Ceacam1

Summary

Gene Symbol: Ceacam1
Description: carcinoembryonic antigen-related cell adhesion molecule 1
Alias: Bgp, Bgp1, C-CAM, CD66a, Cc1, Cea-1, Cea-7, Cea1, Cea7, Hv-2, Hv2, MHVR, MHVR1, Mhv-1, bb-1, mCEA1, mmCGM1, mmCGM1a, mmCGM2, carcinoembryonic antigen-related cell adhesion molecule 1, BGP-1, CEA-related cell adhesion molecule 1, MHV-R, biliary glycoprotein 1, biliary glycoprotein D, carcinoembryonic antigen 1, carcinoembryonic antigen 7, hepatitis virus (MHV-4) susceptibility, hepatitis virus receptor, murine hepatitis virus receptor
Species: mouse
Products:     Ceacam1

Top Publications

  1. Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, et al. The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. J Biol Chem. 1999;274:335-44 pubmed
    Biliary glycoprotein (Bgp, C-CAM, or CD66a) is an immunoglobulin-like cell adhesion molecule and functions as a tumor suppressor protein...
  2. Poy M, Yang Y, Rezaei K, Fernstrom M, Lee A, Kido Y, et al. CEACAM1 regulates insulin clearance in liver. Nat Genet. 2002;30:270-6 pubmed
    We hypothesized that insulin stimulates phosphorylation of CEACAM1 which in turn leads to upregulation of receptor-mediated insulin endocytosis and degradation in the hepatocyte...
  3. Abou Rjaily G, Lee S, May D, Al Share Q, Deangelis A, Ruch R, et al. CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation. J Clin Invest. 2004;114:944-52 pubmed
    Phosphorylation of the cell adhesion protein CEACAM1 increases insulin sensitivity and decreases insulin-dependent mitogenesis in vivo...
  4. Nakajima A, Iijima H, Neurath M, Nagaishi T, Nieuwenhuis E, Raychowdhury R, et al. Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function. J Immunol. 2002;168:1028-35 pubmed
    Carcinoembryonic Ag cell adhesion molecule 1 (CEACAM1) consists of highly related homologs in humans and rodents that are characterized by significant alternate splicing generating isoforms capable of negative intracellular signaling by ..
  5. Leung N, Turbide C, Olson M, Marcus V, Jothy S, Beauchemin N. Deletion of the carcinoembryonic antigen-related cell adhesion molecule 1 (Ceacam1) gene contributes to colon tumor progression in a murine model of carcinogenesis. Oncogene. 2006;25:5527-36 pubmed
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies...
  6. Najjar S, Yang Y, Fernstrom M, Lee S, Deangelis A, Rjaily G, et al. Insulin acutely decreases hepatic fatty acid synthase activity. Cell Metab. 2005;2:43-53 pubmed
    ..FAS activity by inducing phosphorylation of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and its interaction with FAS...
  7. Huang S, Kaw M, Harris M, Ebraheim N, McInerney M, Najjar S, et al. Decreased osteoclastogenesis and high bone mass in mice with impaired insulin clearance due to liver-specific inactivation to CEACAM1. Bone. 2010;46:1138-45 pubmed publisher
    ..Because low bone turnover contributes to decreased bone quality and an increased incidence of fractures, studies on L-SACC1 mice may advance our understanding of altered bone homeostasis in type 2 diabetes. ..
  8. Bickert T, Marshall R, Zhang Z, Ludewig P, Binder M, Klinke A, et al. Acceleration of collateral development by carcinoembryonic antigen-related cell adhesion molecule 1 expression on CD11b/?Gr-1? myeloid cells--brief report. Arterioscler Thromb Vasc Biol. 2012;32:2566-8 pubmed publisher
    ..we demonstrated the relevance for endothelial carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) expression in collateral formation. However, a proarteriogenic role for CEACAM1(+) myeloid cells is unknown...
