Cdc42

Summary

Gene Symbol: Cdc42
Description: cell division cycle 42
Alias: AI747189, AU018915, G25K GTP-binding protein, cell division control protein 42 homolog, cell division cycle 42 homolog
Species: mouse

Top Publications

  1. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
  2. doi Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins
    C Schnack
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Biberach an der Riss, Germany
    Neuroscience 154:1450-7. 2008
  3. doi Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration
    Tim Lämmermann
    Hofschneider Group Leukocyte Migration, Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    Blood 113:5703-10. 2009
  4. pmc Signaling role of Cdc42 in regulating mammalian physiology
    Jaime Melendez
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:2375-81. 2011
  5. pmc Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system
    Jorge A Pereira
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
    J Cell Biol 185:147-61. 2009
  6. pmc Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 103:16520-5. 2006
  7. pmc A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis
    Peter Beemiller
    Cellular and Molecular Biology Graduate Program, and Biophysics Graduate Program, University of Michigan, Ann Arbor, MI, USA
    Mol Biol Cell 21:470-80. 2010
  8. pmc Rho GTPase Cdc42 is essential for B-lymphocyte development and activation
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, OH 45229, USA
    Blood 114:2909-16. 2009
  9. pmc Cdc42 and Gsk3 modulate the dynamics of radial glial growth, inter-radial glial interactions and polarity in the developing cerebral cortex
    Yukako Yokota
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Development 137:4101-10. 2010
  10. doi Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver
    Jolanda van Hengel
    Molecular Cell Biology Unit, VIB, Ghent, Belgium Department of Molecular Biology, Ghent University, Ghent, Belgium
    Gastroenterology 134:781-92. 2008

Research Grants

  1. ANCHORAGE INDEPENDENT GROWTH INDUCED BY CDC42
    Margaret Chou; Fiscal Year: 2004
  2. TRE17 links actin remodeling & vesicle trafficking
    Margaret Chou; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications111 found, 100 shown here

  1. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
    ....
  2. doi Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins
    C Schnack
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Biberach an der Riss, Germany
    Neuroscience 154:1450-7. 2008
    ..with recombinant alpha-synuclein oligomers lead to the identification of several GTPase activating proteins and Cdc42 effector proteins as binding partners...
  3. doi Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration
    Tim Lämmermann
    Hofschneider Group Leukocyte Migration, Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    Blood 113:5703-10. 2009
    ..We here delete the small GTPase Cdc42 in DCs and find that actin flow and actomyosin contraction are still initiated in response to chemotactic cues...
  4. pmc Signaling role of Cdc42 in regulating mammalian physiology
    Jaime Melendez
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:2375-81. 2011
    b>Cdc42 is a member of the Rho GTPase family of intracellular molecular switches regulating multiple signaling pathways involved in actomyosin organization and cell proliferation...
  5. pmc Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system
    Jorge A Pereira
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
    J Cell Biol 185:147-61. 2009
    ..ILK also facilitates axon remyelination, likely by promoting the activation of downstream molecules such as AKT/protein kinase B...
  6. pmc Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly
    Lei Chen
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 103:16520-5. 2006
    ..pathway that establishes this apical-basal polarity of NE is not completely understood, but the Rho-family GTPase Cdc42 may play a critical role because it controls cadherin-based intercellular junctions and cell polarity in many ..
  7. pmc A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis
    Peter Beemiller
    Cellular and Molecular Biology Graduate Program, and Biophysics Graduate Program, University of Michigan, Ann Arbor, MI, USA
    Mol Biol Cell 21:470-80. 2010
    ..phagocytosis by macrophages requires phosphatidylinositol 3-kinase (PI3K) and activation of the Rho-family GTPases Cdc42 and Rac1...
  8. pmc Rho GTPase Cdc42 is essential for B-lymphocyte development and activation
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, OH 45229, USA
    Blood 114:2909-16. 2009
    b>Cdc42 is a member of the Rho GTPase family that has been implicated in several cell functions including proliferation and migration, but its physiologic role needs to be dissected in each cell type...
  9. pmc Cdc42 and Gsk3 modulate the dynamics of radial glial growth, inter-radial glial interactions and polarity in the developing cerebral cortex
    Yukako Yokota
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Development 137:4101-10. 2010
    ..Polarized expression of the cell polarity regulator Cdc42 in radial glia regulates glial endfeet activities and inter-radial glial interactions...
