4-kilobase (kb) H mRNA as well as three additional hybridizing species of 3.5, 2.8, and 1.8 kb, respectively...
  6. Hellwage J, Eberle F, Babuke T, Seeberger H, Richter H, Kunert A, et al. Two factor H-related proteins from the mouse: expression analysis and functional characterization. Immunogenetics. 2006;58:883-93 pubmed
    b>Complement factor H-related (FHR) proteins display structural and functional similarities to each other and to the complement regulator factor H (FH)...
  7. Amadi Obi A, Yu C, Dambuza I, Kim S, MARRERO B, Egwuagu C. Interleukin 27 induces the expression of complement factor H (CFH) in the retina. PLoS ONE. 2012;7:e45801 pubmed publisher
    b>Complement factor H (CFH) is a central regulator of the complement system and has been implicated in the etiology of age-related macular degeneration (AMD), a leading cause of blindness in the elderly...
  8. Pickering M, Cook H, Warren J, Bygrave A, Moss J, Walport M, et al. Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet. 2002;31:424-8 pubmed
    ..Here we show that mice deficient in factor H (Cfh(-/-) mice) develop MPGN spontaneously and are hypersensitive to developing renal injury caused by immune complexes...
  9. Faber C, Williams J, Juel H, Greenwood J, Nissen M, Moss S. Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice. Invest Ophthalmol Vis Sci. 2012;53:6324-30 pubmed
    ..Further, a common variant of complement factor H (CFH) confers increased risk of developing AMD...
  10. Cheng Z, Hellwage J, Seeberger H, Zipfel P, Meri S, Jokiranta T. Comparison of surface recognition and C3b binding properties of mouse and human complement factor H. Mol Immunol. 2006;43:972-9 pubmed
    ..Based on the results in this report it is conceptually attractive to establish a murine model for aHUS. ..
  11. Paixao Cavalcante D, Hanson S, Botto M, Cook H, Pickering M. Factor H facilitates the clearance of GBM bound iC3b by controlling C3 activation in fluid phase. Mol Immunol. 2009;46:1942-50 pubmed publisher
    ..Factor H (CFH)-deficient (Cfh(-/-)) mice spontaneously develop C3 deposition along the glomerular basement membrane (GBM) with ..
  12. Goicoechea de Jorge E, Caesar J, Malik T, Patel M, Colledge M, Johnson S, et al. Dimerization of complement factor H-related proteins modulates complement activation in vivo. Proc Natl Acad Sci U S A. 2013;110:4685-90 pubmed publisher
    ..Variation includes genomic rearrangements within the complement factor H-related (CFHR) locus...
  13. Pickering M, de Jorge E, Martinez Barricarte R, Recalde S, Garcia Layana A, Rose K, et al. Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J Exp Med. 2007;204:1249-56 pubmed
    ..glomerulonephritis type II (MPGN2) are associated with polymorphisms or mutations in the FH gene (Cfh), suggesting the existence of a genotype-phenotype relationship...
  14. Weismann D, Hartvigsen K, Lauer N, Bennett K, Scholl H, Charbel Issa P, et al. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 2011;478:76-81 pubmed publisher
    ..Here we identify complement factor H (CFH) as a major MDA-binding protein that can block both the uptake of MDA-modified proteins by macrophages ..
  15. de Jorge E, Macor P, Paixao Cavalcante D, Rose K, Tedesco F, Cook H, et al. The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol. 2011;22:137-45 pubmed publisher
    ..b>Complement factor H (CFH) is the major regulator of complement activation through the alternative pathway...
  16. Fraczek L, Martin C, Martin B. c-Jun and c-Fos regulate the complement factor H promoter in murine astrocytes. Mol Immunol. 2011;49:201-10 pubmed publisher
    ..This regulation is provided by many proteins, including complement factor H (CFH), a critical regulator of the alternative pathway of complement activation...
