Cdc25a

Summary

Gene Symbol: Cdc25a
Description: cell division cycle 25A
Alias: D9Ertd393e, M-phase inducer phosphatase 1, dual specificity phosphatase Cdc25A
Species: mouse
Products:     Cdc25a

Top Publications

  1. Lee G, White L, Hurov K, Stappenbeck T, Piwnica Worms H. Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion. Proc Natl Acad Sci U S A. 2009;106:4701-6 pubmed publisher
    The CDC25 protein phosphatases (CDC25A, B, and C) drive cell cycle transitions by activating key components of the cell cycle engine. CDC25A and CDC25B are frequently overproduced in human cancers...
  2. Ray D, Terao Y, Nimbalkar D, Hirai H, Osmundson E, Zou X, et al. Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice. Cancer Res. 2007;67:6605-11 pubmed
    b>CDC25A phosphatase activates multiple cyclin-dependent kinases (CDK) during cell cycle progression. Inactivation of CDC25A by ubiquitin-mediated degradation is a major mechanism of DNA damage-induced S-G(2) checkpoint...
  3. Iyirhiaro G, Im D, Boonying W, Callaghan S, During M, Slack R, et al. Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo. J Neurosci. 2017;37:6729-6740 pubmed publisher
    ..The major contributor to the death process appears to be Cdc25A. shRNA-mediated knockdown of Cdc25A protects neurons in a delayed model of hypoxia-induced death in vitro ..
  4. Masyuk T, Radtke B, Stroope A, Banales J, Masyuk A, Gradilone S, et al. Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease. Gastroenterology. 2012;142:622-633.e4 pubmed publisher
    ..We investigated the effects of Cdc25A inhibition in mice and rats via genetic and pharmacologic approaches...
  5. Lock L, Wickramasinghe D, Ernst M, Gilbert D, Copeland N, Jenkins N, et al. The Cdc25 genes map to mouse chromosomes 2, 9, and 18. Mamm Genome. 1996;7:771-2 pubmed
  6. Shreeram S, Hee W, Bulavin D. Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis. Mol Cell Biol. 2008;28:7442-50 pubmed publisher
    The cell division cycle 25A (Cdc25A) phosphatase is a critical regulator of cell cycle progression under normal conditions and after stress...
  7. Wickramasinghe D, Becker S, Ernst M, Resnick J, Centanni J, Tessarollo L, et al. Two CDC25 homologues are differentially expressed during mouse development. Development. 1995;121:2047-56 pubmed
    ..comparison of the mouse genes with human CDC25 genes reveal that they are most likely the mouse homologs of human CDC25A and CDC25B respectively...
  8. Motoyama N, Naka K. DNA damage tumor suppressor genes and genomic instability. Curr Opin Genet Dev. 2004;14:11-6 pubmed
  9. Gonzalez C, Dorfman V, Vitullo A. IGF1 regulation of BOULE and CDC25A transcripts via a testosterone-independent pathway in spermatogenesis of adult mice. Reprod Biol. 2015;15:48-55 pubmed publisher
    ..b>CDC25A (a cell cycle regulator) has been proposed as a putative substrate for the RNA-binding proteins of DAZ family...