  10. doi Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver
    Jolanda van Hengel
    Molecular Cell Biology Unit, VIB, Ghent, Belgium Department of Molecular Biology, Ghent University, Ghent, Belgium
    Gastroenterology 134:781-92. 2008
    The Rho small guanosine triphosphatase Cdc42 is critical for diverse cellular functions, including regulation of actin organization, cell polarity, intracellular membrane trafficking, transcription, cell-cycle progression, and cell ..
  11. pmc Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination
    Bharesh K Chauhan
    The Visual Systems Group, Children s Hospital Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 136:3657-67. 2009
    ..Formation of filopodia is dependent on the Rho family GTPase Cdc42 and the Cdc42 effector IRSp53 (Baiap2). Loss of filopodia results in reduced lens pit invagination...
  12. pmc Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors
    S R Heynen
    Laboratory for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Switzerland
    Mol Vis 17:2934-46. 2011
    Rho GTPases such as RAS-related C3 botulinum substrate 1 (RAC1) and cell division cycle 42 homolog (S. cerevisiae; CDC42) have been linked to cellular processes including movement, development, and apoptosis...
  13. pmc Developmental expression of three small GTPases in the mouse eye
    Dianne C Mitchell
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX, USA
    Mol Vis 13:1144-53. 2007
    ..To explore this possibility, we examined the expression patterns of three major Rho-GTPases: RhoA, Rac1, and Cdc42 in embryonic, postnatal (one day after birth), and adult (two-month old) mouse eye.
  14. ncbi Activation of endogenous Cdc42 visualized in living cells
    Perihan Nalbant
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Science 305:1615-9. 2004
    Signaling proteins are tightly regulated spatially and temporally to perform multiple functions. For Cdc42 and other guanosine triphosphatases, the subcellular location of activation is a critical determinant of cell behavior...
  15. pmc Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP
    Haein Park
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Mol Biol Cell 20:4500-8. 2009
    b>Cdc42 is a key regulator of the actin cytoskeleton and activator of Wiskott-Aldrich syndrome protein (WASP)...
  16. doi Cadherin-cadherin engagement promotes cell survival via Rac1/Cdc42 and signal transducer and activator of transcription-3
    Rozanne Arulanandam
    Department of Microbiology and Immunology, Department of Pathology and Molecular Medicine, and Cancer Research Institute, Queen s University, Ontario, Canada K7L 3N6
    Mol Cancer Res 7:1310-27. 2009
    ..Most importantly, our results also reveal for the first time an unexpected and dramatic surge in total Rac1 and Cdc42 protein levels triggered by cadherin engagement and an increase in Rac1 and Cdc42 activity, which is responsible ..
  17. doi Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets
    Irina Pleines
    Department of Vascular Medicine, University Clinic, University of Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Wurzburg, Germany
    Blood 115:3364-73. 2010
    ..Cytoskeletal reorganization is essential for platelet activation and secretion. The small GTPase Cdc42 has been implicated as an important mediator of filopodia formation and exocytosis in various cell types, but its ..
  18. pmc The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling
    Kathleen Szczur
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Blood 114:4527-37. 2009
    ..Using a mouse model of high Cdc42 activity, we previously demonstrated the importance of Cdc42 activity in neutrophil migration...
  19. doi Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos
    Anna Bielak-Zmijewska
    Department of Embryology, Institute of Zoology, University of Warsaw, Miecznikowa 1, 02 096 Warsaw, Poland
    Dev Biol 322:21-32. 2008
    b>Cdc42 and Rac1 Rho family GTPases, and their interacting protein IQGAP1 are the key regulators of cell polarity...
  20. pmc A role for Cdc42 in macrophage chemotaxis
    W E Allen
    Muscle and Motility Research Centre, Randall Institute, King s College London WC2B 5RL, UK
    J Cell Biol 141:1147-57. 1998
    Three members of the Rho family, Cdc42, Rac, and Rho are known to regulate the organization of actin-based cytoskeletal structures. In Bac1...
  21. pmc Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
    Linda Yang
    Division of Experimental Hematology and Pathology, Cincinnati Children s Research Foundation, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 104:5091-6. 2007
    ..In a conditional-knockout mouse model, we show that Cdc42(-/-) HSCs enter the active cell cycle, resulting in significantly increased number and frequency of the stem/..