  17. Mandal M, Ayyagari R. Complement factor H: spatial and temporal expression and localization in the eye. Invest Ophthalmol Vis Sci. 2006;47:4091-7 pubmed
    b>Complement factor H (CFH) is a component of the mammalian complement system, which regulates the alternative pathway of complement activation and protects the host cell from inappropriate complement activation...
  18. Lundh von Leithner P, Kam J, Bainbridge J, Catchpole I, Gough G, Coffey P, et al. Complement factor h is critical in the maintenance of retinal perfusion. Am J Pathol. 2009;175:412-21 pubmed publisher
    ..Recently, age-related macular degeneration was associated with a single-nucleotide substitution of the complement factor H (CFH) gene, part of the alternative pathway of the complement system, a critical element in the innate ..
  19. Fakhouri F, de Jorge E, Brune F, Azam P, Cook H, Pickering M. Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice. Kidney Int. 2010;78:279-86 pubmed publisher
    Total deficiency of complement factor H (CFH) is associated with dense deposit disease and atypical hemolytic uremic syndrome...
  20. Pickering M, Warren J, Rose K, Carlucci F, Wang Y, Walport M, et al. Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice. Proc Natl Acad Sci U S A. 2006;103:9649-54 pubmed
    ..We investigated the role of C5 activation in a model of MPGN that develops spontaneously in complement factor H-deficient mice (Cfh(-/-))...
  21. Meruelo D, Rossomando A, Offer M, Buxbaum J, Pellicer A. Association of endogenous viral loci with genes encoding murine histocompatibility and lymphocyte differentiation antigens. Proc Natl Acad Sci U S A. 1983;80:5032-6 pubmed
  22. Abrera Abeleda M, Xu Y, Pickering M, Smith R, Sethi S. Mesangial immune complex glomerulonephritis due to complement factor D deficiency. Kidney Int. 2007;71:1142-7 pubmed
    ..complement factor D gene and compare these results to mice with targeted deletion of the inhibitory complement factor H gene...
  23. Munoz Canoves P, Tack B, Vik D. Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells. Biochemistry. 1989;28:9891-7 pubmed
    ..To our knowledge, this is the first time that dexamethasone has been shown to increase the levels of a complement protein.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  24. Harada Y, Bonhomme F, Natsuume Sakai S, Tomita T, Moriwaki K. Serological survey of complement factor H in common laboratory and wild mice: a new third allotype. Immunogenetics. 1989;29:148-54 pubmed
    Antigenic specificities of complement factor H from mice were studied serologically. In addition to previously reported allotypes, referred to as H.1 and H.2, a new allotype of complement factor H, H...
  25. Lesher A, Zhou L, Kimura Y, Sato S, Gullipalli D, Herbert A, et al. Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol. 2013;24:53-65 pubmed publisher
    ..These results show that therapeutic manipulation of the complement system requires rigorous disease-specific target validation. ..
  26. Cunea A, Powner M, Jeffery G. Death by color: differential cone loss in the aging mouse retina. Neurobiol Aging. 2014;35:2584-2591 pubmed publisher
    ..Here, cones are examined in young (3-month-old) and aged (12-month-old) C57 mice and also in complement factor H knock out mice (CFH-/-) that have been proposed as a murine model of age-related macular degeneration...
  27. Woodman M, Cooley A, Avdiushko R, Bowman A, Botto M, Wooten R, et al. Roles for phagocytic cells and complement in controlling relapsing fever infection. J Leukoc Biol. 2009;86:727-36 pubmed publisher
    ..However, we found that Cfh(-/-) mice were infected to levels identical to those seen in wild-type mice. Moreover, only a small minority of B...
  28. Renner B, Coleman K, Goldberg R, Amura C, Holland Neidermyer A, Pierce K, et al. The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells. J Immunol. 2010;185:3086-94 pubmed publisher
    ..However, congenital deficiency of Crry or reduced expression of the protein on the basolateral surface of injured cells permits spontaneous complement activation and tubular injury. ..