  9. Pan H, Shively J. Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor. Immunity. 2010;33:620-31 pubmed publisher
    Although carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) is an activation marker for neutrophils and delays neutrophil apoptosis, the role of CEACAM1 in granulopoiesis and neutrophil-dependent host immune responses ..

More Information

Publications75

  1. Han E, Phan D, Lo P, Poy M, Behringer R, Najjar S, et al. Differences in tissue-specific and embryonic expression of mouse Ceacam1 and Ceacam2 genes. Biochem J. 2001;355:417-23 pubmed
    The intercellular adhesion molecule CEACAM1, also known as C-CAM1 (where CAM is cell-adhesion molecule), can function as a tumour suppressor in several carcinomas, including those of the prostate, breast, bladder and colon...
  2. Ludewig P, Sedlacik J, Gelderblom M, Bernreuther C, Korkusuz Y, Wagener C, et al. Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse model for ischemic stroke. Circ Res. 2013;113:1013-22 pubmed publisher
    ..A functional role for the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in the regulation of reperfusion injury has not yet been demonstrated...
  3. Beauchemin N, Kunath T, Robitaille J, Chow B, Turbide C, Daniels E, et al. Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells. Oncogene. 1997;14:783-90 pubmed
    Biliary glycoprotein (Bgp) is a member of the immunoglobulin superfamily and the carcinoembryonic antigen family...
  4. Chen L, Chen Z, Baker K, Halvorsen E, da Cunha A, Flak M, et al. The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 2012;37:930-46 pubmed publisher
    Carcinoembryonic antigen cell adhesion molecule like I (CEACAM1) is expressed on activated T cells and signals through either a long (L) cytoplasmic tail containing immune receptor tyrosine based inhibitory motifs, which provide ..
  5. Daniels E, Letourneau S, Turbide C, Kuprina N, Rudinskaya T, Yazova A, et al. Biliary glycoprotein 1 expression during embryogenesis: correlation with events of epithelial differentiation, mesenchymal-epithelial interactions, absorption, and myogenesis. Dev Dyn. 1996;206:272-90 pubmed
    Biliary glycoprotein (Bgp1), a carcinoembryonic antigen-related family member of the immunoglobulin superfamily, is involved in normal and neoplastic events...
  6. Arabzadeh A, Chan C, Nouvion A, Breton V, Benlolo S, DeMarte L, et al. Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer. Oncogene. 2013;32:849-60 pubmed publisher
    ..Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a cell adhesion molecule with reduced expression in early phases of CRC development and thus functions as a ..
  7. Dveksler G, Dieffenbach C, Cardellichio C, McCuaig K, Pensiero M, Jiang G, et al. Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59. J Virol. 1993;67:1-8 pubmed
    ..C3H, and C57BL/6 expressed transcripts and proteins of the MHVR isoform and/or its splice variants but not the mmCGM2 isoform...
  8. Lu R, Pan H, Shively J. CEACAM1 negatively regulates IL-1? production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog. 2012;8:e1002597 pubmed publisher
    ..Since neutrophils have abundant expression of the ITIM-containing co-receptor CEACAM1 and Gram-negative bacteria such as Neisseria utilize CEACAM1 as a receptor that inhibits inflammation, we ..
  9. Leung N, Turbide C, Balachandra B, Marcus V, Beauchemin N. Intestinal tumor progression is promoted by decreased apoptosis and dysregulated Wnt signaling in Ceacam1-/- mice. Oncogene. 2008;27:4943-53 pubmed publisher
    The carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is downregulated in colonic and intestinal hyperplastic lesions as well as in other cancers, where it functions as a tumor suppressor...
  10. Park S, Cho Y, Kim H, Hong E, Higashimori T, Lee S, et al. Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1. Am J Physiol Endocrinol Metab. 2006;291:E517-24 pubmed
    Mice with liver-specific overexpression of dominant negative phosphorylation-defective S503A-CEACAM1 mutant (L-SACC1) developed chronic hyperinsulinemia resulting from blunted hepatic clearance of insulin, visceral obesity, and glucose ..