  22. pmc Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:18505-10. 2010
    ..Here we demonstrate that T cell-specific deletion of cell-division cycle 42 (Cdc42) GTPase causes a profound loss of mature T cells...
  23. pmc Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 110:3853-61. 2007
    The Rho GTPase Cdc42 regulates adhesion, migration, and homing, as well as cell cycle progression, of hematopoietic stem cells, but its role in multilineage blood development remains unclear...
  24. ncbi Involvement of the phosphatidylinositol 3-kinase/rac1 and cdc42 pathways in radial migration of cortical neurons
    Daijiro Konno
    Department of Neuroscience D13, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:5082-8. 2005
    ..In the neocortical slice culture, a PI 3-kinase inhibitor suppressed the formation of GTP-bound Rac1 and Cdc42 and radial migration...
  25. pmc Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion
    Zhanxiang Wang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 282:9536-46. 2007
    The small Rho family GTPases Cdc42 and Rac1 have each been shown to function in insulin exocytosis and are presumed to function in actin remodeling and insulin granule mobilization...
  26. pmc Cdc42 is an antihypertrophic molecular switch in the mouse heart
    Marjorie Maillet
    Department of Pediatrics, Division of Molecular Cardiovascular Biology, University of Cincinnati, and Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Clin Invest 119:3079-88. 2009
    ..Here we identify the small GTPase Cdc42 as a signaling intermediate that restrained the cardiac growth response to physiologic and pathologic stimuli...
  27. ncbi Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development
    Xunwei Wu
    University of Copenhagen, Institute of Molecular Pathology, Copenhagen, Denmark
    Dev Dyn 236:2767-78. 2007
    To study the role of Cdc42 in the establishment of epithelial polarity during mammalian development, we generated murine Cdc42-null embryonic stem cells and analyzed peri-implantation development using embryoid bodies (EBs)...
  28. ncbi Cdc42 is implicated in polarity during meiotic resumption and blastocyst formation in the mouse
    Xiang Shun Cui
    National Research Laboratory of Molecular Embryology, Department of Animal Sciences, Chungbuk National University, Seoul, Korea
    Mol Reprod Dev 74:785-94. 2007
    Cell division cycle 42 (Cdc42), a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including: motility, proliferation, apoptosis, and cell morphology...
  29. ncbi Cdc42 and mDia3 regulate microtubule attachment to kinetochores
    Shingo Yasuda
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606 8501, Japan
    Nature 428:767-71. 2004
    ..We now show that one member of this family, Cdc42, and its effector, mDia3, regulate MT attachment to kinetochores.
  30. ncbi Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS
    Tina Thurnherr
    Institute for Cell Biology, Department of Biology, Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 26:10110-9. 2006
    ..Ablation of Cdc42 in cells of the oligodendrocyte lineage did not affect OPC proliferation, directed migration, or in vitro ..
  31. pmc Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Mol Biol Cell 17:4675-85. 2006
    Recent studies in Cdc42 knockout mouse embryonic stem (ES) cells and ES-derived fibroblastoid cell lines raise concern on a body of literature derived by dominant mutant expression approach in a variety of cell lines implicating ..
  32. pmc Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization
    Irina Tskvitaria-Fuller
    Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 177:1708-20. 2006
    ..The Rho family GTPase Cdc42 is a central regulator of cellular polarization...
  33. ncbi Cdc42 regulates cofilin during the establishment of neuronal polarity
    Boyan K Garvalov
    Axonal Growth and Regeneration Group, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Neurosci 27:13117-29. 2007
    ..We analyzed the consequences of loss of Cdc42, a central regulator of polarity in multiple systems, on the polarization of mammalian neurons...
  34. ncbi Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function
    Jie Na
    The Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, United Kingdom
    Curr Biol 16:1249-54. 2006
    ..Here, we show that Cdc42, a key regulator of cytoskeleton and cell polarity in other systems , is essential for meiotic maturation and ..
  35. ncbi Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1
    Frédéric Causeret
    Institut Cochin, GDPM, INSERM U567, CNRS 8104, Universite Paris V, CHU Cochin, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Development 131:2841-52. 2004
    ..axon outgrowth of PCN and prevents nuclei migration toward a netrin 1 source, whereas inhibition of Rac and Cdc42 sub-families impair neurite outgrowth of PCN without affecting migration...