  29. Matsuda Y, Harada Y, Natsuume Sakai S, Lee K, Shiomi T, Chapman V. Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding. Cytogenet Cell Genet. 1992;61:282-5 pubmed
    ..with these methods the mouse complement factor H gene (cfh) was localized to the terminal portion of the F region of Chromosome 1...
  30. Kristensen T, Tack B. Murine protein H is comprised of 20 repeating units, 61 amino acids in length. Proc Natl Acad Sci U S A. 1986;83:3963-7 pubmed
    ..This finding suggests a common evolutionary origin for regions of these proteins. ..
  31. Kingsmore S, Vik D, Kurtz C, Leroy P, Tack B, Weis J, et al. Genetic organization of complement receptor-related genes in the mouse. J Exp Med. 1989;169:1479-84 pubmed
    ..cross, gene linkage relationships among members of the murine complement receptor-related genes, C4bp, Cfh, Mcry, and Mcr2, were analyzed by segregation of RFLP in 200 mice...
  32. Haywood M, Hogarth M, Slingsby J, Rose S, Allen P, Thompson E, et al. Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice. Arthritis Rheum. 2000;43:349-55 pubmed
    ..SLE in the BXSB mouse model has a complex genetic basis and involves at least 5 distinct intervals located on chromosomes 1 and 3. There is evidence that different intervals affect particular aspects of the SLE phenotype. ..
  33. Keir L, Firth R, Aponik L, Feitelberg D, Sakimoto S, Aguilar E, et al. VEGF regulates local inhibitory complement proteins in the eye and kidney. J Clin Invest. 2017;127:199-214 pubmed publisher
    ..Since complement activation and genetic variants in inhibitory complement factor H (CFH) are also features of both ARMD and TMA, we hypothesized that VEGF and CFH interact...
  34. Elliott R, Romejko C, Hohman C. Mapping the gene for LTW-4, a 26,000 molecular weight major protein of mouse liver and kidney. Mol Gen Genet. 1980;180:17-22 pubmed
    ..4 +/- 2.6, between ald and Ltw-4 7.1 +/- 4.6 cM, and between Ltw-4 and Mls 4.3 +/- 2.0 cM. The strain distribution pattern of Ltw-4 is reported for the SWXL recombinant inbred strains and for a large number of inbred strains of mice. ..
  35. Ding J, Kelly U, Landowski M, Toomey C, Groelle M, Miller C, et al. Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice. Am J Pathol. 2015;185:29-42 pubmed publisher
    b>Complement factor H (CFH) is an important regulatory protein in the alternative pathway of the complement system, and CFH polymorphisms increase the genetic risk of age-related macular degeneration dramatically...
  36. Williams J, Greenwood J, Moss S. Retinal changes precede visual dysfunction in the complement factor H knockout mouse. PLoS ONE. 2013;8:e68616 pubmed publisher
    We previously reported that aged mice lacking complement factor H (CFH) exhibit visual defects and structural changes in the retina...
  37. Vik D, Keeney J, Munoz Canoves P, Chaplin D, Tack B. Structure of the murine complement factor H gene. J Biol Chem. 1988;263:16720-4 pubmed
    ..9 kb, and the average intron size is 4.7 kb. Analysis of the genomic organization of the factor H gene has provided insight into the protein structure and will enable the construction of deletion mutants for functional studies. ..
  38. Miwa T, Nonaka M, Okada N, Wakana S, Shiroishi T, Okada H. Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1. Immunogenetics. 1998;48:363-71 pubmed
    ..Genetic mapping by linkage analysis indicated that the mouse Mcp gene is located on distal chromosome 1, closely linked to the complement receptor 2 (Cr2) gene. ..
  39. Smit McBride Z, Oltjen S, Radu R, Estep J, Nguyen A, Gong Q, et al. Localization of complement factor H gene expression and protein distribution in the mouse outer retina. Mol Vis. 2015;21:110-23 pubmed
    To determine the localization of complement factor H (Cfh) mRNA and its protein in the mouse outer retina...