  11. Robitaille J, Izzi L, Daniels E, Zelus B, Holmes K, Beauchemin N. Comparison of expression patterns and cell adhesion properties of the mouse biliary glycoproteins Bbgp1 and Bbgp2. Eur J Biochem. 1999;264:534-44 pubmed
    ..The mouse genome contains two very similar Bgp genes, Bgp1 and Bgp2, whereas the human and rat genomes contain only one BGP gene...
  12. Dveksler G, Pensiero M, Cardellichio C, Williams R, Jiang G, Holmes K, et al. Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV. J Virol. 1991;65:6881-91 pubmed
    ..transmembrane domain, and a short intracytoplasmic tail, MHVR1 is closely related to the murine CEA-related clone mmCGM1 (Mus musculus carcinoembryonic antigen gene family member)...
  13. Horst A, Ito W, Dabelstein J, Schumacher U, Sander H, Turbide C, et al. Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo. J Clin Invest. 2006;116:1596-605 pubmed
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a cellular adhesion molecule of the Ig superfamily, is associated with early stages of angiogenesis...
  14. Horst A, Bickert T, Brewig N, Ludewig P, Van Rooijen N, Schumacher U, et al. CEACAM1+ myeloid cells control angiogenesis in inflammation. Blood. 2009;113:6726-36 pubmed publisher
    ..high levels of the myeloid differentiation antigen carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). In experimental cutaneous leishmaniasis in C57BL/6 wild-type (B6.WT) and B6...
  15. Nagaishi T, Pao L, Lin S, Iijima H, Kaser A, Qiao S, et al. SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity. 2006;25:769-81 pubmed
    ..We show that CEACAM1 adhesion molecule isoforms containing a long cytoplasmic domain inhibited multiple T cell functions as a ..
  16. Greicius G, Severinson E, Beauchemin N, Obrink B, Singer B. CEACAM1 is a potent regulator of B cell receptor complex-induced activation. J Leukoc Biol. 2003;74:126-34 pubmed
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1, CD66a) is a member of the immunoglobulin (Ig) superfamily, previously characterized as an adhesion and signaling molecule in epithelial, endothelial, and hematopoietic ..
  17. Iijima H, Neurath M, Nagaishi T, Glickman J, Nieuwenhuis E, Nakajima A, et al. Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1. J Exp Med. 2004;199:471-82 pubmed
    Carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) is a cell surface molecule that has been proposed to negatively regulate T cell function...
  18. Gu A, Zhang Z, Zhang N, Tsark W, Shively J. Generation of human CEACAM1 transgenic mice and binding of Neisseria Opa protein to their neutrophils. PLoS ONE. 2010;5:e10067 pubmed publisher
    Human CEACAM1 is a cell-cell adhesion molecule with multiple functions including insulin clearance in the liver, vasculogenesis in endothelial cells, lumen formation in the mammary gland, and binding of certain human pathogens...
  19. Dai T, Abou Rjaily G, Al Share Q, Yang Y, Fernstrom M, Deangelis A, et al. Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice. J Biol Chem. 2004;279:45155-61 pubmed
    Inactivation of CEACAM1 in L-SACC1 mice by a dominant-negative transgene in liver impairs insulin clearance and increases serum free fatty acid (FFA) levels, resulting in insulin resistance...
  20. Hemmila E, Turbide C, Olson M, Jothy S, Holmes K, Beauchemin N. Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus A59. J Virol. 2004;78:10156-65 pubmed
    ..We have shown that targeted disruption of the Ceacam1a (MHVR) gene resulting in a partial ablation of the protein in mice (p/p mice) led to reduced susceptibility to MHV-A59 ..