More Information

Publications43

  1. Ruiz S, Mayor Ruiz C, Lafarga V, Murga M, Vega Sendino M, Ortega S, et al. A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors. Mol Cell. 2016;62:307-313 pubmed publisher
    ..We report here on a genome-wide CRISPR-Cas9 screen that identified CDC25A as a major determinant of sensitivity to ATR inhibition...
  2. Marangos P, Carroll J. Oocytes progress beyond prophase in the presence of DNA damage. Curr Biol. 2012;22:989-94 pubmed publisher
    ..In addition, instead of inhibiting cyclin B-CDK1 through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B...
  3. Wang Z, Wang M, Lazo J, Carr B. Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase. J Biol Chem. 2002;277:19470-5 pubmed
    b>Cdc25A, a dual-specificity protein phosphatase, plays a critical role in cell cycle progression. Although cyclin-dependent kinases are established substrates, Cdc25A may also affect other proteins...
  4. Khaled A, Bulavin D, Kittipatarin C, Li W, Alvarez M, Kim K, et al. Cytokine-driven cell cycling is mediated through Cdc25A. J Cell Biol. 2005;169:755-63 pubmed
    ..dependent on interleukin-3 or interleukin-7, or primary lymphocytes dependent on interleukin 7, the phosphatase Cdc25A is the critical mediator of proliferation...
  5. Fernandez Vidal A, Mazars A, Gautier E, Prevost G, Payrastre B, Manenti S. Upregulation of the CDC25A phosphatase down-stream of the NPM/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation. Cell Cycle. 2009;8:1373-9 pubmed
    Here, we demonstrate that the expression of the dual specificity phosphatase CDC25A, a key regulator of cell cycle progression, is deregulated in Ba/F3 cells expressing the oncogenic protein NPM/ALK and in human cell lines derived from ..
  6. Nguyen D, Westbrook T, McCance D. Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest. J Virol. 2002;76:619-32 pubmed
    ..Most pathways that govern cell growth converge on downstream effectors. Among these is the cdc25A tyrosine phosphatase...
  7. Lee G, Origanti S, White L, Sun J, Stappenbeck T, Piwnica Worms H. Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells. PLoS ONE. 2011;6:e15561 pubmed publisher
    ..Humans and mice encode three family members denoted CDC25A, -B and -C and genes encoding these family members can be disrupted individually with minimal phenotypic ..
  8. Ray D, Kiyokawa H. CDC25A levels determine the balance of proliferation and checkpoint response. Cell Cycle. 2007;6:3039-42 pubmed
    Current evidence suggests that CDC25A is not only a major regulator of both G(1)/S and G(2)/M transition during unperturbed cell cycle progression, but also a critical checkpoint mediator...
  9. Ray D, Kiyokawa H. CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability. Cancer Res. 2008;68:1251-3 pubmed publisher
    b>CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers...
  10. Mitchem K, Hibbard E, Beyer L, Bosom K, Dootz G, Dolan D, et al. Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6. Hum Mol Genet. 2002;11:1887-98 pubmed
    ..The spinner mutant is thus a valuable model for insight into mechanisms of human deafness and development of sensory cell function. ..
  11. Yanagida J, Hammiller B, Al Matouq J, Behrens M, Trempus C, Repertinger S, et al. Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A-deficient skin. Carcinogenesis. 2012;33:1754-61 pubmed publisher
    Cell division cycle 25A (CDC25A) is a dual-specificity phosphatase that removes inhibitory phosphates from cyclin-dependent kinases, allowing cell-cycle progression...
  12. Hardiman G, Jenkins N, Copeland N, Gilbert D, Garcia D, Naylor S, et al. Genetic structure and chromosomal mapping of MyD88. Genomics. 1997;45:332-9 pubmed
    ..The broad expression pattern demonstrates that mouse MyD88 expression is not restricted to cells of myeloid lineage as was originally believed. ..
  13. Li M, Yin S, Yuan J, Wei L, Ai J, Hou Y, et al. Cdc25A promotes G2/M transition in oocytes. Cell Cycle. 2008;7:1301-2 pubmed
  14. Dackor J, Strunk K, Wehmeyer M, Threadgill D. Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos. Placenta. 2007;28:1211-8 pubmed
    ..fewer numbers of bromodeoxyuridine (BrdU) positive trophoblast were observed in Egfr nullizygous placentas and Cdc25a and Myc, genes associated with proliferation, were significantly down-regulated in null placentas...
  15. Masyuk T, Lee S, Radtke B, Stroope A, Huang B, Banales J, et al. Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression. Am J Pathol. 2014;184:110-21 pubmed publisher
    ..cholangiocytes, the effects of centrosomal abnormalities on ciliogenesis, and the role of the cell-cycle regulator Cdc25A in centrosomal defects by depleting cholangiocytes of Cdc25A in vitro and in vivo and evaluating centrosome ..
  16. Bhowmick N, Ghiassi M, Aakre M, Brown K, Singh V, Moses H. TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest. Proc Natl Acad Sci U S A. 2003;100:15548-53 pubmed
    ..translocation to the nucleus and inhibitory phosphorylation of the cyclin-dependent kinase-activating phosphatase, Cdc25A. The resultant suppression of Cdk2 activity contributes to G1/S inhibition in NMuMG cells...
  17. Hashimoto H, Nishino A, Shintani N, Hagihara N, Copeland N, Jenkins N, et al. Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor. Genomics. 1999;58:90-3 pubmed
    ..The mouse Vipr1 gene is encoded by a single gene, which was mapped to the distal region of mouse chromosome 9. This region is syntenic with human chromosome 3p, where the human VPAC1 receptor gene has been mapped. ..