  40. Atkinson C, He S, Morris K, Qiao F, Casey S, Goddard M, et al. Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation. J Immunol. 2010;185:7007-13 pubmed publisher
    ..Although total complement blockade may be somewhat more efficacious in terms of reducing inflammation, specific blockade of the alternative pathway is likely to be less immunosuppressive in an already immunocompromised recipient. ..
  41. Banda N, Levitt B, Glogowska M, Thurman J, Takahashi K, Stahl G, et al. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J Immunol. 2009;183:5928-37 pubmed publisher
    ..The relative potency of CR2-fH in vitro was superior to mAbs to factor B and C5. Thus, CR2-fH specifically targets and inhibits the AP of complement in vitro and is effective in CAIA in vivo. ..
  42. Seldin M, Morse H, LeBoeuf R, Steinberg A. Establishment of a molecular genetic map of distal mouse chromosome 1: further definition of a conserved linkage group syntenic with human chromosome 1q. Genomics. 1988;2:48-56 pubmed
    ..with seven probes on Southern hybridization combined with data from previous studies suggest the gene order Cfh, Pep-3/Ren-1,2, Ly-5, Lamb-2, At-3, Apoa-2/Ly-17,Spna-1...
  43. Griffiths M, Neal J, Fontaine M, Das T, Gasque P. Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis. J Immunol. 2009;182:4368-77 pubmed publisher
    ..Our data argue for a key regulatory activity of fH in neuroprotection and provide novel therapeutic avenues for CNS chronic inflammatory diseases. ..
  44. Ruseva M, Takahashi M, Fujita T, Pickering M. C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo. Clin Exp Immunol. 2014;176:84-92 pubmed publisher
    ..Our data indicate that MASP-1 and MASP-3 are not essential for alternative pathway activation in complete FH deficiency. ..
  45. Bora N, Kaliappan S, Jha P, Xu Q, Sohn J, Dhaulakhandi D, et al. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. J Immunol. 2006;177:1872-8 pubmed
    ..Thus, specific blockade of the alternative pathway may represent a therapeutically relevant strategy for the inhibition of CNV. ..
  46. Matsuda Y, Shiroishi T, Moriwaki K, Nonaka M, Natsuume Sakai S. Molecular cloning of the b subunit of mouse coagulation factor XIII and assignment of the gene to chromosome 1: close evolutionary relationship to complement factor H. Genomics. 1993;15:535-42 pubmed
    ..In addition, a significant structural similarity between FXIII-b and complement factor H is described.
  47. Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan J, Ljubanovic D, et al. Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury. Kidney Int. 2016;90:109-22 pubmed publisher
    ..However, widespread activation of the alternative pathway reduces injury by depleting the pool of C3 available at any 1 location. ..
  48. Naylor D, Cinader B. Inheritance, hormonal regulation and properties of polymorphic murine antigens Mud1 and Mud2. Int Arch Allergy Appl Immunol. 1970;39:511-39 pubmed
  49. van der Maten E, Westra D, van Selm S, Langereis J, Bootsma H, van Opzeeland F, et al. Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease. J Infect Dis. 2016;213:1820-7 pubmed publisher
    ..Alternative pathway activity is inhibited by complement factor H (FH)...
  50. Rowan S, Weikel K, Chang M, Nagel B, Thinschmidt J, Carey A, et al. Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice. Invest Ophthalmol Vis Sci. 2014;55:492-501 pubmed publisher
    ..Genetic variations in Complement Factor H (CFH), and dietary glycemic index (GI) are major risk factors for AMD...
  51. Takeda K, Thurman J, Tomlinson S, Okamoto M, Shiraishi Y, Ferreira V, et al. The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. J Immunol. 2012;188:661-7 pubmed publisher
    ..Such an agent may be an effective therapy for the treatment of asthma. ..