  21. Robbins J, Robbins P, Kozak C, Callahan R. The mouse biliary glycoprotein gene (Bgp): partial nucleotide sequence, expression, and chromosomal assignment. Genomics. 1991;10:583-7 pubmed
    ..human carcinoembryonic antigen gene family, was most homologous to the sequence of the human biliary glycoprotein (BGP) gene. Thus, this clone appears to encode a portion of the mouse biliary glycoprotein gene...
  22. Singer B, Scheffrahn I, Heymann R, Sigmundsson K, Kammerer R, Obrink B. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocyt. J Immunol. 2002;168:5139-46 pubmed
    Carcinoembryonic Ag-related cell adhesion molecule 1 (CEACAM1), the primordial carcinoembryonic Ag gene family member, is a transmembrane cell adhesion molecule expressed in leukocytes, epithelia, and blood vessel endothelia in humans ..
  23. Zhou G, Hammarstrom S. Pregnancy-specific glycoprotein (PSG) in baboon (Papio hamadryas): family size, domain structure, and prediction of a functional region in primate PSGs. Biol Reprod. 2001;64:90-9 pubmed
  24. Khairnar V, Duhan V, Maney S, Honke N, Shaabani N, Pandyra A, et al. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Commun. 2015;6:6217 pubmed publisher
    ..Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses...
  25. Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J, Schmidt G, et al. CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo. Oncotarget. 2016;7:63730-63746 pubmed publisher
    We analyzed the molecular basis for carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-controlled inhibition of epithelial-mesenchymal transition (EMT) in a mouse model for mammary adenocarcinoma (WAP-T mice)...
  26. Rueckschloss U, Kuerten S, Ergun S. The role of CEA-related cell adhesion molecule-1 (CEACAM1) in vascular homeostasis. Histochem Cell Biol. 2016;146:657-671 pubmed
    ..Among these molecules, the CEA-related cell adhesion molecule-1 (CEACAM1) is a transmembrane molecule with an extracellular, a transmembrane and a cytoplasmic domain...
  27. Yokomori K, Lai M. Mouse hepatitis virus utilizes two carcinoembryonic antigens as alternative receptors. J Virol. 1992;66:6194-9 pubmed
    ..One of them (1.3 kb) encodes mmCGM1, which has previously been identified as the receptor for MHV, and the other one (0...
  28. Najjar S, Ledford K, Abdallah S, Paus A, Russo L, Kaw M, et al. Ceacam1 deletion causes vascular alterations in large vessels. Am J Physiol Endocrinol Metab. 2013;305:E519-29 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown...
  29. Rahmoun M, Moles J, Pedretti N, Mathieu M, Fremaux I, Raison Peyron N, et al. Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. J Invest Dermatol. 2009;129:671-81 pubmed publisher
    Carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) is a cell-surface glycoprotein, belonging to the carcinoembryonic antigen family, expressed by human neutrophils, epithelial cells, activated T and NK cells...
  30. Solano M, Kowal M, O Rourke G, Horst A, Modest K, Plösch T, et al. Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation. J Clin Invest. 2015;125:1726-38 pubmed publisher
    ..These observations in mice could promote the identification of pregnancies at risk for IUGR and the generation of clinical interventional strategies. ..
  31. Lee S, Heinrich G, Fedorova L, Al Share Q, Ledford K, Fernstrom M, et al. Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. Gastroenterology. 2008;135:2084-95 pubmed publisher
    ..A high-fat diet induces key features of human NASH in insulin-resistant L-SACC1 mice, validating this model as a tool to study the molecular mechanisms of NASH. ..
  32. Peng G, Yang Y, Pasquarella J, Xu L, Qian Z, Holmes K, et al. Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor. J Biol Chem. 2017;292:2174-2181 pubmed publisher
  33. Turbide C, Rojas M, Stanners C, Beauchemin N. A mouse carcinoembryonic antigen gene family member is a calcium-dependent cell adhesion molecule. J Biol Chem. 1991;266:309-15 pubmed
    ..In this paper, we report the characterization of a new mouse family member named mmCGM2; this gene product is highly homologous to the human biliary glycoprotein of the CEA gene family and to a rat ..
