Gene Symbol: Cers4
Description: ceramide synthase 4
Alias: 2900019C14Rik, Lass4, Trh1, ceramide synthase 4, LAG1 homolog, ceramide synthase 4, LAG1 longevity assurance homolog 4, TRAM homolog 1, longevity assurance homolog 4, translocating chain-associating membrane protein homolog 1
Riebeling C, Allegood J, Wang E, Merrill A, Futerman A. Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem. 2003;278:43452-9 pubmed
..b>TRH1 or TRH4-overexpression elevated [3H](dihydro)ceramide synthesis from l-[3-3H]serine and the increase was not ..
Venkataraman K, Futerman A. Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?. FEBS Lett. 2002;528:3-4 pubmed
..We speculate that other family members, some of which contain a Hox domain, may also be involved in the synthesis of specific ceramide pools, perhaps explaining the role of longevity assurance genes in regulating development. ..
Ebel P, Imgrund S, Vom Dorp K, Hofmann K, Maier H, Drake H, et al
. Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. Biochem J. 2014;461:147-58 pubmed publisher
..In order to study the role of CerS4, we generated CerS4-deficient mice (Cers4-/-) and CerS4-specific antibodies...
Peters F, Vorhagen S, Brodesser S, Jakobshagen K, BrÃ¼ning J, Niessen C, et al
. Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling. J Invest Dermatol. 2015;135:1501-1509 pubmed publisher
..Here we demonstrate that ceramide synthase 4 (CerS4) is highly expressed in the epidermis of adult mice where it is localized in the interfollicular ..
Mizutani Y, Kihara A, Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J. 2005;390:263-71 pubmed
..In the mouse, there are at least five Lass family members, Lass1, Lass2, Lass4, Lass5 and the hitherto uncharacterized Lass6...
Halasiddappa L, Koefeler H, Futerman A, Hermetter A. Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases. PLoS ONE. 2013;8:e70002 pubmed publisher
..OxLDL elicits the same cellular ceramide and CerS effects. Thus, it is concluded that PGPC and POVPC are active components that contribute to the capacity of this lipoprotein to elevate ceramide levels in macrophages. ..
Sassa T, Hirayama T, Kihara A. Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. J Biol Chem. 2016;291:7477-87 pubmed publisher
..Phosphorylation modestly increased the catalytic activities of CERS4 and -5 and mildly increased those of CERS3 and -6...
Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, et al
. TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Sci Signal. 2017;10: pubmed publisher
..We found that ceramide synthase 4 (CerS4)-generated ceramide stabilized the association between TβRI and the inhibitory factor Smad7, which ..
Maier H, Meixner M, Hartmann D, Sandhoff R, Wang Eckhardt L, Zöller I, et al
. Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem. 2011;286:25922-34 pubmed publisher
..These results underline the importance of the sebaceous glands and suggest a role of specific sebaceous gland or sebum lipids, synthesized by FA2H, in the hair follicle homeostasis. ..