  52. Sato H, Natsuume Sakai S, Katagiri M, Itakura K. Location of LyM-1 locus on Mus musculus chromosome 1. J Immunogenet. 1981;8:185-9 pubmed
    ..The map distances are estimated to be 12.5 +/- 3.9 for Sas-1 to LyM-1, 6.9 +/- 3.0 for LyM-1 to M1s and 19.4 +/- 4.7 for Sas-1 to M1s. These data clearly indicate that the gene order is Sas-1-LyM-1-M1s on Mus musculus chromosome 1. ..
  53. Natsuume Sakai S, Sudoh K, Kaidoh T, Hayakawa J, Takahashi M. Structural polymorphism of murine complement factor H controlled by a locus located between the Hc and the beta 2M locus on the second chromosome of the mouse. J Immunol. 1985;134:2600-6 pubmed
    ..This was shown by phenotyping the Hc locus and H locus with backcross progenies between A/J (one of strain with H.1) and MoA (one of strain with H.2). The recombination frequency between these two loci was 0.17 +/- 0.046. ..
  54. Szymura J, Taylor B, Klein J. Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse. Biochem Genet. 1982;20:1211-9 pubmed
    ..Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus. ..
  55. Alexander J, Hack B, Jacob A, Chang A, Haas M, Finberg R, et al. Abnormal immune complex processing and spontaneous glomerulonephritis in complement factor H-deficient mice with human complement receptor 1 on erythrocytes. J Immunol. 2010;185:3759-67 pubmed publisher
    Complement receptor 1 (CR1) on human erythrocytes (Es) and complement factor H (CFH) on rodent platelets perform immune adherence, which is a function that allows the processing of immune complexes (ICs) bearing C3 by the mononuclear ..
  56. Tada N, Kimura S, Liu Lam Y, Hammerling U. Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1. Hybridoma. 1983;2:29-38 pubmed
    ..Analysis of BXD and SWXL recombinant inbred strains revealed close linkage between Ly-m22 and Ltw-4 loci on chromosome 1. The estimated recombination frequency is 0.027 +/- 0.081. ..
  57. Soames C, Day A, Sim R. Prediction from sequence comparisons of residues of factor H involved in the interaction with complement component C3b. Biochem J. 1996;315 ( Pt 2):523-31 pubmed
    ..It may be that CPs 3 and 4 interact with C3(NH3) directly, whilst CPs 2 and 5 maintain the correct orientation for CPs 3 and 4 to interact. ..
  58. Morita T, Kubota H, Murata K, Nozaki M, Delarbre C, Willison K, et al. Evolution of the mouse t haplotype: recent and worldwide introgression to Mus musculus. Proc Natl Acad Sci U S A. 1992;89:6851-5 pubmed
    ..Hence, polymorphisms among t haplotypes including lethality factors have accumulated during this short time period independently in each M. musculus subspecies. ..
  59. Zebedee S, Barritt D, Epstein R, Raschke W. Analysis of Ly5 chromosome 1 position using allelic differences and recombinant inbred mice. Eur J Immunogenet. 1991;18:155-63 pubmed
    ..Placement of the Ly5 gene with respect to other characterized markers of mouse chromosome 1 for these recombinant inbred mouse strains shows a gene order of Idh-1:Ity:Pep3:[Ly5, Cfh].
  60. Kane S, Farley T, Gordon E, Estep J, Bender H, Moreno J, et al. Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis. J Immunol. 2017;199:3821-3827 pubmed publisher
    ..In this article, we report that transgenic mice lacking Cfh alleles exhibit delayed peripheral prion accumulation, replication, and pathogenesis and onset of terminal ..
  61. Hoh Kam J, Morgan J, Jeffery G. Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology. Exp Eye Res. 2016;149:116-125 pubmed publisher
    ..interactions and 50% of AMD cases have an association with polymorphisms of the complement system including complement factor H. Here we explore interactions between genetic predisposition and environmental conditions in triggering ..
