Gene Symbol: Celsr2
Description: cadherin, EGF LAG seven-pass G-type receptor 2
Alias: Adgrc2, EGFL2, Flamingo1, flamingo, mKIAA0279, mfmi1, cadherin EGF LAG seven-pass G-type receptor 2, cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila), flamingo homolog
Species: mouse
Products:     Celsr2

Top Publications

  1. Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, et al. Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci. 2010;13:700-7 pubmed publisher
    ..We found that the planar cell polarity cadherins Celsr2 and Celsr3 control these processes...
  2. Morgan R, El Kadi A, Theokli C. Flamingo, a cadherin-type receptor involved in the Drosophila planar polarity pathway, can block signaling via the canonical wnt pathway in Xenopus laevis. Int J Dev Biol. 2003;47:245-52 pubmed
    The Flamingo gene encodes a seven-pass transmembrane receptor of the cadherin super family and is one of a growing number of components identified as being necessary for the establishment of planar polarity in the Drosophila wing...
  3. Formstone C, Little P. The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development. Mech Dev. 2001;109:91-4 pubmed
    ..These three genes represent vertebrate homologues of flamingo/starry night, recently identified as an essential component of the Drosophila planar cell polarity pathway and ..
  4. Dawe C, Kooistra M, Fairbridge N, Pisio A, McDermid H. Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development. Dev Dyn. 2011;240:372-83 pubmed publisher
    ..The mechanism of Cecr2 action in neurogenesis and inner ear development is likely complex. ..
  5. Shima Y, Copeland N, Gilbert D, Jenkins N, Chisaka O, Takeichi M, et al. Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development. Dev Dyn. 2002;223:321-32 pubmed
    ..To explore the in vivo roles of Fmi homologs in mammals, we previously cloned one of the mouse homologs, mouse flamingo1/Celsr2...
  6. Fong K, Hufnagel R, Khadka V, Corley M, Maunakea A, Fogelgren B, et al. A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016;9:585-96 pubmed publisher
    ..These results indicate that TET1 is an epigenetic determinant for regulating genes that are crucial to closure of the anterior neural tube and its mutation has implications to craniofacial development, as presented by the tuft mouse. ..
  7. Lahousse S, Beall S, Johnson K. Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1. Toxicol Sci. 2006;91:255-64 pubmed
    ..b>Celsr2 is a unique protein that has structural characteristics of both an adhesion molecule and a G protein coupled ..
  8. Crompton L, Du Roure C, Rodriguez T. Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues. Dev Dyn. 2007;236:3137-43 pubmed
    The Drosophila melanogaster proteins Flamingo and Prickle act in the planar cell polarity (PCP) pathway, which is required for acquisition of epithelial polarity in the wing, eye, and epidermis...
  9. Boutin C, Labedan P, Dimidschstein J, Richard F, Cremer H, Andre P, et al. A dual role for planar cell polarity genes in ciliated cells. Proc Natl Acad Sci U S A. 2014;111:E3129-38 pubmed publisher
    ..Loss of either of these signals is associated with specific defects in the cytoskeleton. Our data reveal unreported functions of PCP and provide an integrated view of planar polarization of the brain ciliated cells. ..

More Information


  1. Shima Y, Kengaku M, Hirano T, Takeichi M, Uemura T. Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Dev Cell. 2004;7:205-16 pubmed
    ..analysis using an RNAi system and organotypic brain slice cultures to address the role of a mammalian Flamingo homolog, Celsr2...
  2. Hirai H, Suzuki F, Kurokawa K, Mitsuya K, Matsuda M. Mouse Flamingo1/Celsr2 relates neuronal reorganization of the hypertrophic dentate granule cells after kainate injection. Brain Res. 2003;966:40-6 pubmed
    ..One of them was highly homologous with mouse Flamingo1/Celsr2, suggesting that mouse Flamingo1/Celsr2 is related to the development of hippocampal sclerosis.
  3. Hermle T, Guida M, Beck S, Helmst├Ądter S, Simons M. Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. EMBO J. 2013;32:245-59 pubmed publisher
    ..So far, six PCP core proteins including the transmembrane proteins Frizzled (Fz), Strabismus (Stbm) and Flamingo (Fmi) have been identified. These proteins form asymmetric PCP domains at apical junctions of epithelial cells...
  4. Formstone C, Barclay J, Rees M, Little P. Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9. Mamm Genome. 2000;11:392-4 pubmed
  5. Sugimura R, He X, Venkatraman A, Arai F, Box A, Semerad C, et al. Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell. 2012;150:351-65 pubmed publisher
    ..Here, we show Flamingo (Fmi) and Frizzled (Fz) 8, members of noncanonical Wnt signaling, both express in and functionally maintain ..
  6. Qu Y, Huang Y, Feng J, Alvarez Bolado G, Grove E, Yang Y, et al. Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A. 2014;111:E2996-3004 pubmed publisher
    ..Here, we show that Celsr2 acts redundantly with Celsr3, and that their combined mutation mimics that of Fzd3...
  7. Chai G, Zhou L, Manto M, Helmbacher F, Clotman F, Goffinet A, et al. Celsr3 is required in motor neurons to steer their axons in the hindlimb. Nat Neurosci. 2014;17:1171-9 pubmed publisher
    ..The function of Celsr3 is Fzd3 dependent but Vangl2 independent. Our results provide evidence that the Celsr3-Fzd3 pathway interacts with EphA-ephrinA reverse signaling to guide motor axons in the hindlimb. ..
  8. Usui T, Shima Y, Shimada Y, Hirano S, Burgess R, Schwarz T, et al. Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell. 1999;98:585-95 pubmed
    We identified a seven-pass transmembrane receptor of the cadherin superfamily, designated Flamingo (Fmi), localized at cell-cell boundaries in the Drosophila wing. In the absence of Fmi, planar polarity was distorted...
  9. Tissir F, De Backer O, Goffinet A, Lambert de Rouvroit C. Developmental expression profiles of Celsr (Flamingo) genes in the mouse. Mech Dev. 2002;112:157-60 pubmed
    Celsr, also called Flamingo (Fmi) genes encode proteins of the cadherin superfamily. Celsr cadherins are seven-pass transmembrane proteins with nine cadherin repeats in the extracellular domain, and an anonymous intracellular C-terminus...
  10. Vogel P, Read R, Hansen G, Payne B, Small D, Sands A, et al. Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012;49:166-81 pubmed publisher
    ..The likely underlying cause in the remaining 4 lines (RIKEN 4930444A02, Celsr2, Mboat7, and transgenic FZD3) was not determined, but it is possible that some of these could also have ciliary ..
  11. Vincent J, Skaug J, Scherer S. The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1. DNA Res. 2000;7:233-5 pubmed
  12. Qu Y, Glasco D, Zhou L, Sawant A, Ravni A, Fritzsch B, et al. Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci. 2010;30:9392-401 pubmed publisher
    ..In zebrafish, mutations in planar cell polarity genes celsr2 and frizzled3a block caudal migration of FBM neurons...