  18. Oh J, Susor A, Schindler K, Schultz R, Conti M. Cdc25A activity is required for the metaphase II arrest in mouse oocytes. J Cell Sci. 2013;126:1081-5 pubmed publisher
    ..Here, we show that a dynamic equilibrium of Cdk1 phosphorylation is required to maintain MII arrest. When the Cdc25A phosphatase is downregulated, mouse oocytes are released from MII arrest and MPF becomes inactivated...
  19. Jaime M, Pujol M, Serratosa J, Pantoja C, Canela N, Casanovas O, et al. The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers. Hepatology. 2002;35:1063-71 pubmed
    ..of CDK2, cyclin E, and p27(Kip1) were similar in both wild-type and p21(Cip1-/-) mice, those of the activator CDC25A were much higher in p21(Cip1-/-) quiescent and regenerating livers than in wild-type animals...
  20. van der Laan S, Tsanov N, Crozet C, Maiorano D. High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency. Mol Cell. 2013;52:366-79 pubmed publisher
    ..DNA damage blocks S phase entry by inhibiting the CDK2 kinase through destruction of its activator, the Cdc25A phosphatase. We observed high Cdc25A levels in G1 that persist even after DNA damage in mouse ESCs...
  21. Kittipatarin C, Li W, Durum S, Khaled A. Cdc25A-driven proliferation regulates CD62L levels and lymphocyte movement in response to interleukin-7. Exp Hematol. 2010;38:1143-56 pubmed publisher
    ..supraphysiological doses, we investigated the mechanism by which the IL-7 proliferative signal transduced through Cdc25A, a key activator of cyclin-dependent kinases, could modulate lymphocyte movement...
  22. Chang K, Vincent F, Shah K. Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death. J Cell Sci. 2012;125:5124-37 pubmed publisher
    ..Using a chemical genetic approach, we identified Cdc25A, Cdc25B and Cdc25C as direct Cdk5 substrates in mouse brain lysates...
  23. Solc P, Saskova A, Baran V, Kubelka M, Schultz R, Motlik J. CDC25A phosphatase controls meiosis I progression in mouse oocytes. Dev Biol. 2008;317:260-9 pubmed publisher
    CDK1 is a pivotal regulator of resumption of meiosis and meiotic maturation of oocytes. CDC25A/B/C are dual-specificity phosphatases and activate cyclin-dependent kinases (CDKs)...
  24. Zhang Y, Qu D, Morris E, O Hare M, Callaghan S, Slack R, et al. The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin. J Neurosci. 2006;26:8819-28 pubmed
    ..However, the mechanism by which CDKs are activated in this model is unclear. The cell division cycle 25A (Cdc25A) phosphatase is a critical regulator of cell cycle CDKs in proliferating cells...
  25. Otto T, Candido S, Pilarz M, Sicinska E, Bronson R, Bowden M, et al. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017;114:10660-10665 pubmed publisher
    ..These results demonstrate that miRNA-mediated repression of the cell cycle is required to allow epithelial cell differentiation. ..
  26. Cozma D, Lukes L, Rouse J, Qiu T, Liu E, Hunter K. A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiers. Genome Res. 2002;12:969-75 pubmed
    ..Among the genes identified by this method were the cell cycle-associated genes Cdc25A and c-Myc, both of which have been implicated in breast cancer...
  27. Paskind M, Johnston C, Epstein P, Timm J, Wickramasinghe D, Belanger E, et al. Structure and promoter activity of the mouse CDC25A gene. Mamm Genome. 2000;11:1063-9 pubmed
    b>CDC25A is a member of a group of highly related, dual-specificity phosphatases that promote cell cycle phase transitions by regulating the activity of cyclin-dependent kinases...
  28. Su Y, Sugiura K, Sun F, Pendola J, Cox G, Handel M, et al. MARF1 regulates essential oogenic processes in mice. Science. 2012;335:1496-9 pubmed publisher
    ..Therefore MARF1, by suppressing levels of specific transcripts, is an essential regulator of important oogenic processes leading to female fertility and the development of healthy offspring. ..
  29. Ray D, Terao Y, Nimbalkar D, Chu L, Donzelli M, Tsutsui T, et al. Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner. Mol Cell Biol. 2005;25:3338-47 pubmed
    Ubiquitin-dependent degradation of Cdc25A is a major mechanism for damage-induced S-phase checkpoint...
  30. Houlihan S, Feng Y. The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. elife. 2014;3:e03297 pubmed publisher
    ..These findings suggest that NDE1-mediated heterochromatin replication is indispensible for neuronal differentiation, and that the loss of NDE1 function may lead to genomic neurological disorders. ..
  31. Gariboldi M, Sturani E, Canzian F, De Gregorio L, Manenti G, Dragani T, et al. Genetic mapping of the mouse CDC25Mm gene, a ras-specific guanine nucleotide-releasing factor, to chromosome 9. Genomics. 1994;21:451-3 pubmed
  32. Sarkar S, Dey B, Dutta A. MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A. Mol Biol Cell. 2010;21:2138-49 pubmed publisher
    ..These microRNAs down-regulate Cdc25A, the phosphatase responsible for removing inhibitory phosphorylation of cdk2, both in myoblasts differentiating ..
  33. Koledova Z, Kafkova L, Krämer A, Divoky V. DNA damage-induced degradation of Cdc25A does not lead to inhibition of Cdk2 activity in mouse embryonic stem cells. Stem Cells. 2010;28:450-61 pubmed publisher
    ..In the presence of DNA damage, Cdk2 kinase activity is abrogated by a deficiency of Cdc25A phosphatase, which is marked by Chk1/Chk2 for proteasomal degradation...
  34. Melkun E, Pilione M, Paulson R. A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells. Blood. 2002;100:3804-11 pubmed
    ..by a gene linked to, but distinct from, Fv2, and suggest that this gene is the dual-specific protein phosphatase Cdc25A, which regulates the G1- to S-phase transition of the cell cycle...