  36. pmc Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development
    Yves Benninger
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 177:1051-61. 2007
    ..We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells...
  37. ncbi Trio controls the mature organization of neuronal clusters in the hindbrain
    Stéphanie Backer
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104, 75014 Paris, France
    J Neurosci 27:10323-32. 2007
    ..Altogether, those results establish a link between Trio activity, the subsequent Rac1 activation, and neuronal clusters organization, as well as a possible recruitment of the Cadherin-11 adhesive receptor to form a complex with Trio...
  38. doi RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Development 140:3139-45. 2013
    ..Although RhoA and Cdc42, members of the Rho family of small GTPases, have been implicated in regulating neuronal migration, their ..
  39. pmc Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice
    Lara Rossi
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Stem Cell 11:302-17. 2012
    ..Finally, we propose recommendations for characterization of HSC function in knockout mice to facilitate cross-study comparisons that would generate a more cohesive picture of HSC biology...
  40. ncbi Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells
    Y Shiraishi
    Department of Molecular Neurobiology, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Neurosci 19:8389-400. 1999
    ..On the other hand, the C-terminal portion of Cupidin bound to Cdc42, a member of Rho family small GTPases, in a GTP-dependent manner in vitro, and Cupidin functionally interacted ..
  41. pmc ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2
    Karina Haebig
    Department of Medical Genetics, Institute of Human Genetics, University of Tuebingen, Tuebingen, Germany
    PLoS ONE 5:e13762. 2010
    ..Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro...
  42. pmc MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity
    Carolina Montenegro-Venegas
    Department of Biology, Universidad de Chile, Santiago, Chile
    Mol Biol Cell 21:3518-28. 2010
    ..Here we show that MAP1B deficiency results in a significant decrease in Rac1 and cdc42 activity and a significant increase in Rho activity...
  43. pmc HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42
    Emhonta Johnson
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 285:29491-501. 2010
    ..ErbB2 induction of migration requires activation of the small GTPases Rac1 and Cdc42. The ability of ErbB2 to activate these small GTPases necessitated expression of p120 catenin, which is itself up-..
  44. pmc Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications
    Xiao Sheng Jiang
    Section on Molecular Dysmorphology, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 19:1347-57. 2010
    ..Phosphorylation of cofilin-1 is regulated by Rho GTPases through Rho-Rock-Limk-Cofilin-1 and Rac/Cdc42-Pak-Limk-Cofilin-1 pathways...
  45. pmc Cdc42 regulates extracellular matrix remodeling in three dimensions
    Nisha S Sipes
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:36469-77. 2011
    ..The Rho GTPase Cdc42 has been shown to regulate cell-ECM interaction in conventional two-dimensional culture conditions by using ..
  46. pmc The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner
    Chang Xie
    The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    J Biol Chem 286:35933-42. 2011
    ..Here, we find that GTP-bound Cdc42 interacts with NPC1L1...
  47. pmc Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis
    Yanmei Qi
    Department of Surgery, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, New Brunswick, 08903 0019, USA
    Arterioscler Thromb Vasc Biol 31:1861-70. 2011
    The goal of this study was to determine the role of Cdc42 in embryonic vasculogenesis and the underlying mechanisms.
  48. doi Rho GTPases in hematopoietic stem/progenitor cell migration
    Wei Liu
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Biol 750:307-19. 2011
    Rho GTPases including RhoA, Rac1, and Cdc42 are a class of intracellular signaling proteins critical for the regulation of cytoskeleton organization, adhesion, and migration...
  49. doi Rab35 regulates neurite outgrowth and cell shape
    Julien Chevallier
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    FEBS Lett 583:1096-101. 2009
    ..Here, we find that Rab35 colocalizes with actin filaments and with Cdc42, Rac1 and RhoA, and that Rab35 can activate Cdc42 both in vivo and in vitro...
  50. pmc The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating rho GTPases
    Brian A Babbin
    Department of Pathology and Laboratory Medicine, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 174:1347-57. 2009
    ..rodentium wild type differentially influenced Rho GTPase activation, suppressed Cdc42 activation, and induced Rho GTPase activation...