  34. Dveksler G, Basile A, Cardellichio C, Beauchemin N, Dieffenbach C, Holmes K. Expression of MHV-A59 receptor glycoproteins in susceptible and resistant strains of mice. Adv Exp Med Biol. 1993;342:267-72 pubmed
  35. Poy M, Ruch R, Fernstrom M, Okabayashi Y, Najjar S. Shc and CEACAM1 interact to regulate the mitogenic action of insulin. J Biol Chem. 2002;277:1076-84 pubmed
    b>CEACAM1, a tumor suppressor (previously known as pp120), is a plasma membrane protein that undergoes phosphorylation on Tyr(488) in its cytoplasmic tail by the insulin receptor tyrosine kinase...
  36. Huang Y, Zhu C, Kondo Y, Anderson A, Gandhi A, Russell A, et al. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015;517:386-90 pubmed publisher
    ..show that TIM-3 is co-expressed and forms a heterodimer with carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on activated T cells and involved in T-cell inhibition...
  37. Mima J, Koshino A, Oka K, Uchida H, Hieda Y, Nohara K, et al. Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation. PLoS ONE. 2013;8:e61653 pubmed publisher
    ..b>Ceacam1 was one of the highly up-regulated genes during palate formation, and this was confirmed by quantitative real-..
  38. McCuaig K, Turbide C, Beauchemin N. mmCGM1a: a mouse carcinoembryonic antigen gene family member, generated by alternative splicing, functions as an adhesion molecule. Cell Growth Differ. 1992;3:165-74 pubmed
    ..family and have cloned a complementary DNA (cDNA) for a mouse carcinoembryonic antigen gene family member (mmCGM1a). Two transcripts expressed in several different adult mouse tissues hybridize to this cDNA, a 1...
  39. Wang Y, Chen Y, Yan Y, Li X, Chen G, He N, et al. Loss of CEACAM1, a Tumor-Associated Factor, Attenuates Post-infarction Cardiac Remodeling by Inhibiting Apoptosis. Sci Rep. 2016;6:21972 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule1 (CEACAM1) is a tumor-associated factor that is known to be involved in apoptosis, but the role of CEACAM1 in cardiovascular disease is unclear...
  40. Jin Y, Lin L, Lin Y, Zheng C. Exogenous carcinoembryonic antigen-related cell adhesion molecule 1 suppresses 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in mice. J Surg Res. 2015;195:113-20 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is known to play an immunomodulatory role in a variety of tumors, but its role in ulcerative colitis (UC) remains to be elucidated...
  41. Park J, Liu B, Chen T, Li H, Hu X, Gao J, et al. Disruption of Nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNS. J Neurosci. 2008;28:12815-9 pubmed publisher
  42. Balasubramanian P, Varde P, Abdallah S, Najjar S, MohanKumar P, MohanKumar S. Differential effects of prenatal stress on metabolic programming in diet-induced obese and dietary-resistant rats. Am J Physiol Endocrinol Metab. 2015;309:E582-8 pubmed publisher
    ..To determine the mechanism underlying the hyperinsulinemia, we measured the levels of CEACAM1 that are responsible for insulin clearance...
  43. Gerstel D, Wegwitz F, Jannasch K, Ludewig P, Scheike K, Alves F, et al. CEACAM1 creates a pro-angiogenic tumor microenvironment that supports tumor vessel maturation. Oncogene. 2011;30:4275-88 pubmed publisher
    We have studied the effects of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) on tumor angiogenesis in murine ductal mammary adenocarcinomas...
  44. Peng G, Sun D, Rajashankar K, Qian Z, Holmes K, Li F. Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor. Proc Natl Acad Sci U S A. 2011;108:10696-701 pubmed publisher
    ..have been confirmed by mutagenesis, providing a structural basis for viral and host specificities of coronavirus/CEACAM1 interactions...