  62. Woodman M, Cooley A, Miller J, Lazarus J, Tucker K, Bykowski T, et al. Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection. Infect Immun. 2007;75:3131-9 pubmed
    ..burgdorferi and indicate that additional mechanisms are employed by the Lyme disease spirochete to evade complement-mediated killing. ..
  63. Johnson S, Tan L, van der Veen S, Caesar J, Goicoechea de Jorge E, Harding R, et al. Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules. PLoS Pathog. 2012;8:e1002981 pubmed publisher
  64. D EUSTACHIO P, Kristensen T, Wetsel R, Riblet R, Taylor B, Tack B. Chromosomal location of the genes encoding complement components C5 and factor H in the mouse. J Immunol. 1986;137:3990-5 pubmed
    ..We have designated the two loci Cfh and C5, respectively...
  65. Ramaglia V, Hughes T, Donev R, Ruseva M, Wu X, Huitinga I, et al. C3-dependent mechanism of microglial priming relevant to multiple sclerosis. Proc Natl Acad Sci U S A. 2012;109:965-70 pubmed publisher
    ..In summary, C3-dependent microglial priming confers susceptibility to other challenges. Our observations are relevant to progression in MS and other neurological diseases exacerbated by acute insults. ..
  66. Renner B, Ferreira V, Cortes C, Goldberg R, Ljubanovic D, Pangburn M, et al. Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney Int. 2011;80:165-73 pubmed publisher
  67. Mock B, Givol D, D Hoostelaere L, Huppi K, Seldin M, Gurfinkel N, et al. Mapping of the bcl-2 oncogene on mouse chromosome 1. Cytogenet Cell Genet. 1988;47:11-5 pubmed
    ..The co-segregation of bcl-2 alleles with allelic forms of two other chromosome 1 loci, Ren-1,2 and Spna-1, in a set of back-cross progeny, positions bcl-2 7.8 cM centromeric from Ren-1,2. ..
  68. Seldin M, Morse H, Steinberg A. A molecular genetic approach to gld "autoimmune" disease. Curr Top Microbiol Immunol. 1988;137:227-32 pubmed
  69. Hoh Kam J, Lenassi E, Malik T, Pickering M, Jeffery G. Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration. Am J Pathol. 2013;183:480-92 pubmed publisher
    ..These include complement factor H (CFH), a negative regulator of C3 activation...
  70. Alexander J, Chaves L, Chang A, Quigg R. The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. Kidney Int. 2012;82:961-8 pubmed publisher
    ..formation of glomerular immune complexes; however, C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CFH) is absent from the plasma. Here we studied the role for C5a receptor (R) in this setting...
  71. Aredo B, Li T, Chen X, Zhang K, Wang C, Gou D, et al. A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice. Invest Ophthalmol Vis Sci. 2015;56:3427-40 pubmed publisher
    Variants of complement factor H (Cfh) affecting short consensus repeats (SCRs) 6 to 8 increase the risk of age-related macular degeneration...
  72. Toomey C, Kelly U, Saban D, Bowes Rickman C. Regulation of age-related macular degeneration-like pathology by complement factor H. Proc Natl Acad Sci U S A. 2015;112:E3040-9 pubmed publisher
    b>Complement factor H (CFH) is a major susceptibility gene for age-related macular degeneration (AMD); however, its impact on AMD pathobiology is unresolved...
  73. Wilcox F, Hirschhorn L, Taylor B, Womack J, Roderick T. Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme. Biochem Genet. 1979;17:1093-107 pubmed
    ..6 +/- 2.9 cM from the M1s locus on the side distal to the centromere. Test-cross data show the following gene order and recombination percentages: Dip-1 19.0 +/- 3.8% Lp 7.4 +/- 2.2% Akp-1. ..
  74. Ding J, Kelly U, Groelle M, Christenbury J, Zhang W, Bowes Rickman C. The role of complement dysregulation in AMD mouse models. Adv Exp Med Biol. 2014;801:213-9 pubmed publisher
    ..A spectrum of complement dysregulation was modeled on the APOE4 AMD mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation, and by crossing them to soluble-..