  51. pmc Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation
    Dejan M Nikolic
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 282:33405-11. 2007
    ..Because of their role in regulating actin polymerization and cell adhesion, Rac and Cdc42 activation were also examined and shown to be increased via an iPLA(2)- and LOX-dependent pathway...
  52. pmc Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis
    Elma Aflaki
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Austria
    Cell Mol Life Sci 68:3933-47. 2011
    ..organization of the actin cytoskeleton, which is regulated by members of the small Rho GTPase family (RhoA, Cdc42, Rac) that are also important for the regulation of signal transduction pathways...
  53. pmc Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42
    Parisa Sinai
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:11912-7. 2010
    ..Polarization was regulated by Cdc42, a small Rho family GTPase universally critical for cytoskeletal dynamics...
  54. pmc Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e18002. 2011
    b>Cdc42 of the Rho GTPase family has been implicated in cell actin organization, proliferation, survival, and migration but its physiological role is likely cell-type specific...
  55. pmc RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac
    Minzhou Huang
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA
    J Cell Biochem 112:1572-84. 2011
    ..In this study, we show that RhoB is essential for activation and trafficking of the key migratory effectors Cdc42 and Rac in mediating the ability of platelet-derived growth factor (PDGF) to stimulate cell movement...
  56. pmc Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture
    Yongjuan Chen
    Save Sight Institute, The University of Sydney, NSW 2001, Sydney, Australia
    Dev Biol 324:161-76. 2008
    ..Components of the Wnt/Planar Cell Polarity (PCP) pathway were downregulated or inhibited. Taken together this supports a role for Wnt/PCP signaling in orchestrating the complex organization and dynamics of the fiber cell cytoskeleton...
  57. pmc Two novel human NUMB isoforms provide a potential link between development and cancer
    Aldona Karaczyn
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Neural Dev 5:31. 2010
    ..Immunocytochemistry analyses show that NUMB5 and NUMB6 interact and complex with CDC42, vimentin and the CDC42 regulator IQGAP1 (IQ (motif) GTPase activating protein 1)...
  58. ncbi The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach
    P Chavrier
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, F R G
    Gene 112:261-4. 1992
    ..These results confirm that the overall diversity of the Rab and Rho protein subfamilies account for more than thirty different members in mammalian cells...
  59. pmc PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex
    Tsutomu Nakamura
    Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    Genes Dev 22:1244-56. 2008
    ..Here we show that PX-RICS, a beta-catenin-interacting GTPase-activating protein (GAP) for Cdc42, mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex...
  60. pmc Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation
    Jost Leemhuis
    Center for Neuroscience, Albert Ludwigs University, 79104 Freiburg, Germany
    J Neurosci 30:14759-72. 2010
    ..Reelin activates the Rho GTPase Cdc42, known for its role in neuronal morphogenesis and directed migration, in an apolipoprotein E receptor 2-, Disabled-..
  61. doi Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells
    Yidong Shen
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Dev Cell 14:342-53. 2008
    Cdc42GAP promotes inactivation of Cdc42, a small GTPase whose activation at the leading edge by guanine nucleotide exchange factors is critical for cell migration...
  62. ncbi CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase
    Bin Wei
    Molecular Immunology Section, Department of Immunology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    J Immunol 179:400-8. 2007
    ..Polarization required PI3K, the guanine nucleotide exchange factor Vav1, the GTP-binding protein Cdc42, as well as myosin L chain kinase...
  63. ncbi Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development
    David R Natale
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Mech Dev 119:S21-6. 2002
    ..E-cadherin-based cell-to-cell adhesion through interactions with beta-catenin and the Rho GTPases, rac1 and cdc42. Our study demonstrates IQGAP-1,-2, rac-1 and cdc42 mRNAs are present throughout murine preimplantation ..
  64. ncbi The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping
    Z Liu
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    Biochem Genet 37:119-38. 1999
    ..The results together predate the occurrence and signify a conserved function of the erythroid-specific Rh membrane structures...
  65. ncbi c-Jun kinase mediates expression of VEGF induced at transcriptional level by Rac1 and Cdc42Hs but not by RhoA
    M Luisa Saníger
    Departamento de Biologia Experimental, Universidad de Jaen, Campus de las Lagunillas s n, 23071 Jaen, Spain
    J Cell Biochem 98:650-60. 2006
    ..We carried out transient and stable transfection with constitutively activated rhoA, rac1, and cdc42 mutants in COS-7 and NIH3T3 cells, respectively in the absence of external stimuli...