  45. Vassão R, de Franco M, Hartz D, Modolell M, Sippel A, Pereira C. Down-regulation of Bgp1(a) viral receptor by interferon-gamma is related to the antiviral state and resistance to mouse hepatitis virus 3 infection. Virology. 2000;274:278-83 pubmed
    ..The expression of the biliary glycoprotein 1(a) (Bgp1(a), the main virus receptor) decreased only in IFN-gamma-activated A/J mouse macrophages, in ..
  46. Heinrich G, Russo L, Castaneda T, Pfeiffer V, Ghadieh H, Ghanem S, et al. Leptin Resistance Contributes to Obesity in Mice with Null Mutation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1. J Biol Chem. 2016;291:11124-32 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance...
  47. Ramakrishnan S, Khuder S, Al Share Q, Russo L, Abdallah S, Patel P, et al. PPARα (Peroxisome Proliferator-activated Receptor α) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition. J Biol Chem. 2016;291:8121-9 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed at high levels in the hepatocyte, consistent with its role in promoting insulin clearance in liver...
  48. Klaile E, Müller M, Kannicht C, Otto W, Singer B, Reutter W, et al. The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38. J Biol Chem. 2007;282:26629-40 pubmed
    The homophilic cell-cell adhesion receptor CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1, CD66a) acts as a regulator of contact-dependent cell survival, differentiation, and growth...
  49. Wynne F, Ball M, McLellan A, Dockery P, Zimmermann W, Moore T. Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature. Reproduction. 2006;131:721-32 pubmed
    ..However, embryo transfer of wild-type embryos to CD9-deficient females indicates that maternal CD9 is not essential for successful pregnancy. ..
  50. Gu A, Tsark W, Holmes K, Shively J. Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 2009;315:1668-82 pubmed publisher
    b>CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1), a type I transmembrane glycoprotein involved in cell-cell adhesion has been shown to act as an angiogenic factor for mouse and human endothelial cells...
  51. Chen W, Chen H, Yu S, Huang C, Wang T, Chen J, et al. Gene expression profiles in hypoxic preconditioning using cDNA microarray analysis: altered expression of an angiogenic factor, carcinoembryonic antigen-related cell adhesion molecule 1. Shock. 2005;24:124-31 pubmed
    ..The HIF-1/vEGF/CEACAM-1 pathway might be important for hypoxia-induced angiogenesis in the heart during hypoxic preconditioning. ..
  52. Heine M, Nollau P, Masslo C, Nielsen P, Freund B, Bruns O, et al. Investigations on the usefulness of CEACAMs as potential imaging targets for molecular imaging purposes. PLoS ONE. 2011;6:e28030 pubmed publisher
    ..This lack of penetration is probably due to the increased interstitial fluid pressure in tumours caused by the absence of functional lymphatic vessels. ..
  53. Xu E, Dubois M, Leung N, Charbonneau A, Turbide C, Avramoglu R, et al. Targeted disruption of carcinoembryonic antigen-related cell adhesion molecule 1 promotes diet-induced hepatic steatosis and insulin resistance. Endocrinology. 2009;150:3503-12 pubmed publisher
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CC1) is a cell adhesion molecule within the Ig superfamily...
  54. Smith M, Click R, Plagemann P. Control of mouse hepatitis virus replication in macrophages by a recessive gene on chromosome 7. J Immunol. 1984;133:428-32 pubmed
    ..We have identified and mapped a new locus that imparts resistance to productive infection of mouse hepatitis virus MHV(A59) in cultured macrophages. This locus maps 41.5 centimorgans from the albino locus on chromosome 7. ..
  55. Blau D, Turbide C, Tremblay M, Olson M, Letourneau S, Michaliszyn E, et al. Targeted disruption of the Ceacam1 (MHVR) gene leads to reduced susceptibility of mice to mouse hepatitis virus infection. J Virol. 2001;75:8173-86 pubmed
    The CEACAM1 glycoproteins (formerly called biliary glycoproteins; BGP, C-CAM, CD66a, or MHVR) are members of the carcinoembryonic antigen family of cell adhesion molecules...
  56. Zeng F, Baldwin D, Schultz R. Transcript profiling during preimplantation mouse development. Dev Biol. 2004;272:483-96 pubmed
    ..These results validate this hypothesis-generating approach by identifying genes involved in critical biological processes that can be the subject of a more traditional hypothesis-driven approach. ..
  57. Lu S, Kappel L, Charbonneau Allard A, Atallah R, Holland A, Turbide C, et al. Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation. PLoS ONE. 2011;6:e21611 pubmed publisher
    ..b>Carcinoembryonic antigen related cell adhesion molecule 1 (Ceacam1) is a transmembrane glycoprotein found on epithelium, T cells, and many tumors...
  58. Ramakrishna C, Bergmann C, Holmes K, Stohlman S. Expression of the mouse hepatitis virus receptor by central nervous system microglia. J Virol. 2004;78:7828-32 pubmed
    Detection of the mouse hepatitis virus receptor within the central nervous system (CNS) has been elusive. Receptor expression on microglia was reduced during acute infection and restored following immune-mediated virus control...
  59. McCuaig K, Rosenberg M, Nedellec P, Turbide C, Beauchemin N. Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms. Gene. 1993;127:173-83 pubmed
    The biliary glycoprotein (BGP)-encoding gene is a member of the human carcinoembryonic antigen (CEA) gene family...
  60. Deangelis A, Heinrich G, Dai T, Bowman T, Patel P, Lee S, et al. Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes. 2008;57:2296-303 pubmed publisher
    Liver-specific inactivation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) by a dominant-negative transgene (l-SACC1 mice) impaired insulin clearance, caused insulin resistance, and increased hepatic lipogenesis...
  61. Miura T, Travanty E, Oko L, Bielefeldt Ohmann H, Weiss S, Beauchemin N, et al. The spike glycoprotein of murine coronavirus MHV-JHM mediates receptor-independent infection and spread in the central nervous systems of Ceacam1a-/- Mice. J Virol. 2008;82:755-63 pubmed
    ..Thus, the ability of the MHV-JHM spike to mediate mCEACAM1a-independent spread in the brain is likely an important factor in the severe neurovirulence of MHV-JHM in wild-type mice. ..
  62. Williams R, Jiang G, Holmes K. Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins. Proc Natl Acad Sci U S A. 1991;88:5533-6 pubmed
    ..Thus, the MHV receptor is, to our knowledge, the first member of the CEA family of glycoproteins to be identified as a virus receptor. ..
  63. Russo L, Ghadieh H, Ghanem S, Al Share Q, Smiley Z, Gatto Weis C, et al. Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis. J Lipid Res. 2016;57:2163-2175 pubmed
    Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid synthase activity...
  64. Nedellec P, Turbide C, Beauchemin N. Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene. Eur J Biochem. 1995;231:104-14 pubmed
    The mouse biliary glycoprotein 1 gene (bgp1) encodes several multifunctional glycoprotein isoforms. These glycoproteins represent members of the carcinoembryonic antigen (CEA) family which belongs to the immunoglobulin superfamily...
  65. Williams R, Jiang G, Snyder S, Frana M, Holmes K. Purification of the 110-kilodalton glycoprotein receptor for mouse hepatitis virus (MHV)-A59 from mouse liver and identification of a nonfunctional, homologous protein in MHV-resistant SJL/J mice. J Virol. 1990;64:3817-23 pubmed
    ..These results suggest that resistance of SJL/J mice to MHV-A59 may be due to absence or mutation of the virus-binding domain in the nonfunctional receptor homolog in SJL/J mice. ..
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    ..A microarray analysis identified the tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) as a possible SOX9 target gene and we demonstrate here that SOX9 upregulates CEACAM1 in human colonic cells...