  66. pmc Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin
    Hideki Yamaguchi
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 168:441-52. 2005
    ..expression analyses revealed that neural WASP (N-WASP), Arp2/3 complex, and their upstream regulators, Nck1, Cdc42, and WIP, are necessary for invadopodium formation...
  67. ncbi Molecular cloning and sequencing of rat Cdc42 GTPase cDNA
    J S Han
    Institute of Biomedical Science and Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea
    Exp Mol Med 32:115-9. 2000
    b>Cdc42 is a member of the Rho family of small GTP-ase and plays an important role in intracellular signaling pathways regulating cell morphology, motility and stimulation of DNA synthesis...
  68. pmc Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein
    X R Ren
    Department of Pathology and Cell Adhesion and Matrix Center, Pathology, and Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Cell Biol 152:971-84. 2001
    ..PSGAP is able to increase GTPase activity of CDC42 and RhoA in vitro and in vivo...
  69. pmc Regulation of Cdc42-mediated morphological effects: a novel function for p53
    Gilles Gadea
    Centre de Recherche en Biochimie Macromoleculaire, CNRS UPR1086, IFR 24, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    EMBO J 21:2373-82. 2002
    ..We investigated the overall effect of p53 on morphological changes induced by RhoA, Rac1 and Cdc42 GTPases in mouse embryonic fibroblasts (MEFs)...
  70. ncbi Leishmania donovani promastigotes induce periphagosomal F-actin accumulation through retention of the GTPase Cdc42
    Robert Lodge
    INRS Institut Armand Frappier, 531, boul des Prairies, Laval, Quebec, Canada H7V 1B7
    Cell Microbiol 7:1647-58. 2005
    ..In this study, we addressed the role of the Rho-family GTPases RhoA, Rac1 and Cdc42 in the uptake of L. donovani promastigotes and in the accumulation of periphagosomal F-actin...
  71. pmc N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts
    Sophie Charrasse
    Centre de Recherche de Biochimie Macromoleculaire, 34293 Montpellier Cedex, France
    J Cell Biol 158:953-65. 2002
    ..We propose that cell-cell contacts formed via N-cadherin trigger signaling events that promote the commitment to myogenesis through the positive regulation of RhoA and negative regulation of Rac1, Cdc42Hs, and JNK activities...
  72. ncbi BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain
    Yi Ting Zhou
    Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, The National University of Singapore, Singapore 117543
    Exp Cell Res 303:263-74. 2005
    The Cdc42 small GTPase regulates cytoskeletal reorganization and cell morphological changes that result in cellular extensions, migration, or cytokinesis...
  73. pmc E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation...
  74. ncbi Complete cDNAs for CDC42 from chicken cochlea and mouse liver
    T W Gong
    Kresge Hearing Research Institute, Department of Otolaryngology Head Neck Surgery, Ann Arbor, MI 48109 0648, USA
    Biochim Biophys Acta 1352:282-92. 1997
    b>CDC42 is a member of the ras superfamily of small GTP-binding proteins that are related through the highly conserved GTP-binding domain and are involved in signal transduction pathways...
  75. ncbi MicroRNA-133 controls cardiac hypertrophy
    Alessandra Carè
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, 00161 Rome, Italy
    Nat Med 13:613-8. 2007
    ..We identified specific targets of miR-133: RhoA, a GDP-GTP exchange protein regulating cardiac hypertrophy; Cdc42, a signal transduction kinase implicated in hypertrophy; and Nelf-A/WHSC2, a nuclear factor involved in ..
  76. ncbi The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor
    Song Xiang
    Department of Biochemistry, SUNY Stony Brook, NY 11794 5215, USA
    J Mol Biol 359:35-46. 2006
    ..to the Dbl family of guanine nucleotide exchange factors, occurs in multiple splice variants, and is specific for Cdc42, a small GTPase belonging to the Rho family. The 2...
  77. ncbi Cdc42 is involved in PKCepsilon- and delta-induced neurite outgrowth and stress fibre dismantling
    Ulrika Trollér
    Lund University, Department of Laboratory Medicine, Molecular Medicine, Entrance 78, 3rd Floor, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Biochem Biophys Res Commun 349:91-8. 2006
    ..This was accompanied by stress fibre loss. Here, we have examined the role of the small GTPases, Rac1, and Cdc42, in these PKC-mediated morphological and cytoskeletal changes...
  78. pmc Vav GEFs are required for beta2 integrin-dependent functions of neutrophils
    M Angelica Martinez Gakidis
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 166:273-82. 2004
    ..Thus, Vav proteins are specifically required for stable adhesion. beta2-induced activation of Cdc42, Rac1, and RhoA is defective in Vav1/3ko neutrophils, and phosphorylation of Pyk2, paxillin, and Akt is also ..
  79. ncbi A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis
    Angela K Nevins
    Department of Biochemistry and Molecular Biology and the Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:1944-52. 2005
    ..SNAP) receptor) proteins, and this is coupled to cortical F-actin reorganization via the Rho family GTPase Cdc42 by an unknown mechanism...
  80. ncbi Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Biol Chem 278:16189-97. 2003
    ..Mechanistically, ethanol stimulation activated Cdc42 and produced H(2)O(2) a reactive oxygen species intermediate in SVEC4-10 cells...
  81. ncbi JNK phosphorylation of paxillin, acting through the Rac1 and Cdc42 signaling cascade, mediates neurite extension in N1E-115 cells
    Junji Yamauchi
    Department of Pharmacology, National Research Institute for Child Health and Development, 2 10 1 Oukura, Setagaya, Tokyo 157 8535, Japan
    Exp Cell Res 312:2954-61. 2006
    ..Here we show that c-Jun N-terminal kinase (JNK), which is controlled by Rho GTPases Rac1 and Cdc42, is activated following neurite extension in mouse N1E-115 neuroblastoma cells as a model...
  82. ncbi Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42
    Jun Peng
    Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, 333 Bostwick Avenue, N E, Grand Rapids, MI 49503, USA
    Curr Biol 13:534-45. 2003
    ..p134 mDia2 (Drf3) have been shown to bind in vitro to activated RhoA-C, and Drf3 has also been shown to bind to Cdc42, little is known about the cellular function of these GTPase effector pairs...
  83. ncbi RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling
    Toshio Okabe
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 278:9920-7. 2003
    ..Here we show that beta-catenin interacts with a novel GTPase-activating protein, named RICS, that acts on Cdc42 and Rac1...
  84. ncbi Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells
    In Duk Jung
    College of Medicine, Konyang University, 320 711, Nonsan, South Korea
    FEBS Lett 532:351-6. 2002
    ..ATX activated Cdc42 and Rac1 and increased complex formation between these small G proteins and p21-activated kinase (PAK)...
  85. ncbi Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA
    S K Prakash
    Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 9:477-88. 2000
    ..These results suggest that ARHGAP6 has two independent functions: one as a GAP with specificity for RhoA and the other as a cytoskeletal protein that promotes actin remodeling...
  86. ncbi Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human
    L L Peters
    The Jackson Laboratory, Bar Harbor, Maine, 04609, USA
    Genomics 54:348-50. 1998
    ..All of the mouse genes mapped within or adjacent to regions of conserved synteny with corresponding human chromosomes. We conclude that a set of four paralogous 4.1 genes has been evolutionarily conserved in rodents and primates...
  87. pmc MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
    G R Fanger
    Division of Basic Sciences, National Jewish Medical and Research Center, Denver, CO 80206, USA
    EMBO J 16:4961-72. 1997
    ..In contrast to MEKK2 and 3, MEKK1 and 4 specifically associated with Rac and Cdc42 and kinase-inactive mutants blocked Rac/Cdc42 stimulation of JNK activity...
  88. ncbi Genomic organization and chromosomal location of murine Cdc42
    P W Marks
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genomics 38:13-8. 1996
    b>cdc42 is a member of the rho family of small GTPases, which are implicated as regulators of cellular morphology. To date, one murine and two human cdc42 isoforms have been identified...
  89. ncbi Identification of genes expressed after noise exposure in the chick basilar papilla
    T W Gong
    Kresge Hearing Research Institute, Department of Otolaryngology Head Neck Surgery, University of Michigan Medical School, Ann Arbor 48109 0648, USA
    Hear Res 96:20-32. 1996
    ..delta-subunit of the neuronal-specific Ca2+/calmodulin-regulated protein kinase II; and the GTP-binding protein CDC42, a member of the ras superfamily of G proteins...
  90. ncbi Oncogene ect2 is related to regulators of small GTP-binding proteins
    T Miki
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892
    Nature 362:462-5. 1993
    ..Thus ect2 is a new member of an expanding family, whose products have transforming properties and interact with Rho-like proteins of the Ras superfamily...
  91. pmc Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling
    Yidan D Zhao
    Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Ill 60612, USA
    Circ Res 105:696-704, 8 p following 704. 2009
    ..Little is known about the contribution of bone marrow-derived progenitor cells (BMPCs) in the regulation endothelial barrier function as defined by microvascular permeability alterations at the level of adherens junctions (AJs)...
  92. ncbi Imaging filopodia dynamics in the mouse blastocyst
    Enrique Salas-Vidal
    Departamento de Fisiologia Molecular y Genetica del Desarrollo, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, A P 510 3, Cuernavaca, Morelos 62271, Mexico
    Dev Biol 265:75-89. 2004
    ..We propose that traversing filopodia are employed by mitotic mTE cells to receive the required signals for cell division after they become distant to the ICM...
  93. ncbi Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility
    Stanislav S Kholmanskikh
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Neurosci 9:50-7. 2006
    ..Lis1 deficiency is associated with deregulation of the Rho-family GTPases Cdc42, Rac1 and RhoA, and ensuing actin cytoskeletal defects, but the link between Lis1 and Rho GTPases remains unclear...
  94. ncbi Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 281:17140-9. 2006
    ..Our findings identify beta-catenin as a regulator of APC targeting to membrane clusters and link these two proteins to cell migration...
  95. pmc Critical role of Cdc42 in mediating endothelial barrier protection in vivo
    Ramaswamy Ramchandran
    Department of Pharmacology and the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Am J Physiol Lung Cell Mol Physiol 295:L363-9. 2008
    Activation of the Rho GTPase Cdc42 has been shown in endothelial cell monolayers to prevent disassembly of interendothelial junctions and the increase in endothelial permeability...
  96. pmc Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia
    Nasreen Akhtar
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, United Kingdom
    J Cell Biol 173:781-93. 2006
    ..Rac1 is required downstream of integrins for activation of the PrlR/Stat5 signaling cascade. Cdc42 is also necessary for milk protein synthesis but functions via a distinct mechanism to Rac1...
  97. ncbi Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42
    Nancy Fidyk
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 45:7750-62. 2006
    The small GTPase Cdc42 has been implicated in a number of cellular responses ranging from the regulation of the actin cytoskeletal architecture to intracellular trafficking and cell cycle progression...
  98. doi A dual role for IQGAP1 in regulating exocytosis
    Eric N Rittmeyer
    Department of Microbiology, Cornell University, Ithaca, NY 14853 2703, USA
    J Cell Sci 121:391-403. 2008
    ..We further show that activation of CDC42 GTPase abolishes this association and inhibits secretion in pancreatic beta-cells...
  99. ncbi Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42
    Hiroshi Ueda
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    J Biol Chem 283:1946-53. 2008
    ..Combined expression of Gbetagamma and FLJ00018 significantly induced activation of Rac and Cdc42 but not RhoA...
  100. pmc A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis
    Zaira García
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    EMBO J 25:4740-51. 2006
    ..We analyzed the mechanism by which p85alpha regulates cytokinesis; p85alpha deletion reduced Cdc42 activation in the cleavage furrow and septin 2 accumulation at this site...
  101. ncbi Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis
    Anita Woods
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 282:23500-8. 2007
    ..Additionally, we provide evidence that Cdc42 also promotes chondrogenesis...

Research Grants9

  1. ANCHORAGE INDEPENDENT GROWTH INDUCED BY CDC42
    Margaret Chou; Fiscal Year: 2004
    The underlying hypothesis of the proposed studies is that the ability of activated Cdc42 to induce anchorage-independent growth derives from its effects on cyclin A...
  2. TRE17 links actin remodeling & vesicle trafficking
    Margaret Chou; Fiscal Year: 2009
    Acquisition of a motile, invasive phenotype is a key step in malignant transformation. The Rho family GTPases Cdc42 and Rac1 play a central role in this process by regulating dynamic actin remodeling and vesicular trafficking, ..